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Article: A new asymmetric synthesis of the anti-tumor alkaloid (R)-(+)-crispine A.

Allin, Steven M / Gaskell, Sean N / Towler, Joannah M R / Page, Philip C Bulman / Saha, Basu / McKenzie, Michael J / Martin, William P

The Journal of organic chemistry

2007 Volume 72, Issue 23, Page(s) 8972–8975

Abstract: We report a novel, facile, and asymmetric approach for the synthesis of the anti-tumor alkaloid (+)-crispine A via a highly diastereoselective N-acyliminium cyclization reaction as a key synthetic step. ...

Abstract	We report a novel, facile, and asymmetric approach for the synthesis of the anti-tumor alkaloid (+)-crispine A via a highly diastereoselective N-acyliminium cyclization reaction as a key synthetic step.
MeSH term(s)	Alkaloids/chemical synthesis ; Alkaloids/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Isoquinolines/chemical synthesis ; Isoquinolines/chemistry ; Magnetic Resonance Spectroscopy/methods ; Magnetic Resonance Spectroscopy/standards ; Molecular Conformation ; Reference Standards ; Stereoisomerism
Chemical Substances	Alkaloids ; Antineoplastic Agents ; Isoquinolines ; crispine A
Language	English
Publishing date	2007-11-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/jo071235x
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Zs.A 4473: Show issues

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Article ; Online: Spontaneous intraperitoneal haemorrhage of the gastric vessels.

Wagner, Benjamin A / Harris, Dwight D / Shalvoy, Matthew R / Bulman, Julie C

BMJ case reports

2022 Volume 15, Issue 10

Abstract: A male in his 70s presented to the emergency department with sudden-onset abdominal pain and syncope. While in the emergency department, he developed worsening hypotension and anaemia. A CT angiogram was suggestive of abdominal apoplexy (spontaneous ... ...

Abstract	A male in his 70s presented to the emergency department with sudden-onset abdominal pain and syncope. While in the emergency department, he developed worsening hypotension and anaemia. A CT angiogram was suggestive of abdominal apoplexy (spontaneous intraperitoneal haemorrhage), which was treated successfully with embolisation of the bleeding vessels. Spontaneous bleeding was thought to be related to his initiation of apixaban 1 week previously. The patient made an excellent recovery and was transitioned back to oral anticoagulation.
MeSH term(s)	Male ; Humans ; Hemoperitoneum/diagnostic imaging ; Hemoperitoneum/etiology ; Hemoperitoneum/therapy ; Abdominal Pain/etiology ; Abdomen ; Angiography ; Anticoagulants
Chemical Substances	Anticoagulants
Language	English
Publishing date	2022-10-19
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2022-250730
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Article ; Online: True Costs of Uterine Artery Embolization: Time-Driven Activity-Based Costing in Interventional Radiology Over a 3-Year Period.

Bulman, Julie C / Kim, Nicole H / Kaplan, Robert S / Schroeppel DeBacker, Sarah E / Brook, Olga R / Sarwar, Ammar

Journal of the American College of Radiology : JACR

2024 Volume 21, Issue 5, Page(s) 721–728

Abstract: Purpose: The aim of this study is to uncover potential areas for cost savings in uterine artery embolization (UAE) using time-driven activity-based costing, the most accurate costing methodology for direct health care system costs.: Methods: One ... ...

Abstract	Purpose: The aim of this study is to uncover potential areas for cost savings in uterine artery embolization (UAE) using time-driven activity-based costing, the most accurate costing methodology for direct health care system costs. Methods: One hundred twenty-three patients who underwent outpatient UAE for fibroids or adenomyosis between January 2020 and December 2022 were retrospectively reviewed. Utilization times were captured from electronic health record time stamps and staff interviews using validated techniques. Capacity cost rates were estimated using institutional data and manufacturer proxy prices. Costs were calculated using time-driven activity-based costing for personnel, equipment, and consumables. Differences in time utilization and costs between procedures by an interventional radiology attending physician only versus an interventional radiology attending physician and trainee were additionally performed. Results: The mean total cost of UAE was $4,267 ± $1,770, the greatest contributor being consumables (51%; $2,162 ± $811), followed by personnel (33%; $1,388 ± $340) and equipment (7%; $309 ± $96). Embolic agents accounted for the greatest proportion of consumable costs, accounting for 51% ($1,273 ± $789), followed by vascular devices (15%; $630 ± $143). The cost of embolic agents was highly variable, driven mainly by the number of vials (range 1-19) of tris-acryl gelatin particles used. Interventional radiology attending physician only cases had significantly lower personnel costs ($1,091 versus $1,425, P = .007) and equipment costs ($268 versus $317, P = .007) compared with interventional radiology attending physician and trainee cases, although there was no significant difference in mean overall costs ($3,640 versus $4,386; P = .061). Conclusions: Consumables accounted for the majority of total cost of UAE, driven by the cost of embolic agents and vascular devices.
MeSH term(s)	Humans ; Female ; Uterine Artery Embolization/economics ; Retrospective Studies ; Leiomyoma/therapy ; Leiomyoma/economics ; Leiomyoma/diagnostic imaging ; Adult ; Radiology, Interventional/economics ; Middle Aged ; Uterine Neoplasms/therapy ; Uterine Neoplasms/economics ; Uterine Neoplasms/diagnostic imaging ; Health Care Costs/statistics & numerical data ; Cost Savings ; Radiography, Interventional/economics
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2274861-1
ISSN	1558-349X ; 1546-1440
ISSN (online)	1558-349X
ISSN	1546-1440
DOI	10.1016/j.jacr.2024.01.002
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Zs.A 6636: Show issues

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Article ; Online: Insect phylogeny structures the bacterial communities in the microbiome of psyllids (Hemiptera: Psylloidea) in Aotearoa New Zealand.

Martoni, Francesco / Bulman, Simon R / Piper, Alexander M / Pitman, Andrew / Taylor, Gary S / Armstrong, Karen F

PloS one

2023 Volume 18, Issue 5, Page(s) e0285587

Abstract: The bacterial microbiome of psyllids has been studied for decades, with a strong focus on the primary and secondary endosymbionts capable of providing essential amino acids for the insects' diet and therefore playing a key role in the insects' ability to ...

Abstract	The bacterial microbiome of psyllids has been studied for decades, with a strong focus on the primary and secondary endosymbionts capable of providing essential amino acids for the insects' diet and therefore playing a key role in the insects' ability to radiate on novel plant hosts. Here, we combine metabarcoding analysis of the bacterial communities hosted by psyllids with a multi-gene phylogenetic analysis of the insect hosts to determine what factors influence the bacterial diversity of the psyllids' microbiomes, especially in the context of the dispersal and evolutionary radiation of these insects in Aotearoa New Zealand. Using multi-gene phylogenetics with COI, 18S and EF-1α sequences from 102 psyllid species, we confirmed for the first time monophyly for all the six genera of native/endemic Aotearoa New Zealand psyllids, with indications that they derive from at least six dispersal events to the country. This also revealed that, after its ancestral arrival, the genus Powellia has radiated onto a larger and more diverse range of plants than either Psylla or Ctenarytaina, which is uncommon amongst monophyletic psyllids globally. DNA metabarcoding of the bacterial 16S gene here represents the largest dataset analysed to date from psyllids, including 246 individuals from 73 species. This provides novel evidence that bacterial diversity across psyllid species is strongly associated with psyllid phylogenetic structure, and to a lesser degree to their host plant association and geographic distribution. Furthermore, while the strongest co-phylogenetic signals were derived from the primary and secondary symbionts, a signal of phylosymbiosis was still retained among the remaining taxa of the bacterial microbiome, suggesting potential vertical transmission of bacterial lineages previously unknown to have symbiotic roles.
MeSH term(s)	Humans ; Animals ; Phylogeny ; Hemiptera/genetics ; New Zealand ; Bacteria/genetics ; Plants ; Symbiosis/genetics ; Microbiota/genetics
Language	English
Publishing date	2023-05-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0285587
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Article ; Online: Research Consensus Panel Follow-Up: A Systematic Review and Update on Cost Research in IR.

Bulman, Julie C / Malik, Muhammad Saad / Lindquester, Will / Hawkins, C Matthew / Liu, Raymond / Sarwar, Ammar

Journal of vascular and interventional radiology : JVIR

2023 Volume 34, Issue 7, Page(s) 1115–1125.e17

Abstract: Purpose: To systematically review cost research in interventional radiology (IR) published since the Society of Interventional Radiology Research Consensus Panel on Cost in December 2016.: Materials and methods: A retrospective assessment of cost ... ...

Abstract	Purpose: To systematically review cost research in interventional radiology (IR) published since the Society of Interventional Radiology Research Consensus Panel on Cost in December 2016. Materials and methods: A retrospective assessment of cost research in adult and pediatric IR since December 2016 to July 2022 was conducted. All cost methodologies, service lines, and IR modalities were screened. Analyses were reported in a standardized fashion to include service lines, comparators, cost variables, analytical processes, and databases used. Results: There were 62 studies published, with most from the United States (58%). Incremental cost-effectiveness ratio, quality-adjusted life-years, and time-driven activity-based costing (TDABC) analyses were performed in 50%, 48%, and 10%, respectively. The most frequently reported service line was interventional oncology (21%). No studies on venous thromboembolism, biliary, or IR endocrine therapies were found. Cost reporting was heterogeneous owing to varying cost variables, databases, time horizons, and willingness-to-pay (WTP) thresholds. IR therapies were more cost-effective than their non-IR counterparts for treating hepatocellular carcinoma ($55,925 vs $211,286), renal tumors ($12,435 vs $19,399), benign prostatic hyperplasia ($6,464 vs $9,221), uterine fibroids ($3,772 vs $6,318), subarachnoid hemorrhage ($1,923 vs $4,343), and stroke ($551,159 vs $577,181). TDABC identified disposable costs contributing most to total IR costs: thoracic duct embolization (68%), ablation (42%), chemoembolization (30%), radioembolization (80%), and venous malformations (75%). Conclusions: Although much of the contemporary cost-based research in IR aligned with the recommendations by the Research Consensus Panel, gaps remained in service lines, standardization of methodology, and addressing high disposable costs. Future steps include tailoring WTP thresholds to nation and health systems, cost-effective pricing for disposables, and standardizing cost sourcing methodology.
MeSH term(s)	Adult ; Humans ; Child ; Cost-Benefit Analysis ; Radiology, Interventional ; Consensus ; Retrospective Studies
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	1137756-2
ISSN	1535-7732 ; 1051-0443
ISSN (online)	1535-7732
ISSN	1051-0443
DOI	10.1016/j.jvir.2023.03.001
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Zs.A 3720: Show issues

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Article ; Online: Inoculum effect of β-lactam antibiotics.

Lenhard, Justin R / Bulman, Zackery P

The Journal of antimicrobial chemotherapy

2019 Volume 74, Issue 10, Page(s) 2825–2843

Abstract: The phenomenon of attenuated antibacterial activity at inocula above those utilized for susceptibility testing is referred to as the inoculum effect. Although the inoculum effect has been reported for several decades, it is currently debatable whether ... ...

Abstract	The phenomenon of attenuated antibacterial activity at inocula above those utilized for susceptibility testing is referred to as the inoculum effect. Although the inoculum effect has been reported for several decades, it is currently debatable whether the inoculum effect is clinically significant. The aim of the present review was to consolidate currently available evidence to summarize which β-lactam drug classes demonstrate an inoculum effect against specific bacterial pathogens. Review of the literature showed that the majority of studies that evaluated the inoculum effect of β-lactams were in vitro investigations of Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Haemophilus influenzae and Staphylococcus aureus. Across all five pathogens, cephalosporins consistently displayed observable inoculum effects in vitro, whereas carbapenems were less susceptible to an inoculum effect. A handful of animal studies were available that validated that the in vitro inoculum effect translates into attenuated pharmacodynamics of β-lactams in vivo. Only a few clinical investigations were available and suggested that an in vitro inoculum effect of cefazolin against MSSA may correspond to an increased likeliness of adverse clinical outcomes in patients receiving cefazolin for bacteraemia. The presence of β-lactamase enzymes was the primary mechanism responsible for an inoculum effect, but the observation of an inoculum effect in multiple pathogens lacking β-lactamase enzymes indicates that there are likely multiple mechanisms that may result in an inoculum effect. Further clinical studies are needed to better define whether interventions made in the clinic in response to organisms displaying an in vitro inoculum effect will optimize clinical outcomes.
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacterial Load ; Disease Models, Animal ; Gram-Negative Bacteria/drug effects ; Gram-Negative Bacteria/enzymology ; Gram-Negative Bacterial Infections/drug therapy ; Hydrolysis ; Microbial Sensitivity Tests/methods ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/enzymology ; Treatment Outcome ; beta-Lactamases/metabolism ; beta-Lactams/pharmacokinetics ; beta-Lactams/pharmacology ; beta-Lactams/therapeutic use
Chemical Substances	Anti-Bacterial Agents ; beta-Lactams ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2019-06-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkz226
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Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Show issues

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Article ; Online: Clinical assessment of the fetal right Quantitative Lung Index.

Kontopoulos, Eftichia / Bulman, Mikaela / Gordienko, Irina / Rodriguez, Maria Jose / Gallardo, Manuel / Copado, Yazmin / Acevedo, Sandra / Quintero, Luis / Quintero, Ruben A

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2023 Volume 36, Issue 2, Page(s) 2242555

Abstract: ... fetal lung size in the right and left lungs: The Quantitative Lung Index for the right lung (QLI-R) and ... of the QLI-R to predict pulmonary hypoplasia and neonatal death.: Materials and methods: Retrospective ... assessment of the QLI-R in patients with left-sided congenital diaphragmatic hernia (CDH-L) and other fetal ...

Abstract	Objectives: We have previously described gestational-age-independent sonographic indices to assess fetal lung size in the right and left lungs: The Quantitative Lung Index for the right lung (QLI-R) and for the left lung (QLI-L), respectively. The purpose of this study was to evaluate the clinical cutoff point of the QLI-R to predict pulmonary hypoplasia and neonatal death. Materials and methods: Retrospective assessment of the QLI-R in patients with left-sided congenital diaphragmatic hernia (CDH-L) and other fetal conditions at risk for fetal pulmonary hypoplasia. Cross-section and longitudinal assessment of the behavior of the QLI-R in untreated and treated patients. ROC curve analysis to determine the optimal cutoff point of the QLI-R in predicting neonatal death. Results: One hundred eighteen patients with CDH-L and other fetal conditions at risk for pulmonary hypoplasia had QLI-R measurements done. Seventeen patients were excluded for various reasons. Eleven patients with conditions other than CDH-L but at risk for pulmonary hypoplasia were used for intraclass coefficient measurements of the QLI-R. Ninety patients had CDH-L, of which 78 did not undergo antenatal intervention and in which the cutoff point for pulmonary hypoplasia and neonatal demise was assessed. Stent tracheal occlusion was performed in the remaining 12 patients with CDH-L, in which the behavior of the QLI after surgery was assessed. Analysis of the ICC showed an overall intra-rater reliability of 0.985 (Cronbach's Alpha-based). There was no correlation between gestational age and QLI-R (-0.73, Pearson correlation, Conclusion: Our study confirms that the QLI-R is a gestational-age-independent measurement of fetal lung size, with a high degree of reproducibility. In a population of expectantly managed CDH-L patients, a cutoff value of the QLI-R of 0.45 or lower is predictive of neonatal death from pulmonary hypoplasia. The QLI-R can be used to monitor fetal lung growth after tracheal occlusion, and an increase in the QLI-R is suggestive of neonatal survival. Further prospective studies are needed to confirm these findings and to explore the use of the QLI in other populations at risk for pulmonary hypoplasia and consequent neonatal demise.
MeSH term(s)	Infant, Newborn ; Humans ; Female ; Pregnancy ; Reproducibility of Results ; Retrospective Studies ; Perinatal Death ; Prenatal Diagnosis ; Lung/diagnostic imaging ; Lung/abnormalities ; Hernias, Diaphragmatic, Congenital/diagnostic imaging ; Hernias, Diaphragmatic, Congenital/surgery ; Fetal Diseases ; Ultrasonography, Prenatal
Language	English
Publishing date	2023-08-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2023.2242555
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Zs.A 3510: Show issues

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Article: Grapevines escaping trunk diseases in New Zealand vineyards have a distinct microbiome structure.

Adejoro, Damola O / Jones, E Eirian / Ridgway, Hayley J / Mundy, Dion C / Vanga, Bhanupratap R / Bulman, Simon R

Frontiers in microbiology

2023 Volume 14, Page(s) 1231832

Abstract: Grapevine trunk diseases (GTDs) are a substantial challenge to viticulture, especially with a lack of available control measures. The lack of approved fungicides necessitates the exploration of alternative controls. One promising approach is the ... ...

Abstract	Grapevine trunk diseases (GTDs) are a substantial challenge to viticulture, especially with a lack of available control measures. The lack of approved fungicides necessitates the exploration of alternative controls. One promising approach is the investigation of disease escape plants, which remain healthy under high disease pressure, likely due to their microbiome function. This study explored the microbiome of grapevines with the disease escape phenotype. DNA metabarcoding of the ribosomal internal transcribed spacer 1 (ITS1) and 16S ribosomal RNA gene was applied to trunk tissues of GTD escape and adjacent diseased vines. Our findings showed that the GTD escape vines had a significantly different microbiome compared with diseased vines. The GTD escape vines consistently harbored a higher relative abundance of the bacterial taxa
Language	English
Publishing date	2023-08-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1231832
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Article ; Online: Extrinsic Arterial Compression by a Venous Stent Graft in a Patient Undergoing Dialysis.

Randhawa, Animan / Bulman, Julie C / Brook, Olga R / Mehta, Sahil V / Faintuch, Salomao / Ahmed, Muneeb / Weinstein, Jeffrey L

Cardiovascular and interventional radiology

2022 Volume 45, Issue 8, Page(s) 1225–1227

MeSH term(s)	Arteriovenous Shunt, Surgical ; Graft Occlusion, Vascular/diagnostic imaging ; Graft Occlusion, Vascular/therapy ; Humans ; Renal Dialysis ; Stents ; Vascular Patency
Language	English
Publishing date	2022-05-17
Publishing country	United States
Document type	Letter
ZDB-ID	603082-8
ISSN	1432-086X ; 0342-7196 ; 0174-1551
ISSN (online)	1432-086X
ISSN	0342-7196 ; 0174-1551
DOI	10.1007/s00270-022-03159-2
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Zs.A 1378: Show issues

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Article ; Online: Improved characterization of aminoglycoside penetration into human lung epithelial lining fluid via population pharmacokinetics.

Shin, Eunjeong / Zhang, Yongzhen / Zhou, Jieqiang / Lang, Yinzhi / Sayed, Alaa R M / Werkman, Carolin / Jiao, Yuanyuan / Kumaraswamy, Monika / Bulman, Zackery P / Luna, Brian M / Bulitta, Jürgen B

Antimicrobial agents and chemotherapy

2024 Volume 68, Issue 2, Page(s) e0139323

Abstract: Aminoglycosides are important treatment options for serious lung infections, but modeling analyses to quantify their human lung epithelial lining fluid (ELF) penetration are lacking. We estimated the extent and rate of penetration for five ... ...

Abstract	Aminoglycosides are important treatment options for serious lung infections, but modeling analyses to quantify their human lung epithelial lining fluid (ELF) penetration are lacking. We estimated the extent and rate of penetration for five aminoglycosides via population pharmacokinetics from eight published studies. The area under the curve in ELF vs plasma ranged from 50% to 100% and equilibration half-lives from 0.61 to 5.80 h, indicating extensive system hysteresis. Aminoglycoside ELF peak concentrations were blunted, but overall exposures were moderately high.
MeSH term(s)	Humans ; Aminoglycosides ; Anti-Bacterial Agents/pharmacokinetics ; Lung ; Amikacin
Chemical Substances	Aminoglycosides ; Anti-Bacterial Agents ; Amikacin (84319SGC3C)
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/aac.01393-23
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Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Einzelsignatur: Show issues

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