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Article ; Online: Bitter Phytochemicals as Novel Candidates for Skin Disease Treatment.

Grădinaru, Teodora-Cristiana / Vlad, Adelina / Gilca, Marilena

2023 Volume 46, Issue 1, Page(s) 299–326

Abstract: Skin diseases represent a global healthcare challenge due to their rising incidence and substantial socio-economic burden. While biological, immunological, and targeted therapies have brought a revolution in improving quality of life and survival rates ... ...

Abstract	Skin diseases represent a global healthcare challenge due to their rising incidence and substantial socio-economic burden. While biological, immunological, and targeted therapies have brought a revolution in improving quality of life and survival rates for certain dermatological conditions, there remains a stringent demand for new remedies. Nature has long served as an inspiration for drug development. Recent studies have identified bitter taste receptors (TAS2Rs) in both skin cell lines and human skin. Additionally, bitter natural compounds have shown promising benefits in addressing skin aging, wound healing, inflammatory skin conditions, and even skin cancer. Thus, TAS2Rs may represent a promising target in all these processes. In this review, we summarize evidence supporting the presence of TAS2Rs in the skin and emphasize their potential as drug targets for addressing skin aging, wound healing, inflammatory skin conditions, and skin carcinogenesis. To our knowledge, this is a pioneering work in connecting information on TAS2Rs expression in skin and skin cells with the impact of bitter phytochemicals on various beneficial effects related to skin disorders.
Language	English
Publishing date	2023-12-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb46010020
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: PlantMolecularTasteDB: A Database of Taste Active Phytochemicals.

Gradinaru, Teodora-Cristiana / Petran, Madalina / Dragos, Dorin / Gilca, Marilena

Frontiers in pharmacology

2022 Volume 12, Page(s) 751712

Language	English
Publishing date	2022-01-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.751712
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Relevance of Phytochemical Taste for Anti-Cancer Activity: A Statistical Inquiry.

Grădinaru, Teodora-Cristiana / Gilca, Marilena / Vlad, Adelina / Dragoș, Dorin

International journal of molecular sciences

2023 Volume 24, Issue 22

Abstract: Targeting inflammation and the pathways linking inflammation with cancer is an innovative therapeutic strategy. Tastants are potential candidates for this approach, since taste receptors display various biological functions, including anti-inflammatory ... ...

Abstract	Targeting inflammation and the pathways linking inflammation with cancer is an innovative therapeutic strategy. Tastants are potential candidates for this approach, since taste receptors display various biological functions, including anti-inflammatory activity (AIA). The present study aims to explore the power different tastes have to predict a phytochemical's anti-cancer properties. It also investigates whether anti-inflammatory phytocompounds also have anti-cancer effects, and whether there are tastes that can better predict a phytochemical's bivalent biological activity. Data from the PlantMolecularTasteDB, containing a total of 1527 phytochemicals, were used. Out of these, only 624 phytocompounds met the inclusion criterion of having 40 hits in a PubMed search, using the name of the phytochemical as the keyword. Among them, 461 phytochemicals were found to possess anti-cancer activity (ACA). The AIA and ACA of phytochemicals were strongly correlated, irrespective of taste/orosensation or chemical class. Bitter taste was positively correlated with ACA, while sweet taste was negatively correlated. Among chemical classes, only flavonoids (which are most frequently bitter) had a positive association with both AIA and ACA, a finding confirming that taste has predictive primacy over chemical class. Therefore, bitter taste receptor agonists and sweet taste receptor antagonists may have a beneficial effect in slowing down the progression of inflammation to cancer.
MeSH term(s)	Humans ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Anti-Inflammatory Agents/metabolism ; Inflammation/metabolism ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Taste/physiology ; Taste Buds/metabolism ; Taste Perception/physiology
Chemical Substances	Anti-Inflammatory Agents
Language	English
Publishing date	2023-11-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242216227
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Phytochemicals and Inflammation: Is Bitter Better?

Dragoș, Dorin / Petran, Madalina / Gradinaru, Teodora-Cristiana / Gilca, Marilena

Plants (Basel, Switzerland)

2022 Volume 11, Issue 21

Abstract: The taste of a herb influences its use in traditional medicine. A molecular basis for the taste-based patterns ruling the distribution of herbal (ethno) pharmacological activities may not be excluded. This study investigated the potential correlations ... ...

Abstract	The taste of a herb influences its use in traditional medicine. A molecular basis for the taste-based patterns ruling the distribution of herbal (ethno) pharmacological activities may not be excluded. This study investigated the potential correlations between the anti-inflammatory activity (AIA) and the phytocompound taste and/or its chemical class. The study relies on information gathered by an extensive literature (articles, books, databases) search and made public as PlantMolecularTasteDB. Out of a total of 1527 phytotastants with reliably documented taste and structure available in PlantMolecularTasteDB, 592 (for each of which at least 40 hits were found on PubMed searches) were included in the statistical analysis. A list of 1836 putative molecular targets of these phytotastants was afterwards generated with SwissTargetPrediction tool. These targets were systematically evaluated for their potential role in inflammation using an international databases search. The correlations between phytochemical taste and AIA, between chemical class and AIA, and between the taste and the number of inflammation related targets were statistically analyzed. Phytochemical taste may be a better predictor of AIA than the chemical class. Bitter phytocompounds have a higher probability of exerting AIA when compared with otherwise phytotastants. Moreover, bitter phytotastants act upon more inflammation related targets than non-bitter tasting compounds.
Language	English
Publishing date	2022-11-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants11212991
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: PhytoMolecularTasteDB: An integrative database on the "molecular taste" of Indian medicinal plants.

Dragos, Dorin / Gilca, Marilena

Data in brief

2018 Volume 19, Page(s) 1237–1241

Abstract: ... of medicinal plant than the phytochemical class?" (Dragos and Gilca, 2018) [1]. It includes a comprehensive list ...

Abstract	PhytoMolecularTaste database (PhytoMolecularTasteDB) described in the present work is related to the article "Main phytocompunds׳ tastes: a better predictor for the ethnopharmacological activities of medicinal plant than the phytochemical class?" (Dragos and Gilca, 2018) [1]. It includes a comprehensive list of plant derived tastants, as well as details on the "phyto-molecular taste" (PMT) (the combination of tastes resulted from the main tastants found in a medicinal plant). To collect the data, we searched publications in various databases and journals by using relevant keywords. Wherever necessary, manual search of lacking information was also performed in several books. We then extracted the reported phytoconstituents and PMT of all the ayurvedic medicinal plants included in DB. Data were compiled in Excel. In total, PhytoMolecularTasteDB includes 431 ayurvedic medicinal plants, 94 EPAs, 223 phytochemical classes, and 438 plant-derived tastants.
Language	English
Publishing date	2018-04-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2018.04.048
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Taste of phytocompounds: A better predictor for ethnopharmacological activities of medicinal plants than the phytochemical class?

Dragos, Dorin / Gilca, Marilena

Journal of ethnopharmacology

2018 Volume 220, Page(s) 129–146

Abstract: Ethnopharmacological relevance: Understanding the patterns that shape traditional medical knowledge is essential for accelerating ethnopharmacological progress. According to Ayurveda, medicinal plants that belong to different taxa, but which have ... ...

Abstract	Ethnopharmacological relevance: Understanding the patterns that shape traditional medical knowledge is essential for accelerating ethnopharmacological progress. According to Ayurveda, medicinal plants that belong to different taxa, but which have similar taste, may display similar (ethno)pharmacological activities (EPAs) (Bhishagratna, 1998; Sharma and Dash, 2006). Aim of the study: To understand the patterns that govern the distribution of herbal EPAs in Ayurveda and to evaluate the potential concordance between chemical class or taste of the constituent phytocompounds and EPAs. Material and methods: A mixed database (PhytoMolecularTasteDB) was constructed for Ayurvedic medicinal plants by integrating modern data (medicinal plant composition, phytochemical taste) with traditional data (ethnopharmacological activities of plant). PhytoMolecularTasteDB contains 431 Ayurvedic medicinal plants, 94 EPAs, 223 chemical classes of phytocompounds and 438 herbal tastants. Potential global or individual associations between chemical classes/taste of the phytoconstituents and EPAs were statistically analyzed. Results: There was no global statistical correlation between the various chemical classes of phytocompounds and EPAs, although there were several individual correlations. The results suggest the existence of a global statistical correlation (besides several individual correlations) between the plant "molecular taste" (various taste-based classes of phytocompounds) and EPAs. Conclusions: These results suggest that phytochemical taste may be more relevant than chemical class for EPAs prediction.
MeSH term(s)	Databases, Factual ; Ethnopharmacology ; Humans ; Medicine, Ayurvedic ; Plant Preparations/chemistry ; Plants, Medicinal/chemistry ; Taste
Chemical Substances	Plant Preparations
Language	English
Publishing date	2018-03-29
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2018.03.034
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Historical ethnobotanical review of medicinal plants used to treat children diseases in Romania (1860s-1970s).

Petran, Madalina / Dragos, Dorin / Gilca, Marilena

Journal of ethnobiology and ethnomedicine

2020 Volume 16, Issue 1, Page(s) 15

Abstract: Background: Romanian ethnopediatrics has a long history of medicinal plant use. The main objective of the present review was to identify, collect, systematize, and prioritize the available bibliographical data related to medicinal plants traditionally ... ...

Abstract	Background: Romanian ethnopediatrics has a long history of medicinal plant use. The main objective of the present review was to identify, collect, systematize, and prioritize the available bibliographical data related to medicinal plants traditionally used to treat various pediatric diseases in Romania during the 1860s-1970s. Methods: Information was mainly obtained by manual systematic search in various relevant historical works focused on the traditional use of medicinal plants in Romania (1860s-1970s), found in the Archives of Romanian Academy Library and National Romanian Library. Results: A total of 153 medicinal plants belonging to 52 families were identified as having ethnopediatric significance. The plant traditional indications, targeted body systems, parts used, and way of administration were provided. We have also proposed one index (expressed as percentage) in order to assess the ethnopediatric applicability area of species: ethnopediatric relative therapeutic versatility (ERTV), which was calculated on the basis of the number of distinct uses mentioned for a species. The species identified to have the highest ERTV scores were Dryopteris filix-mas (100%), Gratiola officinalis (85.71%), Allium sativum (71.42%), Eryngium planum (71.42%), Juglans regia (71.42%), Matricaria chamomilla (71.42%), Plantago major (71.42%). Conclusions: The present study exposed for the first time to the international scientific community important ethnopediatric information contained in several local Romanian bibliographical resources that could guide the local and international researchers towards new directions of plant valorization.
MeSH term(s)	Child ; Ethnopharmacology/history ; History, 19th Century ; History, 20th Century ; Humans ; Medicine, Traditional ; Pediatrics ; Phytotherapy/history ; Plants, Medicinal/chemistry ; Romania
Language	English
Publishing date	2020-03-24
Publishing country	England
Document type	Historical Article ; Journal Article ; Review
ISSN	1746-4269
ISSN (online)	1746-4269
DOI	10.1186/s13002-020-00364-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Extraoral Taste Receptor Discovery: New Light on Ayurvedic Pharmacology.

Gilca, Marilena / Dragos, Dorin

Evidence-based complementary and alternative medicine : eCAM

2017 Volume 2017, Page(s) 5435831

Abstract: More and more research studies are revealing unexpectedly important roles of taste for health and pathogenesis of various diseases. Only recently it has been shown that taste receptors have many extraoral locations (e.g., stomach, intestines, liver, ... ...

Abstract	More and more research studies are revealing unexpectedly important roles of taste for health and pathogenesis of various diseases. Only recently it has been shown that taste receptors have many extraoral locations (e.g., stomach, intestines, liver, pancreas, respiratory system, heart, brain, kidney, urinary bladder, pancreas, adipose tissue, testis, and ovary), being part of a large
Language	English
Publishing date	2017-05-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2017/5435831
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: PhytoMolecularTasteDB

Dorin Dragos / Marilena Gilca

Data in Brief, Vol 19, Iss , Pp 1237-

An integrative database on the “molecular taste” of Indian medicinal plants

2018 Volume 1241

Abstract: ... of medicinal plant than the phytochemical class?” (Dragos and Gilca, 2018) [1]. It includes a comprehensive list ...

Abstract	PhytoMolecularTaste database (PhytoMolecularTasteDB) described in the present work is related to the article “Main phytocompunds׳ tastes: a better predictor for the ethnopharmacological activities of medicinal plant than the phytochemical class?” (Dragos and Gilca, 2018) [1]. It includes a comprehensive list of plant derived tastants, as well as details on the “phyto-molecular taste” (PMT) (the combination of tastes resulted from the main tastants found in a medicinal plant). To collect the data, we searched publications in various databases and journals by using relevant keywords. Wherever necessary, manual search of lacking information was also performed in several books. We then extracted the reported phytoconstituents and PMT of all the ayurvedic medicinal plants included in DB. Data were compiled in Excel. In total, PhytoMolecularTasteDB includes 431 ayurvedic medicinal plants, 94 EPAs, 223 phytochemical classes, and 438 plant-derived tastants.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7 ; Science (General) ; Q1-390
Subject code	580
Language	English
Publishing date	2018-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Historical ethnobotanical review of medicinal plants used to treat children diseases in Romania (1860s–1970s)

Madalina Petran / Dorin Dragos / Marilena Gilca

Journal of Ethnobiology and Ethnomedicine, Vol 16, Iss 1, Pp 1-

2020 Volume 33

Abstract: Abstract Background Romanian ethnopediatrics has a long history of medicinal plant use. The main objective of the present review was to identify, collect, systematize, and prioritize the available bibliographical data related to medicinal plants ... ...

Abstract	Abstract Background Romanian ethnopediatrics has a long history of medicinal plant use. The main objective of the present review was to identify, collect, systematize, and prioritize the available bibliographical data related to medicinal plants traditionally used to treat various pediatric diseases in Romania during the 1860s–1970s. Methods Information was mainly obtained by manual systematic search in various relevant historical works focused on the traditional use of medicinal plants in Romania (1860s–1970s), found in the Archives of Romanian Academy Library and National Romanian Library. Results A total of 153 medicinal plants belonging to 52 families were identified as having ethnopediatric significance. The plant traditional indications, targeted body systems, parts used, and way of administration were provided. We have also proposed one index (expressed as percentage) in order to assess the ethnopediatric applicability area of species: ethnopediatric relative therapeutic versatility (ERTV), which was calculated on the basis of the number of distinct uses mentioned for a species. The species identified to have the highest ERTV scores were Dryopteris filix-mas (100%), Gratiola officinalis (85.71%), Allium sativum (71.42%), Eryngium planum (71.42%), Juglans regia (71.42%), Matricaria chamomilla (71.42%), Plantago major (71.42%). Conclusions The present study exposed for the first time to the international scientific community important ethnopediatric information contained in several local Romanian bibliographical resources that could guide the local and international researchers towards new directions of plant valorization.
Keywords	Medicinal plants ; Ethnopharmacology ; Pediatry ; Ethnopediatry ; Children ; Romania ; Other systems of medicine ; RZ201-999 ; Botany ; QK1-989
Subject code	580
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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