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  1. Article: Editorial: Nature Inspired Protective Agents Against Oxidative Stress.

    Oliverio, Manuela / Bulotta, Stefania / Duarte, Noélia

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 859549

    Language English
    Publishing date 2022-02-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.859549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Storage Effects on Bioactive Phenols in Calabrian Monovarietal Extra Virgin Olive Oils Based on the EFSA Health Claim.

    Frisina, Marialaura / Bonacci, Sonia / Oliverio, Manuela / Nardi, Monica / Vatrano, Thomas Patrizio / Procopio, Antonio

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 20

    Abstract: The beneficial properties of extra virgin olive oil (EVOO) on lipids blood levels were recognized by the European Food Safety Authority (EFSA) with a health claim, specifically referring to EVOOs containing at least 5 mg of hydroxytyrosol and its ... ...

    Abstract The beneficial properties of extra virgin olive oil (EVOO) on lipids blood levels were recognized by the European Food Safety Authority (EFSA) with a health claim, specifically referring to EVOOs containing at least 5 mg of hydroxytyrosol and its secoiridoids derivatives per 20 g of oil. The main purpose of the work was to characterize the phenolic profile of two commercially available Calabrian monovarietal EVOOs (
    Language English
    Publishing date 2023-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12203799
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Functional Compounds of Cold-Pressed Pomegranate Seed Oil: Fatty Acids and Phytosterols Profile as Quality Biomarkers for Origin Discrimination.

    Iriti, Giuseppe / Bonacci, Sonia / Lopreiato, Vincenzo / Frisina, Marialaura / Oliverio, Manuela / Procopio, Antonio

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 13

    Abstract: Cold-pressed pomegranate seed oil (PSO) is a product of the extraction of non-edible pomegranate seeds. Its unique chemical composition in terms of both polyunsaturated fatty acids, especially punicic acid (PA), and secondary metabolites, such as ... ...

    Abstract Cold-pressed pomegranate seed oil (PSO) is a product of the extraction of non-edible pomegranate seeds. Its unique chemical composition in terms of both polyunsaturated fatty acids, especially punicic acid (PA), and secondary metabolites, such as phytosterols, tocopherols and phenols, make it an interesting functional ingredient for food enrichment. It is not clear if the biomarkers profile of PSO depends to factors connected to the geographical origin of seeds. This work presents a statistical comparative analysis, concerning biomolecules composition and geographical origin of 32 commercial cold-pressed PSOs, performed by principal component analysis. The study discriminates between Turkish and Italian PSOs, on the base of the fatty acid profile and phytosterols, and not on the tocopherols and phenols. These results confirmed PA as the main characteristic biomarker of oil genuineness and, for the first time, disclosed a statistically relevant variability of phytosterols, which can be proposed as quality biomarkers for discrimination of geographical origins.
    Language English
    Publishing date 2023-07-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12132599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Reticulon Homology Domain-Containing Proteins and ER-Phagy.

    D'Eletto, Manuela / Oliverio, Serafina / Di Sano, Federica

    Frontiers in cell and developmental biology

    2020  Volume 8, Page(s) 90

    Abstract: The endoplasmic reticulum (ER) is a dynamic membrane system comprising different and interconnected subdomains. The ER structure changes in response to different stress conditions through the activation of a selective autophagic pathway called ER-phagy. ... ...

    Abstract The endoplasmic reticulum (ER) is a dynamic membrane system comprising different and interconnected subdomains. The ER structure changes in response to different stress conditions through the activation of a selective autophagic pathway called ER-phagy. This represents a quality control mechanism for ER turnover and component recycling. Several ER-resident proteins have been indicated as receptors for ER-phagy; among these, there are proteins characterized by the presence of a reticulon homology domain (RHD). RHD-containing proteins promote ER fragmentation by a mechanism that involves LC3 binding and lysosome delivery. Moreover, the presence of a correct RHD structure is closely related to their capability to regulate ER shape and morphology by curvature induction and membrane remodeling. Deregulation of the ER-selective autophagic pathway due to defects in proteins with RHD has been implicated in several human diseases, infectious and neurodegenerative diseases in particular, as well as in cancer development. While the molecular mechanisms and the physiological role of ER-phagy are not yet fully understood, it is quite clear that this process is involved in different cellular signaling pathways and has an impact in several human pathologies.
    Language English
    Publishing date 2020-02-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2020.00090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Highly Efficient Synthesis of 1,2-Disubstituted Benzimidazoles Using Microwave Irradiation.

    Nardi, Monica / Bonacci, Sonia / Herrera Cano, Natividad / Oliverio, Manuela / Procopio, Antonio

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 5

    Abstract: The benzimidazole ring of the heterocyclic pharmacophores is one of the most widespread and studied systems in nature. The benzimidazole derivative synthesis study is a crucial point for the development of a clinically available benzimidazole-based drug. ...

    Abstract The benzimidazole ring of the heterocyclic pharmacophores is one of the most widespread and studied systems in nature. The benzimidazole derivative synthesis study is a crucial point for the development of a clinically available benzimidazole-based drug. Here, we report a simple microwave assisted method for the synthesis of 1,2-disubstituted benzimidazoles. The combination of the molar ratio of
    Language English
    Publishing date 2022-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27051751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Functional Compounds of Cold-Pressed Pomegranate Seed Oil: Fatty Acids and Phytosterols Profile as Quality Biomarkers for Origin Discrimination

    Iriti, Giuseppe / Bonacci, Sonia / Lopreiato, Vincenzo / Frisina, Marialaura / Oliverio, Manuela / Procopio, Antonio

    Foods. 2023 July 05, v. 12, no. 13

    2023  

    Abstract: Cold-pressed pomegranate seed oil (PSO) is a product of the extraction of non-edible pomegranate seeds. Its unique chemical composition in terms of both polyunsaturated fatty acids, especially punicic acid (PA), and secondary metabolites, such as ... ...

    Abstract Cold-pressed pomegranate seed oil (PSO) is a product of the extraction of non-edible pomegranate seeds. Its unique chemical composition in terms of both polyunsaturated fatty acids, especially punicic acid (PA), and secondary metabolites, such as phytosterols, tocopherols and phenols, make it an interesting functional ingredient for food enrichment. It is not clear if the biomarkers profile of PSO depends to factors connected to the geographical origin of seeds. This work presents a statistical comparative analysis, concerning biomolecules composition and geographical origin of 32 commercial cold-pressed PSOs, performed by principal component analysis. The study discriminates between Turkish and Italian PSOs, on the base of the fatty acid profile and phytosterols, and not on the tocopherols and phenols. These results confirmed PA as the main characteristic biomarker of oil genuineness and, for the first time, disclosed a statistically relevant variability of phytosterols, which can be proposed as quality biomarkers for discrimination of geographical origins.
    Keywords biomarkers ; fatty acid composition ; food enrichment ; ingredients ; phytosterols ; pomegranates ; principal component analysis ; provenance ; punicic acid ; secondary metabolites ; seed oils ; tocopherols
    Language English
    Dates of publication 2023-0705
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12132599
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Hydroxytyrosol-Donepezil Hybrids Play a Protective Role in an In Vitro Induced Alzheimer's Disease Model and in Neuronal Differentiated Human SH-SY5Y Neuroblastoma Cells.

    Maiuolo, Jessica / Costanzo, Paola / Masullo, Mariorosario / D'Errico, Antonio / Nasso, Rosarita / Bonacci, Sonia / Mollace, Vincenzo / Oliverio, Manuela / Arcone, Rosaria

    International journal of molecular sciences

    2023  Volume 24, Issue 17

    Abstract: Alzheimer's disease (AD) is the most common neurodegenerative pathology among progressive dementias, and it is characterized by the accumulation in the brain of extracellular aggregates of beta-amyloid proteins and neurofibrillary intracellular tangles ... ...

    Abstract Alzheimer's disease (AD) is the most common neurodegenerative pathology among progressive dementias, and it is characterized by the accumulation in the brain of extracellular aggregates of beta-amyloid proteins and neurofibrillary intracellular tangles consisting of τ-hyperphosphorylated proteins. Under normal conditions, beta-amyloid peptides exert important trophic and antioxidant roles, while their massive presence leads to a cascade of events culminating in the onset of AD. The fibrils of beta-amyloid proteins are formed by the process of fibrillogenesis that, starting from individual monomers of beta-amyloid, can generate polymers of this protein, constituting the hypothesis of the "amyloid cascade". To date, due to the lack of pharmacological treatment for AD without toxic side effects, chemical research is directed towards the realization of hybrid compounds that can act as an adjuvant in the treatment of this neurodegenerative pathology. The hybrid compounds used in this work include moieties of a hydroxytyrosol, a nitrohydroxytyrosol, a tyrosol, and a homovanillyl alcohol bound to the N-benzylpiperidine moiety of donepezil, the main drug used in AD. Previous experiments have shown different properties of these hybrids, including low toxicity and antioxidant and chelating activities. The purpose of this work was to test the effects of hybrid compounds mixed with A
    MeSH term(s) Humans ; Alzheimer Disease/drug therapy ; Donepezil/pharmacology ; Antioxidants/pharmacology ; Neuroblastoma/drug therapy ; tau Proteins
    Chemical Substances Donepezil (8SSC91326P) ; 3,4-dihydroxyphenylethanol (10597-60-1) ; Antioxidants ; tau Proteins
    Language English
    Publishing date 2023-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241713461
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Double-Edged Sword of Oleuropein in Ovarian Cancer Cells: From Antioxidant Functions to Cytotoxic Effects.

    Scicchitano, Stefania / Vecchio, Eleonora / Battaglia, Anna Martina / Oliverio, Manuela / Nardi, Monica / Procopio, Antonio / Costanzo, Francesco / Biamonte, Flavia / Faniello, Maria Concetta

    International journal of molecular sciences

    2023  Volume 24, Issue 1

    Abstract: Oleuropein plays a key role as a pro-oxidant as well as an antioxidant in cancer. In this study, the activity of oleuropein, in an in vitro model of ovarian (OCCs) and breast cancer cells (BCCs) was investigated. Cell viability and cell death were ... ...

    Abstract Oleuropein plays a key role as a pro-oxidant as well as an antioxidant in cancer. In this study, the activity of oleuropein, in an in vitro model of ovarian (OCCs) and breast cancer cells (BCCs) was investigated. Cell viability and cell death were analyzed. Oxidative stress was measured by CM-H2DCFDA flow cytometry assay. Mitochondrial dysfunction was evaluated based on mitochondrial reactive oxygen species (ROS) and GPX4 protein levels. Further, the effects on iron metabolism were analyzed by measuring the intracellular labile iron pool (LIP). We confirmed that high doses of oleuropein show anti-proliferative and pro-apoptotic activity on HEY and MCF-7 cells. Moreover, our results indicate that low doses of oleuropein impair cell viability without affecting the mortality of cells, and also decrease the LIP and ROS levels, keeping them unchanged in MCF-7 cells. For the first time, our data show that low doses of oleuropein reduce erastin-mediated cell death. Interestingly, oleuropein decreases the levels of intracellular ROS and LIP in OCCs treated with erastin. Noteworthily, we observed an increased amount of ROS scavenging enzyme GPX4 together with a consistent reduction in mitochondrial ROS, confirming a reduction in oxidative stress in this model.
    MeSH term(s) Humans ; Female ; Antioxidants/pharmacology ; Reactive Oxygen Species/metabolism ; Iridoids/pharmacology ; Iridoid Glucosides/pharmacology ; Ovarian Neoplasms/drug therapy ; Iron
    Chemical Substances Antioxidants ; Reactive Oxygen Species ; oleuropein (2O4553545L) ; Iridoids ; Iridoid Glucosides ; Iron (E1UOL152H7)
    Language English
    Publishing date 2023-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24010842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Reticulon Homology Domain-Containing Proteins and ER-Phagy

    Manuela D’Eletto / Serafina Oliverio / Federica Di Sano

    Frontiers in Cell and Developmental Biology, Vol

    2020  Volume 8

    Abstract: The endoplasmic reticulum (ER) is a dynamic membrane system comprising different and interconnected subdomains. The ER structure changes in response to different stress conditions through the activation of a selective autophagic pathway called ER-phagy. ... ...

    Abstract The endoplasmic reticulum (ER) is a dynamic membrane system comprising different and interconnected subdomains. The ER structure changes in response to different stress conditions through the activation of a selective autophagic pathway called ER-phagy. This represents a quality control mechanism for ER turnover and component recycling. Several ER-resident proteins have been indicated as receptors for ER-phagy; among these, there are proteins characterized by the presence of a reticulon homology domain (RHD). RHD-containing proteins promote ER fragmentation by a mechanism that involves LC3 binding and lysosome delivery. Moreover, the presence of a correct RHD structure is closely related to their capability to regulate ER shape and morphology by curvature induction and membrane remodeling. Deregulation of the ER-selective autophagic pathway due to defects in proteins with RHD has been implicated in several human diseases, infectious and neurodegenerative diseases in particular, as well as in cancer development. While the molecular mechanisms and the physiological role of ER-phagy are not yet fully understood, it is quite clear that this process is involved in different cellular signaling pathways and has an impact in several human pathologies.
    Keywords autophagy ; reticulon ; membrane ; endoplasmic reticulum ; domain ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Effect of Hydroxytyrosol Derivatives of Donepezil on the Activity of Enzymes Involved in Neurodegenerative Diseases and Oxidative Damage.

    D'Errico, Antonio / Nasso, Rosarita / Rullo, Rosario / Maiuolo, Jessica / Costanzo, Paola / Bonacci, Sonia / Oliverio, Manuela / De Vendittis, Emmanuele / Masullo, Mariorosario / Arcone, Rosaria

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 2

    Abstract: Monoamine oxidase and xanthine oxidase inhibitors represent useful multi-target drugs for the prevention, attenuation, and treatment of oxidative damage and neurodegenerative disorders. Chimeric molecules, constituted by naturally derived compounds ... ...

    Abstract Monoamine oxidase and xanthine oxidase inhibitors represent useful multi-target drugs for the prevention, attenuation, and treatment of oxidative damage and neurodegenerative disorders. Chimeric molecules, constituted by naturally derived compounds linked to drugs, represent lead compounds to be explored for the discovery of new synthetic drugs acting as enzyme inhibitors. We have previously reported that seven hydroxytyrosol-donepezil hybrid compounds play a protective role in an in vitro neuronal cell model of Alzheimer's disease. In this work, we analyzed the effects exerted by the hybrid compounds on the activity of monoamine oxidase A (MAO-A) and B (MAO-B), as well as on xanthine oxidase (XO), enzymes involved in both neurodegenerative disorders and oxidative stress. The results pointed to the identification, among the compounds tested, of selective inhibitors between the two classes of enzymes. While the 4-hydroxy-3-methoxyphenethyl 1-benzylpiperidine-4-carboxylate- (HT3) and the 4-hydroxyphenethyl 1-benzylpiperidine-4-carboxylate- donepezil derivatives (HT4) represented the best inhibitors of MAO-A, with a scarce effect on MAO-B, they were almost ineffective on XO. On the other hand, the 4,5-dihydroxy-2-nitrophenethyl 1-benzylpiperidine-4-carboxylate donepezil derivative (HT2), the least efficient MAO inhibitor, acted like the best XO inhibitor. Therefore, the differential enzymatic targets identified among the hybrid compounds synthesized enhance the possible applications of these polyphenol-donepezil hybrids in neurodegenerative disorders and oxidative stress.
    MeSH term(s) Humans ; Donepezil/pharmacology ; Donepezil/therapeutic use ; Neurodegenerative Diseases/drug therapy ; Xanthine Oxidase ; Monoamine Oxidase Inhibitors/pharmacology ; Monoamine Oxidase Inhibitors/therapeutic use ; Monoamine Oxidase/metabolism ; Oxidative Stress ; Structure-Activity Relationship ; Phenylethyl Alcohol/analogs & derivatives
    Chemical Substances Donepezil (8SSC91326P) ; 3,4-dihydroxyphenylethanol (10597-60-1) ; Xanthine Oxidase (EC 1.17.3.2) ; Monoamine Oxidase Inhibitors ; Monoamine Oxidase (EC 1.4.3.4) ; Phenylethyl Alcohol (ML9LGA7468)
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29020548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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