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  1. Article ; Online: Perspective on G protein-coupled receptors in renal physiology.

    Pluznick, Jennifer L / Fenton, Robert A

    American journal of physiology. Renal physiology

    2023  Volume 325, Issue 6, Page(s) F683–F684

    MeSH term(s) Receptors, G-Protein-Coupled ; Signal Transduction ; Urinary Tract Physiological Phenomena
    Chemical Substances Receptors, G-Protein-Coupled
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00307.2023
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  2. Article ; Online: BMAL1 in the Adrenal Gland: It's About Time-A Perspective on "Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior".

    Moore, Brittni N / Pluznick, Jennifer L

    Function (Oxford, England)

    2023  Volume 4, Issue 2, Page(s) zqad008

    MeSH term(s) ARNTL Transcription Factors/genetics ; Blood Pressure ; Circadian Clocks/genetics ; Adrenal Glands ; Feeding Behavior
    Chemical Substances ARNTL Transcription Factors
    Language English
    Publishing date 2023-02-16
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2633-8823
    ISSN (online) 2633-8823
    DOI 10.1093/function/zqad008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Commensal microbiota regulate renal gene expression in a sex-specific manner.

    Moore, Brittni N / Pluznick, Jennifer L

    American journal of physiology. Renal physiology

    2023  Volume 324, Issue 6, Page(s) F511–F520

    Abstract: The gut microbiome impacts host gene expression not only in the colon but also at distal sites including the liver, white adipose tissue, and spleen. The gut microbiome also influences the kidney and is associated with renal diseases and pathologies; ... ...

    Abstract The gut microbiome impacts host gene expression not only in the colon but also at distal sites including the liver, white adipose tissue, and spleen. The gut microbiome also influences the kidney and is associated with renal diseases and pathologies; however, a role for the gut microbiome to modulate renal gene expression has not been examined. To determine if microbes modulate renal gene expression, we used whole organ RNA sequencing to compare gene expression in C57Bl/6 mice that were germ free (lacking gut microbiota) versus conventionalized (gut microbiota reintroduced using an oral gavage of a fecal slurry composed of mixed stool). 16S sequencing showed that male and female mice were similarly conventionalized, although
    MeSH term(s) Male ; Female ; Animals ; Mice ; Feces ; Gastrointestinal Microbiome ; Colon ; Kidney ; Gene Expression
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00303.2022
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  4. Article ; Online: The gut microbiota in kidney disease.

    Pluznick, Jennifer L

    Science (New York, N.Y.)

    2020  Volume 369, Issue 6510, Page(s) 1426–1427

    MeSH term(s) Animals ; Diet ; Dysbiosis ; Gastrointestinal Microbiome ; Kidney Diseases ; Mice ; Proteome
    Chemical Substances Proteome
    Language English
    Publishing date 2020-09-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abd8344
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  5. Article ; Online: Key amino acids alter activity and trafficking of a well-conserved olfactory receptor.

    Xu, Jiaojiao / Pluznick, Jennifer L

    American journal of physiology. Cell physiology

    2022  Volume 322, Issue 6, Page(s) C1279–C1288

    Abstract: In this study, we elucidate factors that regulate the trafficking and activity of a well-conserved olfactory receptor (OR), olfactory receptor 558 (Olfr558), and its human ortholog olfactory receptor 51E1 (OR51E1). Results indicate that butyrate ... ...

    Abstract In this study, we elucidate factors that regulate the trafficking and activity of a well-conserved olfactory receptor (OR), olfactory receptor 558 (Olfr558), and its human ortholog olfactory receptor 51E1 (OR51E1). Results indicate that butyrate activates Olfr558/OR51E1 leading to the production of cAMP, and evokes Ca
    MeSH term(s) Amino Acids/metabolism ; Animals ; GTP-Binding Proteins/metabolism ; Humans ; Mice ; Protein Transport ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Odorant/genetics
    Chemical Substances Amino Acids ; Olfr558 protein, mouse ; Receptors, G-Protein-Coupled ; Receptors, Odorant ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 2022-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00440.2021
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  6. Article ; Online: The transcription factor Foxi1 promotes expression of V-ATPase and Gpr116 in M-1 cells.

    Kui, Mackenzie / Pluznick, Jennifer L / Zaidman, Nathan A

    American journal of physiology. Renal physiology

    2023  Volume 324, Issue 3, Page(s) F267–F273

    Abstract: The diverse functions of each nephron segment rely on the coordinated action of specialized cell populations that are uniquely defined by their transcriptional profile. In the collecting duct, there are two critical and distinct cell populations: ... ...

    Abstract The diverse functions of each nephron segment rely on the coordinated action of specialized cell populations that are uniquely defined by their transcriptional profile. In the collecting duct, there are two critical and distinct cell populations: principal cells and intercalated cells. Principal cells play key roles in the regulation of water, Na
    MeSH term(s) Animals ; Mice ; Adenosine Triphosphatases/genetics ; Adenosine Triphosphatases/metabolism ; Cell Differentiation ; Chloride-Bicarbonate Antiporters/genetics ; Forkhead Transcription Factors/metabolism ; Gene Expression Regulation ; Kidney/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Transcription Factors/metabolism ; Vacuolar Proton-Translocating ATPases/metabolism
    Chemical Substances Adenosine Triphosphatases (EC 3.6.1.-) ; Atp6v1b1 protein, mouse (EC 3.6.1.-) ; Chloride-Bicarbonate Antiporters ; Forkhead Transcription Factors ; Foxi1 protein, mouse ; Gpr116 protein, mouse ; Receptors, G-Protein-Coupled ; Slc4a9 protein, mouse ; Transcription Factors ; Vacuolar Proton-Translocating ATPases (EC 3.6.1.-)
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00272.2022
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  7. Article ; Online: An evolutionarily conserved olfactory receptor is required for sex differences in blood pressure.

    Xu, Jiaojiao / Choi, Rira / Gupta, Kunal / Warren, Helen R / Santhanam, Lakshmi / Pluznick, Jennifer L

    Science advances

    2024  Volume 10, Issue 12, Page(s) eadk1487

    Abstract: Sex differences in blood pressure are well-established, with premenopausal women having lower blood pressure than men by ~10 millimeters of mercury; however, the underlying mechanisms are not fully understood. We report here that sex differences in blood ...

    Abstract Sex differences in blood pressure are well-established, with premenopausal women having lower blood pressure than men by ~10 millimeters of mercury; however, the underlying mechanisms are not fully understood. We report here that sex differences in blood pressure are absent in olfactory receptor 558 knockout (KO) mice.
    MeSH term(s) Mice ; Animals ; Female ; Male ; Humans ; Blood Pressure/physiology ; Renin ; Receptors, Odorant/genetics ; Sex Characteristics ; Pulse Wave Analysis
    Chemical Substances Renin (EC 3.4.23.15) ; Receptors, Odorant ; Olfr558 protein, mouse
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adk1487
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  8. Article ; Online: Understudied G Protein-Coupled Receptors in the Kidney.

    Zaidman, Nathan A / Pluznick, Jennifer L

    Nephron

    2021  Volume 146, Issue 3, Page(s) 278–281

    Abstract: G protein-coupled receptors (GPCRs) are cell surface proteins which play a key role in allowing cells, tissues, and organs to respond to changes in the external environment in order to maintain homeostasis. Despite the fact that GPCRs are known to play ... ...

    Abstract G protein-coupled receptors (GPCRs) are cell surface proteins which play a key role in allowing cells, tissues, and organs to respond to changes in the external environment in order to maintain homeostasis. Despite the fact that GPCRs are known to play key roles in a variety of tissues, there are a large subset of GPCRs that remain poorly studied. In this minireview, we will summarize what is known regarding the "understudied" GPCRs with respect to renal function, and in so doing will highlight the promise represented by studying this gene family.
    MeSH term(s) Homeostasis ; Humans ; Kidney/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism
    Chemical Substances Receptors, G-Protein-Coupled
    Language English
    Publishing date 2021-07-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000517355
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  9. Article ; Online: Microbial Short-Chain Fatty Acids and Blood Pressure Regulation.

    Pluznick, Jennifer L

    Current hypertension reports

    2017  Volume 19, Issue 4, Page(s) 25

    Abstract: Purpose of review: Microbial short-chain fatty acids (SCFAs) are byproducts of microbial metabolism which can be absorbed into the bloodstream of the host, where they exert effects on host physiology. SCFAs have been known to influence several aspects ... ...

    Abstract Purpose of review: Microbial short-chain fatty acids (SCFAs) are byproducts of microbial metabolism which can be absorbed into the bloodstream of the host, where they exert effects on host physiology. SCFAs have been known to influence several aspects of host physiology, including the regulation of blood pressure. In this review, we will consider recent studies linking SCFAs to blood pressure regulation.
    Recent findings: Several recent studies have found that changes in blood pressure often coordinate with expected changes in SCFAS. Efforts are now well underway to dissect and better understand this potential connection. One way that SCFAs can influence host cells is by interacting with host GPCRs, including Gpr41 and Olfr78, among others. Intriguingly, mice null for Olfr78 are hypotensive, whereas mice null for Gpr41 are hypertensive, implying that these pathways may be physiologically important links between SCFAs and host blood pressure control. In sum, these studies demonstrate that there does indeed appear to be a link between SCFAs and blood pressure, which likely involves host GPCRs, at least in part; however, the details and intricacies of these interactions are not yet fully understood and will greatly benefit from further studies.
    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057367-4
    ISSN 1534-3111 ; 1522-6417
    ISSN (online) 1534-3111
    ISSN 1522-6417
    DOI 10.1007/s11906-017-0722-5
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  10. Article ; Online: Short-Chain Fatty Acid Receptors and Blood Pressure Regulation: Council on Hypertension Mid-Career Award for Research Excellence 2021.

    Xu, Jiaojiao / Moore, Brittni N / Pluznick, Jennifer L

    Hypertension (Dallas, Tex. : 1979)

    2022  Volume 79, Issue 10, Page(s) 2127–2137

    Abstract: The gut microbiome influences host physiology and pathophysiology through several pathways, one of which is microbial production of chemical metabolites which interact with host signaling pathways. Short-chain fatty acids (SCFAs) are a class of gut ... ...

    Abstract The gut microbiome influences host physiology and pathophysiology through several pathways, one of which is microbial production of chemical metabolites which interact with host signaling pathways. Short-chain fatty acids (SCFAs) are a class of gut microbial metabolites known to activate multiple signaling pathways in the host. Growing evidence indicates that the gut microbiome is linked to blood pressure, that SCFAs modulate blood pressure regulation, and that delivery of exogenous SCFAs lowers blood pressure. Given that hypertension is a key risk factor for cardiovascular disease, the examination of novel contributors to blood pressure regulation has the potential to lead to novel approaches or treatments. Thus, this review will discuss SCFAs with a focus on their host G protein-coupled receptors including GPR41 (G protein-coupled receptor 41), GPR43, and GPR109A, as well as OLFR78 (olfactory receptor 78) and OLFR558. This includes a discussion of the ligand profiles, G protein coupling, and tissue distribution of each receptor. We will also review phenotypes relevant to blood pressure regulation which have been reported to date for
    MeSH term(s) Animals ; Awards and Prizes ; Blood Pressure/physiology ; Fatty Acids, Volatile/metabolism ; Hypertension ; Mice ; Mice, Knockout ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Odorant/metabolism
    Chemical Substances Fatty Acids, Volatile ; Olfr558 protein, mouse ; Olfr78 protein, mouse ; Receptors, G-Protein-Coupled ; Receptors, Odorant
    Language English
    Publishing date 2022-08-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.122.18558
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