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  1. Article: [Determination of polybrominated diphenyl ethers in serum using isotope internal standard-gas chromatography-high resolution dual-focus magnetic mass spectrometry].

    Wang, Mengmeng / Xie, Linna / Zhu, Ying / Lu, Yifu

    Se pu = Chinese journal of chromatography

    2022  Volume 40, Issue 4, Page(s) 354–363

    Abstract: A method for the determination of 14 polybrominated diphenyl ethers (PBDEs) in human serum using isotope internal standard-gas chromatography-high resolution dual-focus magnetic mass spectrometry (GC-HRMS) was developed. After thawed to room temperature, ...

    Abstract A method for the determination of 14 polybrominated diphenyl ethers (PBDEs) in human serum using isotope internal standard-gas chromatography-high resolution dual-focus magnetic mass spectrometry (GC-HRMS) was developed. After thawed to room temperature, 0.5 mL serum samples were mixed with
    MeSH term(s) Adolescent ; Gas Chromatography-Mass Spectrometry/methods ; Halogenated Diphenyl Ethers/analysis ; Humans ; Isotopes ; Magnetic Phenomena ; Solid Phase Extraction/methods
    Chemical Substances Halogenated Diphenyl Ethers ; Isotopes
    Language Chinese
    Publishing date 2022-04-12
    Publishing country China
    Document type Journal Article
    ISSN 1000-8713
    ISSN 1000-8713
    DOI 10.3724/SP.J.1123.2021.10017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Electrocatalytic Synthesis of Pyridine Oximes using in Situ Generated NH

    Xiang, Runan / Wang, Shihan / Liao, Peisen / Xie, Fangyan / Kang, Jiawei / Li, Suisheng / Xian, Jiahui / Guo, Linna / Li, Guangqin

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 45, Page(s) e202312239

    Abstract: Pyridine oximes produced from aldehyde or ketone with hydroxylamine ( ... ...

    Abstract Pyridine oximes produced from aldehyde or ketone with hydroxylamine (NH
    Language English
    Publishing date 2023-09-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202312239
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  3. Article ; Online: Zanubrutinib, rituximab and lenalidomide induces deep and durable remission in TP53-mutated B-cell prolymphocytic leukemia: a case report and literature review.

    Xing, Lijie / He, Qiang / Xie, Linna / Wang, Hui / Li, Zengjun

    Haematologica

    2022  Volume 107, Issue 5, Page(s) 1226–1228

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Humans ; Lenalidomide/therapeutic use ; Leukemia, Prolymphocytic, B-Cell/drug therapy ; Piperidines ; Pyrazoles ; Pyrimidines/therapeutic use ; Rituximab/therapeutic use ; Tumor Suppressor Protein p53/genetics
    Chemical Substances Piperidines ; Pyrazoles ; Pyrimidines ; TP53 protein, human ; Tumor Suppressor Protein p53 ; Rituximab (4F4X42SYQ6) ; zanubrutinib (AG9MHG098Z) ; Lenalidomide (F0P408N6V4)
    Language English
    Publishing date 2022-05-01
    Publishing country Italy
    Document type Case Reports ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2021.280259
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  4. Article ; Online: Corrigendum to "Deficiency in AK9 causes asthenozoospermia and male infertility by destabilising sperm nucleotide homeostasis" [EBioMedicine 96(2023) 104798].

    Sha, Yanwei / Liu, Wensheng / Li, Shu / Osadchuk, Ludmila V / Chen, Yongjie / Nie, Hua / Gao, Shuai / Xie, Linna / Qin, Weibing / Zhou, Huiliang / Li, Lin

    EBioMedicine

    2024  Volume 99, Page(s) 104957

    Language English
    Publishing date 2024-01-03
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2023.104957
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    Zs.A 7090: Show issues Location:
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  5. Article ; Online: Convenient dual-wavelength digital holography based on orthogonal polarization strategy with a Wollaston prism.

    Wu, Difeng / Xie, Linna / Han, Xianxin / Zhou, Chengxin / Bu, Zhengyang / Liu, Shengde / Zhong, Liyun / Lu, Xiaoxu

    Applied optics

    2024  Volume 63, Issue 7, Page(s) B70–B75

    Abstract: Dual-wavelength digital holography effectively expands the measurement range of digital holography, but it increases the complexity of optical system due to non-common-path of two wavelengths. Here, by using orthogonal polarization strategy, we present a ...

    Abstract Dual-wavelength digital holography effectively expands the measurement range of digital holography, but it increases the complexity of optical system due to non-common-path of two wavelengths. Here, by using orthogonal polarization strategy, we present a dual-wavelength digital holography based on a Wollaston prism (DWDH-WP) to separate the reference beams of two wavelengths and realize the common-path of two wavelengths. A Wollaston prism is inset into the reference beam path of the off-axis digital holography system, so two orthogonal-polarized reference beams of two different wavelengths separated at different directions are generated. Then a dual-wavelength multiplexed interferogram with orthogonal interference fringes is captured by using a monochrome camera, in which both the polarization orientations and the interference fringe orientations of two wavelengths are orthogonal, so the spectral crosstalk of two wavelengths with arbitrary wavelength difference can be avoided. Compared with the existing DWDH method, the proposed DWDH-WP method can conveniently realize the common-path of the reference beams of two wavelengths, so it reveals obvious advantages in spectral separation, spectral crosstalk, system simplification, and adjustment flexibility. Both effectiveness and flexibility of the proposed DWDH-WP method are demonstrated by the phase measurement of the HeLa cell and vortex phase plate.
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.507354
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  6. Article ; Online: Corrigendum to “Deficiency in AK9 causes asthenozoospermia and male infertility by destabilising sperm nucleotide homeostasis” [EBioMedicine 96(2023) 104798]

    Yanwei Sha / Wensheng Liu / Shu Li / Ludmila V. Osadchuk / Yongjie Chen / Hua Nie / Shuai Gao / Linna Xie / Weibing Qin / Huiliang Zhou / Lin Li

    EBioMedicine, Vol 99, Iss , Pp 104957- (2024)

    2024  

    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  7. Article ; Online: Correlation between PD-1 and sPD-L1 expression levels in peripheral blood of DLBCL patients and their clinicopathological characteristics.

    Wang, Liang / Cao, Congcong / Qiu, Juan / Zhang, Jianing / He, Qiang / Song, Lihua / Xie, Linna / Ma, Ji

    Cellular and molecular biology (Noisy-le-Grand, France)

    2024  Volume 70, Issue 2, Page(s) 44–50

    Abstract: Molecular pathology and clinical characteristics play a crucial role in guiding treatment selection and predicting the prognosis of diffuse large B-cell lymphoma (DLBCL). The programmed cell death protein 1 (PD-1) and its ligand (PD-L1), have emerged as ... ...

    Abstract Molecular pathology and clinical characteristics play a crucial role in guiding treatment selection and predicting the prognosis of diffuse large B-cell lymphoma (DLBCL). The programmed cell death protein 1 (PD-1) and its ligand (PD-L1), have emerged as pivotal regulators of immune checkpoints in cancer. The objectives of this study are to investigate the correlation between the expression levels of PD-1 and soluble PD-L1 (sPD-L1) in the peripheral blood of DLBCL patients, analyze their clinicopathological characteristics, and identify the optimal beneficiary group for PD-1/PD-L1 blockade. Peripheral blood samples were collected from 36 DLBCL patients before their initial treatment at Shandong Cancer Hospital between December 2018 and July 2019. The expression levels of PD-1 and sPD-L1 were measured using flow cytometry and enzyme-linked immunosorbent assay (ELISA), respectively. The clinicopathological characteristics, including age, sex, Ann Arbor stage, International Prognostic Index (IPI) score, response to treatment, etc., were recorded for each patient. The surface expression of PD-1 on peripheral blood T cells was significantly higher in DLBCL patients compared to healthy controls. There was a significant association between elevated PD-1 expression levels and the advanced Ann Arbor stage (P=0.0153) as well as the B group (P=0.0184). Higher sPD-L1 levels were associated with the GCB subtype according to Hans's classification (P=0.0435). The expression levels of PD-1 and sPD-L1 in the peripheral blood of DLBCL patients are significantly correlated with advanced disease stage, B group, and GCB subtype according to Hans's classification. This suggests that the PD-1/PD-L1 axis play a critical role in specific subgroups of DLBCL. Targeting this axis could serve as a potential therapeutic strategy to enhance the clinical outcomes of DLBCL patients. Further studies are necessary to explore the prognostic implications of PD-1 and sPD-L1 expression levels in DLBCL patients.
    MeSH term(s) Humans ; B7-H1 Antigen/genetics ; Programmed Cell Death 1 Receptor/genetics ; Lymphoma, Large B-Cell, Diffuse/genetics ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry
    Chemical Substances B7-H1 Antigen ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2024-02-29
    Publishing country France
    Document type Journal Article
    ZDB-ID 1161779-2
    ISSN 1165-158X ; 0145-5680
    ISSN (online) 1165-158X
    ISSN 0145-5680
    DOI 10.14715/cmb/2024.70.2.7
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    Zs.A 3812: Show issues Location:
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  8. Article ; Online: Infrared Small–Target Detection Under a Complex Background Based on a Local Gradient Contrast Method

    Yang Linna / Xie Tao / Liu Mingxing / Zhang Mingjiang / Qi Shuaihui / Yang Jungang

    International Journal of Applied Mathematics and Computer Science, Vol 33, Iss 1, Pp 33-

    2023  Volume 43

    Abstract: Small target detection under a complex background has always been a hot and difficult problem in the field of image processing. Due to the factors such as a complex background and a low signal-to-noise ratio, the existing methods cannot robustly detect ... ...

    Abstract Small target detection under a complex background has always been a hot and difficult problem in the field of image processing. Due to the factors such as a complex background and a low signal-to-noise ratio, the existing methods cannot robustly detect targets submerged in strong clutter and noise. In this paper, a local gradient contrast method (LGCM) is proposed. Firstly, the optimal scale for each pixel is obtained by calculating a multiscale salient map. Then, a subblockbased local gradient measure is designed; it can suppress strong clutter interference and pixel-sized noise simultaneously. Thirdly, the subblock-based local gradient measure and the salient map are utilized to construct the LGCM. Finally, an adaptive threshold is employed to extract the final detection result. Experimental results on six datasets demonstrate that the proposed method can discard clutters and yield superior results compared with state-of-the-art methods.
    Keywords small target detection ; local gradient contrast ; visual saliency ; infrared image processing ; Mathematics ; QA1-939 ; Electronic computers. Computer science ; QA75.5-76.95
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
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  9. Article ; Online: Jujuboside A Attenuates Polycystic Ovary Syndrome Based on Estrogen Metabolism Through Activating AhR-mediated CYP1A2 Expression.

    Zhou, Nan / Lv, Wenqiang / Chen, Linna / Chen, Kexin / He, Qing / Xie, Guangyan / Ma, Jiachen / Cao, Yijuan / Zhang, Bei / Zhou, Xueyan

    Reproductive sciences (Thousand Oaks, Calif.)

    2024  

    Abstract: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women. This study aimed to investigate the therapeutic effects and mechanism of Jujuboside A on PCOS using a dehydroepiandrosterone (DHEA)-induced PCOS mouse model. ... ...

    Abstract Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women. This study aimed to investigate the therapeutic effects and mechanism of Jujuboside A on PCOS using a dehydroepiandrosterone (DHEA)-induced PCOS mouse model. Estrogen and androgen homeostasis was evaluated in serum from both clinical samples and PCOS mice. The stages of the estrous cycle were determined based on vaginal cytology. The ovarian morphology was observed by stained with hematoxylin and eosin. Moreover, we analyzed protein expression of cytochrome P450 1A1 (CYP1A1), cytochrome P450 1A2 (CYP1A2) and aryl hydrocarbon receptor (AhR) in ovary and KGN cells. Molecular docking, immunofluorescence, and luciferase assay were performed to confirm the activation of AhR by Jujuboside A. Jujuboside A effectively alleviated the disturbance of estrogen homeostasis and restored ovarian function, leading to an improvement in the occurrence and progression of PCOS. Furthermore, the protective effect of JuA against PCOS was dependent on increased CYP1A2 levels regulated by AhR. Our findings suggest that Jujuboside A improves estrogen disorders and may be a potential therapeutic agent for the treatment of PCOS.
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2276411-2
    ISSN 1933-7205 ; 1933-7191
    ISSN (online) 1933-7205
    ISSN 1933-7191
    DOI 10.1007/s43032-024-01511-0
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    Zs.A 4113: Show issues Location:
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  10. Article: Reduction-sensitive N, N'-Bis(acryloyl) cystinamide-polymerized Nanohydrogel as a Potential Nanocarrier for Paclitaxel Delivery.

    Yu, Linna / Kong, Lingping / Xie, Junpeng / Wang, Wei / Chang, Chen / Che, Hongli / Liu, Mingzhe

    Designed monomers and polymers

    2021  Volume 24, Issue 1, Page(s) 98–105

    Abstract: Novel monomer, ...

    Abstract Novel monomer,
    Language English
    Publishing date 2021-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2045059-X
    ISSN 1568-5551 ; 1385-772X
    ISSN (online) 1568-5551
    ISSN 1385-772X
    DOI 10.1080/15685551.2021.1914398
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