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  1. Article ; Online: Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

    Heidelberger, Jan B / Voigt, Andrea / Borisova, Marina E / Petrosino, Giuseppe / Ruf, Stefanie / Wagner, Sebastian A / Beli, Petra

    EMBO reports

    2018  Volume 19, Issue 4

    Abstract: ... activity of the transcription factor c-Myc. ...

    Abstract Valosin-containing protein (VCP) is an evolutionarily conserved ubiquitin-dependent ATPase that mediates the degradation of proteins through the ubiquitin-proteasome pathway. Despite the central role of VCP in the regulation of protein homeostasis, identity and nature of its cellular substrates remain poorly defined. Here, we combined chemical inhibition of VCP and quantitative ubiquitin remnant profiling to assess the effect of VCP inhibition on the ubiquitin-modified proteome and to probe the substrate spectrum of VCP in human cells. We demonstrate that inhibition of VCP perturbs cellular ubiquitylation and increases ubiquitylation of a different subset of proteins compared to proteasome inhibition. VCP inhibition globally upregulates K6-linked ubiquitylation that is dependent on the HECT-type ubiquitin E3 ligase HUWE1. We report ~450 putative VCP substrates, many of which function in nuclear processes, including gene expression, DNA repair and cell cycle. Moreover, we identify that VCP regulates the level and activity of the transcription factor c-Myc.
    MeSH term(s) Cell Line ; Cell Nucleus/metabolism ; Humans ; Models, Biological ; Proteasome Endopeptidase Complex/metabolism ; Protein Binding ; Protein Interaction Mapping ; Protein Interaction Maps ; Protein Transport ; Proteolysis ; Proteome ; Proteomics/methods ; Proto-Oncogene Proteins c-myc/metabolism ; Ubiquitination ; Valosin Containing Protein/metabolism
    Chemical Substances Proteome ; Proto-Oncogene Proteins c-myc ; Proteasome Endopeptidase Complex (EC 3.4.25.1) ; VCP protein, human (EC 3.6.4.6) ; Valosin Containing Protein (EC 3.6.4.6)
    Language English
    Publishing date 2018-02-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.201744754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5433: Show issues Location:
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    Zs.MG 41: Show issues

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  2. Article ; Online: Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents.

    Antonow, Dyeison / Kaliszczak, Maciej / Kang, Gyoung-Dong / Coffils, Marissa / Tiberghien, Arnaud C / Cooper, Nectaroula / Barata, Teresa / Heidelberger, Sibylle / James, Colin H / Zloh, Mire / Jenkins, Terence C / Reszka, Anthony P / Neidle, Stephen / Guichard, Sylvie M / Jodrell, Duncan I / Hartley, John A / Howard, Philip W / Thurston, David E

    Journal of medicinal chemistry

    2010  Volume 53, Issue 7, Page(s) 2927–2941

    Abstract: A comprehensive SAR investigation of the C2-position of pyrrolo[2,1-c][1,4]benzodiazepine (PBD ...

    Abstract A comprehensive SAR investigation of the C2-position of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) monomer antitumor agents is reported, establishing the molecular requirements for optimal in vitro cytotoxicity and DNA-binding affinity. Both carbocyclic and heterocyclic C2-aryl substituents have been studied ranging from single aryl rings to fused ring systems, and also styryl substituents, establishing across a library of 80 analogues that C2-aryl and styryl substituents significantly enhance both DNA-binding affinity and in vitro cytotoxicity, with a correlation between the two. The optimal C2-grouping for both DNA-binding affinity and cytotoxicity was found to be the C2-quinolinyl moiety which, according to molecular modeling, is due to the overall fit of the molecule in the DNA minor groove, and potential specific contacts with functional groups in the floor and walls of the groove. This analogue (14l) was shown to delay tumor growth in a HCT-116 (bowel) human tumor xenograft model.
    MeSH term(s) Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Base Sequence ; Benzodiazepines/chemical synthesis ; Benzodiazepines/chemistry ; Benzodiazepines/metabolism ; Benzodiazepines/pharmacology ; Cattle ; Cell Line, Tumor ; DNA/chemistry ; DNA/genetics ; DNA/metabolism ; Female ; Humans ; Imines/chemistry ; Mice ; Models, Molecular ; Nucleic Acid Conformation ; Nucleic Acid Denaturation/drug effects ; Pyrroles/chemical synthesis ; Pyrroles/chemistry ; Pyrroles/metabolism ; Pyrroles/pharmacology ; Stereoisomerism ; Structure-Activity Relationship ; Xenograft Model Antitumor Assays
    Chemical Substances Antineoplastic Agents ; Imines ; Pyrroles ; pyrrolo(2,1-c)(1,4)benzodiazepine ; Benzodiazepines (12794-10-4) ; DNA (9007-49-2)
    Language English
    Publishing date 2010-04-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/jm901722v
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    Zs.B 151: Show issues Location:
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    Zs.MB 1: Show issues

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  3. Article ; Online: Syntaxin 3 is haplosufficient for long-term photoreceptor survival in the mouse retina.

    Perez-Hurtado, Mariajose / Dao, Calvin / Saenz, Amanda E / Heidelberger, Ruth

    Frontiers in ophthalmology

    2023  Volume 3

    Abstract: Biallelic loss-of-function mutations in the syntaxin 3 gene have been linked to a severe retinal dystrophy in humans that presents in early childhood. In mouse models, biallelic inactivation of the syntaxin 3 gene in photoreceptors rapidly leads to their ...

    Abstract Biallelic loss-of-function mutations in the syntaxin 3 gene have been linked to a severe retinal dystrophy in humans that presents in early childhood. In mouse models, biallelic inactivation of the syntaxin 3 gene in photoreceptors rapidly leads to their death. What is not known is whether a monoallelic syntaxin 3 loss-of-function mutation might cause photoreceptor loss with advancing age. To address this question, we compared the outer nuclear layer of older adult mice (≈ 20 months of age) that were heterozygous for syntaxin 3 with those of similarly-aged control mice. We found that the photoreceptor layer maintains its thickness in mice that are heterozygous for syntaxin 3 relative to controls and that photoreceptor somatic counts are comparable. In addition, dendritic sprouting of the rod bipolar cell dendrites into the outer nuclear layer, which occurs following the loss of functional rod targets, was similar between genotypes. Thus, syntaxin 3 appears to be haplosufficient for photoreceptor survival, even with advancing age.
    Language English
    Publishing date 2023-06-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 3123828-2
    ISSN 2674-0826 ; 2674-0826
    ISSN (online) 2674-0826
    ISSN 2674-0826
    DOI 10.3389/fopht.2023.1208805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The application of the carbon isotopes to a study of animal metabolism.

    HEIDELBERGER, C

    Advances in biological and medical physics

    2014  Volume 2, Page(s) 77–131

    MeSH term(s) Animals ; Carbon ; Carbon Isotopes ; Carbon Radioisotopes ; Metabolism ; Radioactivity
    Chemical Substances Carbon Isotopes ; Carbon Radioisotopes ; Carbon (7440-44-0)
    Language English
    Publishing date 2014-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 170-3
    ISSN 0065-2245
    ISSN 0065-2245
    DOI 10.1016/b978-1-4831-9925-2.50007-5
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    Uc I Zs.252: Show issues Location:
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  5. Article ; Online: Low-Income, African American and American Indian Children's Viewpoints on Body Image Assessment Tools and Body Satisfaction: A Mixed Methods Study.

    Heidelberger, Lindsay / Smith, Chery

    Maternal and child health journal

    2018  Volume 22, Issue 9, Page(s) 1327–1338

    Abstract: Objectives Pediatric obesity is complicated by many factors including psychological issues, such as body dissatisfaction. Body image assessment tools are used with children to measure their acceptance of their body shape or image. Limited research has ... ...

    Abstract Objectives Pediatric obesity is complicated by many factors including psychological issues, such as body dissatisfaction. Body image assessment tools are used with children to measure their acceptance of their body shape or image. Limited research has been conducted with African American and American Indian children to understand their opinions on assessment tools created. This study investigated: (a) children's perception about body image and (b) differences between two body image instruments among low-income, multi-ethnic children. Methods This study uses mixed methodology including focus groups (qualitative) and body image assessment instruments (quantitative). Fifty-one children participated (25 girls, 26 boys); 53% of children identified as African American and 47% as American Indian. The average age was 10.4 years. Open coding methods were used by identify themes from focus group data. SPSS was used for quantitative analysis. Results Children preferred the Figure Rating Scale (FRS/silhouette) instrument over the Children's Body Image Scale (CBIS/photo) because their body parts and facial features were more detailed. Children formed their body image perception with influence from their parents and the media. Children verbalized that they have experienced negative consequences related to poor body image including disordered eating habits, depression, and bullying. Healthy weight children are also aware of weight-related bullying that obese and overweight children face. Conclusions for Practice Children prefer that the images on a body image assessment tool have detailed facial features and are clothed. Further research into body image assessment tools for use with African American and American Indian children is needed.
    MeSH term(s) African Americans/psychology ; Body Image ; Child ; Female ; Focus Groups ; Humans ; Indians, North American/psychology ; Male ; Personal Satisfaction ; Poverty ; Qualitative Research ; Surveys and Questionnaires
    Language English
    Publishing date 2018-02-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1339905-6
    ISSN 1573-6628 ; 1092-7875
    ISSN (online) 1573-6628
    ISSN 1092-7875
    DOI 10.1007/s10995-018-2513-2
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    Zs.A 6170: Show issues Location:
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  6. Article ; Online: Lobular panniculitis and diffuse osteonecrosis occurring during anti-MEK and anti-BRAF combination therapy for metastatic melanoma.

    Tzoumpa, S / Villette, B / Tieng, A C / Bejar, C / Rousset, L / Heidelberger, V / Playe, M / Desbene, C / Khalifa, B / N'Guessan-Koffi, C / Braun, T / Le Jeune, S / Caux, F / Maubec, E

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2023  

    Language English
    Publishing date 2023-03-28
    Publishing country England
    Document type Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19077
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3492: Show issues Location:
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    Zs.MO 413: Show issues

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  7. Article ; Online: Low-Income, Urban Children's Perspectives on Physical Activity: A Photovoice Project.

    Heidelberger, Lindsay / Smith, Chery

    Maternal and child health journal

    2016  Volume 20, Issue 6, Page(s) 1124–1132

    Abstract: ... a) types of activity, (b) social environment, and (c) physical environment where activity took place ...

    Abstract Objectives The purpose of this research was to have ethnically diverse, 9- to 13-year-olds who live in urban, low-income households use Photovoice to represent their physical activity practices and their perception of their physical activity environment. Methods Photovoice methodology was used to allow children to capture their physical activity habits and environment through photographs and interviews. The Social Cognitive Theory was used as the theoretical framework. Heights and weights were taken for all children and BMI was calculated. Photographs were analyzed by recording the content of usable photos in SPSS software. Qualitative analysis of the interview transcripts used the open coding method. Results Participants were 24 children (15 male, 9 female) living in inner city, low-income households. On average, children were 10.9 years old and the mean BMI-for-age percentile was 72 %. Children took a total of 377 pictures and 339 of these were usable. Three themes were identified across interviews and photographs, (a) types of activity, (b) social environment, and (c) physical environment where activity took place. Conclusions for Practice This study provides insight into low-income, urban children's physical activity habits and environment using a novel approach. Potential ways to increase moderate to high intensity activity among this population are to involve church-based organizations, create more safe places to play by increasing green space in urban areas, and to provide financial support for after-school programs and community centers.
    MeSH term(s) Adolescent ; Child ; Exercise ; Female ; Humans ; Interviews as Topic ; Male ; Pediatric Obesity/prevention & control ; Perception ; Photography ; Poverty ; Residence Characteristics ; Social Environment ; Urban Population
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1339905-6
    ISSN 1573-6628 ; 1092-7875
    ISSN (online) 1573-6628
    ISSN 1092-7875
    DOI 10.1007/s10995-015-1898-4
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  8. Article: The Metabolism Of 1,2,5,6 Dibenzanthracene In the Mouse.

    HEIDELBERGER, C

    Der Krebsarzt

    2007  Volume 4, Issue 4, Page(s) 156

    Title translation Der Stoffwechsel von 1,2,5,6 Dibenzanthrazen bei der Maus.
    MeSH term(s) Anthracenes/metabolism
    Chemical Substances Anthracenes ; anthracene (EH46A1TLD7)
    Language German
    Publishing date 2007-12-15
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 200007-6
    ISSN 0368-6698
    ISSN 0368-6698
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  9. Article: The synthesis of DL-tryptophan-beta-C14, indole-3-acetic acid-alpha-C14, and DL-tryptophan-3-C14.

    HEIDELBERGER, C

    The Journal of biological chemistry

    2007  Volume 179, Issue 1, Page(s) 139–142

    MeSH term(s) Indoleacetic Acids ; Tryptophan
    Chemical Substances Indoleacetic Acids ; indoleacetic acid (6U1S09C61L) ; Tryptophan (8DUH1N11BX)
    Language English
    Publishing date 2007-12-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
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  10. Article: Physical Activity Beliefs and Influences from Inner City, Low-Income Children's Perspectives: A Qualitative Study

    Heidelberger, Lindsay / Smith, Chery

    Journal of hunger and environmental nutrition

    2018  Volume 13, Issue 1, Page(s) 70

    Language English
    Document type Article
    ZDB-ID 2251933-6
    ISSN 1932-0248
    Database Current Contents Nutrition, Environment, Agriculture

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    Z 7637: Show issues

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