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Book ; Online: Trust in Government Agencies in the Time of COVID-19

Robinson, Scott E. / Gupta, Kuhika / Ripberger, Joseph / Ross, Jennifer A. / Fox, Andrew / Jenkins-Smith, Hank / Silva, Carol

(Social Sciences)

2021

Series title	Social Sciences
Keywords	Organizational theory & behaviour ; Public administration ; Politics & government ; Health systems & services ; Public Administration ; Non-profit Administration
Language	0\|e
Size	1 Online-Ressource
Publisher	Cambridge University Press
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021618622
ISBN	9781108959551 ; 1108959555
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Practical considerations for laboratories: Implementing a holistic quality management system.

Pillai, Segaran / Calvert, Jennifer / Fox, Elizabeth

Frontiers in bioengineering and biotechnology

2022 Volume 10, Page(s) 1040103

Abstract: ... that accommodates laboratory activities (e.g., basic and applied research; regulatory, clinical, or proficiency ... thus compromising the integrity and credibility of the institution. While there are many LQMS frameworks (e.g ...

Abstract	A laboratory quality management system (LQMS) is an essential element for the effective operation of research, clinical, testing, or production/manufacturing laboratories. As technology continues to rapidly advance and new challenges arise, laboratories worldwide have responded with innovation and process changes to meet the continued demand. It is critical for laboratories to maintain a robust LQMS that accommodates laboratory activities (e.g., basic and applied research; regulatory, clinical, or proficiency testing), records management, and a path for continuous improvement to ensure that results and data are reliable, accurate, timely, and reproducible. A robust, suitable LQMS provides a framework to address gaps and risks throughout the laboratory path of workflow that could potentially lead to a critical error, thus compromising the integrity and credibility of the institution. While there are many LQMS frameworks (e.g., a model such as a consensus standard, guideline, or regulation) that may apply, ensuring that the appropriate framework is adopted based on the type of work performed and that key implementation steps are taken is important for the long-term success of the LQMS and for the advancement of science. Ultimately, it ensures accurate results, efficient operations, and increased credibility, enabling protection of public health and safety. Herein, we explore LQMS framework options for each identified laboratory category and discuss prerequisite considerations for implementation. An analysis of frameworks' principles and conformity requirements demonstrates the extent to which they address basic components of effective laboratory operations and guides optimal implementation to yield a holistic, sustainable framework that addresses the laboratory's needs and the type of work being performed.
Language	English
Publishing date	2022-11-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2022.1040103
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The biosynthesis and role of phosphorylcholine in pathogenic and nonpathogenic bacteria.

Zhang, Yuan / Jen, Freda E-C / Fox, Kate L / Edwards, Jennifer L / Jennings, Michael P

Trends in microbiology

2023 Volume 31, Issue 7, Page(s) 692–706

Abstract: Phosphorylcholine (ChoP) can be found in all life forms. Although this molecule was first thought to be uncommon in bacteria, it is now appreciated that many bacteria express ChoP on their surface. ChoP is usually attached to a glycan structure, but in ... ...

Abstract	Phosphorylcholine (ChoP) can be found in all life forms. Although this molecule was first thought to be uncommon in bacteria, it is now appreciated that many bacteria express ChoP on their surface. ChoP is usually attached to a glycan structure, but in some cases, it is added as a post-translational modification to proteins. Recent findings have demonstrated the role of ChoP modification and phase variation (ON/OFF switching) in bacterial pathogenesis. However, the mechanisms of ChoP synthesis are still unclear in some bacteria. Here, we review the literature and examine the recent developments in ChoP-modified proteins and glycolipids and of ChoP biosynthetic pathways. We discuss how the well-studied Lic1 pathway exclusively mediates ChoP attachment to glycans but not to proteins. Finally, we provide a review of the role of ChoP in bacterial pathobiology and the role of ChoP in modulating the immune response.
MeSH term(s)	Phosphorylcholine/metabolism ; Bacteria/metabolism ; Polysaccharides
Chemical Substances	Phosphorylcholine (107-73-3) ; Polysaccharides
Language	English
Publishing date	2023-02-28
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1158963-2
ISSN	1878-4380 ; 0966-842X
ISSN (online)	1878-4380
ISSN	0966-842X
DOI	10.1016/j.tim.2023.01.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3738: Show issues

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Article ; Online: Health related quality of life during dialysis modality transitions: a qualitative study.

Dumaine, Chance S / Fox, Danielle E / Ravani, Pietro / Santana, Maria J / MacRae, Jennifer M

BMC nephrology

2023 Volume 24, Issue 1, Page(s) 282

Abstract: ... from the KDQOL-36 (symptoms, effects, burden, overall PCS, and overall MCS) improved in our sample (i.e ...

Abstract	Background: Modality transitions represent a period of significant change that can impact health related quality of life (HRQoL). We explored the HRQoL of adults transitioning to new or different dialysis modalities. Methods: We recruited eligible adults (≥ 18) transitioning to dialysis from pre-dialysis or undertaking a dialysis modality change between July and September 2017. Nineteen participants (9 incident and 10 prevalent dialysis patients) completed the KDQOL-36 survey at time of transition and three months later. Fifteen participants undertook a semi-structured interview at three months. Qualitative data were thematically analyzed. Results: Four themes and five sub-themes were identified: adapting to new circumstances (tackling change, accepting change), adjusting together, trading off, and challenges of chronicity (the impact of dialysis, living with a complex disease, planning with uncertainty). From the first day of dialysis treatment to the third month on a new dialysis therapy, all five HRQoL domains from the KDQOL-36 (symptoms, effects, burden, overall PCS, and overall MCS) improved in our sample (i.e., those who remained on the modality). Conclusions: Dialysis transitions negatively impact the HRQoL of people with kidney disease in various ways. Future work should focus on how to best support people during this time.
MeSH term(s)	Adult ; Humans ; Dialysis ; Quality of Life ; Qualitative Research ; Renal Dialysis ; Data Accuracy
Language	English
Publishing date	2023-09-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-023-03330-y
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Article ; Online: Social and cognitive vulnerability to COVID-19-related stress in pregnancy: A case-matched-control study of antenatal mental health.

Songco, Annabel / Minihan, Savannah / Fox, Elaine / Ladouceur, Cecile / Mewton, Louise / Moulds, Michelle / Pfeifer, Jennifer / Van Harmelen, Anne-Laura / Schweizer, Susanne

Journal of affective disorders

2023 Volume 325, Page(s) 739–746

Abstract: ... Its impact was greatest in women with cognitive (i.e., higher intolerance of uncertainty and tendency ... to worry) and social (i.e., higher level of self-reported loneliness) vulnerabilities. Importantly ...

Abstract	Emerging evidence shows that compared to pre-pandemic norms pregnant women report significant increases in clinical levels of depressive and anxiety symptoms during COVID-19. This pre-registered study examined cognitive and social vulnerability factors for poor mental health in pregnancy during COVID-19. Understanding vulnerability profiles is key to identifying women at risk for deteriorating peripartum mental health. N = 742 pregnant women and N = 742 age and country-matched controls from the COVID-19 Risks Across the Lifespan Study were included. Using a case-match control design allowed us to explore whether the cognitive vulnerability profiles would differ between pregnant and non-pregnant women. The findings showed that COVID-19-related stress was associated with heightened levels of depression and anxiety during pregnancy. Its impact was greatest in women with cognitive (i.e., higher intolerance of uncertainty and tendency to worry) and social (i.e., higher level of self-reported loneliness) vulnerabilities. Importantly, our data show that the mental health impacts of the pandemic were greater in pregnant women compared to women who were not pregnant, especially those with cognitive and social vulnerabilities. The results highlight the urgent need to prioritize mental health care for pregnant women to mitigate the impact of COVID-19-related stress on women's postpartum mental health and their infants' well-being.
MeSH term(s)	Infant ; Female ; Humans ; Pregnancy ; Mental Health ; COVID-19/epidemiology ; Anxiety/epidemiology ; Anxiety Disorders ; Cognition ; Depression/epidemiology
Language	English
Publishing date	2023-01-20
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2023.01.053
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Zs.A 1485: Show issues

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Article ; Online: 'Scaling up' our understanding of environmental effects of marine renewable energy development from single devices to large-scale commercial arrays.

Hasselman, Daniel J / Hemery, Lenaïg G / Copping, Andrea E / Fulton, Elizabeth A / Fox, Jennifer / Gill, Andrew B / Polagye, Brian

The Science of the total environment

2023 Volume 904, Page(s) 166801

Abstract: ... yet to realize its full potential due to the limited scale of device deployments (i.e., single devices or small ...

Abstract	Global expansion of marine renewable energy (MRE) technologies is needed to help address the impacts of climate change, to ensure a sustainable transition from carbon-based energy sources, and to meet national energy security needs using locally-generated electricity. However, the MRE sector has yet to realize its full potential due to the limited scale of device deployments (i.e., single devices or small demonstration-scale arrays), and is hampered by various factors including uncertainty about environmental effects and how the magnitude of these effects scale with an increasing number of devices. This paper seeks to expand our understanding of the environmental effects of MRE arrays using existing frameworks and through the adaptation and application of cumulative environmental effects terminology to key stressor-receptor interactions. This approach facilitates the development of generalized concepts for the scaling of environmental effects for key stressor-receptor interactions, identifying high priority risks and revealing knowledge gaps that require investigation to aid expansion of the MRE sector. Results suggest that effects of collision risk for an array may be additive, antagonistic, or synergistic, but are likely dependent on array location and configuration. Effects of underwater noise are likely additive as additional devices are deployed in an array, while the effects of electromagnetic fields may be dominant, additive, or antagonistic. Changes to benthic habitats are likely additive, but may be dependent on array configuration and could be antagonistic or synergistic at the ecosystem scale. Effects of displacement, entanglement, and changes to oceanographic systems for arrays are less certain because little information is available about effects at the current scale of MRE development.
Language	English
Publishing date	2023-09-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.166801
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Zs.A 949: Show issues

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Article ; Online: The Developmental Unfolding of ADHD Symptoms from Early Childhood Through Adolescence: Early Effects of Exuberant Temperament, Parenting and Executive Functioning.

Lorenzo, Nicole E / Bui, Hong N T / Degnan, Kathryn A / McDermott, Jennifer M / Henderson, Heather A / Fox, Nathan A / Chronis-Tuscano, Andrea

Research on child and adolescent psychopathology

2023 Volume 52, Issue 4, Page(s) 621–634

Abstract: ... symptoms from childhood through adolescence (age 5, 7, 9, 12, and 15) via child EF (i.e., inhibitory ...

Abstract	Temperament, parenting, and executive functioning (EF) are individual and contextual factors that have been identified to play a role in the development of Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms. Specifically, exuberant temperament in toddlerhood has been associated with both adaptive and maladaptive outcomes, including ADHD symptoms. Therefore, it is important to understand factors that predict which exuberant children experience increased ADHD symptoms and the specific mechanisms through which early exuberant temperament impacts later ADHD symptoms. Using a multi-method, prospective longitudinal design, this study examined a moderated mediation model wherein the interactive effects of observed exuberance and parenting at age 3 predicted the development of parent-reported ADHD symptoms from childhood through adolescence (age 5, 7, 9, 12, and 15) via child EF (i.e., inhibitory control) at age 4. Parent-child dyads (n = 291) from a longitudinal study on child temperament were included. A piecewise model of ADHD symptom growth demonstrated stability in ADHD symptoms from age 5-9 and a decrease from age 9-15. Results support a moderated mediation model wherein an increase in ADHD symptoms throughout childhood was predicted from early childhood exuberant temperament by way of EF, but only for children whose parents displayed less directive parenting. Findings suggest identifiable early markers of risk, including temperament, parenting, and EF- pointing to possible targets for early intervention/prevention.
MeSH term(s)	Humans ; Child, Preschool ; Adolescent ; Child ; Attention Deficit Disorder with Hyperactivity ; Parenting ; Temperament ; Longitudinal Studies ; Prospective Studies
Language	English
Publishing date	2023-11-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	3041907-4
ISSN	2730-7174 ; 2730-7166
ISSN (online)	2730-7174
ISSN	2730-7166
DOI	10.1007/s10802-023-01140-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Where do heavy drinking college students experience alcohol consequences and where are they perceived to be normative?

Merrill, Jennifer E / Fox, Oliver S / Boyle, Holly K / Haines, Anne / Carey, Kate B

Addictive behaviors

2022 Volume 136, Page(s) 107474

Abstract: ... drinking location, and whether location-specific intervention content (e.g., normative correction) would be ...

Abstract	High levels of alcohol consumption are common among college students and associated with endorsing negative alcohol-related consequences. Research suggests both drinking norms and location are strong predictors of drinking behavior in college students. Yet, normative perceptions of consequences, and whether they are location-specific, are less well-studied. We tested the hypotheses that college students who drink would have the highest levels of descriptive and injunctive norms for negative consequences, and would self-report the greatest number of negative consequences, at large gatherings/parties relative to someone's home/dorm and/or bars/clubs. Additionally, we explored whether specific acute consequences were more likely in some drinking locations versus others. Participants were 96 full-time undergraduate students who engaged in high-risk drinking. At baseline, participants reported descriptive and injunctive norms for negative consequences in three locations (home/dorm, large gathering/party, bar/club). Over a 28-day period, participants self-reported daily experiences of five alcohol-related consequences in these same locations. With repeated measures analyses of variance, we found that participants perceived their peers experienced more negative consequences and were more approving of negative consequences at large gatherings/parties and small gatherings at someone's home/dorm relative to bars/clubs. Likewise, nonparametric analyses demonstrated that the total number of consequences over the 28-day assessment period also differed by location, with participants reporting more consequences at home/dorm and large gathering/party locations than at bars/clubs. Future research is needed to better understand how the impact of norms on behavior differs across drinking location, and whether location-specific intervention content (e.g., normative correction) would be useful.
MeSH term(s)	Alcohol Drinking/epidemiology ; Alcohol Drinking in College ; Ethanol ; Humans ; Peer Group ; Students ; Universities
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2022-08-30
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	197618-7
ISSN	1873-6327 ; 0306-4603
ISSN (online)	1873-6327
ISSN	0306-4603
DOI	10.1016/j.addbeh.2022.107474
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Article ; Online: Successful use of rifampin in a patient with Stevens-Johnson syndrome to rifabutin.

Yonkof, Jennifer R / Tapke, David E / Fox, Charity C / Ogbogu, Princess U

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

2020 Volume 124, Issue 6, Page(s) 624–626

MeSH term(s)	Antibiotics, Antitubercular/adverse effects ; Cross Reactions/immunology ; Humans ; Immunoglobulin E/immunology ; Male ; Middle Aged ; Rifabutin/adverse effects ; Rifampin/administration & dosage ; Rifampin/therapeutic use ; Stevens-Johnson Syndrome/drug therapy ; Stevens-Johnson Syndrome/etiology ; Treatment Outcome
Chemical Substances	Antibiotics, Antitubercular ; Rifabutin (1W306TDA6S) ; Immunoglobulin E (37341-29-0) ; Rifampin (VJT6J7R4TR)
Language	English
Publishing date	2020-03-10
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	1228189-x
ISSN	1534-4436 ; 0003-4738 ; 1081-1206
ISSN (online)	1534-4436
ISSN	0003-4738 ; 1081-1206
DOI	10.1016/j.anai.2020.03.001
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Article ; Online: Qualitative examination of simultaneous alcohol and cannabis use reasons, evaluations, and patterns among heavy drinking young adults.

Boyle, Holly K / Gunn, Rachel L / López, Gabriela / Fox, Oliver S / Merrill, Jennifer E

Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors

2021 Volume 35, Issue 6, Page(s) 638–649

Abstract: ... insight into college students' recent simultaneous use events in order to inform future studies (i.e ...

Abstract	Use of alcohol and cannabis together so their effects overlap (simultaneous use) is common among college students and associated with numerous negative consequences. The aim of this study was to gain insight into college students' recent simultaneous use events in order to inform future studies (i.e., generate hypotheses, inform measures/assessments of simultaneous use, and identify factors influencing simultaneous use). Qualitative interviews of simultaneous use experiences among heavy drinking college students (
MeSH term(s)	Adaptation, Psychological ; Alcohol Drinking ; Alcohol Drinking in College ; Cannabis ; Humans ; Motivation ; Students ; Universities ; Young Adult
Language	English
Publishing date	2021-09-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2101111-4
ISSN	1939-1501 ; 0893-164X
ISSN (online)	1939-1501
ISSN	0893-164X
DOI	10.1037/adb0000746
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