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  1. Article: Liposomes-Based Drug Delivery Systems of Anti-Biofilm Agents to Combat Bacterial Biofilm Formation.

    Makhlouf, Zinb / Ali, Amaal Abdulraqeb / Al-Sayah, Mohammad Hussein

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 5

    Abstract: All currently approved antibiotics are being met by some degree of resistance by the bacteria they target. Biofilm formation is one of the crucial enablers of bacterial resistance, making it an important bacterial process to target for overcoming ... ...

    Abstract All currently approved antibiotics are being met by some degree of resistance by the bacteria they target. Biofilm formation is one of the crucial enablers of bacterial resistance, making it an important bacterial process to target for overcoming antibiotic resistance. Accordingly, several drug delivery systems that target biofilm formation have been developed. One of these systems is based on lipid-based nanocarriers (liposomes), which have shown strong efficacy against biofilms of bacterial pathogens. Liposomes come in various types, namely conventional (charged or neutral), stimuli-responsive, deformable, targeted, and stealth. This paper reviews studies employing liposomal formulations against biofilms of medically salient gram-negative and gram-positive bacterial species reported recently. When it comes to gram-negative species, liposomal formulations of various types were reported to be efficacious against
    Language English
    Publishing date 2023-05-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12050875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Chemical disinfectants of COVID-19: an overview.

    Al-Sayah, Mohammad Hussein

    Journal of water and health

    2020  Volume 18, Issue 5, Page(s) 843–848

    Abstract: The outbreak of coronavirus (COVID-19) has led to a broad use of chemical disinfectants in order to sterilize public spaces and prevent contamination. This paper surveys the chemicals that are effective in deactivating the virus and their mode of action. ...

    Abstract The outbreak of coronavirus (COVID-19) has led to a broad use of chemical disinfectants in order to sterilize public spaces and prevent contamination. This paper surveys the chemicals that are effective in deactivating the virus and their mode of action. It presents the different chemical classes of disinfectants and identifies the chemical features of these compounds that pertain to their biocidal activity, relevant to surface/water disinfection.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Disinfectants/pharmacology ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Disinfectants
    Keywords covid19
    Language English
    Publishing date 2020-10-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2123845-5
    ISSN 1996-7829 ; 1477-8920
    ISSN (online) 1996-7829
    ISSN 1477-8920
    DOI 10.2166/wh.2020.108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7513: Show issues

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  3. Article: Chemical disinfectants of COVID-19: an overview

    Al-Sayah, Mohammad Hussein

    J Water Health

    Abstract: The outbreak of coronavirus (COVID-19) has led to a broad use of chemical disinfectants in order to sterilize public spaces and prevent contamination. This paper surveys the chemicals that are effective in deactivating the virus and their mode of action. ...

    Abstract The outbreak of coronavirus (COVID-19) has led to a broad use of chemical disinfectants in order to sterilize public spaces and prevent contamination. This paper surveys the chemicals that are effective in deactivating the virus and their mode of action. It presents the different chemical classes of disinfectants and identifies the chemical features of these compounds that pertain to their biocidal activity, relevant to surface/water disinfection.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #890253
    Database COVID19

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  4. Article ; Online: Development of Liposome-Based Immunoassay for the Detection of Cardiac Troponin I.

    Radha, Remya / Al-Sayah, Mohammad Hussein

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 22

    Abstract: Cardiovascular diseases (CVDs) are one of the foremost causes of mortality in intensive care units worldwide. The development of a rapid method to quantify cardiac troponin I (cTnI)-the gold-standard biomarker of myocardial infarction (MI) (or "heart ... ...

    Abstract Cardiovascular diseases (CVDs) are one of the foremost causes of mortality in intensive care units worldwide. The development of a rapid method to quantify cardiac troponin I (cTnI)-the gold-standard biomarker of myocardial infarction (MI) (or "heart attack")-becomes crucial in the early diagnosis and treatment of myocardial infarction (MI). This study investigates the development of an efficient fluorescent "sandwich" immunoassay using liposome-based fluorescent signal amplification and thereby enables the sensing and quantification of serum-cTnI at a concentration relevant to clinical settings. The calcein-loaded liposomes were utilized as fluorescent nano vehicles, and these have exhibited appropriate stability and efficient fluorescent properties. The standardized assay was sensitive and selective towards cTnI in both physiological buffer solutions and spiked human serum samples. The novel assay presented noble analytical results with sound dynamic linearity over a wide concentration range of 0 to 320 ng/mL and a detection limit of 6.5 ng/mL for cTnI in the spiked human serum.
    MeSH term(s) Biomarkers/blood ; Early Diagnosis ; Fluoresceins/chemistry ; Humans ; Immunoassay ; Liposomes/chemistry ; Myocardial Infarction/blood ; Troponin I/blood
    Chemical Substances Biomarkers ; Fluoresceins ; Liposomes ; Troponin I ; fluorexon (V0YM2B16TS)
    Language English
    Publishing date 2021-11-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26226988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  5. Article ; Online: Fluorescent Immunoassays for Detection and Quantification of Cardiac Troponin I: A Short Review.

    Radha, Remya / Shahzadi, Syeda Kiran / Al-Sayah, Mohammad Hussein

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 16

    Abstract: Cardiovascular diseases are considered one of the major causes of human death globally. Myocardial infarction (MI), characterized by a diminished flow of blood to the heart, presents the highest rate of morbidity and mortality among all other ... ...

    Abstract Cardiovascular diseases are considered one of the major causes of human death globally. Myocardial infarction (MI), characterized by a diminished flow of blood to the heart, presents the highest rate of morbidity and mortality among all other cardiovascular diseases. These fatal effects have triggered the need for early diagnosis of appropriate biomarkers so that countermeasures can be taken. Cardiac troponin, the central key element of muscle regulation and contraction, is the most specific biomarker for cardiac injury and is considered the "gold standard". Due to its high specificity, the measurement of cardiac troponin levels has become the predominant indicator of MI. Various forms of diagnostic methods have been developed so far, including chemiluminescence, fluorescence immunoassay, enzyme-linked immunosorbent assay, surface plasmon resonance, electrical detection, and colorimetric protein assays. However, fluorescence-based immunoassays are considered fast, accurate and most sensitive of all in the determination of cardiac troponins post-MI. This review represents the strategies, methods and levels of detection involved in the reported fluorescence-based immunoassays for the detection of cardiac troponin I.
    MeSH term(s) Biomarkers/blood ; Fluorescence ; Humans ; Immunoassay ; Myocardial Infarction/blood ; Myocardial Infarction/diagnosis ; Troponin I/blood ; Troponin I/isolation & purification
    Chemical Substances Biomarkers ; Troponin I
    Language English
    Publishing date 2021-08-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26164812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

    Order via subito

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  6. Article ; Online: Development of Liposome-Based Immunoassay for the Detection of Cardiac Troponin I

    Remya Radha / Mohammad Hussein Al-Sayah

    Molecules, Vol 26, Iss 6988, p

    2021  Volume 6988

    Abstract: Cardiovascular diseases (CVDs) are one of the foremost causes of mortality in intensive care units worldwide. The development of a rapid method to quantify cardiac troponin I (cTnI)—the gold-standard biomarker of myocardial infarction (MI) (or “heart ... ...

    Abstract Cardiovascular diseases (CVDs) are one of the foremost causes of mortality in intensive care units worldwide. The development of a rapid method to quantify cardiac troponin I (cTnI)—the gold-standard biomarker of myocardial infarction (MI) (or “heart attack”)—becomes crucial in the early diagnosis and treatment of myocardial infarction (MI). This study investigates the development of an efficient fluorescent “sandwich” immunoassay using liposome-based fluorescent signal amplification and thereby enables the sensing and quantification of serum-cTnI at a concentration relevant to clinical settings. The calcein-loaded liposomes were utilized as fluorescent nano vehicles, and these have exhibited appropriate stability and efficient fluorescent properties. The standardized assay was sensitive and selective towards cTnI in both physiological buffer solutions and spiked human serum samples. The novel assay presented noble analytical results with sound dynamic linearity over a wide concentration range of 0 to 320 ng/mL and a detection limit of 6.5 ng/mL for cTnI in the spiked human serum.
    Keywords myocardial infarction ; cardiac troponin ; cTnI-detection ; calcein liposomes ; fluorescence ; signal quantification ; Organic chemistry ; QD241-441
    Subject code 610
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  7. Article ; Online: Fluorescent Immunoassays for Detection and Quantification of Cardiac Troponin I

    Remya Radha / Syeda Kiran Shahzadi / Mohammad Hussein Al-Sayah

    Molecules, Vol 26, Iss 4812, p

    A Short Review

    2021  Volume 4812

    Abstract: Cardiovascular diseases are considered one of the major causes of human death globally. Myocardial infarction (MI), characterized by a diminished flow of blood to the heart, presents the highest rate of morbidity and mortality among all other ... ...

    Abstract Cardiovascular diseases are considered one of the major causes of human death globally. Myocardial infarction (MI), characterized by a diminished flow of blood to the heart, presents the highest rate of morbidity and mortality among all other cardiovascular diseases. These fatal effects have triggered the need for early diagnosis of appropriate biomarkers so that countermeasures can be taken. Cardiac troponin, the central key element of muscle regulation and contraction, is the most specific biomarker for cardiac injury and is considered the “gold standard”. Due to its high specificity, the measurement of cardiac troponin levels has become the predominant indicator of MI. Various forms of diagnostic methods have been developed so far, including chemiluminescence, fluorescence immunoassay, enzyme-linked immunosorbent assay, surface plasmon resonance, electrical detection, and colorimetric protein assays. However, fluorescence-based immunoassays are considered fast, accurate and most sensitive of all in the determination of cardiac troponins post-MI. This review represents the strategies, methods and levels of detection involved in the reported fluorescence-based immunoassays for the detection of cardiac troponin I.
    Keywords cardiac troponin ; myocardial infarction ; immunoassays ; fluorescence ; biosensors ; cardiovascular diseases ; Organic chemistry ; QD241-441
    Subject code 610
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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