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Article ; Online: The putative cannabinoid-secreting trichome of Trema micrantha (L.) Blume (Cannabaceae).

Teixeira, Simone Pádua / Nascimento, Isabel Cristina / Grejo, Marina Priolo / Leite, Viviane Gonçalves / Machado, Sílvia Rodrigues

Protoplasma

2023 Volume 261, Issue 3, Page(s) 463–475

Abstract: Trema, a genus of the popularly known Cannabaceae, has recently been the subject of cannabinoid bioprospection. T. micrantha is a tree with pharmacological potential widely used in folk medicine. It has two types of glandular trichomes, bulbous and ... ...

Abstract	Trema, a genus of the popularly known Cannabaceae, has recently been the subject of cannabinoid bioprospection. T. micrantha is a tree with pharmacological potential widely used in folk medicine. It has two types of glandular trichomes, bulbous and filiform, spread throughout the plant body. Considering the proximity of this species to Cannabis sativa and Trema orientalis, species containing cannabinoids, the glandular trichomes of T. micrantha are also expected to be related to the secretion of these compounds. Thus, this study aims to detail the morphology of secretory trichomes during the synthesis, storing and release of metabolites in T. micrantha. We tested the proposition that they could be a putative type of cannabinoid-secreting gland. Pistillate and staminate flowers and leaves were collected and processed for ontogenic, histochemical, and ultrastructural analyses. Both types of glandular trichomes originate from a protodermal cell. They are putative cannabinoid-secreting sites because: (1) terpene-phenols and, more specifically, cannabinoids were detected in situ; (2) their secretory subcellular apparatus is consistent with that found in C. sativa: modified plastids, polyribosomes, an extensive rough endoplasmic reticulum, and a moniliform smooth endoplasmic reticulum. Plastids and smooth endoplasmic reticulum are involved in the synthesis of terpenes, while the rough endoplasmic reticulum acts in the phenolic synthesis. These substances cross the plasma membrane by exocytosis and are released outside the trichome through cuticle pores. The study of the cell biology of the putative cannabinoid glands can promote the advancement of prospecting for natural products in plants.
MeSH term(s)	Cannabinoids/analysis ; Cannabinoids/chemistry ; Cannabinoids/metabolism ; Trema/metabolism ; Cannabaceae ; Trichomes/ultrastructure ; Cannabis/metabolism ; Terpenes/chemistry ; Plant Leaves/metabolism
Chemical Substances	Cannabinoids ; Terpenes
Language	English
Publishing date	2023-11-24
Publishing country	Austria
Document type	Journal Article
ZDB-ID	123809-7
ISSN	1615-6102 ; 0033-183X
ISSN (online)	1615-6102
ISSN	0033-183X
DOI	10.1007/s00709-023-01907-w
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Article: Spontaneous Adverse Event Reporting by COVID-19 Vaccinated Healthcare Professionals Through an Electronic Form Implemented by the Hospital Pharmacy.

da Cruz, João Paulo Garcia Lopes / de Carvalho, Cristina da Conceição Ribeiro / da Cruz Silva, Paula Alexandre / Guerreiro, Luis Filipe Campos / Bento, Tatiana Vedes / Costa, Leila Vanessa Carmo Cardoso Martins / Simões, Raquel Filipa Miguel Margarido Duarte / Marques, Rui Pedro Pinheiro Gonçalves / Castro Fernandes, Ana Cristina / Galaio, Luís Miguel Costa de Mendonça / Correia, Ana Isabel B / Leite Resende, Ema Maria S / Gonçalves, João Manuel Braz

Hospital pharmacy

2022 Volume 57, Issue 6, Page(s) 744–751

Abstract: Aim: ...

Abstract	Aim:
Language	English
Publishing date	2022-07-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1468893-1
ISSN	0018-5787
ISSN	0018-5787
DOI	10.1177/00185787221111725
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Article ; Online: Spatial analysis of care for patients undergoing dialysis therapy in the state of Minas Gerais, Brazil, between 2015 and 2019.

Pereira, Claudio Vitorino / Leite, Isabel Cristina Gonçalves / Nogueira, Mário Círio / Ferreira, Gustavo Fernandes

Revista brasileira de epidemiologia = Brazilian journal of epidemiology

2024 Volume 27, Page(s) e240002

Abstract: Objective: To analyze the spatial flow of care for patients undergoing dialysis therapy in the health regions of the State of Minas Gerais.: Methods: Ecological study whose population was patients undergoing dialysis therapy in public, philanthropic ... ...

Abstract	Objective: To analyze the spatial flow of care for patients undergoing dialysis therapy in the health regions of the State of Minas Gerais. Methods: Ecological study whose population was patients undergoing dialysis therapy in public, philanthropic institutions or whose treatment was paid for by the Unified Health System in private clinics in partnership, in the State of Minas Gerais. Patients were grouped by health region of residence. The proportions of patients who underwent dialysis were calculated, as well as enrollment on the kidney transplant list in their own region of residence or outside it. Person correlations of these proportions with socioeconomic and care indicators of the health regions were estimated. Spatial exploratory techniques estimated general (Moran's I) and local (LISA) spatial correlation coefficients. Results: Regions with higher GDP had a higher number of nephrologists and a higher proportion of registrations in the region of residence. A cluster of regions with low GDP was identified further to the northeast of the State (also with lower nephrologist ratio values), a cluster with a high proportion of those registered on the transplant list in the center of the State, and a cluster with a low proportion of dialysis in the same region of residence further southeast. Conclusion: Regional disparities were evident in relation to the proportion of patients registered on the waiting list for kidney transplantation, the proportion of patients undergoing dialysis in the same region of residence and the proportion of patients registered on the waiting list for kidney transplantation in the same region of residence. residence.
MeSH term(s)	Humans ; Brazil ; Renal Dialysis ; Spatial Analysis ; Healthcare Disparities ; Regional Health Planning ; Renal Insufficiency, Chronic/therapy
Language	Portuguese
Publishing date	2024-01-19
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2183366-7
ISSN	1980-5497 ; 1980-5497
ISSN (online)	1980-5497
ISSN	1980-5497
DOI	10.1590/1980-549720240002
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Article ; Online: Factors associated with recent and regular non-use of dental services by students from a university in southeastern Brazil: a cross-sectional study.

de Oliveira Cunha, Rafaela / Leite, Isabel Cristina Gonçalves

BMC oral health

2022 Volume 22, Issue 1, Page(s) 612

Abstract: Background: Lack of use of dental services can be a risk factor for oral health. In addition to recent visits to dental services, it is important to assess the regularity of use of these services, as well as the motivations for visiting the dentist. ... ...

Abstract	Background: Lack of use of dental services can be a risk factor for oral health. In addition to recent visits to dental services, it is important to assess the regularity of use of these services, as well as the motivations for visiting the dentist. There is a gap in literature studies on the patterns of use of oral health services by the young university students. The goal of this study was to assess the factors associated with recent and regular non-use of dental services by young university students, using the Andersen model as a reference. Methods: This was a cross-sectional study with 477 university students between 18 and 24 years old, carried out as a web survey, through which predisposing, enabling and need variables were collected, according to the model proposed by Andersen, to test the factors associated with recent and regular non-use of dental services. Bivariate analyses and robust Poisson regression were performed, with estimation of crude and adjusted prevalence ratios, using confidence intervals of 95%. The variables with p < 0.05 remained in the final model. Results: The prevalence of recent non-use was of 19.5% (95% CI 16.0-23.3%), and of regular non-use, of 53.5% (95% CI 48.9-58.0%). After the adjusted analysis, the following were found to be associated with the outcome of recent non-use: type of service used (PR = 0.91; 95% CI 0.85-0.98) and perceived need for dental treatment (PR = 0.98; 95% CI 0.97-0.99); and the following variables were associated with regular non-use: father's level of education (PR = 0.86; 95% CI 0.78-0.96), area of study (PR = 1.08; 95% CI 1.02-1.15), reason for last dental appointment (PR = 0.81; 95% CI 0.75-0.88), use of dental services throughout childhood (PR = 0.92; 95% CI 0.86-0.97), self-perceived oral health (PR = 0.86; 95% CI 0.76-0.88), and toothaches over the last 2 years (PR = 0.93; 95% CI 0.87-0.99). Conclusion: The motivation for young university students to use dental services are curative treatment needs, not prevention. The results point to the need to implement health prevention and promotion policies in higher education institutions and to expand access to dental services for this young population.
Language	English
Publishing date	2022-12-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-022-02648-7
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Article ; Online: Epidemiological characteristics and adherence of a cohort of elderly people with HIV/AIDS in the Public Health System.

Ferreira, Cristiane Marcos Soares Dias / Leite, Isabel Cristina Gonçalves

Einstein (Sao Paulo, Brazil)

2022 Volume 20, Page(s) eAO6474

Abstract: Objective: To characterize the epidemiological profile of patients aged 50 years or older diagnosed as HIV/AIDS, in a Specialized Service of the Public Health System.: Methods: A retrospective cohort study using secondary data from medical records in ...

Abstract	Objective: To characterize the epidemiological profile of patients aged 50 years or older diagnosed as HIV/AIDS, in a Specialized Service of the Public Health System. Methods: A retrospective cohort study using secondary data from medical records in the period 2014 to 2018. Sociodemographic and clinical characteristics, and features related to treatment adherence were organized in a database. Quantitative variables were expressed as mean (or median) ± standard deviation (or interquartile range), and categorical variables expressed as number and percentage of patients. The Kaplan-Meier method was applied to assess the probability of overall specific survival. Results: Of the 241 initially eligible patients, 149 patients were evaluated, registering 19 deaths in the studied period. There was a predominance of males aged 50-59 years, with severe immunodeficiency upon admission (29.7%), and with a CD4+ T lymphocyte count below 200 cells in 62 (46.3%) of patients. Elderly people aged 61 or over were more adherent. There was an increase in the CD4+ T lymphocyte count by an average of 139.63 in the first 6 months, and 50.51 from the first 6 months to 12 months of follow-up, with an average increase in the first 12 months of 157.63 cells. Specific overall survival in the period was 85%. Conclusion: Patients older than 50 years had an immune response and no viral load detection in the 12-month period, deserving further studies to improve survival.
MeSH term(s)	Acquired Immunodeficiency Syndrome/drug therapy ; Acquired Immunodeficiency Syndrome/epidemiology ; Aged ; CD4 Lymphocyte Count ; Cohort Studies ; Humans ; Male ; Middle Aged ; Public Health ; Retrospective Studies
Language	English
Publishing date	2022-03-25
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2418293-X
ISSN	2317-6385 ; 2317-6385
ISSN (online)	2317-6385
ISSN	2317-6385
DOI	10.31744/einstein_journal/2022AO6474
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Article ; Online: Prevalence and factors associated with anxiety and depressive symptoms in women deprived of liberty in Juiz de Fora-MG, Brazil.

Laurindo, Cosme Rezende / Leite, Isabel Cristina Gonçalves / Cruz, Danielle Teles da

Ciencia & saude coletiva

2022 Volume 27, Issue 12, Page(s) 4493–4509

Abstract: Psychological distress and developing mental disorders in prisons are globally recognized public health issues. This study aimed to identify the prevalence of these symptoms and associated factors in 99 women over 18 years of age in the provisional, ... ...

Title translation	Prevalência e fatores associados a sintomas ansiosos e depressivos em mulheres privadas de liberdade em Juiz de Fora-MG, Brasil.
Abstract	Psychological distress and developing mental disorders in prisons are globally recognized public health issues. This study aimed to identify the prevalence of these symptoms and associated factors in 99 women over 18 years of age in the provisional, closed, and semi-open regimes in Juiz de Fora-MG, Brazil. This cross-sectional census study collected data face-to-face through a semi-structured and multidimensional questionnaire. We assessed outcomes using the Patient Health Questionnaire-4 (PHQ-4). We built a theoretical determination model with three hierarchical blocks for the association analysis. We estimated crude prevalence ratios using the chi-square test and adjusted for each other within each block (p≤0.20). We adopted p≤0.05 for the final Poisson regression model with robust variance. The prevalence of anxiety and depressive symptoms was 75.8% (95%CI 66.1%-83.8%) and 65.7% (95%CI 55.4%-74.9%), respectively. In the final model, anxiety symptoms were associated with depressive symptoms. On the other hand, depressive symptoms were associated with the 20-29 years age group and anxiety symptoms. We identified a prevalence of the outcomes in more than half of the participants, emphasizing the inter-association between them.
MeSH term(s)	Humans ; Female ; Adolescent ; Adult ; Brazil/epidemiology ; Prevalence ; Cross-Sectional Studies ; Depression/epidemiology ; Socioeconomic Factors ; Anxiety/epidemiology ; Freedom
Language	English
Publishing date	2022-06-15
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2078799-6
ISSN	1678-4561 ; 1678-4561
ISSN (online)	1678-4561
ISSN	1678-4561
DOI	10.1590/1413-812320222712.08952022
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Article ; Online: Epidemiological characteristics and adherence of a cohort of elderly people with HIV/AIDS in the Public Health System

Cristiane Marcos Soares Dias Ferreira / Isabel Cristina Gonçalves Leite

Einstein (São Paulo), Vol

2022 Volume 20

Abstract: ABSTRACT Objective To characterize the epidemiological profile of patients aged 50 years or older diagnosed as HIV/AIDS, in a Specialized Service of the Public Health System. Methods A retrospective cohort study using secondary data from medical records ... ...

Abstract	ABSTRACT Objective To characterize the epidemiological profile of patients aged 50 years or older diagnosed as HIV/AIDS, in a Specialized Service of the Public Health System. Methods A retrospective cohort study using secondary data from medical records in the period 2014 to 2018. Sociodemographic and clinical characteristics, and features related to treatment adherence were organized in a database. Quantitative variables were expressed as mean (or median) ± standard deviation (or interquartile range), and categorical variables expressed as number and percentage of patients. The Kaplan-Meier method was applied to assess the probability of overall specific survival. Results Of the 241 initially eligible patients, 149 patients were evaluated, registering 19 deaths in the studied period. There was a predominance of males aged 50-59 years, with severe immunodeficiency upon admission (29.7%), and with a CD4+ T lymphocyte count below 200 cells in 62 (46.3%) of patients. Elderly people aged 61 or over were more adherent. There was an increase in the CD4+ T lymphocyte count by an average of 139.63 in the first 6 months, and 50.51 from the first 6 months to 12 months of follow-up, with an average increase in the first 12 months of 157.63 cells. Specific overall survival in the period was 85%. Conclusion Patients older than 50 years had an immune response and no viral load detection in the 12-month period, deserving further studies to improve survival.
Keywords	Treatment adherence and compliance ; HIV ; AIDS ; Acquired immunodeficiency syndrome ; Aged ; Immunity ; cellular ; Antiretroviral therapy ; highly active ; Medicine ; R
Subject code	616 ; 610
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Instituto Israelita de Ensino e Pesquisa Albert Einstein
Document type	Article ; Online
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Article ; Online: Condição de saúde bucal e a percepção sobre atenção odontológica de gestantes

Rafaela de Oliveira Cunha / Isabel Cristina Gonçalves Leite

HU Revista, Vol

2021 Volume 47

Abstract: Introdução: A gravidez é uma condição sistêmica que envolve mudanças fisiológicas e psicológicas complexas. Esse período também pode envolver uma variedade de alterações bucais, influenciadas por alterações hormonais e comportamentais. Apesar de ... ...

Abstract	Introdução: A gravidez é uma condição sistêmica que envolve mudanças fisiológicas e psicológicas complexas. Esse período também pode envolver uma variedade de alterações bucais, influenciadas por alterações hormonais e comportamentais. Apesar de assistência odontológica durante o pré-natal ser recomendada por diretrizes do Ministério da Saúde como parte integrante dos cuidados durante a gravidez, a demanda por serviços odontológicos ainda é baixa entre as gestantes. Objetivo: Identificar e analisar, por meio de uma investigação quanti-qualitativa, determinantes do atendimento odontológico durante a gravidez, com base em dados subjetivos relativos à percepção de saúde bucal de gestantes, bem como sua condição de saúde bucal. Material e Métodos: Participaram do estudo onze gestantes com pré-natal iniciado no Sistema Único de Saúde. Os dados foram coletados a partir de entrevista semiestruturada e exame clínico bucal. A análise quantitativa foi realizada por meio da distribuição das frequências dos dados tabulados e os dados qualitativos foram analisados por meio de análise de conteúdo temática proposta por Bardin. Resultados: O índice CPO-D das gestantes foi de 7,8, revelando uma alta prevalência de cárie. Em relação a condição periodontal, 81,8% apresentaram sangramento gengival à sondagem e 36,4% presença de bolsa periodontal. Os altos custos do tratamento odontológico, o medo, as crenças populares e a falta de informação das gestantes sobre a assistência odontológica durante a gravidez foram identificados como barreiras ao tratamento odontológico durante a gestação. Conclusão: Os resultados mostraram que, apesar de as gestantes possuírem necessidade de tratamento odontológico e reconhecerem esse fato, existem barreiras que dificultam sua adesão à atenção odontológica. Dentre estas, o desconhecimento da necessidade de tratamento odontológico neste período da vida foi a maior barreira identificada.
Keywords	Saúde Bucal ; Cuidado Pré-Natal ; Gestantes ; Medicine (General) ; R5-920
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Universidade Federal de Juiz de Fora
Document type	Article ; Online
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Article: An unusual fat-containing presacral tumor in an elderly patient.

Leite, Maria Inês / Gonçalves, Afonso / Ferreira, Ana Cristina / Ortiz, Santiago / Esteves, Rui / Távora, Isabel

Case reports in radiology

2014 Volume 2014, Page(s) 674365

Abstract: The authors present a case of a presacral myelolipoma diagnosed in an 84-year-old male patient with longstanding pelvic pain and past medical history of bladder cancer. Pelvic computed tomography (CT) revealed a well-encapsulated and lobulated presacral ... ...

Abstract	The authors present a case of a presacral myelolipoma diagnosed in an 84-year-old male patient with longstanding pelvic pain and past medical history of bladder cancer. Pelvic computed tomography (CT) revealed a well-encapsulated and lobulated presacral mass, with mixed fat and soft-tissue attenuation. Magnetic resonance (MR) imaging provided further confirmation of macroscopic intralesional fat and excluded either adjacent bone invasion or bladder cancer recurrence. A presacral myelolipoma was suspected based on imaging findings, with liposarcoma and teratoma having also been considered for the differential diagnosis. The histological confirmation of the tumor was only attained postoperatively. This case report alerts to the possible presacral location of myelolipomas, which should be considered for every fat-containing lesion detected in this region. The main clinical, imaging, and differential diagnoses of this entity are reviewed in this paper.
Language	English
Publishing date	2014-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2627655-0
ISSN	2090-6870 ; 2090-6862
ISSN (online)	2090-6870
ISSN	2090-6862
DOI	10.1155/2014/674365
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Article ; Online: Heart rate variability in men with lower urinary tract symptoms: a case-control study.

Brum, Christiano Silva / Pedrosa, Daniel Rocha / Leite, Isabel Cristina Gonçalves / Netto, José Murillo Bastos / Figueiredo, André Avarese

International urology and nephrology

2022 Volume 54, Issue 7, Page(s) 1479–1484

Abstract: Purpose: Measurement of heart rate variability (HRV) allows evaluation of autonomic nervous system activity. Decreased HRV is associated with autonomic disbalance, poor health and higher mortality. Our objective is to evaluate the HRV in men with lower ... ...

Abstract	Purpose: Measurement of heart rate variability (HRV) allows evaluation of autonomic nervous system activity. Decreased HRV is associated with autonomic disbalance, poor health and higher mortality. Our objective is to evaluate the HRV in men with lower urinary tract symptoms (LUTS) through a case-control study. Methods: LUTS were considered as the outcome and HRV variables were considered as exposure. The protocol included anamnesis, LUTS assessment, anthropometry, blood pressure and HRV measurement by analyzing the variation in the time interval between consecutive heartbeats or RR intervals. The mathematical study of HRV indicators allowed the assessment of the cardiac autonomic modulation of the volunteers. Results: Eighty nine patients were included in the study, with 34 allocated to the case group (with LUTS) and 55 to the control group (without LUTS). The patients were similar in terms of age and systolic and diastolic blood pressure. Among the HRV variables, the mean VLF index for the very low frequency of the spectrum associated with the frequency domain was significantly higher in volunteers without LUTS. Control group patients presented a mean of 113.18 ± 166.74 ms Conclusions: Men 50-59 years of age without chronic diseases and with LUTS have an unfavorable cardiac autonomic profile indicated by significantly lower levels of the VLF component of HRV compared to men without LUTS.
MeSH term(s)	Autonomic Nervous System ; Case-Control Studies ; Heart ; Heart Rate/physiology ; Humans ; Lower Urinary Tract Symptoms ; Male
Language	English
Publishing date	2022-04-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	204048-7
ISSN	1573-2584 ; 0301-1623 ; 0042-1162
ISSN (online)	1573-2584
ISSN	0301-1623 ; 0042-1162
DOI	10.1007/s11255-022-03213-5
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