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  1. Article ; Online: Recent developments in X-ray diffraction/scattering computed tomography for materials science.

    Omori, Naomi E / Bobitan, Antonia D / Vamvakeros, Antonis / Beale, Andrew M / Jacques, Simon D M

    Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

    2023  Volume 381, Issue 2259, Page(s) 20220350

    Abstract: X-ray diffraction/scattering computed tomography (XDS-CT) methods are a non-destructive class of chemical imaging techniques that have the capacity to provide reconstructions of sample cross-sections with spatially resolved chemical information. While X- ... ...

    Abstract X-ray diffraction/scattering computed tomography (XDS-CT) methods are a non-destructive class of chemical imaging techniques that have the capacity to provide reconstructions of sample cross-sections with spatially resolved chemical information. While X-ray diffraction CT (XRD-CT) is the most well-established method, recent advances in instrumentation and data reconstruction have seen greater use of related techniques like small angle X-ray scattering CT and pair distribution function CT. Additionally, the adoption of machine learning techniques for tomographic reconstruction and data analysis are fundamentally disrupting how XDS-CT data is processed. The following narrative review highlights recent developments and applications of XDS-CT with a focus on studies in the last five years. This article is part of the theme issue 'Exploring the length scales, timescales and chemistry of challenging materials (Part 2)'.
    Language English
    Publishing date 2023-09-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208381-4
    ISSN 1471-2962 ; 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
    ISSN (online) 1471-2962
    ISSN 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
    DOI 10.1098/rsta.2022.0350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Potassium rhythms couple the circadian clock to the cell cycle.

    Rodríguez, Sergio Gil / Crosby, Priya / Hansen, Louise L / Grünewald, Ellen / Beale, Andrew D / Spangler, Rebecca K / Rabbitts, Beverley M / Partch, Carrie L / Stangherlin, Alessandra / O'Neill, John S / van Ooijen, Gerben

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Circadian (~24 h) rhythms are a fundamental feature of life, and their disruption increases the risk of infectious diseases, metabolic disorders, and ... ...

    Abstract Circadian (~24 h) rhythms are a fundamental feature of life, and their disruption increases the risk of infectious diseases, metabolic disorders, and cancer
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.02.587153
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  3. Article ; Online: Multiple-biomarkers show the importance of blue carbon to commercially important fishery species.

    Gorman, Daniel / Beale, David J / Crosswell, Joey / Stephenson, Sarah A / Shah, Rohan M / Hillyer, Katie E / Steven, Andrew D L

    The Science of the total environment

    2023  Volume 881, Page(s) 163162

    Abstract: Coastal blue carbon ecosystems (BCE) support nearshore food webs and provide habitat for many commercially important fish and crustacean species. However, the complex links between catchment vegetation and the carbon food-base of estuarine systems are ... ...

    Abstract Coastal blue carbon ecosystems (BCE) support nearshore food webs and provide habitat for many commercially important fish and crustacean species. However, the complex links between catchment vegetation and the carbon food-base of estuarine systems are difficult to disern. We employed a multi-biomarker approach (stable isotope ratios - δ
    MeSH term(s) Animals ; Carbon/metabolism ; Ecosystem ; Carbon Isotopes/analysis ; Fisheries ; Food Chain ; Fishes/metabolism ; Nitrogen Isotopes/analysis
    Chemical Substances Carbon (7440-44-0) ; Carbon Isotopes ; Nitrogen Isotopes
    Language English
    Publishing date 2023-04-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.163162
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  4. Article: Hand Hygiene Practices and the Risk of Human Coronavirus Infections in a UK Community Cohort.

    Beale, Sarah / Johnson, Anne M / Zambon, Maria / Hayward, Andrew C / Fragaszy, Ellen B

    Wellcome open research

    2021  Volume 5, Page(s) 98

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-06-22
    Publishing country England
    Document type Journal Article
    ISSN 2398-502X
    ISSN 2398-502X
    DOI 10.12688/wellcomeopenres.15796.2
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  5. Article: Public activities preceding the onset of acute respiratory infection syndromes in adults in England - implications for the use of social distancing to control pandemic respiratory infections.

    Hayward, Andrew C / Beale, Sarah / Johnson, Anne M / Fragaszy, Ellen B

    Wellcome open research

    2020  Volume 5, Page(s) 54

    Abstract: Background: ...

    Abstract Background:
    Keywords covid19
    Language English
    Publishing date 2020-03-30
    Publishing country England
    Document type Journal Article
    ISSN 2398-502X
    ISSN 2398-502X
    DOI 10.12688/wellcomeopenres.15795.1
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  6. Article ; Online: Highly selective CO

    Garvin, Matthew / Thompson, Warren A / Tan, Jeannie Z Y / Kampouri, Stavroula / Ireland, Christopher P / Smit, Berend / Brookfield, Adam / Collison, David / Negahdar, Leila / Beale, Andrew M / Maroto-Valer, M Mercedes / McIntosh, Ruaraidh D / Garcia, Susana

    RSC sustainability

    2023  Volume 1, Issue 3, Page(s) 494–503

    Abstract: Metal-Organic Framework (MOF)-derived ... ...

    Abstract Metal-Organic Framework (MOF)-derived TiO
    Language English
    Publishing date 2023-02-17
    Publishing country England
    Document type Journal Article
    ISSN 2753-8125
    ISSN (online) 2753-8125
    DOI 10.1039/d2su00082b
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  7. Article ; Online: Surviving Sepsis Campaign.

    Dellinger, R Phillip / Rhodes, Andrew / Evans, Laura / Alhazzani, Waleed / Beale, Richard / Jaeschke, Roman / Machado, Flavia R / Masur, Henry / Osborn, Tiffany / Parker, Margaret M / Schorr, Christa / Townsend, Sean R / Levy, Mitchell M

    Critical care medicine

    2023  Volume 51, Issue 4, Page(s) 431–444

    MeSH term(s) Humans ; Sepsis/therapy ; Shock, Septic/therapy
    Language English
    Publishing date 2023-03-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1261: Show issues Location:
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  8. Article ; Online: Past, Present and Future - Sample Environments for Materials Research Studies in Scattering and Spectroscopy; A UK perspective.

    Terrill, Nick / Dent, A J / Dobson, Barry / Beale, Andrew M / Allen, Lisa / Bras, Wim

    Journal of physics. Condensed matter : an Institute of Physics journal

    2021  

    Abstract: Small Angle X-Ray Scattering (SAXS) and X-Ray Absorption Fine Structure (XAFS) are two techniques that have been employed at synchrotron sources ever since their inception. Over the course of the development of the techniques, the introduction of sample ... ...

    Abstract Small Angle X-Ray Scattering (SAXS) and X-Ray Absorption Fine Structure (XAFS) are two techniques that have been employed at synchrotron sources ever since their inception. Over the course of the development of the techniques, the introduction of sample environments for added value experiments has grown dramatically. This article reviews past successes, current developments and an exploration of future possibilities for these two X-ray techniques with an emphasis on the developments in the United Kingdom between 1980 - 2020.
    Language English
    Publishing date 2021-09-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472968-4
    ISSN 1361-648X ; 0953-8984
    ISSN (online) 1361-648X
    ISSN 0953-8984
    DOI 10.1088/1361-648X/ac2389
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  9. Article ; Online: Influence of Solvent on Selective Catalytic Reduction of Nitrogen Oxides with Ammonia over Cu-CHA Zeolite.

    Abdul Nasir, Jamal / Guan, Jingcheng / Keal, Thomas W / Desmoutier, Alec W / Lu, You / Beale, Andrew M / Catlow, C Richard A / Sokol, Alexey A

    Journal of the American Chemical Society

    2022  Volume 145, Issue 1, Page(s) 247–259

    Abstract: The copper-exchanged zeolite Cu-CHA has received considerable attention in recent years, owing to its application in the selective catalytic reduction (SCR) of ... ...

    Abstract The copper-exchanged zeolite Cu-CHA has received considerable attention in recent years, owing to its application in the selective catalytic reduction (SCR) of NO
    MeSH term(s) Nitrates ; Ammonia/chemistry ; Zeolites/chemistry ; Solvents ; Nitrogen Oxides/chemistry ; Magnetic Resonance Spectroscopy ; Catalysis
    Chemical Substances Nitrates ; Ammonia (7664-41-7) ; Zeolites (1318-02-1) ; Solvents ; Nitrogen Oxides
    Language English
    Publishing date 2022-12-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.2c09823
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  10. Article ; Online: Comparison of capecitabine concentrations determined by microsampling versus plasma concentrations for therapeutic drug monitoring: a pilot study.

    Shafiei, Mohsen / Galettis, Peter / Beale, Philip / Martin, Jennifer H / McLachlan, Andrew J / Blinman, Prunella

    The Journal of pharmacy and pharmacology

    2023  Volume 76, Issue 2, Page(s) 86–92

    Abstract: Objectives: Therapeutic drug monitoring allows personalized dosing of chemotherapy, but is not well established for capecitabine. The aim of this study was to compare the concentrations of capecitabine and its metabolites obtained simultaneously by ... ...

    Abstract Objectives: Therapeutic drug monitoring allows personalized dosing of chemotherapy, but is not well established for capecitabine. The aim of this study was to compare the concentrations of capecitabine and its metabolites obtained simultaneously by microsampling with plasma sampling and their acceptability to patients.
    Methods: Adults taking capecitabine for cancer had paired (duplicate) microsampling at steady state (hour 2 post dose) using Mitra® devices and venous blood samples for analysis. Capecitabine and metabolites were measured using a validated mass spectrometry assay. Correlation between the sampling methods was determined. Patients' preferences were elicited using a Likert numeric rating scale and pain by a Visual Analog Scale (range, 0-10).
    Key findings: Capecitabine concentrations from 10 patients (60 paired samples) by microsampling and plasma sampling were highly correlated (Pearson correlation: 0.97, Coefficients of determination: 0.94, P < 0.0001). Capecitabine concentrations in capillary sampling were consistently lower than the paired plasma concentration (median capecitabine capillary/plasma concentration ratio = 2851/3846 μg/l 75%). The agreement between sampling matrices showed a 28% bias (95% Cl, 4.02-52.00). Participant ratings showed microsampling was the preferred method by all 10 patients. Most participants reported no pain with microsampling (median 0, range 0-1).
    Conclusion: Capecitabine concentration measured by microsampling and plasma sampling were highly correlated, but consistently lower in microsampling. Microsampling was the preferred method with minimal pain.
    MeSH term(s) Adult ; Humans ; Pilot Projects ; Capecitabine ; Blood Specimen Collection/methods ; Drug Monitoring/methods ; Tandem Mass Spectrometry/methods ; Pain
    Chemical Substances Capecitabine (6804DJ8Z9U)
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 3107-0
    ISSN 2042-7158 ; 0022-3573 ; 0373-1022
    ISSN (online) 2042-7158
    ISSN 0022-3573 ; 0373-1022
    DOI 10.1093/jpp/rgad104
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