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Article ; Online: Efficient Dynamic Nuclear Polarization up to 230 K with Hybrid BDPA-Nitroxide Radicals at a High Magnetic Field.

Menzildjian, Georges / Lund, Alicia / Yulikov, Maxim / Gajan, David / Niccoli, Lorenzo / Karthikeyan, Ganesan / Casano, Gilles / Jeschke, Gunnar / Ouari, Olivier / Lelli, Moreno / Lesage, Anne

The journal of physical chemistry. B

2021 Volume 125, Issue 48, Page(s) 13329–13338

Abstract: Pairing the spectral resolution provided by high magnetic fields at ambient temperature with the enhanced sensitivity offered by dynamic nuclear polarization (DNP) is a major goal of modern solid-state NMR spectroscopy, which will allow one to unlock ... ...

Abstract	Pairing the spectral resolution provided by high magnetic fields at ambient temperature with the enhanced sensitivity offered by dynamic nuclear polarization (DNP) is a major goal of modern solid-state NMR spectroscopy, which will allow one to unlock ever-challenging applications. This study demonstrates that, by combining HyTEK2, a hybrid BDPA-nitroxide biradical polarizing agent, with
MeSH term(s)	Magnetic Fields ; Magnetic Resonance Spectroscopy ; Nitrogen Oxides ; Temperature
Chemical Substances	Nitrogen Oxides ; nitroxyl (GFQ4MMS07W)
Language	English
Publishing date	2021-11-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.1c07307
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Article ; Online: Spatholobus suberectus inhibits lipogenesis and tumorigenesis in triple-negative breast cancer via activation of AMPK-ACC and K-Ras-ERK signaling pathway

Xiaohui Zeng / Guowei Gong / Kumar Ganesan / Yi Wen / Qingqing Liu / Juncheng Zhuo / Jianming Wu / Jianping Chen

Journal of Traditional and Complementary Medicine, Vol 13, Iss 6, Pp 623-

2023 Volume 638

Abstract: ... in vivo by activating AMPK-ACC and K-Ras-ERK signaling pathways using lipidomic and metabolomic techniques ... metabolites and biomarkers, thereby preventing tumorigenesis via the AMPK-ACC and K-Ras-ERK signaling pathways ...

Abstract	Background and aim: Triple-negative breast cancer (TNBC) is a highly invasive type of breast cancer with a poor prognosis. Currently, there are no effective management strategies for TNBC. Earlier, our lab reported the percolation of Spatholobus suberectus for the treatment of breast cancer. Lipid metabolic reprogramming is a hallmark of cancer. However, the anti-TNBC efficiency of S. suberectus extract and its causal mechanism for preventing lipogenesis have not been fully recognized. Hence, the present study aimed to investigate the inhibitory role of S. suberectus extract on lipogenesis and tumorigenesis in TNBC in vitro and in vivo by activating AMPK-ACC and K-Ras-ERK signaling pathways using lipidomic and metabolomic techniques. Experimental procedure: Dried stems of S. suberectus extract inhibited lipogenesis and tumorigenesis and promoted fatty acid oxidation as demonstrated by the identification of the metabolites and fatty acid markers using proteomic and metabolomic analysis, qPCR, and Western blot. Results and conclusion: The results indicated that S. suberectus extract promotes fatty acid oxidation and suppresses lipogenic metabolites and biomarkers, thereby preventing tumorigenesis via the AMPK-ACC and K-Ras-ERK signaling pathways. On the basis of this preclinical evidence, we suggest that this study represents a milestone and complements Chinese medicine. Further studies remain underway in our laboratory to elucidate the active principles of S. suberectus extract. This study suggests that S. suberectus extract could be a promising therapy for TNBC.
Keywords	Spatholobi suberectus ; Lipogenesis ; TNBC ; Therapy ; Natural product ; Proteomic and metabolomic analysis ; Medicine ; R
Subject code	616
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: The INVICTUS rheumatic heart disease research program: Rationale, design and baseline characteristics of a randomized trial of rivaroxaban compared to vitamin K antagonists in rheumatic valvular disease and atrial fibrillation.

Karthikeyan, Ganesan / Connolly, Stuart J / Ntsekhe, Mpiko / Benz, Alexander / Rangarajan, Sumathy / Lewis, Gayle / Yun, Yan / Sharma, Sanjib Kumar / Maklady, Fathi / Elghamrawy, Alaa Eldin / Kazmi, Khawar / Cabral, Tantchou T J / Dayi, Hu / Changsheng, Ma / Gitura, Bernard M / Avezum, Alvaro / Zuhlke, Liesl / Lwabi, Peter / Haileamlak, Abraham /

Ogah, Okechukwu / Chillo, Pilly / Paniagua, Maria / ElSayed, Ahmed / Dans, Antonio / Gondwe-Chunda, Lillian / Molefe-Baikai, Onkabetse Julia / Gonzalez-Hermosillo, Jesus A / Hakim, James / Damasceno, Albertino / Kamanzi, Emmanuel R / Musuku, John / Davletov, Kairat / Connolly, Katherine / Mayosi, Bongani M / Yusuf, Salim

American heart journal

2020 Volume 225, Page(s) 69–77

Abstract: ... patients comparing rivaroxaban with vitamin K antagonists (VKA) in patients with RHD and ...

Abstract	Background: Rheumatic heart disease (RHD) is a neglected disease affecting 33 million people, mainly in low and middle income countries. Yet very few large trials or registries have been conducted in this population. The INVICTUS program of research in RHD consists of a randomized-controlled trial (RCT) of 4500 patients comparing rivaroxaban with vitamin K antagonists (VKA) in patients with RHD and atrial fibrillation (AF), a registry of 17,000 patients to document the contemporary clinical course of patients with RHD, including a focused sub-study on pregnant women with RHD within the registry. This paper describes the rationale, design, organization and baseline characteristics of the RCT and a summary of the design of the registry and its sub-study. Patients with RHD and AF are considered to be at high risk of embolic strokes, and oral anticoagulation with VKAs is recommended for stroke prevention. But the quality of anticoagulation with VKA is poor in developing countries. A drug which does not require monitoring, and which is safe and effective for preventing stroke in patients with valvular AF, would fulfill a major unmet need. Methods: The INVestIgation of rheumatiC AF Treatment Using VKAs, rivaroxaban or aspirin Studies (INVICTUS-VKA) trial is an international, multicentre, randomized, open-label, parallel group trial, testing whether rivaroxaban 20 mg given once daily is non-inferior (or superior) to VKA in patients with RHD, AF, and an elevated risk of stroke (mitral stenosis with valve area ≤2 cm Conclusion: INVICTUS is the largest program of clinical research focused on a neglected cardiovascular disease and will provide new information on the clinical course of patients with RHD, and approaches to anticoagulation in those with concomitant AF.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Pregnancy ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Embolism/prevention & control ; Factor Xa Inhibitors/adverse effects ; Factor Xa Inhibitors/therapeutic use ; Hemorrhage/chemically induced ; Pregnancy Complications, Cardiovascular/drug therapy ; Rheumatic Heart Disease/complications ; Rheumatic Heart Disease/drug therapy ; Rivaroxaban/adverse effects ; Rivaroxaban/therapeutic use ; Stroke/prevention & control ; Vitamin K/antagonists & inhibitors ; Multicenter Studies as Topic ; Randomized Controlled Trials as Topic
Chemical Substances	Factor Xa Inhibitors ; Rivaroxaban (9NDF7JZ4M3) ; Vitamin K (12001-79-5)
Language	English
Publishing date	2020-03-25
Publishing country	United States
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	80026-0
ISSN	1097-6744 ; 0002-8703
ISSN (online)	1097-6744
ISSN	0002-8703
DOI	10.1016/j.ahj.2020.03.018
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Article: Efficient Dynamic Nuclear Polarization up to 230 K with Hybrid BDPA-Nitroxide Radicals at a High Magnetic Field

Menzildjian, Georges / Lund, Alicia / Yulikov, Maxim / Gajan, David / Niccoli, Lorenzo / Karthikeyan, Ganesan / Casano, Gilles / Jeschke, Gunnar / Ouari, Olivier / Lelli, Moreno / Lesage, Anne

Journal of physical chemistry. 2021 Nov. 24, v. 125, no. 48

2021

Abstract: ... DNP matrix, enhancement factors as high as 65 can be obtained at 230 K, 40 kHz magic angle spinning ...

Abstract	Pairing the spectral resolution provided by high magnetic fields at ambient temperature with the enhanced sensitivity offered by dynamic nuclear polarization (DNP) is a major goal of modern solid-state NMR spectroscopy, which will allow one to unlock ever-challenging applications. This study demonstrates that, by combining HyTEK2, a hybrid BDPA-nitroxide biradical polarizing agent, with ortho-terphenyl (OTP), a rigid DNP matrix, enhancement factors as high as 65 can be obtained at 230 K, 40 kHz magic angle spinning (MAS), and 18.8 T. The temperature dependence of the DNP enhancement and its behavior around the glass transition temperature (Tg) of the matrix is investigated by variable-temperature EPR measurements of the electron relaxation properties and numerical simulations. A correlation is suggested between the decrease in enhancement at the passage of the Tg and the concomitant drop of both transverse electron relaxation times in the biradical.
Keywords	ambient temperature ; glass transition temperature ; magnetic fields ; nuclear magnetic resonance spectroscopy ; physical chemistry ; spectral analysis
Language	English
Dates of publication	2021-1124
Size	p. 13329-13338.
Publishing place	American Chemical Society
Document type	Article
ISSN	1520-5207
DOI	10.1021/acs.jpcb.1c07307
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Synthesis of Substituted Isatins from the MBH Adduct of 1,5,6-Trisubstituted Isatins Using (2,4-Dinitrophenyl)hydrazine and K-10 Clay Explored as Protection-Deprotection Chemistry.

Vadivel, Vaithiyanathan / Ganesan, Ravichandran / Kannaiyan, Vishnu / Vellikannu, Ezhumalai / Vijayakumar, Thirumailavan

ACS omega

2019 Volume 4, Issue 5, Page(s) 9563–9568

Abstract: An interesting synthetic transformation of protection-deprotection chemistry in an isatin molecule is achieved. Morita-Baylis-Hillman (MBH) adduct formation used as protection of the C-3 position in the isatin molecule is reported. C-C bond cleavage in ... ...

Abstract	An interesting synthetic transformation of protection-deprotection chemistry in an isatin molecule is achieved. Morita-Baylis-Hillman (MBH) adduct formation used as protection of the C-3 position in the isatin molecule is reported. C-C bond cleavage in the MBH adduct of isatin with the help of phenylhydrazine and C=N bond cleavage in the phenylhydrazone derivative of isatin with the help of K10 clay are studied systematically and reported as deprotection.
Language	English
Publishing date	2019-05-31
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.9b01002
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Article ; Online: Synthesis of Substituted Isatins from the MBH Adduct of 1,5,6-Trisubstituted Isatins Using (2,4-Dinitrophenyl)hydrazine and K‑10 Clay Explored as Protection–Deprotection Chemistry

Vaithiyanathan Vadivel / Ravichandran Ganesan / Vishnu Kannaiyan / Ezhumalai Vellikannu / Thirumailavan Vijayakumar

ACS Omega, Vol 4, Iss 5, Pp 9563-

2019 Volume 9568

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2019-05-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Blocking the K-pathway still allows rapid one-electron reduction of the binuclear center during the anaerobic reduction of the aa3-type cytochrome c oxidase from Rhodobacter sphaeroides.

Ganesan, Krithika / Gennis, Robert B

Biochimica et biophysica acta

2010 Volume 1797, Issue 6-7, Page(s) 619–624

Abstract: The K-pathway is one of the two proton-input channels required for function of cytochrome c oxidase ... In the Rhodobacter sphaeroides cytochrome c oxidase, the K-channel starts at Glu101 in subunit II, which is ... of conserved, polar residues within the K-channel block or inhibit steady state oxidase activity. A large body ...

Abstract	The K-pathway is one of the two proton-input channels required for function of cytochrome c oxidase. In the Rhodobacter sphaeroides cytochrome c oxidase, the K-channel starts at Glu101 in subunit II, which is at the surface of the protein exposed to the cytoplasm, and runs to Tyr288 at the heme a3/CuB active site. Mutations of conserved, polar residues within the K-channel block or inhibit steady state oxidase activity. A large body of research has demonstrated that the K-channel is required to fully reduce the heme/Cu binuclear center, prior to the reaction with O2, presumably by providing protons to stabilize the reduced metals (ferrous heme a3 and cuprous CuB). However, there are conflicting reports which raise questions about whether blocking the K-channel blocks both electrons or only one electron from reaching the heme/Cu center. In the current work, the rate and extent of the anaerobic reduction of the heme/Cu center were monitored by optical and EPR spectroscopies, comparing the wild type and mutants that block the K-channel. The new data show that when the K-channel is blocked, one electron will still readily enter the binuclear center. The one-electron reduction of the resting oxidized ("O") heme/Cu center of the K362M mutant, results in a partially reduced binuclear center in which the electron is distributed about evenly between heme a3 and CuB in the R. sphaeroides oxidase. Complete reduction of the heme/Cu center requires the uptake of two protons which must be delivered through the K-channel.
MeSH term(s)	Amino Acid Substitution ; Anaerobiosis ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Base Sequence ; DNA Primers/genetics ; Electron Spin Resonance Spectroscopy ; Electron Transport ; Electron Transport Complex IV/chemistry ; Electron Transport Complex IV/genetics ; Electron Transport Complex IV/metabolism ; Heme/chemistry ; Models, Molecular ; Mutagenesis, Site-Directed ; Mutant Proteins/chemistry ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Oxidation-Reduction ; Protons ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Rhodobacter sphaeroides/genetics ; Rhodobacter sphaeroides/metabolism
Chemical Substances	Bacterial Proteins ; DNA Primers ; Mutant Proteins ; Protons ; Recombinant Proteins ; Heme (42VZT0U6YR) ; Electron Transport Complex IV (EC 1.9.3.1)
Language	English
Publishing date	2010-03-20
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbabio.2010.03.012
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Article ; Online: Application of Modified K-Means Clustering Algorithm for Satellite Image Segmentation based on Color Information

Ganesan P / Dr V.Rajini

International Journal of Advanced Research in Computer Science, Vol 04, Iss 05, Pp 41-

2013 Volume 44

Abstract: ... The basic k-means clustering algorithm is simple and fast. The main problem associated with this clustering ... random assignments. In this paper, a modified k-means clustering algorithm is proposed for the effective ... The experimental results proved that the improved k-means algorithm is an efficient and effective method ...

Abstract	The Image segmentation is the process of clustering or partitioning the image into number of sub images based on any one characteristics of the image such as colour, intensity or texture. The segmentation is the one of the middle level important process in the image analysis. The number of segmentation algorithms has been developed for various applications. In the field of satellite image processing, the segmentation is one of the vital step for gathering huge amount of information from the satellite images. The basic k-means clustering algorithm is simple and fast. The main problem associated with this clustering is not producing the same result for every run because the resulting clusters depends on the initial random assignments. In this paper, a modified k-means clustering algorithm is proposed for the effective segmentation of the satellite images. This proposed method always produces the same result for every run. The experimental results proved that the improved k-means algorithm is an efficient and effective method for the satellite image segmentation for the exact and accurate segmentation of satellite images.
Keywords	image ; segmentation ; satellite ; kmeans ; clustering ; centroid ; fuzzy ; logic ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q ; DOAJ:Computer Science ; DOAJ:Technology and Engineering
Subject code	006
Language	English
Publishing date	2013-05-01T00:00:00Z
Publisher	International Journal of Advanced Research in Computer Science
Document type	Article ; Online
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Book ; Online: Probabilistic Bounds for Data Storage with Feature Selection and Undersampling

Ganesan, Ghurumuruhan

2023

Abstract: ... and briefly illustrate our result using~$k-$nearest neighbours type classification rules ...

Abstract	In this paper we consider data storage from a probabilistic point of view and obtain bounds for efficient storage in the presence of feature selection and undersampling, both of which are important from the data science perspective. First, we consider encoding of correlated sources for nonstationary data and obtain a Slepian-Wolf type result for the probability of error. We then reinterpret our result by allowing one source to be the set of features to be discarded and other source to be remaining data to be encoded. Next, we consider neighbourhood domination in random graphs where we impose the condition that a fraction of neighbourhood must be present for each vertex and obtain optimal bounds on the minimum size of such a set. We show how such sets are useful for data undersampling in the presence of imbalanced datasets and briefly illustrate our result using~$k-$nearest neighbours type classification rules as an example.
Keywords	Computer Science - Information Theory ; Mathematics - Combinatorics
Subject code	005
Publishing date	2023-09-24
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Structured Hypergraphs in Cellular Mobile Communication Systems

Ganesan, Ashwin

2022

Abstract: ... such that the hypergraph $K_{1,r}$ is realizable? We show that this value is $r=4$. ...

Abstract	An open problem is to extend the results in the literature on unit disk graphs to hypergraph models. Motivated by recent results that the worst-case performance of the distributed maximal scheduling algorithm is characterized by the interference degree of the hypergraph, in the present work we investigate properties of the interference degree of the hypergraph and the structure of hypergraphs arising from physical constraints. We show that the problem of computing the interference degree of a hypergraph is NP-hard and we prove some properties and results concerning this hypergraph invariant. We then investigate which hypergraphs are realizable, i.e. which hypergraphs arise in practice, based on physical constraints, as the interference model of a wireless network. In particular, given the results on the worst-case performance of the maximal scheduling algorithm, a question that arises naturally is: what is the maximal value of $r$ such that the hypergraph $K_{1,r}$ is realizable? We show that this value is $r=4$.
Keywords	Computer Science - Networking and Internet Architecture ; Computer Science - Computational Complexity ; Computer Science - Discrete Mathematics ; Computer Science - Data Structures and Algorithms
Subject code	000
Publishing date	2022-07-01
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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