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  1. Article ; Online: Whole Transcriptome Analysis of Intervention Effect of

    Zhao, Yi / Jia, Nina / Xie, Xiaodong / Chen, Qi / Hu, Tingjun

    Current issues in molecular biology

    2023  Volume 45, Issue 7, Page(s) 6067–6084

    Abstract: 1) Background: ...

    Abstract (1) Background:
    Language English
    Publishing date 2023-07-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb45070383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5122: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Dynamics, impacts, and future projections of Arctic rapid change

    Xian-Yao Chen / Tingjun Zhang

    Advances in Climate Change Research, Vol 12, Iss 4, Pp 445-

    2021  Volume 446

    Keywords Meteorology. Climatology ; QC851-999 ; Social sciences (General) ; H1-99
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The complete mitochondrial genome of

    Chen, Tingjun / Li, Xiangrong / Wang, Yong

    Mitochondrial DNA. Part B, Resources

    2021  Volume 6, Issue 8, Page(s) 2299–2301

    Abstract: ... Lucilia ... ...

    Abstract Lucilia shenyangensis
    Language English
    Publishing date 2021-07-15
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2021.1947911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Recent advances in the development of DprE1 inhibitors using AI/CADD approaches.

    Chen, Kepeng / Xu, Ruolan / Hu, Xueping / Li, Dan / Hou, Tingjun / Kang, Yu

    Drug discovery today

    2024  , Page(s) 103987

    Abstract: Tuberculosis (TB) is a global lethal disease caused by Mycobacterium tuberculosis (Mtb). The flavoenzyme decaprenylphosphoryl-β-d-ribose 2'-oxidase (DprE1) plays a crucial part in the biosynthesis of lipoarabinomannan and arabinogalactan for the cell ... ...

    Abstract Tuberculosis (TB) is a global lethal disease caused by Mycobacterium tuberculosis (Mtb). The flavoenzyme decaprenylphosphoryl-β-d-ribose 2'-oxidase (DprE1) plays a crucial part in the biosynthesis of lipoarabinomannan and arabinogalactan for the cell wall of Mtb and represents a promising target for anti-TB drug development. Therefore, there is an urgent need to discover DprE1 inhibitors with novel scaffolds, improved bioactivity and high drug-likeness. Recent studies have shown that artificial intelligence/computer-aided drug design (AI/CADD) techniques are powerful tools in the discovery of novel DprE1 inhibitors. This review provides an overview of the discovery of DprE1 inhibitors and their underlying mechanism of action and highlights recent advances in the discovery and optimization of DprE1 inhibitors using AI/CADD approaches.
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2024.103987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4725: Show issues Location:
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  5. Article: Value of carotid corrected flow time or changes value of FTc could be more useful in predicting fluid responsiveness in patients undergoing robot-assisted gynecologic surgery: a prospective observational study.

    Tang, Xixi / Liang, Jingqiu / Tan, Dongling / Chen, Qi / Zhou, Chengfu / Yang, Tingjun / Liu, Hongliang

    Frontiers in medicine

    2024  Volume 11, Page(s) 1387433

    Abstract: Background: The aim of this study was to evaluate the ability of point-of-care Doppler ultrasound measurements of carotid corrected flow time and its changes induced by volume expansion to predict fluid responsiveness in patients undergoing robot- ... ...

    Abstract Background: The aim of this study was to evaluate the ability of point-of-care Doppler ultrasound measurements of carotid corrected flow time and its changes induced by volume expansion to predict fluid responsiveness in patients undergoing robot-assisted gynecological surgery.
    Methods: In this prospective study, carotid corrected flow time was measured using Doppler images of the common carotid artery before and after volume expansion. The stroke volume index at each time point was recorded using noninvasive cardiac output monitoring with MostCare. Of the 52 patients enrolled, 26 responded.
    Results: The areas under the receiver operating characteristic curves of the carotid corrected flow time and changes in carotid corrected flow time induced by volume expansion were 0.82 and 0.67, respectively. Their optimal cut-off values were 357 and 19.5 ms, respectively.
    Conclusion: Carotid corrected flow time was superior to changes in carotid corrected flow time induced by volume expansion for predicting fluid responsiveness in this population.
    Language English
    Publishing date 2024-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2024.1387433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A Novel Polysaccharide from

    Zhao, Yi / Chen, Jiaji / Ding, Yiqu / Luo, Mengyuan / Tong, Yanmei / Hu, Tingjun / Wei, Yingyi

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 10

    Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important pathogens in the global swine industry over the past three decades. There is no licensed antiviral medication that can effectively control this ... ...

    Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important pathogens in the global swine industry over the past three decades. There is no licensed antiviral medication that can effectively control this infection. In the present study, the structure of SP-1 isolated and purified from
    Language English
    Publishing date 2023-10-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12101832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Combined signature of N7-methylguanosine regulators with their related genes and the tumor microenvironment: a prognostic and therapeutic biomarker for breast cancer.

    Li, Tingjun / Chen, Zhishan / Wang, Zhitang / Lu, Jingyu / Chen, Debo

    Frontiers in immunology

    2023  Volume 14, Page(s) 1260195

    Abstract: Background: Identifying predictive markers for breast cancer (BC) prognosis and immunotherapeutic responses remains challenging. Recent findings indicate that N: Methods: We utilized bulk RNA-sequencing data from The Cancer Genome Atlas Breast Cancer ...

    Abstract Background: Identifying predictive markers for breast cancer (BC) prognosis and immunotherapeutic responses remains challenging. Recent findings indicate that N
    Methods: We utilized bulk RNA-sequencing data from The Cancer Genome Atlas Breast Cancer Cohort and the GSE42568 and GSE146558 datasets to identify BC-specific m7G-modification regulators and associated genes. We used multiple m7G databases and RNA interference to validate the relationships between BC-specific m7G-modification regulators (METTL1 and WDR4) and related genes. Single-cell RNA-sequencing data from GSE176078 confirmed the association between m7G modifications and TME cells. We constructed an m7G-TME classifier, validated the results using an independent BC cohort (GSE20685;
    Results: Immunohistochemistry and RT-qPCR results indicated that METTL1 and WDR4 overexpression in BC correlated with poor patient prognosis. Moreover, single-cell analysis revealed relationships between m7G modification and TME cells, indicating their potential as indicators of BC prognosis and treatment responses. The m7G-TME classifier enabled patient subgrouping and revealed significantly better survival and treatment responses in the m7G
    Conclusions: The m7G-TME classifier offers a promising tool for predicting prognosis and immunotherapeutic responses in BC, which could support personalized therapeutic strategies.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/diagnosis ; Breast Neoplasms/genetics ; Breast Neoplasms/therapy ; Prognosis ; Biomarkers ; RNA ; Tumor Microenvironment/genetics ; GTP-Binding Proteins
    Chemical Substances 8-methylguanosine ; Biomarkers ; RNA (63231-63-0) ; WDR4 protein, human ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 2023-10-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1260195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Identification of 3-aryl-5-methyl-isoxazole-4-carboxamide derivatives and analogs as novel HIF-2α agonists through docking-based virtual screening and structural modification.

    Chen, Siyuan / Liu, Yao / Wang, Zhe / Qi, Chengcheng / Yu, Yanzhen / Xu, Lei / Hou, Tingjun / Sheng, Rong

    European journal of medicinal chemistry

    2024  Volume 268, Page(s) 116227

    Abstract: Hypoxia-inducible factor-2 (HIF-2) serves as the pivotal transcription factor in cellular responses to low oxygen levels, particularly concerning the regulation of erythropoietin (EPO) production. A docking-based virtual screening on crystal structures ... ...

    Abstract Hypoxia-inducible factor-2 (HIF-2) serves as the pivotal transcription factor in cellular responses to low oxygen levels, particularly concerning the regulation of erythropoietin (EPO) production. A docking-based virtual screening on crystal structures of HIF-2α inhibitors unexpectedly identified 3-phenyl-5-methyl-isoxazole-4-carboxamide derivative v19 as a hit of HIF-2α agonist. Further structural optimizations of compound v19 led to the discovery of a series of HIF-2α agonists with novel scaffolds. The most promising compounds 12g and 14d exhibited potent HIF-2α agonistic activities in vitro with EC
    MeSH term(s) Humans ; Basic Helix-Loop-Helix Transcription Factors ; Transcription Factors/metabolism ; Gene Expression Regulation ; Oxygen ; Anemia ; Hypoxia-Inducible Factor 1, alpha Subunit
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; Transcription Factors ; Oxygen (S88TT14065) ; Hypoxia-Inducible Factor 1, alpha Subunit
    Language English
    Publishing date 2024-02-16
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2024.116227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 784: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article: Cloning, expression and function analysis of trehalose-6-phosphate synthase gene from Marsupenaeus japonicu

    Chen, Tingjun / Li, Zhimin / Liu, Jianyong / Liang, Caifeng

    Gene. 2022 Jan. 15, v. 808

    2022  

    Abstract: Trehalose is an important disaccharide that plays an important role in extreme environmental conditions. Trehalose-6-phosphate synthase (TPS) gene is the key gene for trehalose synthesis in Marsupenaeus japonicus. In this study, a TPS gene was isolated ... ...

    Abstract Trehalose is an important disaccharide that plays an important role in extreme environmental conditions. Trehalose-6-phosphate synthase (TPS) gene is the key gene for trehalose synthesis in Marsupenaeus japonicus. In this study, a TPS gene was isolated and characterized from M. japonicus. The full-length cDNA of TPS gene of M. japonicus (MjTPS) was 3308 bp, encoding 844 amino acids. The protein of the deduced MjTPS contained a glycol_transf_20 domain and a trehalose_PPase domain. The mRNA expression level of MjTPS was the highest in hepatopancreas. The further analysis found that MjTPS gene expression was up-regulated in a short time under low-salinity and high-nitrite stress, indicating that MjTPS gene had certain resistance to low-salinity and high-nitrite stress. Compared with the control group, both the expression of MjTPS and the trehalose content significantly decreased from 3 h to 24 h after MjTPS gene interference,. After RNAi, the mortality of M. japonicus increased, the expression level of MjTPS and the synthesis of downstream products decreased under low-salinity and high-nitrite stress, and what’s more, the expression of immune genes PMO25, ERP, CD, HSP90, HSP70, HSP60, HMC and CLEC2 were significantly changed, implying that MjTPS might be participated in the immune response of M. japonicus. In addition, MjTPS gene silencing could affect the expression of CHI1 and CHS, suggesting that MjTPS might be involved in molting behavior of M. japonicus. These results provide new information for further studying the function of trehalose-6-phosphate synthase in shrimp.
    Keywords Marsupenaeus japonicus ; alpha,alpha-trehalose-phosphate synthase (UDP-forming) ; gene expression ; genes ; hepatopancreas ; immune response ; mortality ; shrimp ; trehalose
    Language English
    Dates of publication 2022-0115
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2021.145971
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  10. Article ; Online: Discovery of Novel Anti-Resistance AR Antagonists Guided by Funnel Metadynamics Simulation.

    Chen, Haiyi / Zhou, Yuxin / Wang, Xinyue / Chai, Xin / Wang, Zhe / Wang, Ercheng / Xu, Lei / Hou, Tingjun / Li, Dan / Duan, Mojie

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2024  , Page(s) e2309261

    Abstract: Androgen receptor (AR) antagonists are widely used for the treatment of prostate cancer (PCa), but their therapeutic efficacy is usually compromised by the rapid emergence of drug resistance. However, the lack of the detailed interaction between AR and ... ...

    Abstract Androgen receptor (AR) antagonists are widely used for the treatment of prostate cancer (PCa), but their therapeutic efficacy is usually compromised by the rapid emergence of drug resistance. However, the lack of the detailed interaction between AR and its antagonists poses a major obstacle to the design of novel AR antagonists. Here, funnel metadynamics is employed to elucidate the inherent regulation mechanisms of three AR antagonists (hydroxyflutamide, enzalutamide, and darolutamide) on AR. For the first time it is observed that the binding of antagonists significantly disturbed the C-terminus of AR helix-11, thereby disrupting the specific internal hydrophobic contacts of AR-LBD and correspondingly the communication between AR ligand binding pocket (AR-LBP), activation function 2 (AF2), and binding function 3 (BF3). The subsequent bioassays verified the necessity of the hydrophobic contacts for AR function. Furthermore, it is found that darolutamide, a newly approved AR antagonist capable of fighting almost all reported drug resistant AR mutants, can induce antagonistic binding structure. Subsequently, docking-based virtual screening toward the dominant binding conformation of AR for darolutamide is conducted, and three novel AR antagonists with favorable binding affinity and strong capability to combat drug resistance are identified by in vitro bioassays. This work provides a novel rational strategy for the development of anti-resistant AR antagonists.
    Language English
    Publishing date 2024-03-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202309261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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