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  1. Article ; Online: New Knowledge About CCR5, HIV Infection, and Disease Progression: Is "Old" Still Valuable?

    Mehlotra, Rajeev K

    AIDS research and human retroviruses

    2020  Volume 36, Issue 10, Page(s) 795–799

    Abstract: C-C chemokine receptor (CCR) 5 (CCR5) is the main HIV-1 coreceptor involved in virus entry and cell-to-cell spread during acute and chronic infections: such CCR5 and T cell tropic viruses are adapted to and replicate in ... ...

    Abstract C-C chemokine receptor (CCR) 5 (CCR5) is the main HIV-1 coreceptor involved in virus entry and cell-to-cell spread during acute and chronic infections: such CCR5 and T cell tropic viruses are adapted to and replicate in CD4
    MeSH term(s) Disease Progression ; HIV Infections ; HIV-1/genetics ; Humans ; Polymorphism, Single Nucleotide ; Receptors, CCR2/genetics ; Receptors, CCR5/genetics
    Chemical Substances CCR5 protein, human ; Receptors, CCR2 ; Receptors, CCR5
    Language English
    Publishing date 2020-09-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/AID.2020.0060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Chemokine receptor gene polymorphisms and COVID-19: Could knowledge gained from HIV/AIDS be important?

    Mehlotra, Rajeev K

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2020  Volume 85, Page(s) 104512

    Abstract: Emerging results indicate that an uncontrolled host immune response, leading to a life-threatening condition called cytokine release syndrome (also termed "cytokine storm"), is the major driver of pathology in severe COVID-19. In this pandemic, ... ...

    Abstract Emerging results indicate that an uncontrolled host immune response, leading to a life-threatening condition called cytokine release syndrome (also termed "cytokine storm"), is the major driver of pathology in severe COVID-19. In this pandemic, considerable effort is being focused on identifying host genomic factors that increase susceptibility or resistance to the complications of COVID-19 and translating these findings to improved patient care. In this regard, the chemokine receptor-ligand nexus has been reported as potentially important in severe COVID-19 disease pathogenesis and its treatment. Valuable genomic insights into the chemokine receptor-ligand nexus have been gained from HIV infection and disease progression studies. Applying that knowledge, together with newly discovered potential host genomic factors associated with COVID-19, may lead to a more comprehensive understanding of the pathogenesis and treatment outcomes in COVID-19 patients.
    MeSH term(s) COVID-19/genetics ; COVID-19/immunology ; Chemokines/genetics ; Disease Progression ; Gene Expression Regulation ; HIV Infections/genetics ; HIV Infections/immunology ; Humans ; Ligands ; Polymorphism, Genetic ; Promoter Regions, Genetic
    Chemical Substances Chemokines ; Ligands
    Keywords covid19
    Language English
    Publishing date 2020-08-26
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2020.104512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: CCR5 Promoter Polymorphism -2459G > A: Forgotten or Ignored?

    Mehlotra, Rajeev K

    Cells

    2019  Volume 8, Issue 7

    Abstract: C-C chemokine receptor 5 ( ...

    Abstract C-C chemokine receptor 5 (
    MeSH term(s) Anti-HIV Agents/therapeutic use ; Disease Progression ; Gene Editing ; Genetic Predisposition to Disease ; Genetic Testing ; Genetic Therapy ; HIV Infections/genetics ; HIV Infections/therapy ; Humans ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic/genetics ; Receptors, CCR5/genetics ; Treatment Outcome
    Chemical Substances Anti-HIV Agents ; CCR5 protein, human ; Receptors, CCR5
    Language English
    Publishing date 2019-06-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2661518-6
    ISSN 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells8070651
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  4. Article ; Online: Chemokine receptor gene polymorphisms and COVID-19

    Mehlotra, Rajeev K.

    Infection, Genetics and Evolution

    Could knowledge gained from HIV/AIDS be important?

    2020  Volume 85, Page(s) 104512

    Keywords Microbiology (medical) ; Genetics ; Ecology, Evolution, Behavior and Systematics ; Molecular Biology ; Microbiology ; Infectious Diseases ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2037068-4
    ISSN 1567-1348
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2020.104512
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Human Genetic Variation and HIV/AIDS in Papua New Guinea: Time to Connect the Dots.

    Mehlotra, Rajeev K

    Current HIV/AIDS reports

    2018  Volume 15, Issue 6, Page(s) 431–440

    Abstract: Purpose of review: Human genetic polymorphisms known to influence HIV acquisition and disease progression occur in Papua New Guinea (PNG). However, no genetic association study has been reported so far. In this article, we review research findings, with ...

    Abstract Purpose of review: Human genetic polymorphisms known to influence HIV acquisition and disease progression occur in Papua New Guinea (PNG). However, no genetic association study has been reported so far. In this article, we review research findings, with a view to stimulate genotype-to-phenotype research.
    Recent findings: PNG, a country in Oceania, has a high prevalence of HIV and many sexually transmitted infections. While limited data is available from this country regarding the distribution of human genetic polymorphisms known to influence clinical outcomes of HIV/AIDS, genetic association studies are lacking. Our studies, in the past decade, have revealed that polymorphisms in chemokine receptor-ligand (CCR2-CCR5, CXCL12), innate immune (Toll-like receptor, β-defensin), and antiretroviral drug-metabolism enzyme (CYP2B6, UGT2B7) genes are prevalent in PNG. Although our results need to be validated in further studies, it is urgent to pursue large-scale, comprehensive genetic association studies that include these as well as additional genetic polymorphisms.
    MeSH term(s) Genetic Predisposition to Disease ; Genetic Variation ; HIV ; HIV Infections/epidemiology ; HIV Infections/genetics ; Humans ; Papua New Guinea/epidemiology
    Language English
    Publishing date 2018-09-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2151206-1
    ISSN 1548-3576 ; 1548-3568
    ISSN (online) 1548-3576
    ISSN 1548-3568
    DOI 10.1007/s11904-018-0417-9
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  6. Article: Chemokine receptor gene polymorphisms and COVID-19: Could knowledge gained from HIV/AIDS be important?

    Mehlotra, Rajeev K

    Infect Genet Evol

    Abstract: Emerging results indicate that an uncontrolled host immune response, leading to a life-threatening condition called cytokine release syndrome (also termed "cytokine storm"), is the major driver of pathology in severe COVID-19. In this pandemic, ... ...

    Abstract Emerging results indicate that an uncontrolled host immune response, leading to a life-threatening condition called cytokine release syndrome (also termed "cytokine storm"), is the major driver of pathology in severe COVID-19. In this pandemic, considerable effort is being focused on identifying host genomic factors that increase susceptibility or resistance to the complications of COVID-19 and translating these findings to improved patient care. In this regard, the chemokine receptor-ligand nexus has been reported as potentially important in severe COVID-19 disease pathogenesis and its treatment. Valuable genomic insights into the chemokine receptor-ligand nexus have been gained from HIV infection and disease progression studies. Applying that knowledge, together with newly discovered potential host genomic factors associated with COVID-19, may lead to a more comprehensive understanding of the pathogenesis and treatment outcomes in COVID-19 patients.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #733697
    Database COVID19

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  7. Article: Chemokine receptor gene polymorphisms and COVID-19: Could knowledge gained from HIV/AIDS be important?

    Mehlotra, Rajeev K

    Infection, genetics, and evolution. 2020 Nov., v. 85

    2020  

    Abstract: Emerging results indicate that an uncontrolled host immune response, leading to a life-threatening condition called cytokine release syndrome (also termed “cytokine storm”), is the major driver of pathology in severe COVID-19. In this pandemic, ... ...

    Abstract Emerging results indicate that an uncontrolled host immune response, leading to a life-threatening condition called cytokine release syndrome (also termed “cytokine storm”), is the major driver of pathology in severe COVID-19. In this pandemic, considerable effort is being focused on identifying host genomic factors that increase susceptibility or resistance to the complications of COVID-19 and translating these findings to improved patient care. In this regard, the chemokine receptor-ligand nexus has been reported as potentially important in severe COVID-19 disease pathogenesis and its treatment. Valuable genomic insights into the chemokine receptor-ligand nexus have been gained from HIV infection and disease progression studies. Applying that knowledge, together with newly discovered potential host genomic factors associated with COVID-19, may lead to a more comprehensive understanding of the pathogenesis and treatment outcomes in COVID-19 patients.
    Keywords COVID-19 infection ; HIV infections ; chemokine receptors ; chemokines ; disease progression ; evolution ; genes ; genomics ; immune response ; infection ; ligands ; pandemic ; pathogenesis ; patient care
    Language English
    Dates of publication 2020-11
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2037068-4
    ISSN 1567-1348
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2020.104512
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: CCR5 Promoter Polymorphism −2459G > A

    Rajeev K. Mehlotra

    Cells, Vol 8, Iss 7, p

    Forgotten or Ignored?

    2019  Volume 651

    Abstract: C-C chemokine receptor 5 ( CCR5 ) polymorphisms, particularly a 32-base pair deletion (∆32) in the open reading frame and −2459G > A in the promoter, are well known for their associations with HIV-1 infection and/or disease progression in a variety of ... ...

    Abstract C-C chemokine receptor 5 ( CCR5 ) polymorphisms, particularly a 32-base pair deletion (∆32) in the open reading frame and −2459G > A in the promoter, are well known for their associations with HIV-1 infection and/or disease progression in a variety of studies. In this era of an HIV cure, where all the emphasis is on ∆32, it seems that −2459G > A has been forgotten or ignored. There is significant importance in the incorporation of the CCR5 −2459G > A genotype information into studies evaluating new immunologic and chemotherapeutic strategies, and those designing and implementing better treatment strategies with current antiretroviral therapy, doing so would enable a better understanding of the response to the intervention, due to a mechanistic or constitutive explanation. Until we find a strategy, whether a stem-cell transplantation or CCR5 editing approach or something else, that delivers a cure to the millions, we should make use of every piece of information that may help curtail HIV/AIDS as a threat to public health.
    Keywords CCR5 ; Delta32 ; haplotype ; HIV cure ; host genetics ; promoter polymorphism ; −2459G > ; A ; Biology (General) ; QH301-705.5
    Subject code 306
    Language English
    Publishing date 2019-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Pharmacogenomic variation in the Malagasy population: implications for the antimalarial drug primaquine metabolism.

    Cramer, Estee Y / Bartlett, Jacquelaine / Chan, Ernest R / Gaedigk, Andrea / Ratsimbasoa, Arsene C / Mehlotra, Rajeev K / Williams, Scott M / Zimmerman, Peter A

    Pharmacogenomics

    2023  Volume 24, Issue 11, Page(s) 583–597

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Humans ; Antimalarials/therapeutic use ; Primaquine/therapeutic use ; DNA Copy Number Variations/genetics ; Genome-Wide Association Study ; Pharmacogenetics ; Chloroquine/therapeutic use
    Chemical Substances Antimalarials ; Primaquine (MVR3634GX1) ; Chloroquine (886U3H6UFF)
    Language English
    Publishing date 2023-08-08
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/pgs-2023-0091
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  10. Article ; Online: CYP2D6

    Chan, E Ricky / Mehlotra, Rajeev K / Pirani, Karim A / Ratsimbasoa, Arsene C / Williams, Scott M / Gaedigk, Andrea / Zimmerman, Peter A

    Pharmacogenomics

    2022  Volume 23, Issue 5, Page(s) 315–325

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Africa ; Antimalarials/therapeutic use ; Asia ; Cytochrome P-450 CYP2D6/genetics ; Cytochrome P-450 CYP2D6/metabolism ; Humans ; Pilot Projects ; Primaquine/therapeutic use
    Chemical Substances Antimalarials ; Cytochrome P-450 CYP2D6 (EC 1.14.14.1) ; Primaquine (MVR3634GX1)
    Language English
    Publishing date 2022-03-01
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/pgs-2021-0146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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