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  1. Article ; Online: The spectrum of sex differences in cancer.

    Rubin, Joshua B

    Trends in cancer

    2022  Volume 8, Issue 4, Page(s) 303–315

    Abstract: Sex differences in cellular and systems biology have been evolutionarily selected to optimize reproductive success in all species with little (sperm) and big (ova) gamete producers. They are evident from the time of fertilization and accrue throughout ... ...

    Abstract Sex differences in cellular and systems biology have been evolutionarily selected to optimize reproductive success in all species with little (sperm) and big (ova) gamete producers. They are evident from the time of fertilization and accrue throughout development through genetic, epigenetic, and circulating sex hormone-dependent mechanisms. Among other effects, they significantly impact on chromatin organization, metabolism, cell cycle regulation, immunity, longevity, and cancer risk and survival. Sex differences in cancer should be expected and accounted for in basic, translational, and clinical oncology research.
    MeSH term(s) Female ; Humans ; Male ; Neoplasms/genetics ; Neoplasms/metabolism ; Protein Processing, Post-Translational ; Sex Characteristics ; Spermatozoa/metabolism
    Language English
    Publishing date 2022-02-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2022.01.013
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  2. Article ; Online: Treating sex and gender differences as a continuous variable can improve precision cancer treatments.

    Yang, Wei / Rubin, Joshua B

    Biology of sex differences

    2024  Volume 15, Issue 1, Page(s) 35

    Abstract: Background: The significant sex and gender differences that exist in cancer mechanisms, incidence, and survival, have yet to impact clinical practice. One barrier to translation is that cancer phenotypes cannot be segregated into distinct male versus ... ...

    Abstract Background: The significant sex and gender differences that exist in cancer mechanisms, incidence, and survival, have yet to impact clinical practice. One barrier to translation is that cancer phenotypes cannot be segregated into distinct male versus female categories. Instead, within this convenient but contrived dichotomy, male and female cancer phenotypes are highly overlapping and vary between female- and male- skewed extremes. Thus, sex and gender-specific treatments are unrealistic, and our translational goal should be adaptation of treatment to the variable effects of sex and gender on targetable pathways.
    Methods: To overcome this obstacle, we profiled the similarities in 8370 transcriptomes of 26 different adult and 4 different pediatric cancer types. We calculated the posterior probabilities of predicting patient sex and gender based on the observed sexes of similar samples in this map of transcriptome similarity.
    Results: Transcriptomic index (TI) values were derived from posterior probabilities and allowed us to identify poles with local enrichments for male or female transcriptomes. TI supported deconvolution of transcriptomes into measures of patient-specific activity in sex and gender-biased, targetable pathways. It identified sex and gender-skewed extremes in mechanistic phenotypes like cell cycle signaling and immunity, and precisely positioned each patient's whole transcriptome on an axis of continuously varying sex and gender phenotypes.
    Conclusions: Cancer type, patient sex and gender, and TI value provides a novel and patient- specific mechanistic identifier that can be used for realistic sex and gender-adaptations of precision cancer treatment planning.
    MeSH term(s) Adult ; Child ; Humans ; Male ; Female ; Sex Factors ; Neoplasms/genetics ; Neoplasms/therapy ; Gene Expression Profiling ; Transcriptome
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2587352-0
    ISSN 2042-6410 ; 2042-6410
    ISSN (online) 2042-6410
    ISSN 2042-6410
    DOI 10.1186/s13293-024-00607-1
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  3. Article: Accounting for sex differences variability in the design of sex-adapted cancer treatments.

    Yang, Wei / Rubin, Joshua B

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: The significant sex differences that exist in cancer mechanisms, incidence, and survival, have yet to impact clinical practice. We hypothesized that one barrier to translation is that sex differences in cancer phenotypes resemble sex differences in ... ...

    Abstract The significant sex differences that exist in cancer mechanisms, incidence, and survival, have yet to impact clinical practice. We hypothesized that one barrier to translation is that sex differences in cancer phenotypes resemble sex differences in height: highly overlapping, but distinct, male and female population distributions that vary continuously between female- and male- biased extremes. A consequence of this variance is that sex-specific treatments are rendered unrealistic, and our translational goal should be adaptation of treatment to the unique mix of sex-biased mechanisms that are present in each patient. To develop a tool that could advance this goal, we applied a Bayesian Nearest Neighbor (BNN) analysis to 8370 cancer transcriptomes from 26 different adult and 4 different pediatric cancer types to establish patient-specific Transcriptomic Sex Indices (TSI). TSI precisely partitions an individual patient's whole transcriptome into female- and male- biased components such that cancer type, patient sex, and transcriptomics, provide a novel and patient-specific mechanistic identifier that can be used for sex-adapted, precision cancer treatment planning.
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.22.23288966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Accounting for sex differences as a continuous variable in cancer treatments.

    Yang, Wei / Rubin, Joshua B

    Research square

    2023  

    Abstract: The significant sex differences that exist in cancer mechanisms, incidence, and survival, have yet to impact clinical practice. We propose that one barrier to translation is that sex differences in cancer phenotypes resemble sex differences in height: ... ...

    Abstract The significant sex differences that exist in cancer mechanisms, incidence, and survival, have yet to impact clinical practice. We propose that one barrier to translation is that sex differences in cancer phenotypes resemble sex differences in height: highly overlapping, but distinct, male and female population distributions that vary continuously between female- and male- skewed extremes. A consequence of this variance is that sex-specific treatments are rendered unrealistic, and our translational goal should be adaptation of treatment to the variable sex-effect on targetable pathways. To develop a tool that could advance this goal, we applied a Bayesian Nearest Neighbor (BNN) analysis to 8370 cancer transcriptomes from 26 different adult and 4 different pediatric cancer types to establish patient-specific Transcriptomic Indices (TI). TI precisely positions a patient's whole transcriptome on axes of mechanistic phenotypes like cell cycle signaling and immunity that exhibit skewing in the cancer population relative to sex-identified extremes (poles). Importantly, the TI approach reveals that even when TI values are identical, underlying mechanisms in male and female individuals can differ in identifiable ways. Thus, cancer type, patient sex, and TI value provides a novel and patient- specific mechanistic identifier that can be used for precision cancer treatment planning.
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3120372/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Sexual Differentiation Specifies Cellular Responses to DNA Damage.

    Broestl, Lauren / Rubin, Joshua B

    Endocrinology

    2021  Volume 162, Issue 11

    Abstract: Significant sex differences exist across cellular, tissue organization, and body system scales to serve the distinct sex-specific functions required for reproduction. They are present in all animals that reproduce sexually and have widespread impacts on ... ...

    Abstract Significant sex differences exist across cellular, tissue organization, and body system scales to serve the distinct sex-specific functions required for reproduction. They are present in all animals that reproduce sexually and have widespread impacts on normal development, aging, and disease. Observed from the moment of fertilization, sex differences are patterned by sexual differentiation, a lifelong process that involves mechanisms related to sex chromosome complement and the epigenetic and acute activational effects of sex hormones. In this mini-review, we examine evidence for sex differences in cellular responses to DNA damage, their underlying mechanisms, and how they might relate to sex differences in cancer incidence and response to DNA-damaging treatments.
    MeSH term(s) Adaptation, Physiological/physiology ; Aging/physiology ; Animals ; DNA Damage/physiology ; DNA Repair/physiology ; Female ; Gonadal Steroid Hormones/metabolism ; Gonadal Steroid Hormones/physiology ; Humans ; Male ; Sex Characteristics ; Sex Differentiation/physiology
    Chemical Substances Gonadal Steroid Hormones
    Language English
    Publishing date 2021-09-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqab192
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.72: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: To each, his/her own.

    Rubin, Joshua B / Schlaggar, Bradley L

    Neuro-oncology

    2019  Volume 21, Issue 10, Page(s) 1217–1218

    MeSH term(s) Brain Neoplasms ; Child ; Female ; Humans ; Male
    Language English
    Publishing date 2019-08-14
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/noz143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5307: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Editorial: Sex Difference in Cancer Genomics and Its Impact on Therapy.

    Peng, Sen / Waite, Kristin / Rubin, Joshua B / Barnholtz-Sloan, Jill S

    Frontiers in genetics

    2021  Volume 12, Page(s) 815804

    Language English
    Publishing date 2021-12-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2021.815804
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  8. Article ; Online: Sexual selection and cancer biology.

    Rubin, Joshua B

    Oncotarget

    2015  Volume 6, Issue 18, Page(s) 15714–15715

    MeSH term(s) Biological Evolution ; Female ; Humans ; Male ; Neoplasms/genetics ; Neoplasms/pathology ; Selection, Genetic ; Sex Characteristics
    Language English
    Publishing date 2015-06-30
    Publishing country United States
    Document type Editorial
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.4592
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  9. Article ; Online: Pediatric low-grade gliomas: a brave new world.

    Rubin, Joshua B / Finlay, Jonathan L

    Neuro-oncology

    2018  Volume 20, Issue 2, Page(s) 149–150

    MeSH term(s) Brain Neoplasms ; Child ; Glioma ; Humans
    Language English
    Publishing date 2018-01-24
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/nox221
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5307: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Intersections at the crossroads: Neurofibromatosis type 1, cAMP, sex, and glioma risk.

    Rubin, Joshua B

    Molecular & cellular oncology

    2015  Volume 3, Issue 3, Page(s) e1069917

    Abstract: Cancer predisposition syndromes, particularly neurofibromatosis type 1 (NF1), provide unique vantage points from which to examine the co-contributions of molecular, cellular, and tissue processes to tumor biology. Polymorphisms in adenylate cyclase 8 ... ...

    Abstract Cancer predisposition syndromes, particularly neurofibromatosis type 1 (NF1), provide unique vantage points from which to examine the co-contributions of molecular, cellular, and tissue processes to tumor biology. Polymorphisms in adenylate cyclase 8 affect brain tumor risk in NF1 in a sex-specific fashion, illuminating novel interdependencies in brain tumorigenesis.
    Language English
    Publishing date 2015-08-03
    Publishing country United States
    Document type Journal Article
    ISSN 2372-3556
    ISSN 2372-3556
    DOI 10.1080/23723556.2015.1069917
    Database MEDical Literature Analysis and Retrieval System OnLINE

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