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  1. Article ; Online: Science around the world.

    Gangrade, Navika / Hidalgo, Cecilia / Kanneganti, Thirumala-Devi / Lazennec, Gwendal

    Trends in molecular medicine

    2024  Volume 30, Issue 1, Page(s) 3–5

    Language English
    Publishing date 2024-01-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2023.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4345: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  2. Article ; Online: CXCR2 chemokine receptor - a master regulator in cancer and physiology.

    Lazennec, Gwendal / Rajarathnam, Krishna / Richmond, Ann

    Trends in molecular medicine

    2023  Volume 30, Issue 1, Page(s) 37–55

    Abstract: Recent findings have modified our understanding of the roles of chemokine receptor CXCR2 and its ligands in cancer, inflammation, and immunity. Studies in Cxcr2 tissue-specific knockout mice show that this receptor is involved in, among other things, ... ...

    Abstract Recent findings have modified our understanding of the roles of chemokine receptor CXCR2 and its ligands in cancer, inflammation, and immunity. Studies in Cxcr2 tissue-specific knockout mice show that this receptor is involved in, among other things, cancer, central nervous system (CNS) function, metabolism, reproduction, COVID-19, and the response to circadian cycles. Moreover, CXCR2 involvement in neutrophil function has been revisited not only in physiology but also for its major contribution to cancers. The recent unfolding of the role of CXCR2 in numerous cancers has led to extensive evaluation of multiple CXCR2 antagonists in preclinical and clinical studies. In this review we discuss the potential of targeting CXCR2 for cancer treatment.
    MeSH term(s) Mice ; Animals ; Humans ; Receptors, Interleukin-8B/genetics ; Inflammation/metabolism ; Neutrophils ; Neoplasms/genetics ; Neoplasms/metabolism ; Mice, Knockout
    Chemical Substances Receptors, Interleukin-8B
    Language English
    Publishing date 2023-10-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2023.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Environmental exposure and the role of AhR in the tumor microenvironment of breast cancer.

    Sweeney, Colleen / Lazennec, Gwendal / Vogel, Christoph F A

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 1095289

    Abstract: Activation of the aryl hydrocarbon receptor (AhR) through environmental exposure to chemicals including polycyclic aromatic hydrocarbons (PAHs) and polychlorinated dibenzo-p-dioxins (PCDDs) can lead to severe adverse health effects and increase the risk ... ...

    Abstract Activation of the aryl hydrocarbon receptor (AhR) through environmental exposure to chemicals including polycyclic aromatic hydrocarbons (PAHs) and polychlorinated dibenzo-p-dioxins (PCDDs) can lead to severe adverse health effects and increase the risk of breast cancer. This review considers several mechanisms which link the tumor promoting effects of environmental pollutants with the AhR signaling pathway, contributing to the development and progression of breast cancer. We explore AhR's function in shaping the tumor microenvironment, modifying immune tolerance, and regulating cancer stemness, driving breast cancer chemoresistance and metastasis. The complexity of AhR, with evidence for both oncogenic and tumor suppressor roles is discussed. We propose that AhR functions as a "molecular bridge", linking disproportionate toxin exposure and policies which underlie environmental injustice with tumor cell behaviors which drive poor patient outcomes.
    Language English
    Publishing date 2022-12-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.1095289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: CXCR2 intrinsically drives the maturation and function of neutrophils in mice.

    Delobel, Pauline / Ginter, Benjamin / Rubio, Eliane / Balabanian, Karl / Lazennec, Gwendal

    Frontiers in immunology

    2022  Volume 13, Page(s) 1005551

    Abstract: Neutrophils play a major role in the protection from infections but also in inflammation related to tumor microenvironment. However, cell-extrinsic and -intrinsic cues driving their function at steady state is still fragmentary. ... ...

    Abstract Neutrophils play a major role in the protection from infections but also in inflammation related to tumor microenvironment. However, cell-extrinsic and -intrinsic cues driving their function at steady state is still fragmentary. Using
    MeSH term(s) Animals ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neutrophils/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Receptors, Interleukin-8B/genetics ; Receptors, Interleukin-8B/metabolism
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Receptors, Interleukin-8B ; Cxcr2 protein, mouse
    Language English
    Publishing date 2022-10-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1005551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Les cellules souches mésenchymateuses : Armes ou dangers pour le traitement des cancers ?

    Lazennec, Gwendal

    Medecine sciences : M/S

    2011  Volume 27, Issue 3, Page(s) 285–288

    Abstract: Mesenchymal stem cells (MSC) have attracted recent attention for their cell therapy potential, based in particular on their immunosuppressive properties, which have served as the basis for the treatment of autoimmune diseases. Interestingly, MSC have ... ...

    Title translation Mesenchymal stem cells: weapons or dangers for cancer treatment?.
    Abstract Mesenchymal stem cells (MSC) have attracted recent attention for their cell therapy potential, based in particular on their immunosuppressive properties, which have served as the basis for the treatment of autoimmune diseases. Interestingly, MSC have been used in cell therapy strategies to deliver therapeutical genes. Cell therapy approaches taking advantages of MSC have been proposed, as MSC display a potential tropsim for tumors. However, all these strategies raise a series of questions about the safety of MSC, as MSC could enhance tumor growth and metastasis. This review summarizes recent findngs about MSC in carcinogenesis.
    MeSH term(s) Humans ; Mesenchymal Stem Cell Transplantation/adverse effects ; Mesenchymal Stromal Cells/physiology ; Neoplasms/pathology ; Neoplasms/surgery ; Tropism
    Language French
    Publishing date 2011-03
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2011273285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2872: Show issues Location:
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  6. Article: Recent discoveries concerning the tumor - mesenchymal stem cell interactions.

    Gwendal, Lazennec / Paula Y, Lam

    Biochimica et biophysica acta

    2016  Volume 1866, Issue 2, Page(s) 290–299

    Abstract: Tumor microenvironment plays a crucial role in coordination with cancer cells in the establishment, growth and dissemination of the tumor. Among cells of the microenvironment, mesenchymal stem cells (MSCs) and their ability to evolve into cancer ... ...

    Abstract Tumor microenvironment plays a crucial role in coordination with cancer cells in the establishment, growth and dissemination of the tumor. Among cells of the microenvironment, mesenchymal stem cells (MSCs) and their ability to evolve into cancer associated fibroblasts (CAFs) have recently generated a major interest in the field. Numerous studies have described the potential pro- or anti-tumorigenic action of MSCs. The goal of this review is to synthesize recent and emerging discoveries concerning the mechanisms by which MSCs can be attracted to tumor sites, how they can generate CAFs and by which way MSCs are able to modulate the growth, response to treatments, angiogenesis, invasion and metastasis of tumors. The understanding of the role of MSCs in tumor development has potential and clinical applications in terms of cancer management.
    MeSH term(s) Animals ; Apoptosis ; Cancer-Associated Fibroblasts/physiology ; Cell Communication ; Cell Proliferation ; Humans ; Mesenchymal Stromal Cells/physiology ; Neoplasms/etiology ; Neoplasms/metabolism ; Neoplasms/pathology ; Neovascularization, Physiologic ; Tumor Microenvironment
    Language English
    Publishing date 2016
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbcan.2016.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: CXCR2 Levels Correlate with Immune Infiltration and a Better Prognosis of Triple-Negative Breast Cancers.

    Boissière-Michot, Florence / Jacot, William / Massol, Océane / Mollevi, Caroline / Lazennec, Gwendal

    Cancers

    2021  Volume 13, Issue 10

    Abstract: Chemokines and their receptors are key players in breast cancer progression and outcome. Previous studies have shown that the chemokine receptor CXCR2 was expressed at higher levels by cells of the tumor microenvironment in triple-negative breast cancers ...

    Abstract Chemokines and their receptors are key players in breast cancer progression and outcome. Previous studies have shown that the chemokine receptor CXCR2 was expressed at higher levels by cells of the tumor microenvironment in triple-negative breast cancers (TNBCs). The aim of this study was to focus our attention on a retrospective cohort of 290 TNBC cases and analyze the involvement of CXCR2, CD11b (a marker of granulocytes) and CD66b (a marker of neutrophils) and their link with immune infiltration and immune checkpoint markers. We report that high densities of CXCR2-, CD11b- and CD66b-positive cells were associated with high-grade tumors. Moreover, molecular apocrine TNBCs, defined here as tumors that express both AR and FOXA1 biomarkers, exhibited low levels of CXCR2 and CD11b. High CXCR2 and CD11b levels were correlated with elevated density of tumor-infiltrating lymphocytes (TILs), CD8+ cytotoxic lymphocytes, expression of PD-L1 by tumor and stromal cells and of PD-1 by stromal cells. On the other hand, CD66b levels were associated only with CD8+, stromal PD-L1 and PD-1 expression. In univariate analysis, low levels of CXCR2 were correlated with poor OS and RFS. In multivariate analysis, low levels of CXCR2 were associated with poor OS. Finally, in TNBC treated with adjuvant chemotherapy, CXCR2 density was associated with longer RFS. Overall, our data highlight the potential beneficial association of high levels of CXCR2 with a subgroup of TNBC patients characterized by a better prognosis.
    Language English
    Publishing date 2021-05-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13102328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Retraction: article on estrogen receptor beta in ovarian carcinogenesis.

    Lazennec, Gwendal

    Cancer research

    2005  Volume 65, Issue 12, Page(s) 5480

    Language English
    Publishing date 2005-06-17
    Publishing country United States
    Document type Retraction of Publication
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.can-correction3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.135/5: Show issues Location:
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  9. Article: Prognostic Value of CXCR2 in Breast Cancer.

    Boissière-Michot, Florence / Jacot, William / Fraisse, Julien / Gourgou, Sophie / Timaxian, Colin / Lazennec, Gwendal

    Cancers

    2020  Volume 12, Issue 8

    Abstract: The tumor microenvironment appears essential in cancer progression and chemokines are mediators of the communication between cancer cells and stromal cells. We have previously shown that the ligands of the chemokine receptor CXCR2 were expressed at ... ...

    Abstract The tumor microenvironment appears essential in cancer progression and chemokines are mediators of the communication between cancer cells and stromal cells. We have previously shown that the ligands of the chemokine receptor CXCR2 were expressed at higher levels in triple-negative breast cancers (TNBC). Our hypothesis was that CXCR2 expression could also be altered in breast cancer. Here, we have analyzed the potential role of CXCR2 in breast cancer in a retrospective cohort of 105 breast cancer patients. Expression of CXCR2, CD11b (a marker of granulocytes) and CD66b (a marker of neutrophils) was analyzed by immunohistochemistry on tumor samples. We demonstrated that CXCR2 stained mainly stromal cells and in particular neutrophils. CXCR2, CD11b and CD66b expression were correlated with high grade breast cancers. Moreover, TNBC displayed a higher expression of CXCR2, CD11b and CD66b than hormone receptor positive or Her2 positive tumors. High levels of CXCR2 and CD11b, but not CD66b, were associated with a higher infiltration of T lymphocytes and B lymphocytes. We also observed a correlation between CXCR2 and AP-1 activity. In univariate analyses, CXCR2, but not CD11b or CD66b, was associated with a lower risk of relapse; CXCR2 remained significant in multivariate analysis. Our data suggest that CXCR2 is a stromal marker of TNBC. However, higher levels of CXCR2 predicted a lower risk of relapse.
    Language English
    Publishing date 2020-07-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12082076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Estrogen receptor beta, a possible tumor suppressor involved in ovarian carcinogenesis.

    Lazennec, Gwendal

    Cancer letters

    2006  Volume 231, Issue 2, Page(s) 151–157

    Abstract: Ovarian cancer is one of the leading causes of death from gynecological tumors in women. Several lines of evidence suggest that estrogens may play an important role in ovarian carcinogenesis, through their receptors, ERalpha and ERbeta. Interestingly, ... ...

    Abstract Ovarian cancer is one of the leading causes of death from gynecological tumors in women. Several lines of evidence suggest that estrogens may play an important role in ovarian carcinogenesis, through their receptors, ERalpha and ERbeta. Interestingly, malignant ovarian tumors originating from epithelial surface constitute about 90% of ovarian cancers and expressed low levels of ERbeta, compared to normal tissues. In addition, restoration of ERbeta in ovarian cancer cells, leads to strong inhibition of their proliferation and invasion, while apoptosis is enhanced. In this manuscript, recent data suggesting a possible tumor-suppressor role for ERbeta in ovarian carcinogenesis are discussed.
    MeSH term(s) Estrogen Receptor beta/physiology ; Female ; Genes, Tumor Suppressor ; Humans ; Ovarian Neoplasms/therapy
    Chemical Substances Estrogen Receptor beta
    Language English
    Publishing date 2006-01-18
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2005.01.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1177: Show issues Location:
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