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Book ; Online ; E-Book: Fungal plant pathogens

Alraiss, Kinda / Barker, Rachel / Barton, Victoria / Carson-Taylor, Lucy / Cooke, David / Elliot, Ashleigh / Galsworthy, David / Lane, Charles R. / Beales, Paul A. / Hughes, Kelvin J. D.

applied techniques

2023

Abstract: Since publication of the first edition in 2012, there is increased awareness of plant health and biosecurity. This practical manual deals with recognition of disease symptoms, detection and identification of fungi and methods to characterise them, as ... ...

Author's details	edited by Charles R. Lane, Paul A. Beales, Kelvin J.D. Hughes
Abstract	Since publication of the first edition in 2012, there is increased awareness of plant health and biosecurity. This practical manual deals with recognition of disease symptoms, detection and identification of fungi and methods to characterise them, as well as curation, quarantine, quality assurance, and new chapters on tree health and outreach
Language	English
Size	1 Online Ressource
Edition	2nd edition
Publisher	CAB International
Publishing place	Wallingford, Oxfordshire
Publishing country	Great Britain
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT030340129
ISBN	978-1-80062-057-5 ; 9781800620568 ; 9781800620551 ; 1-80062-057-8 ; 180062056X ; 1800620551
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Host Transcriptome Analysis of Ferret Tissues Following Henipavirus Infection.

Zeng, Tian S / Yang, D S / Kelvin, A A / Kelvin, David J

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2682, Page(s) 281–299

Abstract: Ferrets are commonly used as experimental models of infection for a variety of viruses due to their susceptibility to human respiratory viruses and the close resemblance of pathological outcomes found in human infections. Even though ferret-specific ... ...

Abstract	Ferrets are commonly used as experimental models of infection for a variety of viruses due to their susceptibility to human respiratory viruses and the close resemblance of pathological outcomes found in human infections. Even though ferret-specific reagents are limited, the use of ferrets as a preclinical experimental model of infection has gained considerable interest since the publication of the ferret transcriptome and draft ferret genome. These advances have made it feasible to easily perform whole-genome gene expression analysis in the ferret infection model. Here, we describe methods for genome-wide gene expression analysis using RNA sequence (RNAseq) data obtained from the lung and brain tissues obtained from experimental infections of Hendra (HeV) and Nipah (NiV) viruses in ferrets. We provide detailed methods for RNAseq and representative data for host gene expression profiles of the lung tissues that show early activation of interferon pathways and later activation of inflammation-related pathways.
MeSH term(s)	Animals ; Humans ; Ferrets ; Henipavirus Infections/genetics ; Gene Expression Profiling ; Transcriptome ; Coronavirus
Language	English
Publishing date	2023-08-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3283-3_20
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Book ; Online: Information knowledge and technology for Development in Africa

Kalusopa, Trywell / Bwalya, Kelvin J. / Kwanya, Tom / Britz, Johannes / Ngoepe, Mpho / Ocholla, Dennis N. / Onyancha, Omwoyo B. / Too, Jackson / Shongwe, Mzwandile M. / Evans, Neil D. / Evans, Neil D.

2021

Keywords	Computing & information technology ; Information technology: general issues ; 4IR ; ethics ; bibliometrics ; informatics ; development ; industrial revolution ; knowledge
Language	0\|e
Size	1 electronic resource (238 pages)
Publisher	AOSIS
Publishing place	Durbanville
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021614605
ISBN	9781776341832 ; 177634183X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Inhibition potential of natural flavonoids against selected omicron (B.1.19) mutations in the spike receptor binding domain of SARS-CoV-2: a molecular modeling approach.

Kumar, Anuj / Dutt, Mansi / Dehury, Budheswar / Sganzerla Martinez, Gustavo / Swan, Cynthia L / Kelvin, Alyson A / Richardson, Christopher D / Kelvin, David J

Journal of biomolecular structure & dynamics

2023 , Page(s) 1–15

Abstract: The omicron (B.1.19) variant of contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is considered a variant of concern (VOC) due to its increased transmissibility and highly infectious nature. The spike receptor-binding domain (RBD) ... ...

Abstract	The omicron (B.1.19) variant of contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is considered a variant of concern (VOC) due to its increased transmissibility and highly infectious nature. The spike receptor-binding domain (RBD) is a hotspot of mutations and is regarded as a prominent target for screening drug candidates owing to its crucial role in viral entry and immune evasion. To date, no effective therapy or antivirals have been reported; therefore, there is an urgent need for rapid screening of antivirals. An extensive molecular modelling study has been performed with the primary goal to assess the inhibition potential of natural flavonoids as inhibitors against RBD from a manually curated library. Out of 40 natural flavonoids, five natural flavonoids, namely tomentin A (-8.7 kcal/mol), tomentin C (-8.6 kcal/mol), hyperoside (-8.4 kcal/mol), catechin gallate (-8.3 kcal/mol), and corylifol A (-8.2 kcal/mol), have been considered as the top-ranked compounds based on their binding affinity and molecular interaction profiling. The state-of-the-art molecular dynamics (MD) simulations of these top-ranked compounds in complex with RBD exhibited stable dynamics and structural compactness patterns on 200 nanoseconds. Additionally, complexes of these molecules demonstrated favorable free binding energies and affirmed the docking and simulation results. Moreover, the post-simulation validation of these interacted flavonoids using principal component analysis (PCA) revealed stable interaction patterns with RBD. The integrated results suggest that tomentin A, tomentin C, hyperoside, catechin gallate, and corylifol A might be effective against the emerging variants of SARS-CoV-2 and should be further evaluated using
Language	English
Publishing date	2023-12-19
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2291165
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Article: Potential of Natural Alkaloids From Jadwar (

Kumar, Anuj / Sharma, Mansi / Richardson, Christopher D / Kelvin, David J

Frontiers in molecular biosciences

2022 Volume 9, Page(s) 898874

Abstract: The ongoing pandemic coronavirus disease (COVID-19) caused by a novel corona virus, namely, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has had a major impact on global public health. COVID-19 cases continue to increase across the globe ...

Abstract	The ongoing pandemic coronavirus disease (COVID-19) caused by a novel corona virus, namely, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has had a major impact on global public health. COVID-19 cases continue to increase across the globe with high mortality rates in immunocompromised patients. There is still a pressing demand for drug discovery and vaccine development against this highly contagious disease. To design and develop antiviral drugs against COVID-19, the main protease (M
Language	English
Publishing date	2022-05-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2022.898874
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Article ; Online: Potential of Natural Alkaloids From Jadwar (Delphinium denudatum) as Inhibitors Against Main Protease of COVID-19

Anuj Kumar / Mansi Sharma / Christopher D. Richardson / David J. Kelvin

Frontiers in Molecular Biosciences, Vol

A Molecular Modeling Approach

2022 Volume 9

Abstract	The ongoing pandemic coronavirus disease (COVID-19) caused by a novel corona virus, namely, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has had a major impact on global public health. COVID-19 cases continue to increase across the globe with high mortality rates in immunocompromised patients. There is still a pressing demand for drug discovery and vaccine development against this highly contagious disease. To design and develop antiviral drugs against COVID-19, the main protease (Mpro) has emerged as one of the important drug targets. In this context, the present work explored Jadwar (Delphinium denudatum)–derived natural alkaloids as potential inhibitors against Mpro of SARS-CoV-2 by employing a combination of molecular docking and molecular dynamic simulation–based methods. Molecular docking and interaction profile analysis revealed strong binding on the Mpro functional domain with four natural alkaloids viz. panicutine (−7.4 kcal/mol), vilmorrianone (−7.0 kcal/mol), denudatine (−6.0 kcal/mol), and condelphine (−5.9 kcal/mol). The molecular docking results evaluated by using the MD simulations on 200 nanoseconds confirmed highly stable interactions of these compounds with the Mpro. Additionally, mechanics/generalized Born/Poisson–Boltzmann surface area (MM/G/P/BSA) free energy calculations also affirmed the docking results. Natural alkaloids explored in the present study possess the essential drug-likeness properties, namely, absorption, distribution, metabolism, and excretion (ADME), and are in accordance with Lipinski’s rule of five. The results of this study suggest that these four bioactive molecules, namely, condelphine, denudatine, panicutine, and vilmorrianone, might be effective candidates against COVID-19 and can be further investigated using a number of experimental methods.
Keywords	COVID-19 ; alkaloids ; Jadwar ; molecular docking ; molecular dynamics simulations and free energy ; Biology (General) ; QH301-705.5
Subject code	541
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: LONG-TERM OUTCOMES OF IMPLANT PLACEMENT VERSUS TOOTH PRESERVATION IN PERIODONTALLY COMPROMISED TEETH MAY BE COMPARABLE.

Afrashtehfar, Kelvin I / Hicklin, Stefan P / Schmidlin, Patrick R

The journal of evidence-based dental practice

2023 Volume 24, Issue 1, Page(s) 101931

Abstract: ... Vasilaki D, Hirayama H, Michalakis K. Tooth preservation vs. extraction and implant placement ... in periodontally compromised patients: A systematic review and analysis of studies. J Prosthodont. 2022 Oct;31(8 ...

Abstract	Article title and bibliographic information: Sarafidou K, Lazaridi I, Gotsis S, Kirmanidou Y, Vasilaki D, Hirayama H, Michalakis K. Tooth preservation vs. extraction and implant placement in periodontally compromised patients: A systematic review and analysis of studies. J Prosthodont. 2022 Oct;31(8):e87-e99. doi:10.1111/jopr.13560. Epub 2022 Aug 2. PMID: 35794083 SOURCE OF FUNDING: No external funding was received for this research. Type of study/design: Systematic review (without meta-analysis).
Language	English
Publishing date	2023-10-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2056058-8
ISSN	1532-3390 ; 1532-3382
ISSN (online)	1532-3390
ISSN	1532-3382
DOI	10.1016/j.jebdp.2023.101931
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Article ; Online: A method for tritiation of iboxamycin permits measurement of its ribosomal binding.

Wu, Kelvin J Y / Klepacki, Dorota / Mankin, Alexander S / Myers, Andrew G

Bioorganic & medicinal chemistry letters

2023 Volume 91, Page(s) 129364

Abstract: Hydrogen-tritium exchange is widely employed for radioisotopic labeling of molecules of biological interest but typically involves the metal-promoted exchange of ... ...

Abstract	Hydrogen-tritium exchange is widely employed for radioisotopic labeling of molecules of biological interest but typically involves the metal-promoted exchange of sp
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Clindamycin/chemistry ; Clindamycin/metabolism ; Hydrogen ; Tritium/chemistry ; Ruthenium/chemistry
Chemical Substances	Anti-Bacterial Agents ; Clindamycin (3U02EL437C) ; Hydrogen (7YNJ3PO35Z) ; iboxamycin ; Tritium (10028-17-8) ; Ruthenium (7UI0TKC3U5)
Language	English
Publishing date	2023-06-07
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2023.129364
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Article ; Online: Understanding knowledge, attitudes and practices on Ebola Virus Disease: a multi-site mixed methods survey on preparedness in Rwanda.

Karuhije, Janvier / Nkeshimana, Menelas / Zakham, Fathiah / Hewins, Benjamin / Rutayisire, Justin / Martinez, Gustavo Sganzerla / Kelvin, David / Ndishimye, Pacifique

BMC public health

2023 Volume 23, Issue 1, Page(s) 2417

Abstract: Background: The overall goal of this survey was to understand the knowledge, attitudes, and practices related to the Ebola Virus Disease (EVD) in Rwanda.: Methods: This mixed-method cross-sectional survey was conducted in five selected districts of ... ...

Abstract	Background: The overall goal of this survey was to understand the knowledge, attitudes, and practices related to the Ebola Virus Disease (EVD) in Rwanda. Methods: This mixed-method cross-sectional survey was conducted in five selected districts of Rwanda. Quantitative data were collected from 1,010 participants using Kobo Collect Software and the analysis was performed using SPSS and Python software. Qualitative data were specifically collected from 98 participants through Key Informant Interviews (KIIs) and Focus Group Discussion (FGDs). Interview transcripts were imported into NVIVO 8 for coding and subsequent analysis. Results: As per our quantitative findings, we report that from the 1,010 respondents, 99.6% reported having previously heard of Ebola, 97.2% believed that vaccination is important in combatting the disease and 93.3% of individuals reported a willingness to receive vaccination should one become available. Around 54% of the respondents were correct in identifying that the disease is of a viral origin which originates from wild animals (42.1%). When asked if they believed that Rwanda is at risk of an EVD outbreak, 90% of the respondents believe that the country is at risk of an EVD outbreak, and the cofactors gender and whether people dwell in Rubavu/Rusizi were found to significantly impact their perception of threat. As per our qualitative findings, the respondents mentioned that both geographical proximity and relations with the Democratic Republic of Congo place Rwanda at risk of developing an internal outbreak. Although the respondents seemed to be aware of the Ebola prevention behaviours, it was noted that some of them will require significant time before reintegrating into the community an EVD survivor, as they will first need assurance that the patient has fully recovered. Therefore, the qualitative findings reinforce what we originally reported in the quantitative approach to this study. Conclusion: Our results show that there was high EVD-related knowledge and awareness among the general population in Rwanda. However, for strong public health awareness, preparedness, and protection, a massive investment should always be made in education about EVD with a special focus on districts neighboring countries where the disease is consistently being reported.
MeSH term(s)	Animals ; Humans ; Hemorrhagic Fever, Ebola/epidemiology ; Hemorrhagic Fever, Ebola/prevention & control ; Rwanda/epidemiology ; Cross-Sectional Studies ; Health Knowledge, Attitudes, Practice ; Disease Outbreaks/prevention & control ; Surveys and Questionnaires
Language	English
Publishing date	2023-12-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-023-17251-w
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Article ; Online: PASC (Post Acute Sequelae of COVID-19) is associated with decreased neutralizing antibody titers in both biological sexes and increased ANG-2 and GM-CSF in females.

Jansen, Ethan B / Ostadgavahi, Ali Toloue / Hewins, Benjamin / Buchanan, Rachelle / Thivierge, Brittany M / Sganzerla Martinez, Gustavo / Goncin, Una / Francis, Magen E / Swan, Cynthia L / Scruten, Erin / Bell, Jack / Darbellay, Joseph / Facciuolo, Antonio / Falzarano, Darryl / Gerdts, Volker / Fenton, Mark E / Hedlin, Peter / Kelvin, David J / Kelvin, Alyson A

Scientific reports

2024 Volume 14, Issue 1, Page(s) 9854

Abstract: Post-acute sequelae of COVID-19 (PASC) or the continuation of COVID-19 (Coronavirus disease 2019) symptoms past 12 weeks may affect as many as 30% of people recovering from a SARS-CoV-2 (severe acute respiratory coronavirus 2) infection. The mechanisms ... ...

Abstract	Post-acute sequelae of COVID-19 (PASC) or the continuation of COVID-19 (Coronavirus disease 2019) symptoms past 12 weeks may affect as many as 30% of people recovering from a SARS-CoV-2 (severe acute respiratory coronavirus 2) infection. The mechanisms regulating the development of PASC are currently not known; however, hypotheses include virus reservoirs, pre-existing conditions, microblood clots, immune dysregulation, as well as poor antibody responses. Importantly, virus neutralizing antibodies are essential for COVID-19 recovery and protection from reinfection but there is currently limited information on these immune regulators and associated cytokines in PASC patients. Understanding the key drivers of general and specific symptoms associated with Long COVID and the presence of virus neutralizing antibodies in PASC will aid in the development of therapeutics, diagnostics, and vaccines which currently do not exist. We designed a cross-sectional study to investigate systemic antibody and cytokine responses during COVID-19 recovery and PASC. In total, 195 participants were recruited in one of four groups: (1) Those who never had COVID-19 (No COVID); (2) Those in acute COVID-19 recovery (Acute Recovery) (4-12 weeks post infection); (3) Those who recovered from COVID-19 (Recovered) (+ 12 weeks from infection); and (4) those who had PASC (PASC) (+ 12 weeks from infection). Participants completed a questionnaire on health history, sex, gender, demographics, experiences with COVID-19 acute and COVID-19 recovery/continuing symptoms. Serum samples collected were evaluated for antibody binding to viral proteins, virus neutralizing antibody titers, and serum cytokine levels using Ella SimplePlex Immunoassay™ panels. We found participants with PASC reported more pre-existing conditions (e.g. such as hypertension, asthma, and obesity), and PASC symptoms (e.g. fatigue, brain fog, headaches, and shortness of breath) following COVID-19 than COVID-19 Recovered individuals. Importantly, we found PASC individuals to have significantly decreased levels of neutralizing antibodies toward both SARS-CoV-2 and the Omicron BA.1 variant. Sex analysis indicated that female PASC study participants had sustained antibody levels as well as levels of the inflammatory cytokines GM-CSF and ANG-2 over time following COVID-19. Our study reports people experiencing PASC had lower levels of virus neutralizing antibodies; however, the results are limited by the collection time post-COVID-19 and post-vaccination. Moreover, we found females experiencing PASC had sustained levels of GM-CSF and ANG-2. With lower levels of virus neutralizing antibodies, this data suggests that PASC individuals not only have had a suboptimal antibody response during acute SARS-CoV-2 infection but may also have increased susceptibility to subsequent infections which may exacerbate or prolong current PASC illnesses. We also provide evidence suggesting GM-CSF and ANG-2 to play a role in the sex-bias of PASC. Taken together, our findings maybe important for understanding immune molecular drivers of PASC and PASC subgroups.
MeSH term(s)	Humans ; COVID-19/immunology ; COVID-19/blood ; COVID-19/virology ; Female ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Male ; Middle Aged ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Granulocyte-Macrophage Colony-Stimulating Factor/immunology ; Granulocyte-Macrophage Colony-Stimulating Factor/blood ; Adult ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Cross-Sectional Studies ; Post-Acute COVID-19 Syndrome ; Aged ; Sex Factors ; Angiotensin-Converting Enzyme 2/metabolism
Chemical Substances	Antibodies, Neutralizing ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1) ; Antibodies, Viral ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2024-04-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-60089-4
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