Article ; Online: Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins.
2024 Volume 25, Issue 5, Page(s) 755–763
Abstract: T cell infiltration into tumors is a favorable prognostic feature, but most solid tumors lack productive T cell responses. Mechanisms that coordinate T cell exclusion are incompletely understood. Here we identify hepatocyte activation via interleukin-6/ ... ...
Abstract | T cell infiltration into tumors is a favorable prognostic feature, but most solid tumors lack productive T cell responses. Mechanisms that coordinate T cell exclusion are incompletely understood. Here we identify hepatocyte activation via interleukin-6/STAT3 and secretion of serum amyloid A (SAA) proteins 1 and 2 as important regulators of T cell surveillance of extrahepatic tumors. Loss of STAT3 in hepatocytes or SAA remodeled the tumor microenvironment with infiltration by CD8 |
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MeSH term(s) | Serum Amyloid A Protein/metabolism ; Serum Amyloid A Protein/genetics ; Hepatocytes/metabolism ; Hepatocytes/immunology ; Animals ; Humans ; Mice ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Interleukin-6/metabolism ; STAT3 Transcription Factor/metabolism ; Tumor Microenvironment/immunology ; Mice, Inbred C57BL ; Mice, Knockout ; Tumor Escape ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Pancreatic Neoplasms/immunology ; Pancreatic Neoplasms/metabolism ; Signal Transduction ; Carcinoma, Pancreatic Ductal/immunology ; Carcinoma, Pancreatic Ductal/pathology ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Cell Line, Tumor |
Chemical Substances | Serum Amyloid A Protein ; Interleukin-6 ; STAT3 Transcription Factor ; Saa2 protein, mouse |
Language | English |
Publishing date | 2024-04-19 |
Publishing country | United States |
Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2016987-5 |
ISSN | 1529-2916 ; 1529-2908 |
ISSN (online) | 1529-2916 |
ISSN | 1529-2908 |
DOI | 10.1038/s41590-024-01820-1 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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