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  1. Article ; Online: A twenty year perspective on melanoma therapy.

    Flaherty, Keith T

    Pigment cell & melanoma research

    2023  Volume 36, Issue 6, Page(s) 563–575

    Abstract: Melanoma had long been considered to be particularly addressable with immunotherapy, but that reputation was built on modestly effective cytokine-based immunotherapy. CTLA-4 antibody therapy reinforced this legacy, but PD-1 antibodies transformed the ... ...

    Abstract Melanoma had long been considered to be particularly addressable with immunotherapy, but that reputation was built on modestly effective cytokine-based immunotherapy. CTLA-4 antibody therapy reinforced this legacy, but PD-1 antibodies transformed the melanoma treatment landscape and lead the way for immunotherapy to become standard treatment for more than half of the advanced cancer population. BRAF mutations were discovered in 8% of all cancer and nearly 50% of melanomas. Successful development of BRAF inhibitors and BRAF/MEK combination therapy in melanoma preceded regulatory approval across all cancer types. No cancer type saw outcomes improved by the same margin as melanoma in the decade of the 2010s.
    MeSH term(s) Humans ; Proto-Oncogene Proteins B-raf/genetics ; Melanoma/drug therapy ; Melanoma/genetics ; Immunotherapy ; Combined Modality Therapy ; Cytokines
    Chemical Substances Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Cytokines
    Language English
    Publishing date 2023-09-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2409570-9
    ISSN 1755-148X ; 1600-0749 ; 0893-5785 ; 1755-1471
    ISSN (online) 1755-148X ; 1600-0749
    ISSN 0893-5785 ; 1755-1471
    DOI 10.1111/pcmr.13125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2444: Show issues Location:
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  2. Article ; Online: Tracking early response to immunotherapy.

    Boland, Genevieve M / Flaherty, Keith T

    Nature cancer

    2020  Volume 1, Issue 2, Page(s) 160–162

    MeSH term(s) Immunologic Factors ; Immunotherapy/adverse effects
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2020-01-20
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2662-1347
    ISSN (online) 2662-1347
    DOI 10.1038/s43018-020-0032-8
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  3. Article: New drugs in development for melanoma.

    Flaherty, Keith T

    Clinical advances in hematology & oncology : H&O

    2015  Volume 13, Issue 11, Page(s) 717–719

    MeSH term(s) Antineoplastic Agents/therapeutic use ; Drug Discovery ; Humans ; Melanoma/drug therapy ; United States ; United States Food and Drug Administration
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
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  4. Article ; Online: When are signal transduction targeted therapies acting as immunotherapy?

    Flaherty, Keith T

    Cancer biology & therapy

    2015  Volume 16, Issue 5, Page(s) 645–647

    MeSH term(s) Antineoplastic Agents/administration & dosage ; Female ; Humans ; Indoles/administration & dosage ; Male ; Melanoma/drug therapy ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; Proto-Oncogene Proteins B-raf/genetics ; Sulfonamides/administration & dosage
    Chemical Substances Antineoplastic Agents ; Indoles ; Sulfonamides ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Language English
    Publishing date 2015-03-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2146305-0
    ISSN 1555-8576 ; 1538-4047
    ISSN (online) 1555-8576
    ISSN 1538-4047
    DOI 10.1080/15384047.2015.1030553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effectively targeting CRAF: rational serendipity targeting SRC?

    Flaherty, Keith T

    Pigment cell & melanoma research

    2015  Volume 28, Issue 3, Page(s) 242–243

    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Drug Resistance, Neoplasm/drug effects ; Female ; Humans ; Melanoma/drug therapy ; Phenylurea Compounds/pharmacology ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; Pyrazines/pharmacology ; src-Family Kinases/antagonists & inhibitors
    Chemical Substances Antineoplastic Agents ; Phenylurea Compounds ; Protein Kinase Inhibitors ; Pyrazines ; src-Family Kinases (EC 2.7.10.2) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Language English
    Publishing date 2015-05
    Publishing country England
    Document type Comment ; News
    ZDB-ID 2409570-9
    ISSN 1755-148X ; 1600-0749 ; 0893-5785 ; 1755-1471
    ISSN (online) 1755-148X ; 1600-0749
    ISSN 0893-5785 ; 1755-1471
    DOI 10.1111/pcmr.12360
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  6. Article ; Online: Author Correction: From genes to drugs: targeted strategies for melanoma.

    Flaherty, Keith T / Hodi, F Stephen / Fisher, David E

    Nature reviews. Cancer

    2020  Volume 20, Issue 12, Page(s) 757

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Language English
    Publishing date 2020-10-12
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2062767-1
    ISSN 1474-1768 ; 1474-175X
    ISSN (online) 1474-1768
    ISSN 1474-175X
    DOI 10.1038/s41568-020-00311-3
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    Zs.A 5563: Show issues Location:
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    Zs.MG 24: Show issues

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  7. Article: AACR Cancer Progress Report 2017:

    Tessmer, Marlowe S / Flaherty, Keith T

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2017  Volume 23, Issue 18, Page(s) 5325

    MeSH term(s) Humans ; Neoplasms/therapy
    Language English
    Publishing date 2017-09-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-17-2302
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    Zs.A 4223: Show issues Location:
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  8. Article: Response to Immune Checkpoint Antibodies: Not All Responses Are Created Equal.

    Cohen, Justine V / Flaherty, Keith T

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2018  Volume 25, Issue 3, Page(s) 910–911

    Abstract: Early reports from immunotherapy trials conclude durable responses. Long-term data may indicate otherwise. Better delineation of clinical courses of long-term survivors will accelerate the discovery and application of biomarkers. Two pressing issues ... ...

    Abstract Early reports from immunotherapy trials conclude durable responses. Long-term data may indicate otherwise. Better delineation of clinical courses of long-term survivors will accelerate the discovery and application of biomarkers. Two pressing issues among those treated with anti-PD-1/PD-L1 are understanding whether responders can have therapy abbreviated and overcoming resistance in nonresponders.
    MeSH term(s) Antibodies, Monoclonal ; B7-H1 Antigen ; Humans ; Immunologic Factors ; Immunotherapy ; Programmed Cell Death 1 Receptor
    Chemical Substances Antibodies, Monoclonal ; B7-H1 Antigen ; Immunologic Factors ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2018-12-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-18-3296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: When Tissue Is No Longer the Issue: Tissue-Agnostic Cancer Therapy Comes of Age.

    Luoh, Shiuh-Wen / Flaherty, Keith T

    Annals of internal medicine

    2018  Volume 169, Issue 4, Page(s) 233–239

    Abstract: Matching unique features of cancer types with effective therapies is a cornerstone of precision medicine. Clinical success has been seen in inhibiting specific molecular alterations that drive the growth of cancer cells and targeting molecules whose ... ...

    Abstract Matching unique features of cancer types with effective therapies is a cornerstone of precision medicine. Clinical success has been seen in inhibiting specific molecular alterations that drive the growth of cancer cells and targeting molecules whose elevated expression is confined to cancer cells. In addition, cancer cells can have vulnerabilities induced by somatic mutations they carry; attacks on these vulnerabilities range from specific molecular alterations pointing to direct drug strategies to harnessing immune recognition of genetically altered epitopes produced by the cancer cells. Recent advances have found that the success of biomarker-driven cancer therapy may be relevant across sites of origin. For example, cancer types that show DNA mismatch repair deficiency, such as colon, biliary, and endometrial cancer, are more sensitive to immune checkpoint inhibition. Several large, ongoing clinical trials with a "basket" design are combining tumor tissue genomics with potential off-the-shelf therapies in drug development, and more tissue-agnostic biomarker therapies are reaching the bedside.
    MeSH term(s) Antineoplastic Agents, Immunological/therapeutic use ; Biomarkers, Tumor ; Cell Cycle Checkpoints/drug effects ; Cell Cycle Checkpoints/immunology ; Female ; Humans ; Molecular Targeted Therapy ; Mutation ; Neoplasms/drug therapy ; Neoplasms/genetics ; Precision Medicine
    Chemical Substances Antineoplastic Agents, Immunological ; Biomarkers, Tumor
    Language English
    Publishing date 2018-07-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M17-2832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Melanoma in 2017: Moving treatments earlier to move further forwards.

    Davies, Michael A / Flaherty, Keith T

    Nature reviews. Clinical oncology

    2017  Volume 15, Issue 2, Page(s) 75–76

    MeSH term(s) Clinical Trials, Phase III as Topic ; Humans ; Imidazoles/adverse effects ; Imidazoles/therapeutic use ; Immunotherapy/trends ; Lymphatic Metastasis ; Melanoma/drug therapy ; Melanoma/immunology ; Melanoma/pathology ; Neoplasm Staging ; Oximes/adverse effects ; Oximes/therapeutic use ; Progression-Free Survival ; Pyridones/administration & dosage ; Pyridones/therapeutic use ; Pyrimidinones/administration & dosage ; Pyrimidinones/therapeutic use ; Sentinel Lymph Node/drug effects ; Sentinel Lymph Node/pathology
    Chemical Substances Imidazoles ; Oximes ; Pyridones ; Pyrimidinones ; trametinib (33E86K87QN) ; dabrafenib (QGP4HA4G1B)
    Language English
    Publishing date 2017-11-28
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/nrclinonc.2017.183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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