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Article: Propylthiouracil-Induced Antineutrophil Cytoplasmic Antibody-Associated Vasculitis with Overlap IgA Nephropathy: A Case Report.

Oakman, Georgina / Ong, Cindy

2024 Volume 14, Issue 1, Page(s) 36–41

Abstract: Background: The anti-thyroid medication propylthiouracil (PTU) is a recognised cause of drug-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Pauci-immune crescentic glomerulonephritis is the characteristic feature of this ...

Abstract	Background: The anti-thyroid medication propylthiouracil (PTU) is a recognised cause of drug-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Pauci-immune crescentic glomerulonephritis is the characteristic feature of this condition on renal biopsy. We present a case of PTU-induced AAV with the unusual histological finding of overlap IgA nephropathy (IgAN) in a young female with treatment-resistant Graves' disease. Case report: A 26-year-old female presented with an acute kidney injury, macroscopic haematuria, and proteinuria 14 months after starting PTU for Graves' disease. She had a history of established thyroid eye disease and a previous severe adverse reaction to carbimazole. Her autoantibodies were strongly positive for myeloperoxidase-ANCA (199 U/mL). Renal biopsy demonstrated both necrotising crescentic glomerulonephritis and prominent (3+) mesangial deposition of IgA. She was treated with glucocorticoids and rituximab with sustained improvement in her renal function but persisting mild proteinuria and microscopic haematuria. PTU was ceased following a dose of radioactive iodine (RAI). Twelve months post-RAI, her Graves' orbitopathy remained stable, and her thyroid function was gradually normalising. Conclusion: This was a case of drug-induced AAV with histological features of overlap IgAN. We suggest that this patient had pre-existing subclinical IgAN and then developed AAV secondary to PTU. The management of her thyroid disease was complex given the PTU-induced vasculitis, previous reaction to carbimazole, the risks of a thyroidectomy on immunosuppression, and the possible worsening of her eye disease with RAI. The glucocorticoids and Rituximab prescribed for vasculitis may have prevented the progression of her Graves' orbitopathy after RAI.
Language	English
Publishing date	2024-03-04
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2809879-1
ISSN	2296-9705
ISSN	2296-9705
DOI	10.1159/000536618
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Diseases of the Antrum of Highmore.

Oakman, C H

The Dental register

2021 Volume 54, Issue 6, Page(s) 271–281

Language	English
Publishing date	2021-03-10
Publishing country	United States
Document type	Journal Article
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Article: Diseases of the Antrum of Highmore.

Oakman, C H

The Dental register

2021 Volume 54, Issue 5, Page(s) 256–264

Language	English
Publishing date	2021-03-10
Publishing country	United States
Document type	Journal Article
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Article ; Online: Incidence of anti-neutrophil cytoplasmic antibody-associated renal vasculitis: a retrospective study in rural and regional Victoria, Australia.

Oakman, Georgina / Bach, Cindy-Anne / Ong, Cindy

Internal medicine journal

2023 Volume 54, Issue 3, Page(s) 461–466

Abstract: Background: The epidemiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) varies worldwide. Previous Australian studies described a higher incidence of AAV in rural areas; however, this has not yet been investigated in ... ...

Abstract	Background: The epidemiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) varies worldwide. Previous Australian studies described a higher incidence of AAV in rural areas; however, this has not yet been investigated in Victoria. Aims: To calculate the incidence of AAV in rural and regional Victoria and characterise the demographics and clinical outcomes of this cohort. Methods: We performed a retrospective review of patients with newly diagnosed AAV confirmed on renal biopsy at Bendigo Health between 2013 and 2021. Cases were classified according to the 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology criteria. Local disease incidence was calculated using Estimated Resident Population data for our catchment, the Loddon Mallee region. Results: Twenty-eight cases of new AAV were identified; 17 were classified as microscopic polyangiitis (MPA) and the remainder as granulomatosis with polyangiitis (GPA). The median age at diagnosis was 68 years (interquartile range (IQR): 59-77). The incidence per million person-years was 9.3 for AAV overall (95% CI: 6.2-13.5), 5.7 for MPA (95% CI: 3.3-9.1) and 3.7 for GPA (95% CI: 1.8-6.6). With a median follow-up time of 3.3 years (IQR: 1.9-5.6), one-quarter of patients relapsed (n = 7, 25%), and six required ongoing renal-replacement therapy (21%). Conclusions: The calculated incidence of AAV in rural and regional Victoria is not higher than the reported incidence in most urban Australian cohorts. This study may underestimate the true local disease incidence as only patients with renal vasculitis were included.
MeSH term(s)	Humans ; Aged ; Retrospective Studies ; Antibodies, Antineutrophil Cytoplasmic ; Victoria ; Incidence ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis ; Microscopic Polyangiitis/diagnosis ; Microscopic Polyangiitis/therapy ; Granulomatosis with Polyangiitis/complications ; Granulomatosis with Polyangiitis/diagnosis
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic
Language	English
Publishing date	2023-05-29
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2045436-3
ISSN	1445-5994 ; 1444-0903
ISSN (online)	1445-5994
ISSN	1444-0903
DOI	10.1111/imj.16127
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Zs.A 792: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 424: Show issues

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Article ; Online: PALVEN: phase Ib trial of palbociclib, letrozole and venetoclax in estrogen receptor- and BCL2-positive advanced breast cancer.

Muttiah, Christine / Whittle, James R / Oakman, Catherine / Lindeman, Geoffrey J

Future oncology (London, England)

2022 Volume 18, Issue 15, Page(s) 1805–1816

Abstract: The addition of a CDK4/6 inhibitor to endocrine therapy improves progression-free and overall survival in women with metastatic estrogen receptor-positive breast cancer. In that setting, CDK4/6 inhibitors induce a potent cell-cycle arrest (which may be ... ...

Abstract	The addition of a CDK4/6 inhibitor to endocrine therapy improves progression-free and overall survival in women with metastatic estrogen receptor-positive breast cancer. In that setting, CDK4/6 inhibitors induce a potent cell-cycle arrest (which may be accompanied by tumor senescence) but fail to induce apoptotic cell death. Venetoclax is a potent inhibitor of BCL2, a pro-survival protein overexpressed in the majority of estrogen receptor-positive cancers. Pre-clinical findings indicate that venetoclax augments tumor response to the CDK4/6 inhibitor palbociclib by triggering apoptosis, including in senescent cells. The PALVEN phase Ib trial will further examine this finding. The primary objective is to identify the maximum tolerated dose and determine the recommended phase II dose for palbociclib, letrozole and venetoclax combination therapy.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols ; Breast Neoplasms/pathology ; Bridged Bicyclo Compounds, Heterocyclic ; Clinical Trials, Phase I as Topic ; Female ; Humans ; Letrozole/therapeutic use ; Piperazines ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-bcl-2/genetics ; Pyridines ; Receptor, ErbB-2/metabolism ; Receptors, Estrogen/metabolism ; Sulfonamides
Chemical Substances	BCL2 protein, human ; Bridged Bicyclo Compounds, Heterocyclic ; Piperazines ; Protein Kinase Inhibitors ; Proto-Oncogene Proteins c-bcl-2 ; Pyridines ; Receptors, Estrogen ; Sulfonamides ; Letrozole (7LKK855W8I) ; Receptor, ErbB-2 (EC 2.7.10.1) ; palbociclib (G9ZF61LE7G) ; venetoclax (N54AIC43PW)
Language	English
Publishing date	2022-02-21
Publishing country	England
Document type	Journal Article ; Clinical Trial Protocol
ZDB-ID	2274956-1
ISSN	1744-8301 ; 1479-6694
ISSN (online)	1744-8301
ISSN	1479-6694
DOI	10.2217/fon-2021-1450
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Zs.A 6478: Show issues

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Article ; Online: Impact of anakinra use on clinical outcomes in children with moderate or severe multisystem inflammatory syndrome in children: a propensity score matched retrospective cohort study.

Akkoyun, Esra B / Most, Zachary / Katragadda, Harita / Yu, Andrew / Nassi, Lorien / Oakman, Nicole / Ginsburg, Sarah / Maamari, Mia

Pediatric rheumatology online journal

2023 Volume 21, Issue 1, Page(s) 141

Abstract: Background: The treatment of children with multisystem inflammatory syndrome in children (MIS-C ... regimens for MIS-C remain unknown, we aimed to assess the effect of anakinra in reducing hospital stay ... in patients with MIS-C.: Methods: We included children admitted from May 2020 to May 2021 diagnosed ...

Abstract	Background: The treatment of children with multisystem inflammatory syndrome in children (MIS-C) related to SARS-CoV-2 infection involves immunomodulatory therapies such as IVIG and steroids. Anakinra, an interleukin-1 receptor inhibitor, has also been used, but its effectiveness is not established yet. As optimal regimens for MIS-C remain unknown, we aimed to assess the effect of anakinra in reducing hospital stay in patients with MIS-C. Methods: We included children admitted from May 2020 to May 2021 diagnosed with MIS-C based on CDC criteria. The exposure of interest was anakinra use at any point during admission. The anakinra exposed group and the anakinra unexposed group were propensity score matched based on demographic and clinical severity indicators at initial presentation. Our primary outcome was length of hospital stay. Secondary outcomes were duration of vasoactive support, vasoactive inotropic score (VIS), level of respiratory support, time to fever resolution, reduction of CRP levels, and length of ICU stay. We used Wilcoxon rank sum, t-test, Chi square and Fisher's exact tests. Results: Of 138 children diagnosed with MIS-C, 79% had moderate or severe illness and 41% received anakinra. Of those, 31 patients who received anakinra were propensity score matched to 31 who did not. The length of stay in the hospital but not in the ICU was longer in the anakinra group. There were no differences in median duration of vasoactive support, fever resolution, CRP reduction, or VIS. Conclusions: In patients with moderate to severe MIS-C, use of anakinra was associated with longer duration of hospital stay.
MeSH term(s)	Humans ; Child ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Propensity Score ; Retrospective Studies ; COVID-19 ; Fever
Chemical Substances	Interleukin 1 Receptor Antagonist Protein
Language	English
Publishing date	2023-11-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2279468-2
ISSN	1546-0096 ; 1546-0096
ISSN (online)	1546-0096
ISSN	1546-0096
DOI	10.1186/s12969-023-00924-6
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Article: When patients die: patient memorials and group reflection in an internal medicine residency program.

Oakman, Nicole / Lim, Jonathan / Bui, Christine / Kaplan, Holland / Sherman, Stephanie

Proceedings (Baylor University. Medical Center)

2020 Volume 34, Issue 1, Page(s) 56–58

Abstract: Patient death is a formative and emotional experience for physicians. Medical trainees are particularly susceptible to the emotional impact of patient death. However, few studies have examined how trainees process patient death. This study describes ... ...

Abstract	Patient death is a formative and emotional experience for physicians. Medical trainees are particularly susceptible to the emotional impact of patient death. However, few studies have examined how trainees process patient death. This study describes annual patient memorials organized at a large multisite academic graduate medical education program. Peer-led, 1-hour patient memorial services were organized for internal medicine residents, including large and small group reflection, a moment of silence, and collective art projects. At the conclusion of each memorial, participants completed a 10-question survey regarding their experience during the memorial and their prior experiences with patient death. Ninety-nine surveys were analyzed over 2 years. Of resident respondents, 84% reported feeling comfortable or very comfortable participating in the memorials, and 93% rated reflection on patient death as important or very important. When asked how they reflect on patient death, 67% of residents reported processing patient death independently, while only 23% reported processing patient death with their medical teams. Patient memorials with small and large group discussions are easily adopted and replicated. Residents reflect on patient death frequently but often independently rather than with their medical teams. Patient memorials provide a venue for collective mourning and group reflection to support trainees.
Language	English
Publishing date	2020-09-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703932-8
ISSN	1525-3252 ; 0899-8280
ISSN (online)	1525-3252
ISSN	0899-8280
DOI	10.1080/08998280.2020.1818164
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Zs.A 6987: Show issues

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Article ; Online: What Are the Key Workplace Influences on Pathways of Work Ability? A Six-Year Follow Up.

Oakman, Jodi / Neupane, Subas / Prakash, K C / Nygård, Clas-Håkan

International journal of environmental research and public health

2019 Volume 16, Issue 13

Abstract: Objective: To study the trajectories of work ability and investigate the impact of multisite pain and working conditions on pathways of work ability over a six-year period.: Methods: The longitudinal study was conducted with Finnish food industry ... ...

Abstract	Objective: To study the trajectories of work ability and investigate the impact of multisite pain and working conditions on pathways of work ability over a six-year period. Methods: The longitudinal study was conducted with Finnish food industry workers ( Results: Three trajectories of work ability emerged: decreasing (5%), increasing (5%), and good (90%). In the former two trajectories, the mean score of work ability changed from good to poor and poor to good during follow-up, while in the latter, individuals maintained good work ability during the follow-up. In the multivariable adjusted model, number of pain sites was significantly associated with higher odds of belonging to the trajectory of poor work ability (Odds ratio (OR) 4 pain sites 2.96, 1.25-7.03). Conclusions: A substantial number of employees maintained good work ability across the follow up. However, for employees with poor work ability, multisite musculoskeletal pain has an important influence, with effective prevention strategies required to reduce its prevalence.
MeSH term(s)	Female ; Finland/epidemiology ; Follow-Up Studies ; Food Industry ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Musculoskeletal Pain/epidemiology ; Occupational Diseases/epidemiology ; Posture ; Work Capacity Evaluation ; Workplace/psychology
Language	English
Publishing date	2019-07-03
Publishing country	Switzerland
Document type	Journal Article
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph16132363
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Article ; Online: Strict Preanalytical Oral Glucose Tolerance Test Blood Sample Handling Is Essential for Diagnosing Gestational Diabetes Mellitus.

Potter, Julia M / Hickman, Peter E / Oakman, Carmen / Woods, Catherine / Nolan, Christopher J

Diabetes care

2020 Volume 43, Issue 7, Page(s) 1438–1441

Abstract: Objective: Preanalytical processing of blood samples can affect plasma glucose measurement because ongoing glycolysis by cells prior to centrifugation can lower its concentration. In June 2017, ACT Pathology changed the processing of oral glucose ... ...

Abstract	Objective: Preanalytical processing of blood samples can affect plasma glucose measurement because ongoing glycolysis by cells prior to centrifugation can lower its concentration. In June 2017, ACT Pathology changed the processing of oral glucose tolerance test (OGTT) blood samples for pregnant women from a delayed to an early centrifugation protocol. The effect of this change on the rate of gestational diabetes mellitus (GDM) diagnosis was determined. Research design and methods: All pregnant women in the Australian Capital Territory (ACT) are recommended for GDM testing with a 75-g OGTT using the World Health Organization diagnostic criteria. From January 2015 to May 2017, OGTT samples were collected into sodium fluoride (NaF) tubes and kept at room temperature until completion of the test (delayed centrifugation). From June 2017 to October 2018, OGTT samples in NaF tubes were centrifuged within 10 min (early centrifugation). Results: A total of 7,509 women were tested with the delayed centrifugation protocol and 4,808 with the early centrifugation protocol. The mean glucose concentrations for the fasting, 1-h, and 2-h OGTT samples were, respectively, 0.24 mmol/L (5.4%), 0.34 mmol/L (4.9%), and 0.16 mmol/L (2.3%) higher using the early centrifugation protocol ( Conclusions: The findings of this study highlight the critical importance of the preanalytical processing protocol of OGTT blood samples used for diagnosing GDM. Delay in centrifuging of blood collected into NaF tubes will result in substantially lower rates of diagnosis than if blood is centrifuged early.
MeSH term(s)	Adult ; Australia ; Blood Glucose/analysis ; Blood Specimen Collection/methods ; Blood Specimen Collection/standards ; Centrifugation/standards ; Clinical Laboratory Techniques/methods ; Clinical Laboratory Techniques/standards ; Diabetes, Gestational/blood ; Diabetes, Gestational/diagnosis ; Endocrinology/methods ; Endocrinology/standards ; False Positive Reactions ; Fasting/blood ; Female ; Glucose Tolerance Test/methods ; Glucose Tolerance Test/standards ; Guideline Adherence/standards ; Humans ; Pre-Analytical Phase/methods ; Pre-Analytical Phase/standards ; Pregnancy ; Reproducibility of Results ; Specimen Handling/methods ; Specimen Handling/standards ; Time Factors ; Young Adult
Chemical Substances	Blood Glucose
Language	English
Publishing date	2020-04-29
Publishing country	United States
Document type	Evaluation Study ; Journal Article
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc20-0304
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Zs.A 1434: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 365: Show issues

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Article: Understory Vegetation Responses to 15 Years of Repeated Fuel Reduction Treatments in the Southern Appalachian Mountains, USA

Oakman, Emily C / Barrett, Kyle / Hagan, Donald L / Waldrop, Thomas A

Forests. 2019 Apr. 20, v. 10, no. 4

2019

Abstract: ... treatment 2x + burned 4x (MB), and control (C) on the changes in understory vegetation guilds ...

Abstract	Decades of fire exclusion in the Southern Appalachian Mountains led to fuel accumulation and conversion from open oak-pine woodlands to closed-canopy mesic forests dominated by shade-tolerant hardwoods and shrubs that often do not support a diverse understory. Southern Appalachian forest managers and scientists recognize this and are implementing silvicultural treatments such as prescribed burning, mechanical treatments or a combination of these to restore forest structure. In this study, conducted at the Southern Appalachian Fire and Fire Surrogate Study site in Green River Game Land, North Carolina, we assessed the effects of four fuel reduction methods: burned 4x (B), mechanical treatment 2x (M), mechanical treatment 2x + burned 4x (MB), and control (C) on the changes in understory vegetation guilds from pretreatment to post-treatment years (2001–2016). The MB treatment was most effective at meeting the restoration objectives, as it resulted in increases in oak (Δ<inf>MB</inf> = 23,400 stems/ha) and pine (Δ<inf>MB</inf> = 900 stems/ha) stem density, importance value—calculated as the sum of relative cover and frequency—for graminoids (Δ<inf>MB</inf> = 26.0), and density of oak stems >50 cm in height (Δ<inf>MB</inf> = 7133 stems/ha). The B and M treatments were generally less effective, but nonetheless met a subset of the restoration objectives. The B treatment reduced ericaceous shrub cover (Δ<inf>B</inf> = −1.2%) and increased oak stems 10–50 cm in height (Δ<inf>B</inf> = 10,017 stems/ha), while the M treatment resulted in only modest increases of mesic hardwoods, specifically for yellow-poplar (Δ<inf>M</inf> = 200 stems/ha) and blackgum (Δ<inf>M</inf> = 200 stems/ha) as compared with other treatments, but significantly increased mountain laurel and rhododendron cover (Δ<inf>M</inf> = 10.0%). Overall, these fire and fire surrogate treatments had some success in restoring understory structure, but our findings suggest a slow response in understory herbaceous vegetation.
Keywords	forests ; fuels ; graminoids ; hardwood ; Kalmia latifolia ; Liriodendron tulipifera ; mechanical methods ; prescribed burning ; Rhododendron ; shade tolerance ; shrubs ; stems ; understory ; woodlands ; Appalachian region ; Green River ; North Carolina
Language	English
Dates of publication	2019-0420
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527081-3
ISSN	1999-4907
ISSN	1999-4907
DOI	10.3390/f10040350
Database	NAL-Catalogue (AGRICOLA)

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