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  1. Article: HNAS-Reg: Hierarchical Neural Architecture Search for Deformable Medical Image Registration.

    Wu, Jiong / Fan, Yong

    Proceedings. IEEE International Symposium on Biomedical Imaging

    2023  Volume 2023

    Abstract: Convolutional neural networks (CNNs) have been widely used to build deep learning models for medical image registration, but manually designed network architectures are not necessarily optimal. This paper presents a hierarchical NAS framework (HNAS-Reg), ...

    Abstract Convolutional neural networks (CNNs) have been widely used to build deep learning models for medical image registration, but manually designed network architectures are not necessarily optimal. This paper presents a hierarchical NAS framework (HNAS-Reg), consisting of both convolutional operation search and network topology search, to identify the optimal network architecture for deformable medical image registration. To mitigate the computational overhead and memory constraints, a partial channel strategy is utilized without losing optimization quality. Experiments on three datasets, consisting of 636 T1-weighted magnetic resonance images (MRIs), have demonstrated that the proposal method can build a deep learning model with improved image registration accuracy and reduced model size, compared with state-of-the-art image registration approaches, including one representative traditional approach and two unsupervised learning-based approaches.
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article
    ISSN 1945-7928
    ISSN 1945-7928
    DOI 10.1109/isbi53787.2023.10230534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Exploring the direction-dependency of conductive filament formation and oxygen vacancy migration behaviors in HfO

    Zhang, Donglan / Wang, Jiong / Wu, Qing / Du, Yong

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 4, Page(s) 3521–3534

    Abstract: Oxygen vacancy ( ... ...

    Abstract Oxygen vacancy (V
    Language English
    Publishing date 2023-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d2cp05803k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effect of rehabilitation nursing based on target management theory on swallowing function and Quality of Life in patients with stroke dysphagia.

    Yu, Chenya / Wu, Jiong / Yu, Susu

    Journal of neurosurgical sciences

    2023  Volume 68, Issue 1, Page(s) 140–142

    MeSH term(s) Humans ; Deglutition Disorders/etiology ; Deglutition ; Quality of Life ; Rehabilitation Nursing ; Stroke ; Treatment Outcome ; Stroke Rehabilitation
    Language English
    Publishing date 2023-09-05
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 193139-8
    ISSN 1827-1855 ; 0390-5616 ; 0026-4881
    ISSN (online) 1827-1855
    ISSN 0390-5616 ; 0026-4881
    DOI 10.23736/S0390-5616.23.06087-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Specific types of femoral head fractures: be alert for pre-, intra-, and post-operative ipsilateral femoral neck fractures following fracture-dislocation of the femoral head.

    Wu, Shenghui / Mei, Jiong

    Journal of experimental orthopaedics

    2023  Volume 10, Issue 1, Page(s) 104

    Abstract: Purpose: Ipsilateral femoral head and neck fractures (iFHNFs) are rare types of fractures that confer extremely poor prognosis among femoral head fractures (FHFs). Owing to the rarity of FHFs, it is challenging to diagnose iFHNFs. In addition, the ... ...

    Abstract Purpose: Ipsilateral femoral head and neck fractures (iFHNFs) are rare types of fractures that confer extremely poor prognosis among femoral head fractures (FHFs). Owing to the rarity of FHFs, it is challenging to diagnose iFHNFs. In addition, the clinical features of iFHNF have not yet been comprehensively elucidated. Therefore, this retrospective study aimed to summarize and analyze the clinical characteristics of iFHNF using a clinical diagnostic simulation based on a prospectively maintained database.
    Methods: Clinical data of consecutive patients with FHFs, including gender, age, injury side, and associated injuries, were collected and analyzed from a prospectively maintained orthopedic database at a large level-I trauma center for a clinical diagnostic simulation. Patients were stratified according to the presence or absence of iFHNF. Moreover, propensity score matching (PSM) was used to create 1:1 age- and gender-matched couples. Lastly, clinical factors were compared and identified between the two groups before and after matching.
    Results: A total of 218 FHF patients were included. Fifteen patients were diagnosed with ipsilateral femoral neck fractures (iFNFs), including preoperative, intraoperative, and postoperative types. There were 177 male and 41 female patients, with a mean age of 40.0 ± 16.5 years. The incidence of two factors, namely acetabular fracture and posterior hip dislocation, were significantly different between the two groups (P < 0.05). Following PSM, 15 pairs of patients were generated. Comparisons revealed that the incidence of posterior hip dislocation was significantly different between the two groups (P < 0.05).
    Conclusions: There were three types of iFHNFs. In the context of FHFs, posterior hip dislocation was associated with iFNFs. Thus, surgeons should remain vigilant, not only intraoperatively but also postoperatively, for iFNFs following FHF and concomitant posterior hip dislocation.
    Level of evidence: Diagnostic level IV.
    Language English
    Publishing date 2023-10-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2780021-0
    ISSN 2197-1153
    ISSN 2197-1153
    DOI 10.1186/s40634-023-00666-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The influence of successor's implicit power and explicit power on dual innovation---The mediating effect of board dissent.

    Feifei, Wang / Jiong, Wu / Russo, Marcello / Gao, Luyang

    PloS one

    2022  Volume 17, Issue 11, Page(s) e0275603

    Abstract: This study explores the influence of the power of family business successors on firm innovation under the theory of social embeddedness. Based on the 2000-2019 unbalanced panel data of listed Chinese family enterprises, this study empirically examines ... ...

    Abstract This study explores the influence of the power of family business successors on firm innovation under the theory of social embeddedness. Based on the 2000-2019 unbalanced panel data of listed Chinese family enterprises, this study empirically examines the differences in the influence of the implicit and explicit power of successors on incremental and radical innovation respectively. Our findings show that explicit power has a more positive impact on incremental innovation, while implicit power is more conducive to promoting radical innovation. In addition, the study finds that the reason why the explicit power of succession does not have a significant impact on radical innovation, that is, the reason why board dissent is not related to radical innovation, is that some of the major innovation decisions in the enterprise are not all made at formal meetings. The research conclusions not only extend the theoretical application of social embeddedness in family enterprises, but also provide certain practical guidance for promoting enterprise innovation.
    MeSH term(s) Dissent and Disputes ; Commerce ; China
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0275603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: SARS-CoV-2 Omicron variant: viral spread dynamics, disease burden, and vaccine effectiveness.

    Sun, Shengzhi / Wu, Jiong / Chen, Rui / Levitt, Michael

    Current medicine (Cham, Switzerland)

    2022  Volume 1, Issue 1, Page(s) 14

    Language English
    Publishing date 2022-08-30
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2731-0868
    ISSN (online) 2731-0868
    DOI 10.1007/s44194-022-00014-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Causal relationship between atrial fibrillation/warfarin and cutaneous melanoma: a two-sample Mendelian randomization study.

    Xiaowu, Wang / Qiang, Zhou / Yike, Han / Wu, Zhixuan / Yiheng, Jin / Xuemei, Chen / Sen, Lin / Jiong, Chen

    Frontiers in medicine

    2024  Volume 11, Page(s) 1336849

    Abstract: Purpose: In recent years, the relationship between malignant tumors and atrial fibrillation has attracted more and more attention. Atrial fibrillation can also cause a series of adverse events, such as the risk of thromboembolism. Also, Warfarin is ... ...

    Abstract Purpose: In recent years, the relationship between malignant tumors and atrial fibrillation has attracted more and more attention. Atrial fibrillation can also cause a series of adverse events, such as the risk of thromboembolism. Also, Warfarin is often used here. But, the relationship between cutaneous melanoma and atrial fibrillation, and between cutaneous melanoma and warfarin is still unclear. Therefore, we used a two-sample Mendelian randomization to assess the causal relationship between atrial fibrillation/warfarin and cutaneous melanoma (cM).
    Methods: Firstly, atrial fibrillation (ukb-b-11550;
    Results: A causal relationship between atrial fibrillation and cutaneous melanoma was observed, and between warfarin and cutaneous melanoma.
    Conclusion: The atrial fibrillation may play a causal role in the development of cutaneous melanoma, but the mechanism and the causal relationship between warfarin and cutaneous melanoma needs to be further elucidated.
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2024.1336849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis.

    Qian, Yufan / Chu, Genglei / Zhang, Lei / Wu, Zhikai / Wang, Qiuyuan / Guo, Jiong Jiong / Zhou, Feng

    Journal of nanobiotechnology

    2024  Volume 22, Issue 1, Page(s) 72

    Abstract: Osteoarthritis (OA) is one of the most prevalent chronic musculoskeletal diseases among the elderly population. In this study, macrophage-derived exosomes were isolated and identified. Exosomes were subjected to microRNA (miRNA) sequencing and ... ...

    Abstract Osteoarthritis (OA) is one of the most prevalent chronic musculoskeletal diseases among the elderly population. In this study, macrophage-derived exosomes were isolated and identified. Exosomes were subjected to microRNA (miRNA) sequencing and bioinformatic analysis, and differentially expressed miRNAs were verified. miR-26b-5p target genes were confirmed through target-site mutation combined with a dual-luciferase reporter assay. The effects of miR-26b-5p on macrophage polarization and chondrocyte hypertrophy were assessed in vitro. miR-26b-5p agomir was applied to mice with OA induced by anterior cruciate ligament transection (ACLT). The therapeutic effects of miR-26b-5p were evaluated via pain behavior experiments and histological observations. In vitro, miR-26b-5p repolarized M1 macrophages to an anti-inflammatory M2 type by targeting the TLR3 signaling pathway. miR-26b-5p could target COL10A1, further inhibiting chondrocyte hypertrophy induced by M1 macrophage-conditioned medium (M1-CM). In vivo, miR-26b-5p agomir ameliorated gait abnormalities and mechanical allodynia in OA mice. miR-26b-5p treatment attenuated synovitis and cartilage degeneration, thereby delaying OA progression. In conclusion, M2 macrophage-derived exosomal miR-26b-5p could protect articular cartilage and ameliorate gait abnormalities in OA mice by targeting TLR3 and COL10A1. miR-26b-5p further affected macrophage polarization and chondrocyte hypertrophy. Thus, this exosomal miR-26b-5p-based strategy might be a potential method for OA treatment.
    MeSH term(s) Aged ; Animals ; Humans ; Mice ; Chondrocytes/metabolism ; Hypertrophy/metabolism ; Hypertrophy/pathology ; Macrophages/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Osteoarthritis/metabolism ; Toll-Like Receptor 3/metabolism ; Collagen Type X/genetics ; Collagen Type X/metabolism ; Exosomes/genetics
    Chemical Substances MicroRNAs ; TLR3 protein, human ; TLR3 protein, mouse ; Toll-Like Receptor 3 ; Col10a1 protein, mouse ; Collagen Type X
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2100022-0
    ISSN 1477-3155 ; 1477-3155
    ISSN (online) 1477-3155
    ISSN 1477-3155
    DOI 10.1186/s12951-024-02336-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Insight into the Antibiotic Resistance of Bacteria Isolated from Popular Aquatic Products Collected in Zhejiang, China.

    Wu, Jiajia / Ye, Fan / Qu, Jiong / Dai, Zhiyuan

    Polish journal of microbiology

    2023  Volume 72, Issue 1, Page(s) 61–67

    Abstract: The present study was aimed to obtain a close insight into the distribution and diversity of antibiotic-resistant bacteria (ARB) and antibiotic-resistance genes (ARGs) among the aquatic products collected in Zhejiang, China. A total of 136 presumptive ... ...

    Abstract The present study was aimed to obtain a close insight into the distribution and diversity of antibiotic-resistant bacteria (ARB) and antibiotic-resistance genes (ARGs) among the aquatic products collected in Zhejiang, China. A total of 136 presumptive ARB picked up from six aquatic samples were classified into 22 genera and 49 species based on the 16S rDNA sequencing.
    MeSH term(s) Humans ; Genes, Bacterial ; Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Drug Resistance, Microbial/genetics ; Aeromonas/genetics ; Anti-Bacterial Agents/pharmacology
    Chemical Substances Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-24
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2234080-4
    ISSN 2544-4646 ; 1733-1331
    ISSN (online) 2544-4646
    ISSN 1733-1331
    DOI 10.33073/pjm-2023-010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Antioxidant PDA-PEG nanoparticles alleviate early osteoarthritis by inhibiting osteoclastogenesis and angiogenesis in subchondral bone.

    Wu, Zhikai / Yuan, Kai / Zhang, Qian / Guo, Jiong Jiong / Yang, Huilin / Zhou, Feng

    Journal of nanobiotechnology

    2022  Volume 20, Issue 1, Page(s) 479

    Abstract: Accumulating evidence suggests that osteoclastogenesis and angiogenesis in subchondral bone are critical destructive factors in the initiation and progression of osteoarthritis (OA). Herein, methoxypolyethylene glycol amine (mPEG- ... ...

    Abstract Accumulating evidence suggests that osteoclastogenesis and angiogenesis in subchondral bone are critical destructive factors in the initiation and progression of osteoarthritis (OA). Herein, methoxypolyethylene glycol amine (mPEG-NH
    MeSH term(s) Mice ; Animals ; Osteogenesis ; Antioxidants ; Osteoarthritis/drug therapy ; Bone and Bones ; Nanoparticles/therapeutic use
    Chemical Substances Antioxidants
    Language English
    Publishing date 2022-11-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2100022-0
    ISSN 1477-3155 ; 1477-3155
    ISSN (online) 1477-3155
    ISSN 1477-3155
    DOI 10.1186/s12951-022-01697-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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