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Article: Diagnostic Value of Color Doppler Ultrasound Combined with Superb Microvascular Imaging in the Detection of Small Renal Tumors Less than 3 cm Treated with Jinkui Shenqi Pills.

Gong, Yuping / Li, Shuhui

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 5327331

Abstract	The purpose of this study was to investigate the diagnostic value of color Doppler ultrasound combined with superb microvascular imaging (SMI) in the detection of small renal tumors less than 3 cm treated with Jinkui Shenqi pills. 50 cases were randomly selected from the patients with angioleiomyoma (a kind of small renal tumor) less than 3 cm confirmed by pathological examination and treated in our hospital from January 2018 to January 2020. All patients were treated with Jinkui Shenqi pills. All patients were first detected by color Doppler ultrasound and then by SMI. The results of color Doppler ultrasound were used as the control group, while those of color Doppler ultrasound combined with SMI were used as the experimental group. After that, the specificity, sensitivity, positive and negative detection results, and detection accuracy were compared between the two groups. The specificity and sensitivity in the experimental group were significantly higher than those in the control group, with statistical significance (
Language	English
Publishing date	2021-09-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/5327331
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Article: [Regulatory effect of Jinkui Shenqi Pills on the gene expression of the Nrf2 signaling pathway in cyclophosphamide-induced testis injury in mice].

Jiang, Ping / Xu, Qing-Hong / Chen, Cun-Wu / Xia, Lun-Bin / Huang, Ren-Shu / She, Dei-Yong / Liu, Gang / Yan, Hang / Zhong, Zhi-Mei / Bao, Li-Li / Zuo, Rui-Hua

Zhonghua nan ke xue = National journal of andrology

2020 Volume 26, Issue 2, Page(s) 160–166

Abstract: Objective: To investigate the protective effect of Jinkui Shenqi Pills (JSP) against ... Conclusions: Jinkui Shenqi Pills can effectively inhibit cyclophosphamide-induced testis injury, which may be ...

Abstract	Objective: To investigate the protective effect of Jinkui Shenqi Pills (JSP) against cyclophosphamide-induced testis injury (TI) and its anti-oxidation mechanism in mice. Methods: Thirty male mice were equally divided into a blank control, a TI model control and a JSP treatment group. The mice in the JSP treatment group were treated intragastrically with JSP and the blank controls with normal saline at 1.2 g/kg qd for 7 days, and then the animals in both the TI model control and JSP treatment groups were injected intraperitoneally with cyclophosphamide at 50 mg/kg, once a week, for 35 days, to induce testis injury. After modeling, all the mice were weighed and sacrificed, followed by detection of the serum T content, measurement of the testis weight, examination of semen parameters in the caudad epididymis, and determination of the levels of super oxide dismutase (SOD) and malondialdehyde (MDA) in the testis tissue and the expressions of relevant genes by qRT-PCR. Results: The mice of the TI model control group, compared with the blank controls, showed significant decreases in the body weight (［34.63 ± 1.92］ vs ［48.32 ± 1.64］ g, P<0.05), testis weight (［80.00 ± 3.90］ vs ［140.00 ± 6.10］ mg, P<0.05), testicular organ coefficient (［0.22 ± 0.01］ vs ［0.31 ±0.03］%, P<0.05), sperm motility (［48.66 ± 8.08］% vs ［89.33 ± 4.04］%, P<0.05), sperm concentration (［28.42 ± 5.26］ vs ［77.67 ± 8.73］ ×10⁶/ml, P<0.05), and levels of serum T (［8.75 ± 0.96］ vs ［21.75 ± 1.71］ pg/ml, P<0.05) and SOD (［140.82 ± 10.08］ vs ［358.52 ± 40.41］ U/mg prot, P<0.05), but remarkable increases in the sperm deformity rate (［37.33 ± 2.08］ vs ［15.33±1.53］%, P<0.05) and MDA level (［54.89±6.09］ vs ［30.21±2.17］ nmol/ng prot, P<0.05). The mice of the JSP treatment group, in comparison with the TI model controls, exhibited markedly increased body weight (［39.80±2.89］ vs ［34.63±1.92］g, P<0.05), testis weight (［130.00 ± 11.00］ vs ［80.00 ± 3.90］ mg, P<0.05), testicular organ coefficient (［0.28 ± 0.01］ vs ［0.22 ± 0.01］%, P<0.05), sperm motility (［76.00 ± 5.29］% vs ［48.66 ± 8.08］%, P<0.05), sperm concentration (［56.08 ± 4.29］ vs ［28.42 ± 5.26］ ×10⁶/ml, P<0.05), and levels of serum T (［15.50 ± 1.29］ vs ［8.75 ± 0.96］ pg/ml, P<0.05) and SOD (［206.59 ± 16.38］ vs ［140.82 ± 10.08］ U/mg prot, P<0.05), but decreased sperm deformity rate (［25.01 ± 2.99］% vs ［37.33 ± 2.08］%, P<0.05) and MDA level (［35.84 ± 3.61］ vs ［54.89 ± 6.09］ nmol/ng prot, P<0.05). The mRNA expressions of NOQ-1, Nrf2 and HO-1 in the testis tissue were significantly lower and that of Caspase-3 remarkably higher in the TI model control than in the blank control group (P<0.05), while those of Nrf2 and HO-1 significantly higher and that of Caspase-3 markedly lower in the JSP treatment group than in the TI model controls (P<0.05). Histopathological images displayed reduced layers of spermatogenic cells in the seminiferous tubules, complete exfoliation of the spermatogenic cells in some of the tubules and decreased number of sperm cells in the TI model controls, which were all found normal in the JSP treatment group. Conclusions: Jinkui Shenqi Pills can effectively inhibit cyclophosphamide-induced testis injury, which may be related to its effect of regulating the gene expression of the Nrf2 signaling pathway and enhancing the activity of antioxidant enzymes.
MeSH term(s)	Animals ; Cyclophosphamide ; Drugs, Chinese Herbal/pharmacology ; Gene Expression ; Male ; Mice ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Signal Transduction ; Sperm Count ; Sperm Motility ; Spermatozoa ; Testis/drug effects ; Testis/metabolism
Chemical Substances	Drugs, Chinese Herbal ; NF-E2-Related Factor 2 ; Nfe2l2 protein, mouse ; Cyclophosphamide (8N3DW7272P)
Language	Chinese
Publishing date	2020-12-14
Publishing country	China
Document type	Journal Article
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Diagnostic Value of Color Doppler Ultrasound Combined with Superb Microvascular Imaging in the Detection of Small Renal Tumors Less than 3 cm Treated with Jinkui Shenqi Pills

Yuping Gong / Shuhui Li

Evidence-Based Complementary and Alternative Medicine, Vol

2021 Volume 2021

Abstract: ... treated with Jinkui Shenqi pills. 50 cases were randomly selected from the patients with angioleiomyoma ... in our hospital from January 2018 to January 2020. All patients were treated with Jinkui Shenqi pills ... than 3 cm treated with Jinkui Shenqi pills were all significantly higher than those of color Doppler ...

Abstract	The purpose of this study was to investigate the diagnostic value of color Doppler ultrasound combined with superb microvascular imaging (SMI) in the detection of small renal tumors less than 3 cm treated with Jinkui Shenqi pills. 50 cases were randomly selected from the patients with angioleiomyoma (a kind of small renal tumor) less than 3 cm confirmed by pathological examination and treated in our hospital from January 2018 to January 2020. All patients were treated with Jinkui Shenqi pills. All patients were first detected by color Doppler ultrasound and then by SMI. The results of color Doppler ultrasound were used as the control group, while those of color Doppler ultrasound combined with SMI were used as the experimental group. After that, the specificity, sensitivity, positive and negative detection results, and detection accuracy were compared between the two groups. The specificity and sensitivity in the experimental group were significantly higher than those in the control group, with statistical significance (P<0.05). The cases of positive and negative detection results in the experimental group were significantly higher than those in the control group, with statistical significance (P<0.05). The detection accuracy in the experimental group was significantly higher than that in the control group, with statistical significance (P<0.05). The specificity, sensitivity, positive and negative detection results, and detection accuracy of color Doppler ultrasound combined with SMI in the detection of small renal tumors less than 3 cm treated with Jinkui Shenqi pills were all significantly higher than those of color Doppler ultrasound; therefore, the application of color Doppler ultrasound combined with SMI for the diagnosis of small renal tumors is of high value.
Keywords	Other systems of medicine ; RZ201-999
Subject code	630
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Jinkui Shenqi Pills Ameliorate Asthma with "Kidney Yang Deficiency" by Enhancing the Function of the Hypothalamic-Pituitary-Adrenal Axis to Regulate T Helper 1/2 Imbalance.

Ji, Bing / Li, Yuan-Yuan / Yang, Wei-Ji / Zhang, Li-Zong / Fang, Ming-Sun / Fu, Hui-Ying / Shou, Qi-Yang

Evidence-based complementary and alternative medicine : eCAM

2018 Volume 2018, Page(s) 7253240

Abstract: The aim of the study was to investigate the effects and underlying mechanism of JKSQP in a rat model of asthma with kidney-yang deficiency (KYD). ...

Abstract	The aim of the study was to investigate the effects and underlying mechanism of JKSQP in a rat model of asthma with kidney-yang deficiency (KYD).
Language	English
Publishing date	2018-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2018/7253240
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Jinkui Shenqi Pills Ameliorate Asthma with “Kidney Yang Deficiency” by Enhancing the Function of the Hypothalamic-Pituitary-Adrenal Axis to Regulate T Helper 1/2 Imbalance

Bing Ji / Yuan-yuan Li / Wei-ji Yang / Li-zong Zhang / Ming-sun Fang / Hui-ying Fu / Qi-yang Shou

Evidence-Based Complementary and Alternative Medicine, Vol

2018 Volume 2018

Abstract: The aim of the study was to investigate the effects and underlying mechanism of JKSQP in a rat model of asthma with kidney-yang deficiency (KYD). Materials and Methods. Hydrocortisone (HYD) was used to establish the rat model of KYD; rats were then ... ...

Abstract	The aim of the study was to investigate the effects and underlying mechanism of JKSQP in a rat model of asthma with kidney-yang deficiency (KYD). Materials and Methods. Hydrocortisone (HYD) was used to establish the rat model of KYD; rats were then sensitized and challenged with ovalbumin (OVA). JKSQP was administered to OVA-challenged rats, and the changes in signs and symptoms of KYD were observed. The leukocyte number and subpopulations in bronchoalveolar lavage fluid (BALF) were counted and the cells were stained with Wright–Giemsa dye. Serum adrenocorticotropic hormone (ACTH), corticosterone (CORT), corticotropin-releasing hormone (CRH), total immunoglobulin E (IgE), and OVA-specific IgE levels were determined using relevant enzyme-linked immunosorbent assays (ELISA) kits. Results. JKSQP not only reversed the phenomenon of KYD but also significantly inhibited the number of leukocyte and eosinophils in the BALF, increasing the level of interferon (IFN)-γ and decreasing the levels of interleukin-4 (IL-4) and IgE in the serum compared with the OVA-challenged groups. Conclusions. Taken together, the antiasthma effects of JKSQP were likely mediated by the enhancement of the function of the hypothalamic-pituitary-adrenal axis and the reversal of T helper 1/2 imbalance.
Keywords	Other systems of medicine ; RZ201-999
Subject code	630
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Investigation of JinKui ShenQi pills by ultraviolet spectra and tandem mass spectrometry].

Li, Wen-lan / Sun, Zhi / Cheng, Bin / Ji, Yu-bin / Bai, Jing

Guang pu xue yu guang pu fen xi = Guang pu

2008 Volume 28, Issue 8, Page(s) 1914–1918

Abstract: On the base of establishing the fingerprint of JinKui ShenQi pills, the ultraviolet spectra ... among in JinKui ShenQi pills from different origins were separated well by HPLC. Although there was difference ... that the presented fingerprint of JinKui ShenQi pills contained plenty of information quite valuable for the quality ...

Abstract	On the base of establishing the fingerprint of JinKui ShenQi pills, the ultraviolet spectra-mass spectrometry/mass spectrometry, method was used to identify the fingerprint. Seperation was performed on the Symmetry Shield RP18 (5 microm, 4. 6 mm X 15 mm) analytical column with mobile phase consisting of 1% acetic acid and acetonitrile with gradient elute at the flow rate of 1.0 mL x min(-1), and the ultraviolet detection wavelength was set at 248 nm. Using the above-mentioned chromatographic condition, the fingerprint of different samples was established and the same fingerprint was defined. The fingerprints of different samples were compared with similarity evaluation software published by Pharmacopeia committee codex (2004A). The mass spectrograph with API-ESI ionization source was used, setting the flow rate at 0.5 mL x min(-1) after splitting stream. The pressure of atomization room was 50 Psi, the flow rate of dry gas was 9.0 L x min(-1), the capillary voltage was 4 kV, and the transmission voltage was 70 V. The negative scanner mode was chosen, scan scope was 100-2000, using ion trap to analyze quasimolecular ion peak and the selected fragment ion, and TIC chromatography and second order mass chromatogram were recorded. The major constituents among in JinKui ShenQi pills from different origins were separated well by HPLC. Although there was difference among different origins, they showed nineteen identical characteristic absorption bands. Three fingerprints chemical compositions such as loganin, cinnamal and paeonol were identified based on the retention time and ultraviolet spectra of standard preparation. According to their ultraviolet spectra, molecular weight and fragmentation information, ten peaks in the fingerprint were identified by ultraviolet spectroscopy-mass, spectrometry/massg spectrometry. They are 1,2,3-tri-O-galloyl-glucose, loganin, paeoniflorin, 1,2,3,6-tetro-O-galloyl-glucose, soya-cerebroside, cornuside, and PGG, benzoyl-oxypaeoniflorin. The result showed that the presented fingerprint of JinKui ShenQi pills contained plenty of information quite valuable for the quality evaluation as well as chemical characterization of JinKui ShenQi pills.
MeSH term(s)	Acetophenones/analysis ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal/chemistry ; Iridoids/analysis ; Principal Component Analysis/methods ; Spectrophotometry, Ultraviolet ; Tandem Mass Spectrometry
Chemical Substances	Acetophenones ; Drugs, Chinese Herbal ; Iridoids ; paeonol (3R834EPI82) ; loganin (H7WJ16Q93C)
Language	Chinese
Publishing date	2008-08
Publishing country	China
Document type	Journal Article
ISSN	1000-0593
ISSN	1000-0593
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Gene chip study on cerebral gene of effect of Jinkui Shenqiwan and Youguiwan on mouse model of kidney-yang asthenia with syndrome disproved according to therapeutic efficacy of drugs used].

Yang, Yuhua / Li, Zhen / Sun, Jing

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2009 Volume 34, Issue 9, Page(s) 1124–1128

Abstract: Objective: To inquire into the cerebral gene change of effect of Jingui Shenqiwan and Youguiwan for animal model of kidney-yang asthenia caused by excessive physical and sexual activities, which may study the effect mechanism of the medicine with ... ...

Abstract	Objective: To inquire into the cerebral gene change of effect of Jingui Shenqiwan and Youguiwan for animal model of kidney-yang asthenia caused by excessive physical and sexual activities, which may study the effect mechanism of the medicine with syndrome disproved therapeutic efficacy of drugs used. Method: Male mice of Kunming species, weight 35-40 g, and female weight 28-35 g were randomly divided into four groups: control group, model group and treatment groups of Jigui Shenqiwan and Youguiwan in which there were ten male mice, fifteen ones, ten ones and ten ones, respectively. All of them were fed normally, and poured into their stomach with 0.5 mL of distill water for each mouse in the control group and model group, and with 0.5 mL suspension of the drugs (including 1.1 g x kg(-1) drug) for each one in the treatment groups every day. The mice in the model group and treatment groups were kept by means of each male mouse with six female mice in the same cage, and all male mice swam until they gradully submerged and were scooped up from water once everyday for lasting four weeks to induce the kidney-yang asthenia with excessive physical and sexual activities. Animals' manifestation such as fearing cold, activity and responses, mouse' fur and so on were observed. The brain gene were detected with the mouse brain gene chip of 36K Mouse genome array made by Capital Bio Corp. Beijing, China, and the differential expression gene were screened according to the ratio equal to or above 2 and equal to or below 0.5 with the related fluorescent intensity comparing the two groups, which could be further verified in the light of partly differential expression gene with qRT-PCR. Result: The mouse model of kidney-yang asthenia in the model group was successfully induced by way of excessive physical and sexual activities. There were twenty-three genes among up-regulated genes in the model group versus control group but down-regulated genes in the treatment groups versus model group, chiefly including the genes association with inflammation/immunization, neurotransmissions/ signal transduction and so on. There were six genes among the down-regulated genes in the model group versus control group but upregulated in the treatment groups versus model group, mainly involving the related genes of cellular cycle and structure, neurotransmissions/signal transduction, transcription and et al. Conclusion: Jigui Shenqiwan and Youguiwan may make it markedly up-regulated to notably down-regulated genes of hormone and melanin-concentrating hormone (MCH) for model of mouse of kidney-yang asthenia, and promote cellular proliferation, which can inquire into effect mechanism of the drug in genetic level at the same time.
MeSH term(s)	Animals ; Asthenia/drug therapy ; Asthenia/genetics ; Brain/metabolism ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Female ; Gene Expression Regulation/drug effects ; Kidney/drug effects ; Kidney/metabolism ; Male ; Mice ; Motor Activity ; Oligonucleotide Array Sequence Analysis ; Reverse Transcriptase Polymerase Chain Reaction ; Sexual Behavior, Animal ; Syndrome
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2009-05
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3056: Show issues

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Article ; Online: Recent Developments of Nontraditional Single-Molecule Toroics.

Li, Xiao-Lei / Ma, Zhifang / Tang, Jinkui

Chemistry (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e202304369

Abstract: Single-molecule toroics (SMTs), defined as a type of molecules with toroidal arrangement of magnetic moment associated with bi-stable non-magnetic ground states, are promising candidates for high-density information storage and the development of ... ...

Abstract	Single-molecule toroics (SMTs), defined as a type of molecules with toroidal arrangement of magnetic moment associated with bi-stable non-magnetic ground states, are promising candidates for high-density information storage and the development of molecule based multiferroic materials with linear magneto-electric coupling and multiferroic behavior. The design and synthesis of SMTs by arranging the magnetic anisotropy axis in a circular pattern at the molecular level have been of great interest to scientists for last two decades since the first detection of the SMT behavior in the seminal Dy
Language	English
Publishing date	2024-02-27
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202304369
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Article ; Online: Correction: Survival benefits and challenges of adjuvant chemotherapy for high-grade osteosarcoma: a population-based study.

Wang, Jinkui / Li, Mujie / Guo, Peng / He, Dawei

Journal of orthopaedic surgery and research

2023 Volume 18, Issue 1, Page(s) 834

Language	English
Publishing date	2023-11-06
Publishing country	England
Document type	Published Erratum
ZDB-ID	2252548-8
ISSN	1749-799X ; 1749-799X
ISSN (online)	1749-799X
ISSN	1749-799X
DOI	10.1186/s13018-023-04326-y
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Article ; Online: Development of a nomogram to predict the prognosis of patients with secondary bone tumors in the intensive care unit: a retrospective analysis based on the MIMIC IV database.

Li, Weikang / Li, Jinliang / Cai, Jinkui

Journal of cancer research and clinical oncology

2024 Volume 150, Issue 3, Page(s) 164

Abstract: Purpose: The present study aimed to develop a nomogram to predict the prognosis of patients with secondary bone tumors in the intensive care unit to facilitate risk stratification and treatment planning.: Methods: We used the MIMIC IV 2.0 (the ... ...

Abstract	Purpose: The present study aimed to develop a nomogram to predict the prognosis of patients with secondary bone tumors in the intensive care unit to facilitate risk stratification and treatment planning. Methods: We used the MIMIC IV 2.0 (the Medical Information Mart for Intensive Care IV) to retrieve patients with secondary bone tumors as a study cohort. To evaluate the predictive ability of each characteristic on patient mortality, stepwise Cox regression was used to screen variables, and the selected variables were included in the final Cox proportional hazard model. Finally, the performance of the model was tested using the decision curve, calibration curve, and receiver operating characteristic (ROC) curve. Results: A total of 1028 patients were enrolled after excluding cases with missing information. In the training cohort, albumin, APSIII (Acute Physiology Score III), chemotherapy, lactate, chloride, hepatic metastases, respiratory failure, SAPSII (Simplified Acute Physiology Score II), and total protein were identified as independent risk factors for patient death and then incorporated into the final model. The model showed good and robust prediction performance. Conclusion: We developed a nomogram prognostic model for patients with secondary bone tumors in the intensive care unit, which provides effective survival prediction information.
MeSH term(s)	Humans ; Nomograms ; Retrospective Studies ; Prognosis ; Bone Neoplasms ; Intensive Care Units ; Lactic Acid
Chemical Substances	Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2024-03-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-024-05667-9
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