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Article ; Online: The first case report of Pityriasis lichenoides chronica following COVID-19 mRNA vaccination.

Dawoud, Noha Mohammed / Aslam, Huma / Ali, Ishraga Mahmoud / Dawoud, Marwa Mohammed

2022 Volume 35, Issue 6, Page(s) e15445

MeSH term(s)	COVID-19/prevention & control ; Humans ; Pityriasis Lichenoides/diagnosis ; RNA, Messenger ; Vaccination
Chemical Substances	RNA, Messenger
Language	English
Publishing date	2022-03-21
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.15445
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Article ; Online: 320 cardiac MDCT angiography in preoperative assessment of TOF and its variants

Eman Abdel Sadek Taha Elreweny / Mohammed Mahmoud Dawoud / Alaa Basiouni Said Mahmoud / Mohamed A. Amin / Hossam Mohammed Abdel Hafiz Zaitoun

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 53, Iss 1, Pp 1-

Does it worth it?

2022 Volume 24

Abstract: Abstract Background Tetralogy of Fallot is the most common cyanotic congenital heart disease encountering a large spectrum of anatomical presentations with differing surgical approaches, and long-term outcomes ranging from ventricular septal defect with ... ...

Abstract	Abstract Background Tetralogy of Fallot is the most common cyanotic congenital heart disease encountering a large spectrum of anatomical presentations with differing surgical approaches, and long-term outcomes ranging from ventricular septal defect with limited aortic overriding and mild pulmonary obstruction to a critical form of VSD and pulmonary atresia. TOF variants include PA/VSD, TOF/CAVC, TOF/DORV and TOF with absent pulmonary valve. Also, it may be accompanied with many associated intracardiac and extracardiac anomalies that may be of value when imaging and planning the surgical procedure. Results Our study included 22 cases of classic TOF, 18 with PA/VSD (12 were of type A, 5 were of type B and 1 was of type C), 3 with TOF/CAVC and 7 TOF/DORV. Sub-valvular RVOTO was detected in 94% of patients. A statistically significant difference was depicted between Echocardiography and MDCT in detecting supravalvular RVOTO, however no statistically significant difference was found in sub-valvular and valvular RVOTO detection. MDCT could efficiently characterize pulmonary arterial tree with statistically significant difference between both Echocardiography and MDCT in assessment of main, right and left pulmonary arteries with P value = 0.036,0.014 and 0.023 respectively. With calculation of Mc-Goon ratio in all patients, it was favorable (> 1.2) in 33 patients (66%). MDCT entailed 19 patients with PDA versus 15 depicted by Echocardiography and 25 MAPCAs per 11patients compared 8 MAPCAs per 7 patients detected by Echocardiography. Right sided aortic arch was found in 10 patients and 24 patients showed abnormal branching pattern. Coronary artery abnormalities were identified in eight patients. MDCT showed 100% sensitivity and 100% specificity in depicting aortic, coronary and other associated extracardiac vascular anomalies. Conclusion MDCT offers comprehensive anatomical assessment of TOF, and its variants providing superiority over echocardiography and comparable results to cardiac catherization with 100% ...
Keywords	TOF ; Variants ; MDCT ; Associated anomalies ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
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Article ; Online: Diffusion‐weighted imaging and conventional magnetic resonance imaging for detection of non-palpable undescended testis

Nagwa Emad Ali Mohammed / Manal Ezzat Badwey / Salah Abdelmonsef Nagla / Rasha Mahmoud Dawoud

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 53, Iss 1, Pp 1-

2022 Volume 9

Abstract: Abstract Background MRI is noninvasive imaging tool and does not imply ionizing radiation and applies multiplanes images, but it is sometimes less efficient in locating intraabdominal functioning testicles and it fails to locate most of the atrophied ... ...

Abstract	Abstract Background MRI is noninvasive imaging tool and does not imply ionizing radiation and applies multiplanes images, but it is sometimes less efficient in locating intraabdominal functioning testicles and it fails to locate most of the atrophied testicles. Our aim in this study was to assess the value of the combined conventional MR imaging and DWI in the detection of non-palpable undescended testes in pediatric patients and correlate the results with the laparoscopic finding. Results This prospective study was carried out from January 2020 to February 2022 on 60 pediatric patients with 68 non-palpable undescended testes referred from Urology department to the radiodiagnosis and medical imaging department at our institute for MR imaging evaluation of clinically diagnosed non-palpable undescended testis, and their age ranged from 6 months to 17 years with mean age of 4.24 ± 4.67 years. The conventional MRI sensitivity was 85.71%, specificity was 100%, NPV was 60%, and PPV was 100% with accuracy of 88.23%. The combined DWI and MRI sensitivity was 92.86%, specificity was 100%, NPV was 75%, and PPV was 100% with accuracy of 94.12%. DWI was able to detect all viable abdominal testes, while only detecting 26 (out of 28) inguinal testes. Combined assessment was able to detect all viable abdominal and inguinal testes. Conclusions Combined DWI with a high b value and conventional MRI including T1WI, T2WI and fat-suppression T2WI showed considerable diagnostic performance compared to conventional MRI alone improving the preoperative sensitivity and accuracy of detection of non-palpable undescended testes.
Keywords	Undescended testes ; Ultrasonography ; Diffusion-weighted imaging ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
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Article ; Online: Cerebellum and brain stem volume loss in relapsing remission multiple sclerosis by MRI volumetry

Magdy Elzayady / Naglaa Lotfy Debees / Mohamed Khalil / Mohammed Mahmoud Dawoud

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 52, Iss 1, Pp 1-

relation to neurological disability score and number of relapses

2021 Volume 9

Abstract: Abstract Background MRI is the method of choice in the diagnosis of MS as well as in monitoring the disease activity. MRI volumetry is used to assess whole or regional brain volume loss which reflects neurodegenerative aspect of the disease and plays an ... ...

Abstract	Abstract Background MRI is the method of choice in the diagnosis of MS as well as in monitoring the disease activity. MRI volumetry is used to assess whole or regional brain volume loss which reflects neurodegenerative aspect of the disease and plays an important role in all stages of disease. The aim of this work is to study MRI volumetry in the evaluation of cerebellum and brain stem volume loss in RRMS patients and its correlation with neurological disability score and number of relapses. Results Volumes of whole brainstem, medulla, and pons showed a significant decrease in RRMS cases compared to controls (p < 0.05). Brainstem volume had a mean volume of 22.17 and 25.09 cm3 in cases and controls, respectively. However, midbrain volume showed no significant difference between cases and controls (p = 0.134). Volume of left cerebellar cortex showed a significant decrease in RRMS cases compared to controls (p < 0.001). It had mean volumes of 81.64 and 92.14 ml in cases and controls, respectively, at left cerebellar hemisphere, while right cerebellar hemisphere cortex volumes were 80.37 and 91.97 ml in cases and controls, respectively. Cerebellar white matter showed no significant volume decrease in cases and controls. Conclusion Volumetric MR imaging is an important tool for quantifying the MS disease, assesses MS activity, progression, and tissue loss. The degree and the pattern of atrophy on MRI images correlate significantly with the neurological disability score and number of relapses.
Keywords	MRI volumetry in RRMS ; Brain stem volume loss in MS ; Cerebellar volume loss in MS ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	616
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
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Article ; Online: Chest CT in COVID-19 pneumonia

Mohammed Mahmoud Dawoud / Tamer Mahmoud Dawoud / Noha Yousef Amin Ali / Hanan Ahmad Nagy

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 51, Iss 1, Pp 1-

a correlation of lung abnormalities with duration and severity of symptoms

2020 Volume 12

Abstract: Abstract Background After the spread of COVID-19 pneumonia, chest CT examination was used as a substantial non-invasive complement to RT-PCR for diagnosing and as a rapid screening tool when RT-PCR results are unavailable. Our study aimed at the analysis ...

Abstract	Abstract Background After the spread of COVID-19 pneumonia, chest CT examination was used as a substantial non-invasive complement to RT-PCR for diagnosing and as a rapid screening tool when RT-PCR results are unavailable. Our study aimed at the analysis of the lung abnormalities detected by chest CT in COVID-19 pneumonia according to the severity and duration of symptoms. Results In the early phase (n = 60), 32 patients had negative CT findings and 28 patients had positive findings with a mean total lung severity score of 2.13. In the intermediate phase (n = 116), 4 patients had negative CT findings and 112 patients had positive findings with a mean total lung severity score of 16.08. In the late phase (n = 36), all patients had positive findings with a mean total lung severity score of 17.83. CT lung abnormalities were progressed on follow-up CT studies. We found a high total lung severity score in many patients with mild symptoms with a mean of 14.77 and a low total lung severity score in many patients with moderate to severe symptoms with a mean of 9.14. Conclusion Chest CT should be used as a routine examination for diagnosing COVID-19 pneumonia and follow-up of disease advance. The progression of lung abnormalities was related to the duration more than the severity of symptoms.
Keywords	Coronavirus ; COVID-19 pneumonia ; Computed tomography ; Duration and severity ; Ground-glass opacity ; PCR ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Diagnostic accuracy of apparent diffusion coefficient ratio in distinguishing common pediatric CNS posterior fossa tumors

Marwa Mohamed Mahmoud Esa / Emad Mohammed Mashaly / Yasser Fouad El-Sawaf / Mohammed Mahmoud Dawoud

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 51, Iss 1, Pp 1-

2020 Volume 11

Abstract: Abstract Background Pilocytic astrocytoma, medulloblastoma, and ependymoma are the most common pediatric CNS tumors seen at posterior cranial fossa and final diagnosis obtained by histopathology after surgical excision. Routine MRI study gives an idea ... ...

Abstract	Abstract Background Pilocytic astrocytoma, medulloblastoma, and ependymoma are the most common pediatric CNS tumors seen at posterior cranial fossa and final diagnosis obtained by histopathology after surgical excision. Routine MRI study gives an idea about site and extension of the tumors but provide a little information about type and grade of tumors. ADC ratio had high sensitivity and specificity in differentiation between these tumors as regard type and grade according to tumor cellularity. Patients and methods Prospective study conducted on thirty pediatric patients (11 males and 19 females) with CNS posterior fossa masses, their ages ranged from 2 to 17 years (mean age of 8.7 years), conventional MRI, DWI, ADC value, and ADC ratio were done for all patients. Results ADC values were significantly different between pilocytic astrocytomas (1.43 ± 0.28 × 10−3) and medulloblastomas (0.71 ± 0. 21 × 10−3) with a P value < 0.001, also there was a significant difference when comparing medulloblastomas (0.71 ± 0.21 × 10−3) with ependymomas (1.04 × 10−3 ± 0.21) with a P value < 0.001. ADC ratio at a cutoff > 1.7 showed significant good power of discrimination of astrocytoma (AUC = 0.85) from ependymoma with 87.5% sensitivity and 93.3% specificity. Similarly, at cutoff ≤ 1.6-> 1.2 was a significant good predictor of ependymoma (AUC = 0.85) with 87.8% sensitivity and 99.5% specificity. While, ADC ratio ≤ 1.2 was significant excellent discriminator of medulloblastoma (AUC = 0.99) with 100% sensitivity and 90% specificity. Conclusion ADC ratio is a simple way used in distinguishing juvenile pilocytic astrocytoma, ependymoma, and medulloblastoma, which are the most frequent pediatric posterior fossa tumors. Cutoff ADC ratio of more than 1.7 characteristic of JPA with 87.5% sensitivity and 93.3% specificity, ADC ratio less than 1.1 characteristic of medulloblastoma with 100% sensitivity and 90% specificity. ADC ratios more than 1.1 and less than 1.7 characteristic of ependymoma with 87.8% sensitivity and 99.5% ...
Keywords	Apparent diffusion coefficient (ADC) ratio ; Ependymoma ; Medulloblastoma ; Pilocytic astrocytoma ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	310
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association of Normal and Mutated APOL1 G2 Rs60910145 alleles with SCD, Body Mass Index, and Renal Function Biomarkers and Indices.

Ismail, Abazar Mahmoud / Nour, Bakri Mohammed / Abakar, Adam Dawoud / Almugadam, Babiker Saad / Altayb, Hisham N / Ahmed, Rania TagEsir / Elkarsany, Mubarak Elsaeed Mustafa

Current research in translational medicine

2023 Volume 72, Issue 1, Page(s) 103414

Abstract: Purpose of the study: The current study aimed to detect the frequency of normal and mutated APOL1 alleles in sickle cell disease (SCD) patients and test their relation with Microalbuminuria, Creatinine, Urea, Glomerular Filtration Rate (GFR), and Body ... ...

Abstract	Purpose of the study: The current study aimed to detect the frequency of normal and mutated APOL1 alleles in sickle cell disease (SCD) patients and test their relation with Microalbuminuria, Creatinine, Urea, Glomerular Filtration Rate (GFR), and Body Mass Index (BMI). Patients and methods: The study included 156 SCD subjects. Serum Creatinine (mg/dl) and Urea (mg/dl) as well as Microalbuminuria (mg/l) level were measured by using Biosystems kit (Biosystems, Barcelona, Spain) and Mindary BA88A semi-automated biochemistry analyzer. Glomerular filtration rate and body mass index were calculated by equations. Blood DNA extraction was achieved by using the modified G-DEX™IIb Genomic DNA Extraction Kit protocol. The PCR was done for the detection of the APOL1 G2 rs60910145 alleles by using allele-specific PCR and primers. Results: The CC allele was more frequent in study cases (66.7%) than TT allele. The frequency of a mutated allele (CC) was insignificantly higher in males (67.8%) than in females (65.2%) and in rural (70.9%) than urban areas. It is also higher in Shankhab compared to other tribes and subjects 26-37 years compared to other, P˃0.05. Interstingly, the subjects who carry the CC allele showed a significantly higher level of Microalbuminuria, Creatinine, BMI, and Urea compared to those carry TT allele. Moreover, GFR is also higher in subjects who carry CC than TT allele but it is not significant. Conculsion: Altogether, the study findings highlighted the link of normal and mutated APOL1 G2 rs60910145 alleles with SCD and displayed the significant value of mutated APOL1 allele in the prediction of early nephropathy in SCD patients.
MeSH term(s)	Male ; Female ; Humans ; Alleles ; Body Mass Index ; Apolipoprotein L1/genetics ; Creatinine ; Anemia, Sickle Cell/complications ; Biomarkers ; Kidney ; Urea ; DNA
Chemical Substances	Apolipoprotein L1 ; Creatinine (AYI8EX34EU) ; Biomarkers ; Urea (8W8T17847W) ; DNA (9007-49-2) ; APOL1 protein, human
Language	English
Publishing date	2023-09-29
Publishing country	France
Document type	Journal Article
ISSN	2452-3186
ISSN (online)	2452-3186
DOI	10.1016/j.retram.2023.103414
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Article ; Online: Added value of strain elastosonography in prediction of malignancy in solitary thyroid nodule

Mohammed M. Dawoud / Rasha Mahmoud Dawoud

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 48, Iss 4, Pp 905-

2017 Volume 912

Abstract: Aim and objectives: To evaluate the diagnostic accuracy of elastosonographyin prediction of malignancy in solitary thyroid nodule. Methodology: 60 patients (37 females and 23 male) with solitary thyroid nodule were included, their age ranged from 21 to ... ...

Abstract	Aim and objectives: To evaluate the diagnostic accuracy of elastosonographyin prediction of malignancy in solitary thyroid nodule. Methodology: 60 patients (37 females and 23 male) with solitary thyroid nodule were included, their age ranged from 21 to 52 years (mean age 30.6 years), grey scale, color-power Doppler US and elastography were performed for all patient. Results: Presence of hypoechogenicity, absent halo sign, irregular margins, microcalcifications and predominant intranodular vascularity were the most US patterns predictive of malignancy. Suspicious nodule by elastography (Astria score 3 and 4) were found in 19 nodules (31.7%), 9 of them were benign and 10 of them were malignant with sensitivity 58.82%, specificity 79.07% and accuracy 73.33%, combined suspicious US findings (TIRAD 4&5) and suspicious elastography score (3&4) were most predictive of malignancy which was found in 16 out of 17 nodules with sensitivity 94.12%, specificity 76.74% and accuracy 81.67%. Conclusion: Combined gray scale, color Doppler US and elastography were more sensitive and accurate than US features alone in prediction of malignancy of solitary thyroid nodules with sensitivity 94.12%, specificity 76.74% and accuracy 81.67%.
Keywords	TI-RADS ; Strain elastosonography ; Solitary thyroid nodule ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2017-12-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
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Article ; Online: Diagnostic performance of 320 cardiac MDCT angiography in assessment of PDA either isolated or associated with duct dependent congenital heart disease

Samar Abdelatty Gad / Ekhlas Abdelmonem Shaban / Mohammed Mahmoud Dawoud / Mohamed Ahmed Youssef

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 52, Iss 1, Pp 1-

2021 Volume 16

Abstract: Abstract Background Patent ductus arteriosus (PDA) is one of most common congenital heart defects, it's a unique vascular structure that provides direct communication between pulmonary and systemic circulation. MDCT angiography is a good imaging modality ...

Abstract	Abstract Background Patent ductus arteriosus (PDA) is one of most common congenital heart defects, it's a unique vascular structure that provides direct communication between pulmonary and systemic circulation. MDCT angiography is a good imaging modality for evaluation of the PDAs and detection of their exact morphological type; course and diameters, which is important before percutaneous closure or stenting procedure of the PDA, also for selection of closure hardware. The aim of this study was to assess the role of MDCT angiography in qualitative and quantitative evaluation of PDA and associated cardiac and\or extracardiac anomalies. Results Echocardiography detected PDA in 28\30 cases while cardiac MDCT detected PDA in all studied 30 cases confirmed by cardiac catheterization and/or operation. MDCT angiography had sensitivity 100% and specificity 100% for PDA detection. PDA originated from aortic isthmus in 15 cases, inferior surface of aortic arch in 11 cases and innominate artery in 4 cases. The most common morphological type of PDA was type A (cone\46.67%) followed by type C (tubular\23.3%), type D (complex\10%), type E (elongated\13.33%) and type B (window\6.67%). The spearman correlation coefficient test demonstrated poor correlation between size of aortic end and MPA (P = 0.75), and between size of pulmonary end and diameter of MPA (P = 0.99) and also demonstrated fair correlation between length of PDA and MPA (P = 0.018). PDA was isolated in 4\30 cases and associated with cardiac and\or extra cardiac anomalies in 26\30 cases included; ASD (n = 18), VSD (n = 16), pulmonary atresia (n = 7), transposition of great arteries (n = 5), teratology of Fallot (n = 4), aortic coarctation (n = 4), persistent truncus arteriosus (n = 3), tricuspid atresia (n = 3), anomalous of pulmonary venous return (n = 3), hypoplastic segment of aorta (n = 2), Ebstein's anomaly (n = 1), bicuspid aortic arch (n = 1) and left hypoplastic heart syndrome (n = 1). Conclusion Cardiac MDCT angiography was superior to Echocardiography in ...
Keywords	Ductus arteriosus ; PDA ; Cardiac MDCT ; Congenital heart disease ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Insights Into MRI Neuroimaging Patterns of COVID-19 in Children: A Retrospective Comprehensive Analysis.

Nada, Mohamad Gamal / Almalki, Yassir Edrees / Basha, Mohammad Abd Alkhalik / Metwally, Maha Ibrahim / Dessouky, Riham / Radwan, Mohamed Hesham Saleh Saleh / Zaitoun, Mohamed M A / Abdalla, Ahmed A El-Hamid M / Bessar, Ahmed A A / Tantwy, Engy Fathy / Assy, Mostafa Mohamad / Dawoud, Bassant Mahmoud / Hanna, Diana / Gohary, Mahmoud M / Alduraibi, Sharifa Khalid / Lduraibi, Alaa K / Eldib, Diaa Bakry / Khater, Hamada M / Sarhan, Noha T /

Hamed, Dina Esmat / Saadawy, Sara F / Huneif, Mohammed A / Abdelkhalik Basha, Ahmed M / Libda, Yasmin Ibrahim

Academic radiology

2024

Abstract: Rationale and objectives: Neurological complications associated with coronavirus disease (COVID-19) have been reported in children; however, data on neuroimaging findings remain limited. This study aimed to comprehensively examine neuroimaging patterns ... ...

Abstract	Rationale and objectives: Neurological complications associated with coronavirus disease (COVID-19) have been reported in children; however, data on neuroimaging findings remain limited. This study aimed to comprehensively examine neuroimaging patterns of COVID-19 in children and their relationship with clinical outcomes. Materials and methods: This retrospective cross-sectional study involved reviewing the medical records and MRI scans of 95 children who developed new neurological symptoms within 2-4 weeks of clinical and laboratory confirmation of COVID-19. Patients were categorized into four groups based on guidelines approved by the Centers for Disease Control and Prevention (CDC). Initial brain/spinal MRI was performed. Images were reviewed by three blinded radiologists, and the findings were analyzed and categorized based on the observed patterns in the brain and spinal cord. Follow-up MRI was performed and analyzed to track lesion progression. Results: Encephalopathy was the most common neurological symptom (50.5%). The most common initial MRI involvement patterns were non-confluent multifocal hyperintense white matter (WM) lesions (36.8%) and ischemia (18.9%). Most patients who underwent follow-up MRI (n = 56) showed complete resolution (69.9%); however, some patients developed encephalomalacia and myelomalacia (23.2% and 7.1%, respectively). Non-confluent hyperintense WM lesions were associated with good outcomes (45.9%, P = 0.014), whereas ischemia and hemorrhage were associated with poor outcomes (44.1%, P < 0.001). Conclusion: This study revealed diverse neuroimaging patterns in pediatric COVID-19 patients. Non-confluent WM lesions were associated with good outcomes, whereas ischemia and hemorrhage were associated with poorer prognoses. Understanding these patterns is crucial for their early detection, accurate diagnosis, and appropriate management.
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1355509-1
ISSN	1878-4046 ; 1076-6332
ISSN (online)	1878-4046
ISSN	1076-6332
DOI	10.1016/j.acra.2024.03.018
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