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Article ; Online: Recombinant ling zhi-8 enhances Tregs function to restore glycemic control in streptozocin-induced diabetic rats.

Xiao, Hongyu / Fang, Zhi / He, Xueling / Ding, Ping / Cao, Yongkai / Chan, Shamyuen / Hou, Shaozhen / Liang, Jian

The Journal of pharmacy and pharmacology

2020 Volume 72, Issue 12, Page(s) 1946–1955

Abstract: Objectives: To explore the effect of recombinant LZ-8 (rLZ-8) on streptozocin (STZ)-induced diabetic rats and further illustrate its underlying mechanism.: Methods: Rats were intraperitoneally injected with single-dose STZ 50 mg/kg for induction of ... ...

Abstract	Objectives: To explore the effect of recombinant LZ-8 (rLZ-8) on streptozocin (STZ)-induced diabetic rats and further illustrate its underlying mechanism. Methods: Rats were intraperitoneally injected with single-dose STZ 50 mg/kg for induction of type 1 diabetes (T1D), and then, the diabetic rats were treated with rLZ-8 for 3 months. The clinical symptoms, fasting blood glucose, insulin, cytokines, histopathology, flow cytometry and immunofluorescence were used to evaluate the therapeutic effect and underlying mechanism of rLZ-8 on alleviating diabetes mellitus (DM). Key findings: Treatment with rLZ-8 obviously alleviated the clinical symptoms of T1D and dose-dependently reduced the levels of blood glucose, blood lipid and haemoglobin A1c (HbA1c) in diabetic rat model. Meanwhile, rLZ-8 markedly increased insulin secretion and protected against STZ-induced pancreatic tissue injury. Additionally, rLZ-8 dramatically inhibited the levels of TNF-α and IL-1β, and obviously increased the level of IL-10 in serum and pancreas. Further investigation indicated that rLZ-8 treatment significantly increased the number of regulatory T cells (Tregs) and up-regulated the expression of Foxp3 to restore balance between anti-inflammatory and inflammatory cytokines. Conclusions: These data suggest that rLZ-8 can antagonize STZ-induced T1D, and its mechanism may be related to inhibit inflammation and enhance Tregs generation.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Biomarkers/blood ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Cytokines/blood ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/immunology ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/chemically induced ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 1/immunology ; Fungal Proteins/pharmacology ; Glycemic Control ; Hypoglycemic Agents/pharmacology ; Inflammation Mediators/blood ; Male ; Rats, Sprague-Dawley ; Recombinant Proteins/pharmacology ; Streptozocin ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism
Chemical Substances	Anti-Inflammatory Agents ; Biomarkers ; Blood Glucose ; Cytokines ; Fungal Proteins ; Hypoglycemic Agents ; Inflammation Mediators ; Recombinant Proteins ; LZ-8 protein, Ganoderma lucidum (127187-71-7) ; Streptozocin (5W494URQ81)
Language	English
Publishing date	2020-08-17
Publishing country	England
Document type	Journal Article
ZDB-ID	3107-0
ISSN	2042-7158 ; 0022-3573 ; 0373-1022
ISSN (online)	2042-7158
ISSN	0022-3573 ; 0373-1022
DOI	10.1111/jphp.13360
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Diagnosing and Treating Hypertensive Disorders of Pregnancy? The Answer May Now Be Less BAFF-ling.

Chan, Christopher T / Lieu, Maggie / Sobey, Christopher G / Drummond, Grant R / Vinh, Antony

Hypertension (Dallas, Tex. : 1979)

2017 Volume 70, Issue 5, Page(s) 884–886

Language	English
Publishing date	2017-11
Publishing country	United States
Document type	Editorial
ZDB-ID	423736-5
ISSN	1524-4563 ; 0194-911X ; 0362-4323
ISSN (online)	1524-4563
ISSN	0194-911X ; 0362-4323
DOI	10.1161/HYPERTENSIONAHA.117.09849
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Article ; Online: Gui-ling-gao, a traditional Chinese functional food, prevents oxidative stress-induced apoptosis in H9c2 cardiomyocytes.

Li, Fan / Wu, Jian-Hong / Wang, Qing-Hua / Shu, Yuan-Lan / Wan, Chun-Wai / Chan, Chi-On / Kam-Wah Mok, Daniel / Chan, Shun-Wan

Food & function

2013 Volume 4, Issue 5, Page(s) 745–753

Abstract: ... body health status. Gui-ling-gao (GLG, also known as turtle jelly) is a well-known traditional ...

Abstract	Functional foods have become an increasingly popular alternative to prevent diseases and maintain body health status. Gui-ling-gao (GLG, also known as turtle jelly) is a well-known traditional functional food popular in Southern China and Hong Kong. This study aimed to investigate the antioxidative and anti-apoptotic effects of GLG, a traditional Chinese functional food, on preventing oxidative stress-induced injury in H9c2 cardiomyocytes. In this study, the antioxidative capacities of GLG were measured by using both a cell-free assay [2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl assay] and biological methods [2,2'-azobis(2-amidinopropane)-induced haemolysis assay and H(2)O(2)-induced cell damage on H9c2 cardiomyocytes]. Additionally, the total phenolic content was measured using the Folin-Ciocalteu method. Furthermore, the anti-apoptotic effect of GLG was evaluated by nuclear staining and a DNA fragmentation assay. GLG was found to have good antioxidant activities and high total phenolic content. In H(2)O(2)-induced cell damage on H9c2 cells, GLG was demonstrated to ameliorate the apoptotic effects, such as nuclear condensations, increased intracellular caspase-3 activity and inter-nucleosomal DNA cleavage, induced by H(2)O(2). The present study demonstrated for the first time that GLG possesses anti-apoptotic potential in vitro and this effect may be mediated, in part, by its antioxidative function. Additionally, the antioxidative capacities of GLG were proved both chemically and biologically. This study provides scientific evidence to prove the anecdotal health-beneficial claim that the consumption of GLG could help the body to handle endogenous toxicants such as free radicals.
MeSH term(s)	Amidines/adverse effects ; Animals ; Antioxidants/analysis ; Antioxidants/pharmacology ; Apoptosis/drug effects ; Cell Line ; Cell Survival/drug effects ; China ; Chromatography, High Pressure Liquid ; DNA Fragmentation/drug effects ; Functional Food/analysis ; Hydrogen Peroxide/metabolism ; Linear Models ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Oxidative Stress/drug effects ; Phenols/analysis ; Phenols/pharmacology ; Rats
Chemical Substances	Amidines ; Antioxidants ; Phenols ; 2,2'-azobis(2-amidinopropane) (7381JDR72F) ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2013-04-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/c3fo30182f
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Article: Gui-ling-gao, a traditional Chinese functional food, prevents oxidative stress-induced apoptosis in H9c2 cardiomyocytes

Li, Fan / Wu, Jian-Hong / Wang, Qing-Hua / Shu, Yuan-Lan / Wan, Chun-Wai / Chan, Chi-On / Kam-Wah Mok, Daniel / Chan, Shun-Wan

Food & function. 2013 Apr. 30, v. 4, no. 5

2013

Abstract: ... body health status. Gui-ling-gao (GLG, also known as turtle jelly) is a well-known traditional ...

Abstract	Functional foods have become an increasingly popular alternative to prevent diseases and maintain body health status. Gui-ling-gao (GLG, also known as turtle jelly) is a well-known traditional functional food popular in Southern China and Hong Kong. This study aimed to investigate the antioxidative and anti-apoptotic effects of GLG, a traditional Chinese functional food, on preventing oxidative stress-induced injury in H9c2 cardiomyocytes. In this study, the antioxidative capacities of GLG were measured by using both a cell-free assay [2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl assay] and biological methods [2,2′-azobis(2-amidinopropane)-induced haemolysis assay and H₂O₂-induced cell damage on H9c2 cardiomyocytes]. Additionally, the total phenolic content was measured using the Folin–Ciocalteu method. Furthermore, the anti-apoptotic effect of GLG was evaluated by nuclear staining and a DNA fragmentation assay. GLG was found to have good antioxidant activities and high total phenolic content. In H₂O₂-induced cell damage on H9c2 cells, GLG was demonstrated to ameliorate the apoptotic effects, such as nuclear condensations, increased intracellular caspase-3 activity and inter-nucleosomal DNA cleavage, induced by H₂O₂. The present study demonstrated for the first time that GLG possesses anti-apoptotic potential in vitro and this effect may be mediated, in part, by its antioxidative function. Additionally, the antioxidative capacities of GLG were proved both chemically and biologically. This study provides scientific evidence to prove the anecdotal health-beneficial claim that the consumption of GLG could help the body to handle endogenous toxicants such as free radicals.
Keywords	DNA damage ; DNA fragmentation ; antioxidant activity ; apoptosis ; cardiomyocytes ; caspase-3 ; cell free system ; free radicals ; functional foods ; health status ; hemolysis ; hydrogen peroxide ; jellies ; staining ; toxic substances ; China
Language	English
Dates of publication	2013-0430
Size	p. 745-753.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/c3fo30182f
Database	NAL-Catalogue (AGRICOLA)

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Article: Gui-ling-gao (turtle jelly), a traditional Chinese functional food, exerts anti-inflammatory effects by inhibiting iNOS and pro-inflammatory cytokine expressions in splenocytes isolated from BALB/c mice

Zhang, Huan / Wu, Min-Yi / Guo, De-Jian / Wan, Chun-Wai / Lau, Ching-Ching / Chan, Chi-On / Mok, Daniel Kam-Wah / Chan, Shun-Wan

Journal of functional foods. 2013 Apr., v. 5, no. 2

2013

Abstract: Gui-ling-gao (GLG), also known as turtle jelly, is a popular medicinal Chinese health ...

Abstract	Gui-ling-gao (GLG), also known as turtle jelly, is a popular medicinal Chinese health/functional food prepared from several traditional Chinese medicinal herbs. The present study aimed at examining and explaining the anti-inflammatory properties of GLG by using lipopolysaccharide (LPS)-induced inflammation in splenocytes isolated from BALB/c mice. Additionally, the effects of GLG on mRNA and protein expressions of inducible nitric oxide synthase (iNOS) and pro-inflammatory cytokines in LPS-stimulated splenocyte proliferation were evaluated by real-time RT-PCR and Western blot assays. We demonstrated that GLG significantly inhibited LPS-induced splenocyte proliferation in a concentration-dependent manner. LPS-mediated up-regulations in the gene and protein expressions of iNOS, interleukin-1β (IL-1β) and tumour necrosis factor-alpha (TNF-α) were suppressed by GLG. These findings suggest for the first time that GLG exerts anti-inflammatory effects by inhibiting the expression of iNOS and pro-inflammatory cytokines such as IL-1β and TNF-α. The current study provides strong scientific evidence for the health-beneficial claim that consumption of GLG could help the body to modulate the immune system.
Keywords	Western blotting ; anti-inflammatory activity ; functional foods ; genes ; immune system ; inducible nitric oxide synthase ; inflammation ; interleukin-1beta ; jellies ; lipopolysaccharides ; medicinal plants ; messenger RNA ; mice ; prepared foods ; reverse transcriptase polymerase chain reaction ; splenocytes ; tumor necrosis factor-alpha
Language	English
Dates of publication	2013-04
Size	p. 625-632.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2511964-3
ISSN	1756-4646
ISSN	1756-4646
DOI	10.1016/j.jff.2013.01.004
Database	NAL-Catalogue (AGRICOLA)

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Article: Structural changes in natural actomyosin and surimi from ling cod (Ophiodon elongatus) during frozen storage in the absence or presence of cryoprotectants.

Sultanbawa, Y / Li-Chan, E C

Journal of agricultural and food chemistry

2001 Volume 49, Issue 10, Page(s) 4716–4725

Abstract: Surimi and natural actomyosin (NAM) from ling cod (Ophiodon elongatus) were subjected ...

Abstract	Surimi and natural actomyosin (NAM) from ling cod (Ophiodon elongatus) were subjected to frozen storage in the absence or presence of cryoprotectants (sorbitol, sucrose, lactitol, and Litesse, either individually or in combination). Effects of frozen storage were studied for NAM frozen at -10 degrees C for 10 days and for surimi after eight freeze-thaw cycles. A commercial blend cryoprotectant (4% sucrose and 4% sorbitol), individual cryoprotectants at 8%, and optimal blends at 4, 5.5, 6, and 8%, were effective in maintaining the gel strength of surimi and NAM gels. Surimi or NAM frozen in the absence of cryoprotectants or with only 4% individual cryoprotectants, showed increased percent alpha-helical content by Raman analysis. Increased disulfide content was also observed in the treatment without cryoprotectants by the Raman SS stretching band and by chemical determination. Tyrosine residues were in a buried environment before and after freezing for all treatments, and surface hydrophobicity measured by 1-anilinonaphthalene-8-sulfonate decreased after frozen storage in the absence of cryoprotectants.
MeSH term(s)	Actomyosin/chemistry ; Animals ; Chemical Phenomena ; Chemistry, Physical ; Cryoprotective Agents/pharmacology ; Disulfides/chemistry ; Fish Products/analysis ; Fishes ; Frozen Foods ; Gels ; Hydrophobic and Hydrophilic Interactions ; Proteins/analysis ; Spectrum Analysis, Raman ; Sulfhydryl Compounds/analysis ; Water
Chemical Substances	Cryoprotective Agents ; Disulfides ; Gels ; Proteins ; Sulfhydryl Compounds ; Water (059QF0KO0R) ; Actomyosin (9013-26-7)
Language	English
Publishing date	2001-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/jf001281x
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Article ; Online: Correspondence on Caffeine intake interacts with Asian gene variants in Parkinson's disease: author's reply.

Tan, Eng-King / Chan, Ling-Ling

The Lancet regional health. Western Pacific

2023 Volume 42, Page(s) 100994

Language	English
Publishing date	2023-12-26
Publishing country	England
Document type	Journal Article
ISSN	2666-6065
ISSN (online)	2666-6065
DOI	10.1016/j.lanwpc.2023.100994
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Cryoprotective effects of sugar and polyol blends in ling cod surimi during frozen storage

Sultanbawa, Y / Li-Chan, E.C.Y

Food research international (Ottawa, Ont.) Food research international. 1998. v. 31 (2)

1998

Abstract: Cryoprotectant blends were investigated for their potential to stabilize ling cod surimi during ...

Abstract	Cryoprotectant blends were investigated for their potential to stabilize ling cod surimi during frozen storage at -18 degrees C for 4 months. A central composite rotatable design was used to formulate 25 blends containing lactitol, Litesse, sucrose, and sorbitol, at final total concentrations of 4-12%. Although decreases in % salt extractable proteins (SEP) (79 leads to 48%), apparent viscosity (3640 leads to 390 centipoises) and water binding capacity (WBC) (1.33 leads to 0.94 g/g) were observed, the gel strength, color, pH and myosin-to-actin ratio did not change significantly after frozen storage of surimi containing any of the cryoprotectant blends. In contrast data observed for surimi with no cryoprotectants were significantly different from those with the cryoprotectant blends over the storage period. All blends gave surimi and cooked gels comparable to those obtained with commercial mix (4% sucrose, 4% sorbitol), with the 4% blend containing 1% of each cryoprotectant being the most economical and the lowest in calorie content.
Keywords	fish products ; frozen storage ; cryoprotectants ; sucrose ; sorbitol ; lactitol ; denaturation ; cod (fish)
Language	English
Size	p. 87-98.
Document type	Article
ZDB-ID	1111695-x
ISSN	0963-9969
ISSN	0963-9969
Database	NAL-Catalogue (AGRICOLA)

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Article: The Alice Ho Miu Ling Nethersole Hospital.

Chan, G

Xianggang hu li za zhi. The Hong Kong nursing journal

1969 Volume 6, Page(s) 16–17

MeSH term(s)	Hong Kong ; Hospitals, General
Language	English
Publishing date	1969-05
Publishing country	China
Document type	Journal Article
ISSN	0073-3253
ISSN	0073-3253
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Article: Structural changes in natural actomyosin and surimi from ling cod (Ophiodon elongatus) during frozen storage in the absence or presence of cryoprotectants

Sultanbawa, Y / Li-Chan, E.C.Y

Journal of agricultural and food chemistry. Oct 2001. v. 49 (10)

2001

Abstract: Surimi and natural actomyosin (NAM) from ling cod (Ophiodon elongatus) were subjected ...

Abstract	Surimi and natural actomyosin (NAM) from ling cod (Ophiodon elongatus) were subjected to frozen storage in the absence or presence of cryoprotectants (sorbitol, sucrose, lactitol, and Litesse, either individually or in combination). Effects of frozen storage were studied for NAM frozen at -10 degrees C for 10 days and for surimi after eight freeze-thaw cycles. A commercial blend cryoprotectant (4% sucrose and 4% sorbitol), individual cryoprotectants at 8%, and optimal blends at 4, 5.5, 6, and 8%, were effective in maintaining the gel strength of surimi and NAM gels. Surimi or NAM frozen in the absence of cryoprotectants or with only 4% individual cryoprotectants, showed increased percent alpha-helical content by Raman analysis. Increased disulfide content was also observed in the treatment without cryoprotectants by the Raman SS stretching band and by chemical determination. Tyrosine residues were in a buried environment before and after freezing for all treatments, and surface hydrophobicity measured by 1-anilinonaphthalene-8-sulfonate decreased after frozen storage in the absence of cryoprotectants.
Keywords	water content ; fish ; frozen storage ; fish products ; gels ; contractile proteins ; molecular conformation ; hydrophobicity ; sulfhydryl groups ; cryoprotectants ; sucrose ; sorbitol ; lactitol ; freezing ; thawing ; protein content ; gelation ; marine fish
Language	English
Dates of publication	2001-10
Size	p. 4716-4725.
Document type	Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
Database	NAL-Catalogue (AGRICOLA)

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Z 1185: Show issues

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