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  1. Article ; Online: Coronary sinus reducer: a new hope for refractory angina?

    Monti, Caterina B / Palmisano, Anna

    Lancet (London, England)

    2024  Volume 403, Issue 10436, Page(s) 1514–1515

    MeSH term(s) Humans ; Coronary Sinus/surgery ; Angina Pectoris/drug therapy ; Treatment Outcome
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(24)00474-4
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  2. Article ; Online: Solitary cutaneous focal mucinosis: In-vivo line-field confocal optical coherence tomography (LC-OCT) features correlate to histopathology.

    Palmisano, Gerardo / Cappilli, Simone / Lugli, Anna P / Di Stefani, Alessandro / Peris, Ketty

    International journal of dermatology

    2024  

    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.17118
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  3. Article ; Online: Effectiveness and safety of mycophenolate mofetil and rituximab combination therapy for immune idiopathic myopathies.

    Campochiaro, Corrado / Farina, Nicola / De Luca, Giacomo / Batani, Veronica / Trignani, Giorgia / Vignale, Davide / Palmisano, Anna / Matucci-Cerinic, Marco / Dagna, Lorenzo

    Arthritis research & therapy

    2024  Volume 26, Issue 1, Page(s) 79

    Abstract: Introduction: Idiopathic inflammatory myopathies (IIM) represent a rare and heterogenous group diseases, and their treatment is not fully defined yet. According to previous small case series, the combination of mycophenolate mofetil (MMF) and rituximab ( ...

    Abstract Introduction: Idiopathic inflammatory myopathies (IIM) represent a rare and heterogenous group diseases, and their treatment is not fully defined yet. According to previous small case series, the combination of mycophenolate mofetil (MMF) and rituximab (RTX) may be effective in controlling difficult-to-treat patients. Our aim was to further explore the efficacy and safety of this combined approach in patients with IIM.
    Methods: Patients with IIM treated with the RTX/MMF combination in our Center were retrospectively identified. After the start of combination therapy, the efficacy was evaluated at 12 months (T12) according the 2016 ACR/EULAR response criteria for IIM. Cardiac imaging and pulmonary function tests were used to monitor disease activity in patients with myocarditis and interstitial lung disease, respectively. Adverse events were recorded over the follow-up period.
    Results: Among the 20 patients (median age 61 years; 70% female) included in the study, anti-synthetase syndrome was the most prevalent IIM subgroup (60%). At treatment start, muscle, heart, and lung were the most commonly actively affected organs. After 12 months, a moderate or major response was observed in all patients, and creatine kinase was significantly decreased (p-value = 0.012). Cardiac imaging and enzymes monitoring showed a reduction of heart inflammation, while pulmonary function tests improved in patients with lung involvement. No severe side effects were observed.
    Conclusion: Our data show that combination of RTX and MMF is effective and safe in patients with severe and refractory IIM. Therefore, this combined treatment might represent a feasible approach for difficult-to-treat IIM cases.
    MeSH term(s) Humans ; Female ; Middle Aged ; Male ; Rituximab/adverse effects ; Mycophenolic Acid/adverse effects ; Retrospective Studies ; Treatment Outcome ; Myositis/drug therapy ; Myositis/chemically induced
    Chemical Substances Rituximab (4F4X42SYQ6) ; Mycophenolic Acid (HU9DX48N0T)
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2107602-9
    ISSN 1478-6362 ; 1478-6354
    ISSN (online) 1478-6362
    ISSN 1478-6354
    DOI 10.1186/s13075-024-03310-z
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  4. Article ; Online: Toward a One-Stop Shop CT Protocol in Acute Chest Pain Syndrome.

    Vignale, Davide / Palmisano, Anna / Colantoni, Caterina / Brunetti, Lisa / Nicoletti, Valeria / Gnasso, Chiara / Esposito, Antonio

    Radiology

    2022  Volume 306, Issue 1, Page(s) E3–E4

    MeSH term(s) Humans ; Chest Pain ; Syndrome ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2022-09-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.220844
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  5. Article: The Neural Correlates of Developmental Prosopagnosia: Twenty-Five Years on.

    Manippa, Valerio / Palmisano, Annalisa / Ventura, Martina / Rivolta, Davide

    Brain sciences

    2023  Volume 13, Issue 10

    Abstract: Faces play a crucial role in social interactions. Developmental prosopagnosia (DP) refers to the lifelong difficulty in recognizing faces despite the absence of obvious signs of brain lesions. In recent decades, the neural substrate of this condition has ...

    Abstract Faces play a crucial role in social interactions. Developmental prosopagnosia (DP) refers to the lifelong difficulty in recognizing faces despite the absence of obvious signs of brain lesions. In recent decades, the neural substrate of this condition has been extensively investigated. While early neuroimaging studies did not reveal significant functional and structural abnormalities in the brains of individuals with developmental prosopagnosia (DPs), recent evidence identifies abnormalities at multiple levels within DPs' face-processing networks. The current work aims to provide an overview of the convergent and contrasting findings by examining twenty-five years of neuroimaging literature on the anatomo-functional correlates of DP. We included 55 original papers, including 63 studies that compared the brain structure (MRI) and activity (fMRI, EEG, MEG) of healthy control participants and DPs. Despite variations in methods, procedures, outcomes, sample selection, and study design, this scoping review suggests that morphological, functional, and electrophysiological features characterize DPs' brains, primarily within the ventral visual stream. Particularly, the functional and anatomical connectivity between the Fusiform Face Area and the other face-sensitive regions seems strongly impaired. The cognitive and clinical implications as well as the limitations of these findings are discussed in light of the available knowledge and challenges in the context of DP.
    Language English
    Publishing date 2023-09-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13101399
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  6. Article ; Online: A pathogenic role for brain-derived neurotrophic factor (BDNF) in fibrous dysplasia of bone.

    Palmisano, Biagio / Farinacci, Giorgia / Campolo, Federica / Tavanti, Chiara / Stefano, Alessia / Donsante, Samantha / Ippolito, Ernesto / Giannicola, Giuseppe / Venneri, Mary Anna / Corsi, Alessandro / Riminucci, Mara

    Bone

    2024  Volume 181, Page(s) 117047

    Abstract: Brain derived neurotrophic factor (BDNF) is a neurotrophin, expressed in the central nervous system and in peripheral tissues, that is regulated by the Gsα/cAMP pathway. In bone, it regulates osteogenesis and stimulates RANKL secretion and osteoclast ... ...

    Abstract Brain derived neurotrophic factor (BDNF) is a neurotrophin, expressed in the central nervous system and in peripheral tissues, that is regulated by the Gsα/cAMP pathway. In bone, it regulates osteogenesis and stimulates RANKL secretion and osteoclast formation in osteolytic tumors such as Multiple Myeloma. Fibrous dysplasia (FD) of bone is a rare genetic disease of the skeleton caused by gain-of-function mutations of the Gsα gene in which RANKL-dependent enhanced bone resorption is a major cause of bone fragility and clinical morbidity. We observed that BDNF transcripts are expressed in human FD lesions. Specifically, immunolocalization studies performed on biopsies obtained from FD patients revealed the expression of BDNF in osteoblasts and, to a lower extent, in the spindle-shaped cells within the fibrous tissue. Therefore, we hypothesized that BDNF can play a role in the pathogenesis of FD by stimulating RANKL secretion and bone resorption. To test this hypothesis, we used the EF1α-Gsα
    MeSH term(s) Humans ; Mice ; Animals ; Brain-Derived Neurotrophic Factor ; Bone and Bones/metabolism ; Fibrous Dysplasia of Bone/genetics ; Osteoclasts/metabolism ; Bone Resorption
    Chemical Substances Brain-Derived Neurotrophic Factor
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632515-4
    ISSN 1873-2763 ; 8756-3282
    ISSN (online) 1873-2763
    ISSN 8756-3282
    DOI 10.1016/j.bone.2024.117047
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    Zs.MO 332: Show issues

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  7. Article ; Online: Dataset of Sentinel-1 surface soil moisture time series at 1 km resolution over Southern Italy.

    Balenzano, Anna / Mattia, Francesco / Satalino, Giuseppe / Lovergine, Francesco P / Palmisano, Davide / Davidson, Malcolm W J

    Data in brief

    2021  Volume 38, Page(s) 107345

    Abstract: This paper describes the specifications of the surface soil volumetric water content ( ...

    Abstract This paper describes the specifications of the surface soil volumetric water content (
    Language English
    Publishing date 2021-09-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2786545-9
    ISSN 2352-3409 ; 2352-3409
    ISSN (online) 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2021.107345
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  8. Article ; Online: A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages.

    Hahn, Anne M / Vogg, Lisa / Brey, Stefanie / Schneider, Andrea / Schäfer, Simon / Palmisano, Ralph / Pavlova, Anna / Sandrock, Inga / Tan, Likai / Fichtner, Alina S / Prinz, Immo / Ravens, Sarina / Winkler, Thomas H

    Cell reports

    2023  Volume 42, Issue 5, Page(s) 112558

    Language English
    Publishing date 2023-05-13
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112558
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  9. Article ; Online: Mind the "commissural drop" when crossing the aortic valve!

    Ghizzoni, Giulia / Ancona, Marco B / Romano, Vittorio / Bellini, Barbara / Ferri, Luca / Russo, Filippo / Vella, Ciro / Gentile, Domitilla / Chionchio, Giulia / Macelletti, Veronica / Ancona, Francesco / Agricola, Eustachio / Palmisano, Anna / Esposito, Antonio / Montorfano, Matteo

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2023  Volume 102, Issue 3, Page(s) 538–541

    MeSH term(s) Humans ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Treatment Outcome ; Transcatheter Aortic Valve Replacement/adverse effects ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.30763
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  10. Article ; Online: Coronary physiology thresholds associated with microvascular obstruction in myocardial infarction.

    Benenati, Stefano / Montorfano, Matteo / Pica, Silvia / Crimi, Gabriele / Ancona, Marco / Montone, Rocco A / Rinaldi, Riccardo / Gramegna, Mario / Esposito, Antonio / Palmisano, Anna / Tavano, Davide / Monizzi, Giovanni / Bartorelli, Antonio / Porto, Italo / Ambrosio, Giuseppe / Camici, Paolo Guido

    Heart (British Cardiac Society)

    2024  Volume 110, Issue 4, Page(s) 271–280

    Abstract: Objectives: To ascertain whether invasive assessment of coronary physiology soon after recanalisation of the culprit artery by primary percutaneous coronary intervention is associated with the development of microvascular obstruction by cardiac magnetic ...

    Abstract Objectives: To ascertain whether invasive assessment of coronary physiology soon after recanalisation of the culprit artery by primary percutaneous coronary intervention is associated with the development of microvascular obstruction by cardiac magnetic resonance in patients with ST-segment elevation myocardial infarction (STEMI).
    Methods: Between November 2020 and December 2021, 102 consecutive patients were prospectively enrolled in five tertiary centres in Italy. Coronary flow reserve (CFR) and index of microvascular resistance (IMR) were measured in the culprit vessel soon after successful primary percutaneous coronary intervention. Optimal cut-off points of IMR and CFR to predict the presence of microvascular obstruction were estimated, stratifying the population accordingly in four groups. A comparison with previously proposed stratification models was carried out.
    Results: IMR
    Conclusions: IMR and CFR are associated with the presence of microvascular obstruction in STEMI. Patients with an IMR>31 units and a CFR≤1.25 have higher prevalence of microvascular obstruction, lower left ventricular ejection fraction, larger infarct size and area at risk.
    Trial registration number: NCT04677257.
    MeSH term(s) Humans ; Coronary Circulation ; Magnetic Resonance Imaging ; Microcirculation/physiology ; Myocardial Infarction/complications ; Myocardial Infarction/diagnosis ; Percutaneous Coronary Intervention ; ST Elevation Myocardial Infarction ; Stroke Volume ; Treatment Outcome ; Vascular Resistance ; Ventricular Function, Left/physiology ; Prospective Studies
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Clinical Study ; Journal Article ; Multicenter Study
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2023-323169
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