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Article ; Online: Adversarial learning-based domain adaptation algorithm for intracranial artery stenosis detection on multi-source datasets.

Gao, Yuan / Ma, Chenbin / Guo, Lishuang / Liu, Guiyou / Zhang, Xuxiang / Ji, Xunming

2024 Volume 170, Page(s) 108001

Abstract: Intracranial arterial stenosis (ICAS) is characterized by the pathological narrowing or occlusion of the inner lumen of intracranial blood vessels. However, the retina can indirectly react to cerebrovascular disease. Therefore, retinal fundus images (RFI) ...

Abstract	Intracranial arterial stenosis (ICAS) is characterized by the pathological narrowing or occlusion of the inner lumen of intracranial blood vessels. However, the retina can indirectly react to cerebrovascular disease. Therefore, retinal fundus images (RFI) serve as valuable noninvasive and easily accessible screening tools for early detection and diagnosis of ICAS. This paper introduces an adversarial learning-based domain adaptation algorithm (ALDA) specifically designed for ICAS detection in multi-source datasets. The primary objective is to achieve accurate detection and enhanced generalization of ICAS based on RFI. Given the limitations of traditional algorithms in meeting the accuracy and generalization requirements, ALDA overcomes these challenges by leveraging RFI datasets from multiple sources and employing the concept of adversarial learning to facilitate feature representation sharing and distinguishability learning. In order to evaluate the performance of the ALDA algorithm, we conducted experimental validation on multi-source datasets. We compared its results with those obtained from other deep learning algorithms in the ICAS detection task. Furthermore, we validated the potential of ALDA for detecting diabetic retinopathy. The experimental results clearly demonstrate the significant improvements achieved by the ALDA algorithm. By leveraging information from diverse datasets, ALDA learns feature representations that exhibit enhanced generalizability and robustness. This makes it a reliable auxiliary diagnostic tool for clinicians, thereby facilitating the prevention and treatment of cerebrovascular diseases.
MeSH term(s)	Humans ; Constriction, Pathologic ; Arteries ; Fundus Oculi ; Retina ; Algorithms
Language	English
Publishing date	2024-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2024.108001
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Zs.A 653: Show issues

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Article ; Online: Microfluidics for diagnosis and treatment of cardiovascular disease.

Ma, Yonggeng / Liu, Chenbin / Cao, Siyu / Chen, Tianshu / Chen, Guifang

Journal of materials chemistry. B

2023 Volume 11, Issue 3, Page(s) 546–559

Abstract: Cardiovascular disease (CVD), a type of circulatory system disease related to the lesions of the cardiovascular system, has become one of the main diseases that endanger human health. Currently, the clinical diagnosis of most CVDs relies on a combination ...

Abstract	Cardiovascular disease (CVD), a type of circulatory system disease related to the lesions of the cardiovascular system, has become one of the main diseases that endanger human health. Currently, the clinical diagnosis of most CVDs relies on a combination of imaging technology and blood biochemical test. However, the existing technologies for diagnosis of CVDs still have limitations in terms of specificity, detection range, and cost. In order to break through the current bottleneck, microfluidic with the advantages of low cost, simple instruments and easy integration, has been developed to play an important role in the early prevention, diagnosis and treatment of CVDs. Here, we have reviewed the recent various applications of microfluidic in the clinical diagnosis and treatment of CVDs, including microfluidic devices for detecting CVD markers, the cardiovascular models based on microfluidic, and the microfluidic used for CVDs drug screening and delivery. In addition, we have briefly looked forward to the prospects and challenges of microfluidics in diagnosis and treatment of CVDs.
MeSH term(s)	Humans ; Microfluidics/methods ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/drug therapy ; Lab-On-A-Chip Devices
Language	English
Publishing date	2023-01-18
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d2tb02287g
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Article ; Online: Evaluation of the Yield of DNA Double-Strand Breaks for Carbon Ions Using Monte Carlo Simulation and DNA Fragment Distribution.

Liang, Ying / Wu, Jianan / Ding, Zhen / Liu, Chenbin / Fu, Qibin

International journal of radiation oncology, biology, physics

2023 Volume 117, Issue 1, Page(s) 252–261

Abstract: Purpose: The aim of this work was to provide a method to evaluate the yield of DNA double-strand breaks (DSBs) for carbon ions, overcoming the bias in existing methods due to the nonrandom distribution of DSBs.: Methods and materials: A previously ... ...

Abstract	Purpose: The aim of this work was to provide a method to evaluate the yield of DNA double-strand breaks (DSBs) for carbon ions, overcoming the bias in existing methods due to the nonrandom distribution of DSBs. Methods and materials: A previously established biophysical program based on the radiation track structure and a multilevel chromosome model was used to simulate DNA damage induced by x-rays and carbon ions. The fraction of activity retained (FAR) as a function of absorbed dose or particle fluence was obtained by counting the fraction of DNA fragments larger than 6 Mbp. Simulated FAR curves for the 250 kV x-rays and carbon ions at various energies were compared with measurements using constant-field gel electrophoresis. The doses or fluences at the FAR of 0.7 based on linear interpolation were used to estimate the simulation error for the production of DSBs. Results: The relative difference of doses at the FAR of 0.7 between simulation and experiment was -8.5% for the 250 kV x-rays. The relative differences of fluences at the FAR of 0.7 between simulations and experiments were -17.5%, -42.2%, -18.2%, -3.1%, 10.8%, and -14.5% for the 34, 65, 130, 217, 2232, and 3132 MeV carbon ions, respectively. In comparison, the measurement uncertainty was about 20%. Carbon ions produced remarkably more DSBs and DSB clusters per unit dose than x-rays. The yield of DSBs for carbon ions, ranging from 10 to 16 Gbp Conclusions: The estimated yields of DSBs for carbon ions increased from 10 Gbp
MeSH term(s)	Humans ; DNA Breaks, Double-Stranded ; Monte Carlo Method ; Ions ; Relative Biological Effectiveness ; DNA Damage ; DNA ; Carbon
Chemical Substances	Ions ; DNA (9007-49-2) ; Carbon (7440-44-0)
Language	English
Publishing date	2023-03-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2023.03.049
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Zs.A 1218: Show issues

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Article ; Online: Incidence of Ventriculomegaly in Patients With Craniosynostosis.

Liu, Baihui / Li, Jun / Zhang, Songchunyuan / Wang, Yueqing / Dong, Chenbin

The Journal of craniofacial surgery

2023 Volume 35, Issue 1, Page(s) e56–e58

Abstract: Hydrocephalus is variously associated with syndromic craniosynostosis (CS), while it is randomly encountered in nonsyndromic CS. But actually, the ventriculomegaly in CS is less described. In this study, the authors aim to establish whether ... ...

Abstract	Hydrocephalus is variously associated with syndromic craniosynostosis (CS), while it is randomly encountered in nonsyndromic CS. But actually, the ventriculomegaly in CS is less described. In this study, the authors aim to establish whether ventriculomegaly is common in patients with CS, in both syndromic and nonsyndromic. Retrospective measurements of Evans index (EI) were taken from thin-section computed tomography scans of 169 preoperative CS patients to assess cerebral ventricular volume. EI >0.3 indicates ventricular enlargement. A total of 169 CS patients who underwent computed tomography scan from February 2018 to December 2021 were retrospectively evaluated, including 114 males and 55 females. The average age at diagnosis was 16 months (range: 1-103 mo). Among them, 37 with syndromic CS, including 17 ventricular megaly patients, had an EI >0.3 (46.0%), and 4 of them had intracranial hypertension and needed ventriculoperitoneal shunt treatment before cranial vault remolding. One hundred and thirty-two had nonsyndromic CS (100 single-suture CS, 32 multisuture CS), and 26 of them had an EI of 0.3 or greater (19.7%). Ventrocular megaly is common among patients with CS. Early craniotomy may stabilize ventricular dilation.
MeSH term(s)	Male ; Female ; Humans ; Infant ; Child, Preschool ; Child ; Retrospective Studies ; Incidence ; Craniosynostoses/complications ; Craniosynostoses/diagnostic imaging ; Craniosynostoses/epidemiology ; Skull/surgery ; Hydrocephalus/diagnostic imaging ; Hydrocephalus/epidemiology ; Hydrocephalus/surgery
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000009805
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Zs.A 3761: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 175: Show issues

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Article ; Online: Tumor-associated antigen-specific cell imaging based on upconversion luminescence and nucleic acid rolling circle amplification.

Zhan, Ying / Mao, Yichun / Sun, Pei / Liu, Chenbin / Gou, Hongquan / Qi, Haipeng / Chen, Guifang / Hu, Song / Tian, Bo

Mikrochimica acta

2024 Volume 191, Issue 5, Page(s) 248

Abstract: Tumor-associated antigen (TAA)-based diagnosis has gained prominence for early tumor screening, treatment monitoring, prognostic assessment, and minimal residual disease detection. However, limitations such as low sensitivity and difficulty in extracting ...

Abstract	Tumor-associated antigen (TAA)-based diagnosis has gained prominence for early tumor screening, treatment monitoring, prognostic assessment, and minimal residual disease detection. However, limitations such as low sensitivity and difficulty in extracting non-specific binding membrane proteins still exist in traditional detection methods. Upconversion luminescence (UCL) exhibits unique physical and chemical properties under wavelength near-infrared light excitation. Rolling circle amplification (RCA) is an efficient DNA amplification technique with amplification factors as high as 10
MeSH term(s)	Luminescence ; Diagnostic Imaging ; Cell Membrane ; Nucleic Acid Amplification Techniques ; Nucleic Acids
Chemical Substances	Nucleic Acids
Language	English
Publishing date	2024-04-08
Publishing country	Austria
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	89-9
ISSN	1436-5073 ; 0026-3672
ISSN (online)	1436-5073
ISSN	0026-3672
DOI	10.1007/s00604-024-06331-2
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Z 8.1: Show issues

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Article ; Online: Robust reconstruction of fluorescence molecular tomography based on adaptive adversarial learning strategy.

Zhang, Peng / Song, Fan / Ma, Chenbin / Liu, Zeyu / Wu, Huijie / Sun, Yangyang / Feng, Youdan / He, Yufang / Zhang, Guanglei

Physics in medicine and biology

2023 Volume 68, Issue 4

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Animals ; Image Processing, Computer-Assisted/methods ; Algorithms ; Phantoms, Imaging ; Tomography, Optical ; Artifacts
Language	English
Publishing date	2023-02-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/acb638
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Zs.A 199: Show issues

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Article ; Online: Bioactive triple peptide inhibits inflammasome activation to alleviate

Cui, Chenbin / Liu, Qi / Duan, Bingbing / Liu, Xiangchen / Wei, Hongkui / Peng, Jian

Food & function

2022 Volume 13, Issue 6, Page(s) 3512–3525

Abstract: Over the past years, ...

Abstract	Over the past years,
MeSH term(s)	Animals ; Inflammasomes/metabolism ; Inflammation/drug therapy ; Inflammation/microbiology ; Mice ; Mice, Inbred C57BL ; Peptides/metabolism ; Peptides/pharmacology ; Salmonella Infections, Animal/drug therapy ; Salmonella Infections, Animal/microbiology ; Salmonella typhimurium ; Virulence
Chemical Substances	Inflammasomes ; Peptides
Language	English
Publishing date	2022-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d1fo03891e
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Z 7872: Show issues

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Article: Distribution Patterns and Determinants of Invasive Alien Plants in China.

Chen, Jing / Zhang, Yanjing / Liu, Wei / Wang, Chenbin / Ma, Fangzhou / Xu, Haigen

Plants (Basel, Switzerland)

2023 Volume 12, Issue 12

Abstract: In recent years, invasive alien plants (IAPs) have caused serious ecological disasters and economic losses in China. This study combined three IAP species richness-related indices (species richness of IAPs, first records of IAPs, and the relative species ...

Abstract	In recent years, invasive alien plants (IAPs) have caused serious ecological disasters and economic losses in China. This study combined three IAP species richness-related indices (species richness of IAPs, first records of IAPs, and the relative species richness of IAPs), as well as indices reflecting distribution and dispersal patterns (average similarity coefficient of IAPs) and invasiveness (average risk score of IAPs), to conduct an integrated regional-invasion risk assessment based on the principal component analysis (PCA) method. Partial least-squares (PLS) regression was conducted to explore the explanatory power of 12 environmental and anthropogenic factors on different invasion indices. The results indicated that coastal provinces and Yunnan had high IAP introduction risk, as well as high synthetic-risk scores. The dispersal of IAPs in mid-latitude provinces should be particularly prevented. For species richness of IAPs, more environmental factors with variable importance for the project (VIP) values higher than 1 were retained in the optimal model, reflecting the importance of environmental filtering on IAPs. Visitors were the most important predictor for first records of IAPs. Compared to species richness (
Language	English
Publishing date	2023-06-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12122341
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Article ; Online: Lantern-shaped flexible RNA origami for Smad4 mRNA delivery and growth suppression of colorectal cancer.

Hu, Muren / Feng, Chang / Yuan, Qianqin / Liu, Chenbin / Ge, Bujun / Sun, Fenyong / Zhu, Xiaoli

Nature communications

2023 Volume 14, Issue 1, Page(s) 1307

Abstract: mRNA delivery has shown high application value in the treatment of various diseases, but its effective delivery is still a major challenge at present. Herein, we propose a lantern-shaped flexible RNA origami for mRNA delivery. The origami is composed of ... ...

Abstract	mRNA delivery has shown high application value in the treatment of various diseases, but its effective delivery is still a major challenge at present. Herein, we propose a lantern-shaped flexible RNA origami for mRNA delivery. The origami is composed of a target mRNA scaffold and only two customized RGD-modified circular RNA staples, which can compress the mRNA into nanoscale and facilitate its endocytosis by cells. In parallel, the flexible structure of the lantern-shaped origami allows large regions of the mRNA to be exposed and translated, exhibiting a good balance between endocytosis and translation efficiency. The application of lantern-shaped flexible RNA origami in the context of the tumor suppressor gene, Smad4 in colorectal cancer models demonstrates promising potential for accurate manipulation of protein levels in in vitro and in vivo settings. This flexible origami strategy provides a competitive delivery method for mRNA-based therapies.
MeSH term(s)	Humans ; RNA ; RNA, Messenger/genetics ; RNA, Circular ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/therapy ; Colorectal Neoplasms/metabolism ; Smad4 Protein/genetics ; Smad4 Protein/metabolism
Chemical Substances	RNA (63231-63-0) ; RNA, Messenger ; RNA, Circular ; SMAD4 protein, human ; Smad4 Protein
Language	English
Publishing date	2023-03-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-37020-y
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Article ; Online: China Biodiversity Observation Network for better global sustainability developments.

Yi, Jianfeng / Ma, Fangzhou / Li, Jiaqi / Liu, Wei / Cao, Yun / Wan, Yaqiong / Wang, Chenbin / Chen, Mengmeng / Yu, Dandan / Xu, Haigen

Eco-Environment & Health (Online)

2022 Volume 1, Issue 4, Page(s) 201–203

Abstract: Image 1. ...

Abstract	Image 1.
Language	English
Publishing date	2022-12-27
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-9850
ISSN (online)	2772-9850
DOI	10.1016/j.eehl.2022.11.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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