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Article ; Online: Chest Imaging Tests versus RT-PCR Testing for COVID-19 Pneumonia: There Is No Best, Only a Better Fit.

Meng, Xianchun / Liu, Yuying

2020 Volume 297, Issue 3, Page(s) E345

MeSH term(s)	Betacoronavirus ; COVID-19 ; COVID-19 Testing ; China ; Clinical Laboratory Techniques ; Coronavirus ; Coronavirus Infections/diagnosis ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Tomography, X-Ray Computed
Keywords	covid19
Language	English
Publishing date	2020-10-20
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.2020203792
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Article ; Online: Comment on 'Neutrophils: driving progression and poor prognosis in hepatocellular carcinoma?'

Liu, Yuying / Meng, Xianchun

British journal of cancer

2018 Volume 119, Issue 6, Page(s) 779–780

MeSH term(s)	Carcinoma, Hepatocellular ; Disease Progression ; Humans ; Liver Neoplasms ; Neutrophils ; Prognosis
Language	English
Publishing date	2018-09-12
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-018-0241-4
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Article: Chest Imaging Tests versus RT-PCR Testing for COVID-19 Pneumonia: There Is No Best, Only a Better Fit

Meng, Xianchun / Liu, Yuying

Radiology

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #880990
Database	COVID19

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Article ; Online: Clean technology investment considering synergistic effects: a case from the steel sintering process

Guo, Jianxin / Tan, Xianchun / Meng, Xiaoyan / Li, Yanping

Environ Dev Sustain. 2022 Dec., v. 24, no. 12 p.13748-13770

2022

Abstract: The dual objectives of air pollutant control and carbon emission reduction highlight the importance of determining investment methods in end-of-pipe (EOP) technology to achieve cost optimization goals. This paper aims to bridge the gap between the ... ...

Abstract	The dual objectives of air pollutant control and carbon emission reduction highlight the importance of determining investment methods in end-of-pipe (EOP) technology to achieve cost optimization goals. This paper aims to bridge the gap between the cooperative control theory and practical applications. We propose a framework using optimal control theory to obtain a technology investment path while considering the two-way synergy effect. To verify the effectiveness of the model, we considered three typical technologies in ultra-low emission transformation of a certain steel process. The used case in the study set the emission reduction of [Formula: see text], [Formula: see text] and [Formula: see text] as 55%, 70% and 80% compared to their basic cases, respectively. Considering the synergy effect, the peaks of the installed capacity of three technologies including carbon capture, denitrification, and desulfurization were obtained as 0.12 million tons, 5 million tons, and 15 million tons. Also, the related net emissions for the pollutant were 300, 400, and 1000 million tons. We found that terminal desulfurization and denitrification technology increase [Formula: see text] emissions accounting for about 2% due to the negative synergy. However, the negative emission contribution from carbon abatement technology is greater accounting for about 40%. We also found that different policy objectives and emission factors have a greater impact on the investment path. These results demonstrate that we cannot completely ignore the negative emission reduction effects when adopting these EOP technologies. It is necessary to reevaluate these negative effects to the greatest extent so as to develop a more reasonable technological path, which is a guarantee for achieving the expected emission reduction targets.
Keywords	air pollutants ; carbon ; denitrification ; desulfurization ; issues and policy ; models ; steel ; sustainable technology
Language	English
Dates of publication	2022-12
Size	p. 13748-13770.
Publishing place	Springer Netherlands
Document type	Article ; Online
ZDB-ID	1438730-x
ISSN	1387-585X
ISSN	1387-585X
DOI	10.1007/s10668-021-02009-4
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Arenobufagin regulates the p62-Keap1-Nrf2 pathway to induce autophagy-dependent ferroptosis in HepG2 cells.

Yang, YuTing / Liu, Chun / Wang, Meng / Cheng, Hui / Wu, Huan / Luo, ShengYong / Zhang, Mei / Duan, XianChun / Li, Qinglin

Naunyn-Schmiedeberg's archives of pharmacology

2024

Abstract: Hepatocellular carcinoma (HCC) is the most prevalent type of primary liver cancer, accounting for the overwhelming majority of malignant liver tumors. Therefore, how to effectively prevent and cure HCC has become a research hotspot. Many studies have ... ...

Abstract	Hepatocellular carcinoma (HCC) is the most prevalent type of primary liver cancer, accounting for the overwhelming majority of malignant liver tumors. Therefore, how to effectively prevent and cure HCC has become a research hotspot. Many studies have shown that arenobufagin can induce apoptosis, ferroptosis, and autophagy of tumor cells. An increasing number of studies have shown that autophagy is closely linked to ferroptosis. In this study, HepG2 cells and BALB/c nude mice were used as research objects to explore the effect and preliminary mechanism of hepatoma cell autophagy and ferroptosis induced by arenobufagin. We found that arenobufagin can significantly inhibit tumor growth in vivo, and interestingly, we found that arenobufagin inhibited ferroptosis-related proteins Nrf2 and COX-2 in a dose-dependent manner and decreased the levels of reduced glutathione (GSH) and superoxide dismutase (T-SOD) in tissues, while increased the level of reduced malondialdehyde (MDA). In addition, we found that arenobufagin increased the levels of COX-2 and MDA in cells, decreased the levels of Nrf2, GSH, and T-SOD, increased the levels of tissue reactive oxygen species (ROS) and lipid ROS in a dose-dependent manner, and promoted ferroptosis in HepG2 cells. HepG2 cells were preprotected by autophagy inhibitor chloroquine (CQ) and ferroptosis inhibitor deferoxamine (DFO), and then treated with arenobufagin. It was found that CQ partially reversed the changes of COX-2 and Nrf2 expression and lipid peroxidation induced by arenobufagin-induced autophagy and HepG2 cells. Interestingly, CQ partially reversed the inhibition of arenobufagin on cytoplasmic junction protein (Keap1) and heme oxygenase-1 (HO-1) in p62-Keap1-Nrf2 pathway. At the same time, we found that the effect of arenobufagin on oxidative stress of HepG2 cells overexpressed by Nrf2 was significantly less than that of the control group. To sum up, arenobufagin promotes autophagy-dependent ferroptosis of HepG2 cells by inducing autophagy and regulating p62-Keap1-Nrf2 pathway. It is suggested that arenobufagin can be used as a potential intervention therapy.
Language	English
Publishing date	2024-01-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-023-02916-5
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Article ; Online: N6-methyladenosine reader hnRNPA2B1 recognizes and stabilizes NEAT1 to confer chemoresistance in gastric cancer.

Wang, Jiayao / Zhang, Jiehao / Liu, Hao / Meng, Lingnan / Gao, Xianchun / Zhao, Yihan / Wang, Chen / Gao, Xiaoliang / Fan, Ahui / Cao, Tianyu / Fan, Daiming / Zhao, Xiaodi / Lu, Yuanyuan

Cancer communications (London, England)

2024 Volume 44, Issue 4, Page(s) 469–490

Abstract: Background: Chemoresistance is a major cause of treatment failure in gastric cancer (GC). Heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) is an N6-methyladenosine (m: Methods: The expression of hnRNPA2B1 among public datasets were analyzed ... ...

Abstract	Background: Chemoresistance is a major cause of treatment failure in gastric cancer (GC). Heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) is an N6-methyladenosine (m Methods: The expression of hnRNPA2B1 among public datasets were analyzed and validated by quantitative PCR (qPCR), Western blotting, immunofluorescence, and immunohistochemical staining. The biological functions of hnRNPA2B1 in GC chemoresistance were investigated both in vitro and in vivo. RNA sequencing, methylated RNA immunoprecipitation, RNA immunoprecipitation, and RNA stability assay were performed to assess the association between hnRNPA2B1 and the binding RNA. The role of hnRNPA2B1 in maintenance of GC stemness was evaluated by bioinformatic analysis, qPCR, Western blotting, immunofluorescence, and sphere formation assays. The expression patterns of hnRNPA2B1 and downstream regulators in GC specimens from patients who received adjuvant chemotherapy were analyzed by RNAscope and multiplex immunohistochemistry. Results: Elevated expression of hnRNPA2B1 was found in GC cells and tissues, especially in multidrug-resistant (MDR) GC cell lines. The expression of hnRNPA2B1 was associated with poor outcomes of GC patients, especially in those who received 5-fluorouracil treatment. Silencing hnRNPA2B1 effectively sensitized GC cells to chemotherapy by inhibiting cell proliferation and inducing apoptosis both in vitro and in vivo. Mechanically, hnRNPA2B1 interacted with and stabilized long noncoding RNA NEAT1 in an m Conclusion: Our findings indicated that hnRNPA2B1 interacts with and stabilizes lncRNA NEAT1, which contribute to the maintenance of stemness property via Wnt/β-catenin pathway and exacerbate chemoresistance in GC.
MeSH term(s)	Humans ; Stomach Neoplasms/metabolism ; Drug Resistance, Neoplasm/genetics ; Cell Line, Tumor ; Heterogeneous-Nuclear Ribonucleoproteins ; RNA/pharmacology
Chemical Substances	Heterogeneous-Nuclear Ribonucleoproteins ; RNA (63231-63-0)
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ISSN	2523-3548
ISSN (online)	2523-3548
DOI	10.1002/cac2.12534
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Article: LncRNA HCG11 Facilitates Nasopharyngeal Carcinoma Progression Through Regulating miRNA-490-3p/MAP3K9 Axis.

Zheng, Jian / Zhao, Zhuochen / Ren, Huijun / Wang, Yongfeng / Meng, Xianchun / Zhang, Wenjing / Zhang, Cai / Ming, Liang / Lu, Xiubo

Frontiers in oncology

2022 Volume 12, Page(s) 872033

Abstract: Purpose: Long noncoding RNAs (LncRNAs) play complex but important roles in the progression of various tumors. This study aimed to elucidate the functional mechanisms of the HLA complex group 11 (HCG11) in nasopharyngeal carcinoma (NPC).: Patients and ... ...

Abstract	Purpose: Long noncoding RNAs (LncRNAs) play complex but important roles in the progression of various tumors. This study aimed to elucidate the functional mechanisms of the HLA complex group 11 (HCG11) in nasopharyngeal carcinoma (NPC). Patients and methods: HCG11 levels in NPC specimens were determined by fluorescence Results: HCG11 was highly expressed in NPC tissues and was positively associated with tumor stage, lymphatic metastasis, and poor prognosis. Functionally, HCG11 knockdown inhibited proliferation and migration and induced apoptosis of NPC cells. Mechanistically, miR-490-3p is a direct target of HCG11, oncogenic functions of HCG11 in NPC cell proliferation and migration can be partially reversed by the miR-490-3p inhibitor. HCG11 significantly increased mitogen-activated protein kinase MAPK kinase 9 (MAP3K9) levels by inhibiting miR-490-3p. Conclusion: HCG11 facilitates NPC progression
Language	English
Publishing date	2022-04-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.872033
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Article ; Online: [Gene cloning, heterologous expression and activity identification of latroeggtoxin-Ⅵ].

Yan, Shuai / Tang, Xiaochao / Yu, Dianmei / Wang, Haiyan / Meng, Wenwen / Tang, Pingping / Wang, Xianchun

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

2021 Volume 37, Issue 2, Page(s) 635–645

Abstract: One of the distinct characters of Latrodectus tredecimguttatus is that its toxic components exist not only in the venomous glands, but also in the tissues outside the venomous glands and even in the eggs. Investigation on the toxins outside the venomous ... ...

Abstract	One of the distinct characters of Latrodectus tredecimguttatus is that its toxic components exist not only in the venomous glands, but also in the tissues outside the venomous glands and even in the eggs. Investigation on the toxins outside the venomous glands can deepen our understanding of spider toxins and discover new lead molecules with important application prospects. In order to explore the low-abundance proteinaceous toxins in the L. tredecimguttatus eggs, we used bioinformatic strategies to mine a gene sequence encoding a peptide toxin from the transcriptome of L. tredecimguttatus eggs, and then heterologously expressed the gene successfully with a 3'-RACE combined with nest PCR strategy. Biological activity analyses indicated that the expressed peptide toxin, named latroeggtoxin-Ⅵ (LETX-Ⅵ), could inhibit Na⁺ channel currents in ND7/23 cells and promote dopamine release from PC12 cells, without obvious toxicity against Periplaneta americana and bacteria as well as fungi including Staphylococcus aureus and Candida albicans, demonstrating that LETX-Ⅵ is a mammal-specific neurotoxin with a potential application prospect in development of the tool reagents for neurobiological study and the drugs for treating related diseases.
MeSH term(s)	Animals ; Arthropod Proteins/genetics ; Black Widow Spider/genetics ; Cloning, Molecular ; Rats ; Spider Venoms/genetics ; Transcriptome
Chemical Substances	Arthropod Proteins ; Spider Venoms
Language	Chinese
Publishing date	2021-03-01
Publishing country	China
Document type	Journal Article
ZDB-ID	1042206-7
ISSN	1872-2075 ; 1042-749X
ISSN (online)	1872-2075
ISSN	1042-749X
DOI	10.13345/j.cjb.200245
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Article ; Online: An interprovincial input-output database distinguishing firm ownership in China from 1997 to 2017.

Chen, Quanrun / Gao, Yuning / Pan, Chen / Xu, Dingyi / Cai, Kun / Guan, Dabo / He, Qi / Li, Shantong / Liu, Wanqi / Meng, Bo / Wang, Zhi / Wang, Yang / Xu, Xianchun / Yang, Peihao / Zhang, Meichen / Zhou, Yuanqi

Scientific data

2023 Volume 10, Issue 1, Page(s) 293

Abstract: Input-Output (IO) data describing supply-demand relationships between buyers and sellers for goods and services within an economy have been used not only in economics but also in scientific, environmental, and interdisciplinary research. However, most ... ...

Abstract	Input-Output (IO) data describing supply-demand relationships between buyers and sellers for goods and services within an economy have been used not only in economics but also in scientific, environmental, and interdisciplinary research. However, most conventional IO data are highly aggregated, resulting in challenges for researchers and practitioners who face complex issues in large countries such as China, where firms within the same IO sector may have significant differences in technologies across subnational regions and different ownerships. This paper is the first attempt to compile China's interprovincial IO (IPIO) tables with separate information for mainland China-, Hong Kong, Macau, Taiwan-, and foreign-owned firms inside each province/industry pair. To do this, we collect relevant Chinese economic census data, firm surveys, product level Custom trade statistics, and firm value-added tax invoices and consistently integrate them into a 42-sector, 31-province IO account covering 5 benchmark years between 1997-2017. This work provides a solid foundation for a diverse range of innovative IO-based research in which firm heterogeneity information about location and ownership matters.
Language	English
Publishing date	2023-05-18
Publishing country	England
Document type	Dataset ; Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-023-02183-2
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Article ; Online: Antigen clearance at the peak of the primary immune response induces experimental autoimmune encephalomyelitis.

Zheng, Peiguo / Wei, Xufeng / Cao, Xuezhen / Ma, Panhong / Dong, Rui / Tang, Hongwei / Meng, Xianchun / Liu, Xinjing / Zhang, Cai / Zhang, Shuijun / Ming, Liang

European journal of immunology

2023 Volume 53, Issue 3, Page(s) e2250122

Abstract: Autoimmune demyelinating diseases can be induced by an immune response against myelin peptides; however, the exact mechanism underlying the development of such diseases remains unclear. In experimental autoimmune encephalomyelitis, we found that the ... ...

Abstract	Autoimmune demyelinating diseases can be induced by an immune response against myelin peptides; however, the exact mechanism underlying the development of such diseases remains unclear. In experimental autoimmune encephalomyelitis, we found that the clearance of exogenous myelin antigen at the peak of the primary immune response is key to the pathogenesis of the disease. The generation of effector T cells requires continuous antigen stimulation, whereas redundant antigen traps and exhausts effector T cells in the periphery, which induces resistance to the disease. Moreover, insufficient antigenic stimulation fails to induce disease efficiently owing to insufficient numbers of effector T cells. When myelin antigen is entirely cleared, the number of effector T cells reaches a peak, which facilitates infiltration of more effector T cells into the central nervous system. The peripheral antigen clearance initiates the first wave of effector T cell entry into the central nervous system and induces chronic inflammation. The inflamed central nervous system recruits the second wave of effector T cells that worsen inflammation, resulting in loss of self-tolerance. These findings provide new insights into the mechanism underlying the development of autoimmune demyelinating diseases, which may potentially impact future treatments.
MeSH term(s)	Animals ; Encephalomyelitis, Autoimmune, Experimental ; T-Lymphocytes ; Central Nervous System/pathology ; Inflammation ; Immunity
Language	English
Publishing date	2023-01-19
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.202250122
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