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Article ; Online: Determining the phosphorus release curve for Sunphase HT phytase in nursery pig diets.

Kim, Ty H / Gaffield, Katelyn N / Tokach, Mike D / DeRouchey, Joel M / Woodworth, Jason C / Goodband, Robert D / Gebhardt, Jordan T / Zhou, Ying / Song, Xuerong / Wu, Xiuyi

Translational animal science

2023 Volume 8, Page(s) txad140

Abstract: A total of 280 pigs (DNA 241 × 600, initially 10.4 ± 0.24 kg) were used in a 21-d study to determine the available P ( ...

Abstract	A total of 280 pigs (DNA 241 × 600, initially 10.4 ± 0.24 kg) were used in a 21-d study to determine the available P (
Language	English
Publishing date	2023-12-18
Publishing country	England
Document type	Journal Article
ISSN	2573-2102
ISSN (online)	2573-2102
DOI	10.1093/tas/txad140
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Article ; Online: Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders.

Koller, Dora / Friligkou, Eleni / Stiltner, Brendan / Pathak, Gita A / Løkhammer, Solveig / Levey, Daniel F / Zhou, Hang / Hatoum, Alexander S / Deak, Joseph D / Kember, Rachel L / Treur, Jorien L / Kranzler, Henry R / Johnson, Emma C / Stein, Murray B / Gelernter, Joel / Polimanti, Renato

Molecular psychiatry

2024

Abstract: Individuals suffering from chronic pain develop substance use disorders (SUDs) more often than others. Understanding the shared genetic influences underlying the comorbidity between chronic pain and SUDs will lead to a greater understanding of their ... ...

Abstract	Individuals suffering from chronic pain develop substance use disorders (SUDs) more often than others. Understanding the shared genetic influences underlying the comorbidity between chronic pain and SUDs will lead to a greater understanding of their biology. Genome-wide association statistics were obtained from the UK Biobank for multisite chronic pain (MCP, N
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-024-02446-3
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Article ; Online: The Camden Coalition Care Management Program Improved Intermediate Care Coordination: A Randomized Controlled Trial.

Finkelstein, Amy / Cantor, Joel C / Gubb, Jesse / Koller, Margaret / Truchil, Aaron / Zhou, Ruohua Annetta / Doyle, Joseph

Health affairs (Project Hope)

2023 Volume 43, Issue 1, Page(s) 131–139

Abstract: When a randomized evaluation finds null results, it is important to understand why. We investigated two very different explanations for the finding from a randomized evaluation that the Camden Coalition's influential care management program-which ... ...

Abstract	When a randomized evaluation finds null results, it is important to understand why. We investigated two very different explanations for the finding from a randomized evaluation that the Camden Coalition's influential care management program-which targeted high-use, high-need patients in Camden, New Jersey-did not reduce hospital readmissions. One explanation is that the program's underlying theory of change was not right, meaning that intensive care coordination may have been insufficient to change patient outcomes. Another explanation is a failure of implementation, suggesting that the program may have failed to achieve its goals but could have succeeded if it had been implemented with greater fidelity. To test these two explanations, we linked study participants to Medicaid data, which covered 561 (70 percent) of the original 800 participants, to examine the program's impact on facilitating postdischarge ambulatory care-a key element of care coordination. We found that the program increased ambulatory visits by 15 percentage points after fourteen days postdischarge, driven by an increase in primary care; these effects persisted through 365 days. These results suggest that care coordination alone may be insufficient to reduce readmissions for patients with high rates of hospital admissions and medically and socially complex conditions.
MeSH term(s)	United States ; Humans ; Aftercare ; Patient Discharge ; Hospitalization ; New Jersey ; Patient Readmission
Language	English
Publishing date	2023-12-20
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	632712-6
ISSN	1544-5208 ; 0278-2715
ISSN (online)	1544-5208
ISSN	0278-2715
DOI	10.1377/hlthaff.2023.01151
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Article ; Online: Longitudinal outcomes one year following implicit bias training in medical students.

Gill, Anne C / Zhou, Yuanyuan / Greely, Jocelyn T / Beasley, Anitra D / Purkiss, Joel / Juneja, Malvika

Medical teacher

2022 Volume 44, Issue 7, Page(s) 744–751

Abstract: Purpose: Training in implicit bias is broadly recognized as important in medical education and is mandated by some accrediting bodies. This study examined medical students' retention of concepts immediately following and one-year post participation in ... ...

Abstract	Purpose: Training in implicit bias is broadly recognized as important in medical education and is mandated by some accrediting bodies. This study examined medical students' retention of concepts immediately following and one-year post participation in an implicit bias workshop. Methods: Study subjects were 272 third-year medical students who participated in workshops held between 2018-2020 that used the Implicit Associations Test (IAT) as a trigger for discussions in small groups. We developed a survey and administered it to students to capture their awareness of implicit bias pre-, post-, and one-year post-workshop attendance. Repeated Measures Analyses and independent-samples t-tests were used to examine for differences in responses on each of the seven survey items and a tabulated 7-item average of these seven items. Results: Six of seven survey items and the tabulated 7-item average examined by Repeated Measures Analyses showed statistically significant increases between the pre-, post-, and one-year post-surveys ( Conclusions: The findings support one-year retention of knowledge and attitudes gained from an implicit bias workshop and suggest similar retention at two years. Future educational interventions that train learners to recognize and manage implicit and explicit behaviors in clinical practice are needed.
MeSH term(s)	Attitude of Health Personnel ; Bias, Implicit ; Education, Medical ; Humans ; Students, Medical ; Surveys and Questionnaires
Language	English
Publishing date	2022-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	424426-6
ISSN	1466-187X ; 0142-159X
ISSN (online)	1466-187X
ISSN	0142-159X
DOI	10.1080/0142159X.2021.2023120
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Article ; Online: Molecular polariton electroabsorption.

Cheng, Chiao-Yu / Krainova, Nina / Brigeman, Alyssa N / Khanna, Ajay / Shedge, Sapana / Isborn, Christine / Yuen-Zhou, Joel / Giebink, Noel C

Nature communications

2022 Volume 13, Issue 1, Page(s) 7937

Abstract: We investigate electroabsorption (EA) in organic semiconductor microcavities to understand whether strong light-matter coupling non-trivially alters their nonlinear optical [[Formula: see text]] response. Focusing on strongly-absorbing squaraine (SQ) ... ...

Abstract	We investigate electroabsorption (EA) in organic semiconductor microcavities to understand whether strong light-matter coupling non-trivially alters their nonlinear optical [[Formula: see text]] response. Focusing on strongly-absorbing squaraine (SQ) molecules dispersed in a wide-gap host matrix, we find that classical transfer matrix modeling accurately captures the EA response of low concentration SQ microcavities with a vacuum Rabi splitting of [Formula: see text] meV, but fails for high concentration cavities with [Formula: see text] meV. Rather than new physics in the ultrastrong coupling regime, however, we attribute the discrepancy at high SQ concentration to a nearly dark H-aggregate state below the SQ exciton transition, which goes undetected in the optical constant dispersion on which the transfer matrix model is based, but nonetheless interacts with and enhances the EA response of the lower polariton mode. These results indicate that strong coupling can be used to manipulate EA (and presumably other optical nonlinearities) from organic microcavities by controlling the energy of polariton modes relative to other states in the system, but it does not alter the intrinsic optical nonlinearity of the organic semiconductor inside the cavity.
Language	English
Publishing date	2022-12-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-35589-4
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Article ; Online: Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample.

Kember, Rachel L / Vickers-Smith, Rachel / Zhou, Hang / Xu, Heng / Jennings, Mariela / Dao, Cecilia / Davis, Lea / Sanchez-Roige, Sandra / Justice, Amy C / Gelernter, Joel / Vujkovic, Marijana / Kranzler, Henry R

The American journal of psychiatry

2023 Volume 180, Issue 8, Page(s) 584–593

Abstract: ... measured by the score on the consumption subscale of the Alcohol Use Disorders Identification Test [AUDIT-C ... loci associated with AUD and 22 loci associated with AUDIT-C score, including ancestry-specific and ... seven additional loci for AUD and eight additional loci for AUDIT-C score. Although the heterogeneity ...

Abstract	Objective: Recent genome-wide association studies (GWASs) of alcohol-related phenotypes have uncovered key differences in the underlying genetic architectures of alcohol consumption and alcohol use disorder (AUD), with the two traits having opposite genetic correlations with psychiatric disorders. Understanding the genetic factors that underlie the transition from heavy drinking to AUD has important theoretical and clinical implications. Methods: The authors used longitudinal data from the cross-ancestry Million Veteran Program sample to identify 1) novel loci associated with AUD and alcohol consumption (measured by the score on the consumption subscale of the Alcohol Use Disorders Identification Test [AUDIT-C]), 2) the impact of phenotypic variation on genetic discovery, and 3) genetic variants with direct effects on AUD that are not mediated through alcohol consumption. Results: The authors identified 26 loci associated with AUD and 22 loci associated with AUDIT-C score, including ancestry-specific and novel loci. In secondary GWASs that excluded individuals who report abstinence, the authors identified seven additional loci for AUD and eight additional loci for AUDIT-C score. Although the heterogeneity of the abstinent group biases the GWAS findings, unique variance between alcohol consumption and disorder remained after the abstinent group was excluded. Finally, using mediation analysis, the authors identified a set of variants with effects on AUD that are not mediated through alcohol consumption. Conclusions: Differences in genetic architecture between alcohol consumption and AUD are consistent with their having different biological contributions. Genetic variants with direct effects on AUD are potentially relevant to understanding the transition from heavy alcohol consumption to AUD and may be targets for translational prevention and treatment efforts.
MeSH term(s)	Humans ; Alcoholism/genetics ; Genome-Wide Association Study ; Alcohol Drinking/genetics ; Phenotype ; Veterans
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280045-7
ISSN	1535-7228 ; 0002-953X
ISSN (online)	1535-7228
ISSN	0002-953X
DOI	10.1176/appi.ajp.21090892
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Article ; Online: A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan.

Su, Yijing / Zhou, Yi / Bennett, Mariko L / Li, Shiying / Carceles-Cordon, Marc / Lu, Lu / Huh, Sooyoung / Jimenez-Cyrus, Dennisse / Kennedy, Benjamin C / Kessler, Sudha K / Viaene, Angela N / Helbig, Ingo / Gu, Xiaosong / Kleinman, Joel E / Hyde, Thomas M / Weinberger, Daniel R / Nauen, David W / Song, Hongjun / Ming, Guo-Li

Cell stem cell

2023 Volume 30, Issue 1, Page(s) 113

Language	English
Publishing date	2023-01-04
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2375354-7
ISSN	1875-9777 ; 1934-5909
ISSN (online)	1875-9777
ISSN	1934-5909
DOI	10.1016/j.stem.2022.12.007
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Zs.A 6589: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program.

Cheng, Youshu / Dao, Cecilia / Zhou, Hang / Li, Boyang / Kember, Rachel L / Toikumo, Sylvanus / Zhao, Hongyu / Gelernter, Joel / Kranzler, Henry R / Justice, Amy C / Xu, Ke

Translational psychiatry

2023 Volume 13, Issue 1, Page(s) 148

Abstract: Smoking behaviors and alcohol use disorder (AUD), both moderately heritable traits, commonly co-occur in the general population. Single-trait genome-wide association studies (GWAS) have identified multiple loci for smoking and AUD. However, GWASs that ... ...

Abstract	Smoking behaviors and alcohol use disorder (AUD), both moderately heritable traits, commonly co-occur in the general population. Single-trait genome-wide association studies (GWAS) have identified multiple loci for smoking and AUD. However, GWASs that have aimed to identify loci contributing to co-occurring smoking and AUD have used small samples and thus have not been highly informative. Applying multi-trait analysis of GWASs (MTAG), we conducted a joint GWAS of smoking and AUD with data from the Million Veteran Program (N = 318,694). By leveraging GWAS summary statistics for AUD, MTAG identified 21 genome-wide significant (GWS) loci associated with smoking initiation and 17 loci associated with smoking cessation compared to 16 and 8 loci, respectively, identified by single-trait GWAS. The novel loci for smoking behaviors identified by MTAG included those previously associated with psychiatric or substance use traits. Colocalization analysis identified 10 loci shared by AUD and smoking status traits, all of which achieved GWS in MTAG, including variants on SIX3, NCAM1, and near DRD2. Functional annotation of the MTAG variants highlighted biologically important regions on ZBTB20, DRD2, PPP6C, and GCKR that contribute to smoking behaviors. In contrast, MTAG of smoking behaviors and alcohol consumption (AC) did not enhance discovery compared with single-trait GWAS for smoking behaviors. We conclude that using MTAG to augment the power of GWAS enables the identification of novel genetic variants for commonly co-occuring phenotypes, providing new insights into their pleiotropic effects on smoking behavior and AUD.
MeSH term(s)	Humans ; Genome-Wide Association Study ; Alcoholism/genetics ; Veterans ; Phenotype ; Alcohol Drinking/genetics ; Smoking/genetics ; Polymorphism, Single Nucleotide ; Genetic Predisposition to Disease
Language	English
Publishing date	2023-05-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2609311-X
ISSN	2158-3188 ; 2158-3188
ISSN (online)	2158-3188
ISSN	2158-3188
DOI	10.1038/s41398-023-02409-2
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Article ; Online: Draft genome sequence of two "Candidatus Intestinicoccus colisanans" strains isolated from faeces of healthy humans.

Zhou, Joyce / Boyd, Joel A / Nyeverecz, Bozica / Vivian, Charlotte / Angel, Nicola / Wood, David L A / Hugenholtz, Philip / Tyson, Gene W / Krause, Lutz / Ó Cuív, Páraic

BMC research notes

2023 Volume 16, Issue 1, Page(s) 174

Abstract: ... to range in size from 2.9 to 3.3 Mb with a G + C content of approximately 51%. The gene repertoire ...

Abstract	Objectives: In order to provide a better insight into the functional capacity of the human gut microbiome, we isolated a novel bacterium, "Candidatus Intestinicoccus colisanans" gen. nov. sp. nov., and performed whole genome sequencing. This study will provide new insights into the functional potential of this bacterium and its role in modulating host health and well-being. We expect that this data resource will be useful in providing additional insight into the diversity and functional potential of the human microbiome. Data description: Here, we report the first draft genome sequences of "Candidatus Intestinicoccus colisanans" strains MH27-1 and MH27-2, recovered from faeces collected from healthy human donors. The genomes were sequenced using short-read Illumina technology and whole-genome-based comparisons and phylogenomics reconstruction indicate that "Candidatus Intestinicoccus colisanans" represents a novel genus and species within the family Acutalibacteraceae. Both genomes were estimated to be > 98% completed and to range in size from 2.9 to 3.3 Mb with a G + C content of approximately 51%. The gene repertoire of "Candidatus Intestinicoccus colisanans" indicate it is likely a saccharolytic gut bacterium.
MeSH term(s)	Humans ; Feces ; Gastrointestinal Microbiome/genetics ; Health Status ; Phylogeny ; Tissue Donors
Language	English
Publishing date	2023-08-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2413336-X
ISSN	1756-0500 ; 1756-0500
ISSN (online)	1756-0500
ISSN	1756-0500
DOI	10.1186/s13104-023-06447-3
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Article ; Online: A multi-ancestry genetic study of pain intensity in 598,339 veterans.

Toikumo, Sylvanus / Vickers-Smith, Rachel / Jinwala, Zeal / Xu, Heng / Saini, Divya / Hartwell, Emily E / Pavicic, Mirko / Sullivan, Kyle A / Xu, Ke / Jacobson, Daniel A / Gelernter, Joel / Rentsch, Christopher T / Stahl, Eli / Cheatle, Martin / Zhou, Hang / Waxman, Stephen G / Justice, Amy C / Kember, Rachel L / Kranzler, Henry R

Nature medicine

2024 Volume 30, Issue 4, Page(s) 1075–1084

Abstract: Chronic pain is a common problem, with more than one-fifth of adult Americans reporting pain daily or on most days. It adversely affects the quality of life and imposes substantial personal and economic costs. Efforts to treat chronic pain using opioids ... ...

Abstract	Chronic pain is a common problem, with more than one-fifth of adult Americans reporting pain daily or on most days. It adversely affects the quality of life and imposes substantial personal and economic costs. Efforts to treat chronic pain using opioids had a central role in precipitating the opioid crisis. Despite an estimated heritability of 25-50%, the genetic architecture of chronic pain is not well-characterized, in part because studies have largely been limited to samples of European ancestry. To help address this knowledge gap, we conducted a cross-ancestry meta-analysis of pain intensity in 598,339 participants in the Million Veteran Program, which identified 126 independent genetic loci, 69 of which are new. Pain intensity was genetically correlated with other pain phenotypes, level of substance use and substance use disorders, other psychiatric traits, education level and cognitive traits. Integration of the genome-wide association studies findings with functional genomics data shows enrichment for putatively causal genes (n = 142) and proteins (n = 14) expressed in brain tissues, specifically in GABAergic neurons. Drug repurposing analysis identified anticonvulsants, β-blockers and calcium-channel blockers, among other drug groups, as having potential analgesic effects. Our results provide insights into key molecular contributors to the experience of pain and highlight attractive drug targets.
MeSH term(s)	Adult ; Humans ; Chronic Pain/drug therapy ; Chronic Pain/genetics ; Veterans ; Genome-Wide Association Study/methods ; Pain Measurement ; Quality of Life ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide/genetics
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Meta-Analysis ; Journal Article
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-024-02839-5
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