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Article ; Online: Multiparametric MRI Radiomics for the Identification of HER2-Low Breast Cancers.

Du, Siyao / Gao, Si / Wang, Mengfan / Zhang, Lina

2024 Volume 310, Issue 1, Page(s) e232092

MeSH term(s)	Humans ; Female ; Breast Neoplasms/diagnostic imaging ; Multiparametric Magnetic Resonance Imaging ; Radiomics
Language	English
Publishing date	2024-01-01
Publishing country	United States
Document type	Letter
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.232092
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Article ; Online: Time Course Changes of Synthetic Relaxation Time During Neoadjuvant Chemotherapy in Breast Cancer: The Optimal Parameter for Treatment Response Evaluation.

Zhao, Ruimeng / Du, Siyao / Gao, Si / Shi, Jing / Zhang, Lina

Journal of magnetic resonance imaging : JMRI

2023 Volume 58, Issue 4, Page(s) 1290–1302

Abstract: Background: Synthetic MRI (syMRI) has enabled quantification of multiple relaxation parameters (T1/T2 relaxation time [T1/T2], proton density [PD]), and their longitudinal change during neoadjuvant chemotherapy (NAC) promises to be valuable parameters ... ...

Abstract	Background: Synthetic MRI (syMRI) has enabled quantification of multiple relaxation parameters (T1/T2 relaxation time [T1/T2], proton density [PD]), and their longitudinal change during neoadjuvant chemotherapy (NAC) promises to be valuable parameters for treatment response evaluation in breast cancer. Purpose: To investigate the time course changes of syMRI parameters during NAC and evaluate their value as predictors for pathological complete response (pCR) in breast cancer. Study type: Retrospective, longitudinal. Population: A total of 129 women (median age, 50 years; range, 28-69 years) with locally advanced breast cancer who underwent NAC; all performed multiple conventional breast MRI examinations with added syMRI during NAC. Field strength/sequence: A 3.0 T, T1-weighted dynamic contrast enhanced and syMRI acquired by a multiple-dynamic, multiple-echo sequence. Assessment: Breast MRI was set at four time-points: baseline, after one cycle, after three or four cycles of NAC and preoperation. SyMRI parameters and tumor diameters were measured and their changes from baseline were calculated. All parameters were compared between pCR and non-pCR. Interaction between syMRI parameters and clinicopathological features was analyzed. Statistical tests: Mann-Whitney U tests, random effects model of repeated measurement, receiver operating characteristic (ROC) analysis, interaction analysis. Results: Median synthetic T1/T2/PD and tumor diameter generally decreased throughout NAC. Absolute T1 at early-NAC, T1, and PD at mid-NAC were significantly lower in the pCR group. After early-NAC, the T1 change was significantly higher in the pCR (median ± IQR, 18.17 ± 11.33) than the non-pCR group (median ± IQR, 10.90 ± 10.03), with the highest area under the ROC curves (AUC) of 0.769 (95% CI, 0.684-0.838). Interaction analysis showed that histological grade III patients had higher odds ratio (OR) (OR = 1.206) compared to grade II patients (OR = 1.067). Data conclusion: Synthetic T1 changes after one cycle of NAC maybe useful for early evaluating NAC response in breast cancer during whole treatment cycles. However, its discriminative ability is significantly affected by histological grade. Evidence level: 4 TECHNICAL EFFICACY: Stage 2.
MeSH term(s)	Humans ; Female ; Middle Aged ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Neoadjuvant Therapy ; Retrospective Studies ; Magnetic Resonance Imaging ; Breast/diagnostic imaging ; Breast/pathology ; Treatment Outcome
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.28597
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Zs.A 3648: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Impact of pupil and defocus ring intersection area on retinal defocus.

Guo, Yujuan / Zhang, Mingxu / Tong, Yuting / Ma, Xiaoqi / Wang, Siyao / Li, Yu / Du, Yuqin / Zhou, Yuehua

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

2024 Volume 44, Issue 2, Page(s) 472–480

Abstract: Purpose: With the rising prevalence of myopia, especially among the young, orthokeratology (Ortho-K) stands out as a promising approach, not only to reduce myopia but also to control the progression of axial length (AL). This study examined how the ... ...

Abstract	Purpose: With the rising prevalence of myopia, especially among the young, orthokeratology (Ortho-K) stands out as a promising approach, not only to reduce myopia but also to control the progression of axial length (AL). This study examined how the intersection area between the pupil and defocus ring influenced retinal defocus and axial growth after Ortho-K. Methods: A case-control study was conducted with 100 participants (100 eyes). Both AL and the refraction difference value (RDV), that is, the peripheral refractive error measured with respect to the central value after wearing Ortho-K lenses, were determined. Subjects were categorised into two groups based on the size of the intersection area after 3 months of lens wear: Group A (<4.58 mm Results: Group B demonstrated significantly lower changes in AL and RDV at 30-40° and 40-53° compared with Group A after 3 months of lens wear (all p < 0.05). After 6 months of lens wear, Group B showed significantly lower changes in AL and RDV in the 40-53° region compared with Group A (all p < 0.05). Correlation analysis revealed that as the intersection area increased, the changes in AL and RDV at 0-53°, 30-40° and 40-53° eccentricity decreased after both 3 and 6 months of lens wear (all p < 0.01). Conclusions: A larger intersection area between the pupil and defocus ring within a certain time period can cause a greater amount of myopic defocus at 30-53° from the fovea. The results suggest that a larger intersection area might lead to more effective control of axial growth.
MeSH term(s)	Humans ; Pupil ; Case-Control Studies ; Myopia ; Retina ; Refractive Errors ; Refraction, Ocular ; Axial Length, Eye ; Orthokeratologic Procedures/methods
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	604564-9
ISSN	1475-1313 ; 0275-5408
ISSN (online)	1475-1313
ISSN	0275-5408
DOI	10.1111/opo.13276
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Article ; Online: MRI-based tumor shrinkage patterns after early neoadjuvant therapy in breast cancer: correlation with molecular subtypes and pathological response after therapy.

Wang, Mengfan / Du, Siyao / Gao, Si / Zhao, Ruimeng / Liu, Shasha / Jiang, Wenhong / Peng, Can / Chai, Ruimei / Zhang, Lina

Breast cancer research : BCR

2024 Volume 26, Issue 1, Page(s) 26

Abstract: Background: MRI-based tumor shrinkage patterns (TSP) after neoadjuvant therapy (NAT) have been associated with pathological response. However, the understanding of TSP after early NAT remains limited. We aimed to analyze the relationship between TSP ... ...

Abstract	Background: MRI-based tumor shrinkage patterns (TSP) after neoadjuvant therapy (NAT) have been associated with pathological response. However, the understanding of TSP after early NAT remains limited. We aimed to analyze the relationship between TSP after early NAT and pathological response after therapy in different molecular subtypes. Methods: We prospectively enrolled participants with invasive ductal breast cancers who received NAT and performed pretreatment DCE-MRI from September 2020 to August 2022. Early-stage MRIs were performed after the first (1st-MRI) and/or second (2nd-MRI) cycle of NAT. Tumor shrinkage patterns were categorized into four groups: concentric shrinkage, diffuse decrease (DD), decrease of intensity only (DIO), and stable disease (SD). Logistic regression analysis was performed to identify independent variables associated with pathologic complete response (pCR), and stratified analysis according to tumor hormone receptor (HR)/human epidermal growth factor receptor 2 (HER2) disease subtype. Results: 344 participants (mean age: 50 years, 113/345 [33%] pCR) with 345 tumors (1 bilateral) had evaluable 1st-MRI or 2nd-MRI to comprise the primary analysis cohort, of which 244 participants with 245 tumors had evaluable 1st-MRI (82/245 [33%] pCR) and 206 participants with 207 tumors had evaluable 2nd-MRI (69/207 [33%] pCR) to comprise the 1st- and 2nd-timepoint subgroup analysis cohorts, respectively. In the primary analysis, multivariate analysis showed that early DD pattern (OR = 12.08; 95% CI 3.34-43.75; p < 0.001) predicted pCR independently of the change in tumor size (OR = 1.37; 95% CI 0.94-2.01; p = 0.106) in HR Conclusion: The diffuse decrease pattern in HR Trial registration: Trial registration at https://www.chictr.org.cn/ . Registration number: ChiCTR2000038578, registered September 24, 2020.
MeSH term(s)	Humans ; Middle Aged ; Female ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Triple Negative Breast Neoplasms/diagnostic imaging ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/genetics ; Neoadjuvant Therapy ; Treatment Outcome ; Receptor, ErbB-2/genetics ; Magnetic Resonance Imaging ; Predictive Value of Tests ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Retrospective Studies
Chemical Substances	Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2015059-3
ISSN	1465-542X ; 1465-5411
ISSN (online)	1465-542X
ISSN	1465-5411
DOI	10.1186/s13058-024-01781-1
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Article ; Online: Compressible polydopamine modified pomelo peel powder/poly(ethyleneimine)/κ-carrageenan aerogel with pH-tunable charge for selective removal of anionic and cationic dyes.

Yu, Jincheng / Tian, Siyao / Yao, Anrong / Hu, Haoyi / Lan, Jianwu / Yang, Lin / Du, Xiaosheng / Lin, Shaojian

Carbohydrate polymers

2023 Volume 323, Page(s) 121377

Abstract: In this work, a novel biomass-based aerogel, polydopamine decorated pomelo peel powder/polyethyleneimine/κ-carrageenan (PPEKC) aerogel, was developed for dye wastewater treatment. The as-prepared PPEKC aerogel possessed a robust structure and good ... ...

Abstract	In this work, a novel biomass-based aerogel, polydopamine decorated pomelo peel powder/polyethyleneimine/κ-carrageenan (PPEKC) aerogel, was developed for dye wastewater treatment. The as-prepared PPEKC aerogel possessed a robust structure and good compressible resilience. As expected, this aerogel presented remarkable efficacy in eliminating both anionic and cationic dyes. The experimental maximum adsorption capacities were 2016.7 mg g
Language	English
Publishing date	2023-09-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2023.121377
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Article: Development of a human-size magnetic particle imaging device for sentinel lymph node biopsy of breast cancer.

Bai, Shi / Gai, Lingke / Zhang, Qinyang / Kang, Yue / Liu, Zhiyao / He, Yuan / Liu, Wenzhong / Jiang, Tao / Du, Zhongzhou / Du, Siyao / Gao, Si / Zhang, Min / Li, Tianshu

Frontiers in bioengineering and biotechnology

2024 Volume 12, Page(s) 1327521

Abstract: In this study, a novel human-size handheld magnetic particle imaging (MPI) system was developed for the high-precision detection of sentinel lymph nodes for breast cancer. The system consisted of a highly sensitive home-made MPI detection probe, a set of ...

Abstract	In this study, a novel human-size handheld magnetic particle imaging (MPI) system was developed for the high-precision detection of sentinel lymph nodes for breast cancer. The system consisted of a highly sensitive home-made MPI detection probe, a set of concentric coils pair for spatialization, a solenoid coil for uniform excitation at 8 kHz@1.5 mT, and a full mirrored coil set positioned far away from the scanning area. The mirrored coils formed an extremely effective differential pickup structure which suppressed the system noise as high as 100 dB. The different combination of the inner and outer gradient current made the field free point (FFP) move in the Z direction with a uniform intensity of 0.54T/m, while the scanning in the XY direction was implemented mechanically. The third-harmonic signal of the Superparamagnetic Iron Oxide Nanoparticles (SPIONs) at the FFP was detected and then reconstructed synchronously with the current changes. Experiment results showed that the tomographic detection limit was 30 mm in the Z direction, and the sensitivity was about 10 μg Fe SPIONs at 40 mm distance with a spatial resolution of about 5 mm. In the rat experiment, 54 μg intramuscular injected SPIONs were detected successfully in the sentinel lymph node, in which the tracer content was about 1.2% total injected Fe. Additionally, the effective detection time window was confirmed from 4 to 6 min after injection. Relevant clinical ethics are already in the application process. Large mammalian SLNB MPI experiments and 3D preoperative SLNB imaging will be performed in the future.
Language	English
Publishing date	2024-02-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2024.1327521
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Article ; Online: Small-Molecule Allosteric Inhibitors of Human Aspartate Transcarbamoylase Suppress Proliferation of Bone Osteosarcoma Epithelial Cells.

Wang, Chao / Zhang, Bidong / Cong, Yingying / Du, Xiaochen / Chen, Siyao / Visser, Lidia / Ruiz-Moreno, Angel / Zhang, Lili / Reggiori, Fulvio / Alexander, Domling / Groves, Matthew Robert

ChemMedChem

2024 , Page(s) e202300688

Abstract: Aspartate transcarbamoylase (ATC) is the first committed step in de novo pyrimidine biosynthesis in eukaryotes and plants. A potent transition state analog of human ATCase (PALA) has previously been assessed in clinical trials for the treatment of cancer, ...

Abstract	Aspartate transcarbamoylase (ATC) is the first committed step in de novo pyrimidine biosynthesis in eukaryotes and plants. A potent transition state analog of human ATCase (PALA) has previously been assessed in clinical trials for the treatment of cancer, but was ultimately unsuccessful. Additionally, inhibition of this pathway has been proposed to be a target to suppress cell proliferation in E. coli, the malarial parasite and tuberculosis. In this manuscript we screened a 70-member library of ATC inhibitors developed against the malarial and tubercular ATCases for inhibitors of the human ATC. Four compounds showed low nanomolar inhibition (IC50 30-120 nM) in an in vitro activity assay. These compounds significantly outperform PALA, which has a triphasic inhibition response under identical conditions, in which significant activity remains at PALA concentrations above 10 μM. Evidence for a druggable allosteric pocket in human ATC is provided by both in vitro enzyme kinetic, homology modeling and in silico docking. These compounds also suppress the proliferation of U2OS osteoblastoma cells by promoting cell cycle arrest in G0/G1 phase. This report provides the first evidence for an allosteric pocket in human ATC, which greatly enhances its druggability and demonstrates the potential of this series in cancer therapy.
Language	English
Publishing date	2024-04-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2218496-X
ISSN	1860-7187 ; 1860-7179
ISSN (online)	1860-7187
ISSN	1860-7179
DOI	10.1002/cmdc.202300688
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Article ; Online: Microplastics in three types of human arteries detected by pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS).

Liu, Sheng / Wang, Chenyang / Yang, Yunxiao / Du, Zhiyong / Li, Li / Zhang, Meng / Ni, Siyao / Yue, Zhijian / Yang, Kexin / Wang, Yu / Li, Xinxin / Yang, Yaochen / Qin, Yanwen / Li, Jianrong / Yang, Yaoguo / Zhang, Ming

Journal of hazardous materials

2024 Volume 469, Page(s) 133855

Abstract: Microplastics are ubiquitous in the environment. Human body can be exposed to microplastics through inhalation and ingestion and some microplastics can enter the blood and accumulate in various tissues and organs throughout the body. Animal experiments ... ...

Abstract	Microplastics are ubiquitous in the environment. Human body can be exposed to microplastics through inhalation and ingestion and some microplastics can enter the blood and accumulate in various tissues and organs throughout the body. Animal experiments have suggested that microplastics may promote atherosclerosis. However, data on microplastics in human arteries and clinical evidence supporting a link between microplastics and atherosclerosis are currently lacking. Pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) was used in this study to detect microplastics in three types of human arteries: coronary and carotid arteries with atherosclerotic plaques, as well as the aorta without plaques. Microplastics were detected in all 17 arterial samples, with an average concentration of 118.66 ± 53.87 μg/g tissue. Four types of microplastics were identified: polyethylene terephthalate (PET, 73.70%), polyamide-66 (PA-66, 15.54%), polyvinyl chloride (PVC, 9.69%), and polyethylene (PE, 1.07%). Most importantly, the concentration of microplastics in arteries containing atherosclerotic plaques, both coronary arteries (156.50 ± 42.14 vs. 76.26 ± 14.86 μg/g tissue, P = 0.039), and carotid arteries (133.37 ± 60.52 vs. 76.26 ± 14.86 μg/g tissue, P = 0.015), was significantly higher than that in aortas which did not contain atherosclerotic plaques, suggesting that microplastics might be associated with atherosclerosis in humans. This study provides valuable data for further hazard assessments of microplastics on human cardiovascular health.
MeSH term(s)	Humans ; Microplastics ; Plastics/analysis ; Plaque, Atherosclerotic ; Pyrolysis ; Arteries/chemistry ; Atherosclerosis ; Gas Chromatography-Mass Spectrometry ; Water Pollutants, Chemical/chemistry
Chemical Substances	Microplastics ; Plastics ; Water Pollutants, Chemical
Language	English
Publishing date	2024-02-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2024.133855
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Article ; Online: Clogging and Water Quality Change Effects of Typical Metal Pollutants under Intermittent Managed Aquifer Recharge Using Urban Stormwater

Siyao Ma / Yalin Song / Xueyan Ye / Xinqiang Du / Jingjia Ma

International Journal of Environmental Research and Public Health, Vol 18, Iss 13272, p

2021 Volume 13272

Abstract: Managed aquifer recharge (MAR) using urban stormwater facilitates relieving water supply pressure, restoring the ecological environment, and developing sustainable water resources. However, compared to conventional water sources, such as river water and ... ...

Abstract	Managed aquifer recharge (MAR) using urban stormwater facilitates relieving water supply pressure, restoring the ecological environment, and developing sustainable water resources. However, compared to conventional water sources, such as river water and lake water, MAR using urban stormwater is a typically intermittent recharge mode. In order to study the clogging and water quality change effects of Fe, Zn, and Pb, the typical mental pollutants in urban stormwater, a series of intermittent MAR column experiments were performed. The results show that the type of pollutant, the particle size of the medium and the intermittent recharge mode have significant impacts on the pollutant retention and release, which has led to different clogging and water quality change effects. The metals that are easily retained in porous media have greater potential for clogging and less potential for groundwater pollution. The fine medium easily becomes clogged, but it is beneficial in preventing groundwater contamination. There is a higher risk of groundwater contamination for a shallow buried aquifer under intermittent MAR than continuous MAR, mainly because of the de-clogging effect of porous media during the intermittent period.
Keywords	clogging ; water quality change ; urban stormwater ; intermittent MAR ; metal contamination ; Medicine ; R
Subject code	333
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Clogging and Water Quality Change Effects of Typical Metal Pollutants under Intermittent Managed Aquifer Recharge Using Urban Stormwater.

Ma, Siyao / Song, Yalin / Ye, Xueyan / Du, Xinqiang / Ma, Jingjia

International journal of environmental research and public health

2021 Volume 18, Issue 24

Abstract	Managed aquifer recharge (MAR) using urban stormwater facilitates relieving water supply pressure, restoring the ecological environment, and developing sustainable water resources. However, compared to conventional water sources, such as river water and lake water, MAR using urban stormwater is a typically intermittent recharge mode. In order to study the clogging and water quality change effects of Fe, Zn, and Pb, the typical mental pollutants in urban stormwater, a series of intermittent MAR column experiments were performed. The results show that the type of pollutant, the particle size of the medium and the intermittent recharge mode have significant impacts on the pollutant retention and release, which has led to different clogging and water quality change effects. The metals that are easily retained in porous media have greater potential for clogging and less potential for groundwater pollution. The fine medium easily becomes clogged, but it is beneficial in preventing groundwater contamination. There is a higher risk of groundwater contamination for a shallow buried aquifer under intermittent MAR than continuous MAR, mainly because of the de-clogging effect of porous media during the intermittent period.
MeSH term(s)	Environmental Pollutants ; Groundwater ; Metals ; Water Pollutants, Chemical/analysis ; Water Quality ; Water Supply
Chemical Substances	Environmental Pollutants ; Metals ; Water Pollutants, Chemical
Language	English
Publishing date	2021-12-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph182413272
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