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  1. Article ; Online: Child Mind Institute Summit: Telehealth and the Coronavirus.

    Ruhle, Stephanie / Koplewicz, Harold S / Harris, Nadine Burke

    Journal of child and adolescent psychopharmacology

    2021  Volume 31, Issue 4, Page(s) 315–321

    MeSH term(s) Adolescent ; COVID-19 ; Child ; Child Health ; Child, Preschool ; Humans ; Infant ; Mental Health ; Pandemics ; Telemedicine ; Young Adult
    Language English
    Publishing date 2021-05-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1055410-5
    ISSN 1557-8992 ; 1044-5463
    ISSN (online) 1557-8992
    ISSN 1044-5463
    DOI 10.1089/cap.2021.29201.rdt
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3091: Show issues Location:
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  2. Article ; Online: Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cells.

    Albanese, Manuel / Chen, Hong-Ru / Gapp, Madeleine / Muenchhoff, Maximilian / Yang, Hsiu-Hui / Peterhoff, David / Hoffmann, Katja / Xiao, Qianhao / Ruhle, Adrian / Ambiel, Ina / Schneider, Stephanie / Mejías-Pérez, Ernesto / Stern, Marcel / Wratil, Paul R / Hofmann, Katharina / Amann, Laura / Jocham, Linda / Fuchs, Thimo / Ulivi, Alessandro F /
    Besson-Girard, Simon / Weidlich, Simon / Schneider, Jochen / Spinner, Christoph D / Sutter, Kathrin / Dittmer, Ulf / Humpe, Andreas / Baumeister, Philipp / Wieser, Andreas / Rothenfusser, Simon / Bogner, Johannes / Roider, Julia / Knolle, Percy / Hengel, Hartmut / Wagner, Ralf / Laketa, Vibor / Fackler, Oliver T / Keppler, Oliver T

    Cell reports. Medicine

    2024  Volume 5, Issue 4, Page(s) 101483

    Abstract: Immune cell phenotyping frequently detects lineage-unrelated receptors. Here, we report that surface receptors can be transferred from primary macrophages to CD4 T cells and identify the Fcγ receptor CD32 as driver and cargo of this trogocytotic transfer. ...

    Abstract Immune cell phenotyping frequently detects lineage-unrelated receptors. Here, we report that surface receptors can be transferred from primary macrophages to CD4 T cells and identify the Fcγ receptor CD32 as driver and cargo of this trogocytotic transfer. Filamentous CD32
    MeSH term(s) Humans ; CD4-Positive T-Lymphocytes ; HIV-1 ; Receptors, IgG/metabolism ; Autoantibodies/metabolism ; Trogocytosis ; HIV Infections ; HIV Seropositivity
    Chemical Substances Receptors, IgG ; Autoantibodies
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2024.101483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Development of PSMA-PET-guided CT-based radiomic signature to predict biochemical recurrence after salvage radiotherapy.

    Spohn, Simon K B / Schmidt-Hegemann, Nina-Sophie / Ruf, Juri / Mix, Michael / Benndorf, Matthias / Bamberg, Fabian / Makowski, Marcus R / Kirste, Simon / Rühle, Alexander / Nouvel, Jerome / Sprave, Tanja / Vogel, Marco M E / Galitsnaya, Polina / Gschwend, Jürgen E / Gratzke, Christian / Stief, Christian / Löck, Steffen / Zwanenburg, Alex / Trapp, Christian /
    Bernhardt, Denise / Nekolla, Stephan G / Li, Minglun / Belka, Claus / Combs, Stephanie E / Eiber, Matthias / Unterrainer, Lena / Unterrainer, Marcus / Bartenstein, Peter / Grosu, Anca-L / Zamboglou, Constantinos / Peeken, Jan C

    European journal of nuclear medicine and molecular imaging

    2023  Volume 50, Issue 8, Page(s) 2537–2547

    Abstract: Purpose: To develop a CT-based radiomic signature to predict biochemical recurrence (BCR) in prostate cancer patients after sRT guided by positron-emission tomography targeting prostate-specific membrane antigen (PSMA-PET).: Material and methods: ... ...

    Abstract Purpose: To develop a CT-based radiomic signature to predict biochemical recurrence (BCR) in prostate cancer patients after sRT guided by positron-emission tomography targeting prostate-specific membrane antigen (PSMA-PET).
    Material and methods: Consecutive patients, who underwent
    Results: Among 99 patients, median interval until BCR was the radiomic models outperformed clinical models and combined clinical-radiomic models for prediction of BCR with a C-index of 0.71 compared to 0.53 and 0.63 in the test sets, respectively. In contrast to the other models, the radiomic model achieved significantly improved patient stratification in Kaplan-Meier analysis. The radiomic and clinical-radiomic model achieved a significantly better time-dependent net reclassification improvement index (0.392 and 0.762, respectively) compared to the clinical model. Decision curve analysis demonstrated a clinical net benefit for both models. Mean intensity was the most predictive radiomic feature.
    Conclusion: This is the first study to develop a PSMA-PET-guided CT-based radiomic model to predict BCR after sRT. The radiomic models outperformed clinical models and might contribute to guide personalized treatment decisions.
    MeSH term(s) Male ; Humans ; Gallium Radioisotopes ; Gallium Isotopes ; Positron Emission Tomography Computed Tomography/methods ; Prostatectomy ; Neoplasm Recurrence, Local/diagnostic imaging ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/surgery
    Chemical Substances Gallium Radioisotopes ; Gallium Isotopes
    Language English
    Publishing date 2023-03-16
    Publishing country Germany
    Document type Multicenter Study ; Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-023-06195-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1227: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Evidence for increased SARS-CoV-2 susceptibility and COVID-19 severity related to pre-existing immunity to seasonal coronaviruses.

    Wratil, Paul R / Schmacke, Niklas A / Karakoc, Burak / Dulovic, Alex / Junker, Daniel / Becker, Matthias / Rothbauer, Ulrich / Osterman, Andreas / Spaeth, Patricia M / Ruhle, Adrian / Gapp, Madeleine / Schneider, Stephanie / Muenchhoff, Maximilian / Hellmuth, Johannes C / Scherer, Clemens / Mayerle, Julia / Reincke, Martin / Behr, Juergen / Kääb, Stefan /
    Zwissler, Bernhard / von Bergwelt-Baildon, Michael / Eberle, Josef / Kaderali, Lars / Schneiderhan-Marra, Nicole / Hornung, Veit / Keppler, Oliver T

    Cell reports

    2021  Volume 37, Issue 13, Page(s) 110169

    Abstract: The importance of pre-existing immune responses to seasonal endemic coronaviruses (HCoVs) for the susceptibility to SARS-CoV-2 infection and the course of COVID-19 is the subject of an ongoing scientific debate. Recent studies postulate that immune ... ...

    Abstract The importance of pre-existing immune responses to seasonal endemic coronaviruses (HCoVs) for the susceptibility to SARS-CoV-2 infection and the course of COVID-19 is the subject of an ongoing scientific debate. Recent studies postulate that immune responses to previous HCoV infections can either have a slightly protective or no effect on SARS-CoV-2 pathogenesis and, consequently, be neglected for COVID-19 risk stratification. Challenging this notion, we provide evidence that pre-existing, anti-nucleocapsid antibodies against endemic α-coronaviruses and S2 domain-specific anti-spike antibodies against β-coronavirus HCoV-OC43 are elevated in patients with COVID-19 compared to pre-pandemic donors. This finding is particularly pronounced in males and in critically ill patients. Longitudinal evaluation reveals that antibody cross-reactivity or polyclonal stimulation by SARS-CoV-2 infection are unlikely to be confounders. Thus, specific pre-existing immunity to seasonal coronaviruses may increase susceptibility to SARS-CoV-2 and predispose individuals to an adverse COVID-19 outcome, guiding risk management and supporting the development of universal coronavirus vaccines.
    MeSH term(s) Adult ; Antibodies/immunology ; Antibodies, Viral/immunology ; COVID-19/etiology ; COVID-19/immunology ; Coronavirus/immunology ; Coronavirus Infections/immunology ; Coronavirus OC43, Human/immunology ; Coronavirus OC43, Human/pathogenicity ; Cross Reactions/immunology ; Female ; Germany ; Humans ; Immunity, Humoral/immunology ; Immunoglobulin G/immunology ; Longitudinal Studies ; Male ; Middle Aged ; Pandemics ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Seasons ; Severity of Illness Index ; Spike Glycoprotein, Coronavirus/immunology
    Chemical Substances Antibodies ; Antibodies, Viral ; Immunoglobulin G ; Spike Glycoprotein, Coronavirus
    Language English
    Publishing date 2021-12-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2021.110169
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  5. Article ; Online: COVID-19 in Patients Receiving CD20-depleting Immunochemotherapy for B-cell Lymphoma.

    Gaitzsch, Erik / Passerini, Verena / Khatamzas, Elham / Strobl, Carolin D / Muenchhoff, Maximilian / Scherer, Clemens / Osterman, Andreas / Heide, Michael / Reischer, Anna / Subklewe, Marion / Leutbecher, Alexandra / Tast, Benjamin / Ruhle, Adrian / Weiglein, Tobias / Stecher, Stephanie-Susanne / Stemmler, Hans J / Dreyling, Martin / Girl, Philipp / Georgi, Enrico /
    Wölfel, Roman / Mateyka, Laura / D'Ippolito, Elvira / Schober, Kilian / Busch, Dirk H / Kager, Juliane / Spinner, Christoph D / Treiber, Matthias / Rasch, Sebastian / Lahmer, Tobias / Iakoubov, Roman / Schneider, Jochen / Protzer, Ulrike / Winter, Christof / Ruland, Jürgen / Quante, Michael / Keppler, Oliver T / von Bergwelt-Baildon, Michael / Hellmuth, Johannes / Weigert, Oliver

    HemaSphere

    2021  Volume 5, Issue 7, Page(s) e603

    Abstract: The clinical and immunological impact of B-cell depletion in the context of coronavirus disease 2019 (COVID-19) is unclear. We conducted a prospectively planned analysis of COVID-19 in patients who received B-cell depleting anti-CD20 antibodies and ... ...

    Abstract The clinical and immunological impact of B-cell depletion in the context of coronavirus disease 2019 (COVID-19) is unclear. We conducted a prospectively planned analysis of COVID-19 in patients who received B-cell depleting anti-CD20 antibodies and chemotherapy for B-cell lymphomas. The control cohort consisted of age- and sex-matched patients without lymphoma who were hospitalized because of COVID-19. We performed detailed clinical analyses, in-depth cellular and molecular immune profiling, and comprehensive virological studies in 12 patients with available biospecimens. B-cell depleted lymphoma patients had more severe and protracted clinical course (median hospitalization 88 versus 17 d). All patients actively receiving immunochemotherapy (n = 5) required ICU support including long-term mechanical ventilation. Neutrophil recovery following granulocyte colony stimulating factor stimulation coincided with hyperinflammation and clinical deterioration in 4 of the 5 patients. Immune cell profiling and gene expression analysis of peripheral blood mononuclear cells revealed early activation of monocytes/macrophages, neutrophils, and the complement system in B-cell depleted lymphoma patients, with subsequent exacerbation of the inflammatory response and dysfunctional interferon signaling at the time of clinical deterioration of COVID-19. Longitudinal immune cell profiling and functional in vitro assays showed SARS-CoV-2-specific CD8
    Language English
    Publishing date 2021-06-28
    Publishing country United States
    Document type Journal Article
    ISSN 2572-9241
    ISSN (online) 2572-9241
    DOI 10.1097/HS9.0000000000000603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Genomic epidemiology reveals multiple introductions of SARS-CoV-2 followed by community and nosocomial spread, Germany, February to May 2020.

    Muenchhoff, Maximilian / Graf, Alexander / Krebs, Stefan / Quartucci, Caroline / Hasmann, Sandra / Hellmuth, Johannes C / Scherer, Clemens / Osterman, Andreas / Boehm, Stephan / Mandel, Christopher / Becker-Pennrich, Andrea Sabine / Zoller, Michael / Stubbe, Hans Christian / Munker, Stefan / Munker, Dieter / Milger, Katrin / Gapp, Madeleine / Schneider, Stephanie / Ruhle, Adrian /
    Jocham, Linda / Nicolai, Leo / Pekayvaz, Kami / Weinberger, Tobias / Mairhofer, Helga / Khatamzas, Elham / Hofmann, Katharina / Spaeth, Patricia M / Bender, Sabine / Kääb, Stefan / Zwissler, Bernhard / Mayerle, Julia / Behr, Juergen / von Bergwelt-Baildon, Michael / Reincke, Martin / Grabein, Beatrice / Hinske, Christian Ludwig / Blum, Helmut / Keppler, Oliver T

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

    2021  Volume 26, Issue 43

    Abstract: BackgroundIn the SARS-CoV-2 pandemic, viral genomes are available at unprecedented speed, but spatio-temporal bias in genome sequence sampling precludes phylogeographical inference without additional contextual data.AimWe applied genomic epidemiology to ... ...

    Abstract BackgroundIn the SARS-CoV-2 pandemic, viral genomes are available at unprecedented speed, but spatio-temporal bias in genome sequence sampling precludes phylogeographical inference without additional contextual data.AimWe applied genomic epidemiology to trace SARS-CoV-2 spread on an international, national and local level, to illustrate how transmission chains can be resolved to the level of a single event and single person using integrated sequence data and spatio-temporal metadata.MethodsWe investigated 289 COVID-19 cases at a university hospital in Munich, Germany, between 29 February and 27 May 2020. Using the ARTIC protocol, we obtained near full-length viral genomes from 174 SARS-CoV-2-positive respiratory samples. Phylogenetic analyses using the Auspice software were employed in combination with anamnestic reporting of travel history, interpersonal interactions and perceived high-risk exposures among patients and healthcare workers to characterise cluster outbreaks and establish likely scenarios and timelines of transmission.ResultsWe identified multiple independent introductions in the Munich Metropolitan Region during the first weeks of the first pandemic wave, mainly by travellers returning from popular skiing areas in the Alps. In these early weeks, the rate of presumable hospital-acquired infections among patients and in particular healthcare workers was high (9.6% and 54%, respectively) and we illustrated how transmission chains can be dissected at high resolution combining virus sequences and spatio-temporal networks of human interactions.ConclusionsEarly spread of SARS-CoV-2 in Europe was catalysed by superspreading events and regional hotspots during the winter holiday season. Genomic epidemiology can be employed to trace viral spread and inform effective containment strategies.
    MeSH term(s) COVID-19 ; Cross Infection/epidemiology ; Genome, Viral ; Genomics ; Germany/epidemiology ; Hospitals ; Humans ; Phylogeny ; SARS-CoV-2
    Language English
    Publishing date 2021-10-29
    Publishing country Sweden
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1338803-4
    ISSN 1560-7917 ; 1025-496X
    ISSN (online) 1560-7917
    ISSN 1025-496X
    DOI 10.2807/1560-7917.ES.2021.26.43.2002066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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