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  1. Article ; Online: Child-Turcotte-Pugh Score, MELD Score and MELD-Na Score as Predictors of Short-Term Mortality among Patients with End-Stage Liver Disease in Northern India.

    Acharya, Gagandeep / Kaushik, Rajeev Mohan / Gupta, Rohit / Kaushik, Reshma

    Inflammatory intestinal diseases

    2019  Volume 5, Issue 1, Page(s) 1–10

    Abstract: Background and objectives: Child-Turcotte-Pugh (CTP), Model for End-Stage Liver Disease (MELD) and MELD-sodium (MELD-Na) scores are used for predicting disease severity and mortality among patients with end-stage liver disease. However, data regarding ... ...

    Abstract Background and objectives: Child-Turcotte-Pugh (CTP), Model for End-Stage Liver Disease (MELD) and MELD-sodium (MELD-Na) scores are used for predicting disease severity and mortality among patients with end-stage liver disease. However, data regarding their usefulness in predicting the short-term outcome of end-stage liver disease are not available in India. This prospective study compared the CTP score, MELD score and MELD-Na score as predictors of short-term outcome among patients with end-stage liver disease.
    Methods: CTP, MELD and MELD-Na scores were determined in 171 patients with end-stage liver disease at a tertiary healthcare centre in India at the time of admission, and the concordance (C-) statistics of the three scores for 3-month mortality were assessed and compared. The aetiology of end-stage liver disease and the clinical presentation were determined.
    Results: The CTP score, MELD score and MELD-Na score on day 1 were significantly higher among non-survivors than among survivors (
    Conclusions: The CTP, MELD and MELD-Na scores were very good predictors of mortality at 3 months among patients with end-stage liver disease. The CTP score was superior to the MELD and MELD-Na scores in predicting 3-month mortality.
    Keywords covid19
    Language English
    Publishing date 2019-11-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2817967-5
    ISSN 2296-9365 ; 2296-9403
    ISSN (online) 2296-9365
    ISSN 2296-9403
    DOI 10.1159/000503921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Chemoprofiling and medicinal potential of underutilized leaves of Cyperus scariosus.

    Gandhi, Yashika / Kumar, Vijay / Singh, Gagandeep / Prasad, Shyam Baboo / Mishra, Sujeet K / Soni, Hemant / Rawat, Hemant / Singh, Simranjeet / Charde, Vaibhav / Gupta, Akhil / Dhanjal, Daljeet Singh / Jha, Sudhanshu Kumar / Tandon, Smriti / Bhagwat, Prateeksha / Arya, Jagdish C / Ramamurthy, Praveen C / Acharya, Rabinarayan / Narasimhaji, Ch Venkata / Singh, Arjun /
    Singh, Ravindra / Srikanth, Narayanam / Webster, Thomas J

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 7263

    Abstract: Agro-waste is the outcome of the under-utilization of bioresources and a lack of knowledge to re-use this waste in proper ways or a circular economy approach. In the Indian medicinal system, the root of Cyperus scariosus (CS) is used at a large scale due ...

    Abstract Agro-waste is the outcome of the under-utilization of bioresources and a lack of knowledge to re-use this waste in proper ways or a circular economy approach. In the Indian medicinal system, the root of Cyperus scariosus (CS) is used at a large scale due to their vital medicinal properties. Unfortunately, the aerial part of CS is treated as agro-waste and is an under-utilized bioresource. Due to a lack of knowledge, CS is treated as a weed. This present study is the first ever attempt to explore CS leaves as medicinally and a nutrient rich source. To determine the food and nutritional values of the neglected part of Cyperus scariosus R.Br. (CS), i.e. CS leaves, phytochemicals and metal ions of CS were quantified by newly developed HPLC and ICPOES-based methods. The content of the phytochemicals observed in HPLC analysis for caffeic acid, catechin, epicatechin, trans-p-coumaric acid, and trans-ferulic acid was 10.51, 276.15, 279.09, 70.53, and 36.83 µg/g, respectively. In GC-MS/MS analysis, fatty acids including linolenic acid, phytol, palmitic acid, etc. were identified. In ICPOES analysis, the significant content of Na, K, Ca, Cu, Fe, Mg, Mn, and Zn was observed. The TPC and TFC of the CS leaves was 17.933 mg GAE eq./g and 130.767 mg QCE eq./g along with an IC
    MeSH term(s) Cyperus ; Plant Extracts/chemistry ; Tandem Mass Spectrometry ; Antioxidants/analysis ; Phytochemicals/pharmacology ; Phytochemicals/analysis ; Plant Leaves/chemistry
    Chemical Substances Plant Extracts ; Antioxidants ; Phytochemicals
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-58041-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Comparative Analysis of Phytochemicals, Metal Ions, Volatile Metabolites in Heart Wood, Stem Bark and Leaves of Salix alba L. along with in Vitro Antioxidant, Antacid, Antimicrobial Activities for Sake of Environment Conservation by Substitution of Stem Bark With Leaf.

    Gandhi, Yashika / Rawat, Hemant / Singh Dhanjal, Daljeet / Kumar, Vijay / Charde, Vaibhav / Soni, Hemant / Mishra, Sujeet K / Singh, Gagandeep / Singh, Simranjeet / Sharma, Preeti / Shakya, Santosh K / Narsimhaji, C V / Meena, Ajay K / Singh, Arjun / Singh, Ravindra / Srikanth, Naryanam / Acharya, Rabinarayan

    Chemistry & biodiversity

    2023  Volume 20, Issue 12, Page(s) e202301234

    Abstract: The genus of Salix is used in food, medicine and nutraceuticals, and standardized by using the single marker compound Salicin only. Stem bark is the official part used for the preparation of various drugs, nutraceuticals and food products, which may lead ...

    Abstract The genus of Salix is used in food, medicine and nutraceuticals, and standardized by using the single marker compound Salicin only. Stem bark is the official part used for the preparation of various drugs, nutraceuticals and food products, which may lead to overexploitation and damage of tree. There is need to search substitution of the stem bark with leaf of Salix alba L. (SA), which is yet not reported. Comparative phytochemicals viz. Salicin, Procyanidin B1 and Catechin were quantified in the various parts of SA viz. heart wood (SA-HW), stem bark (SA-SB) and leaves (SA-L) of Salix alba L.by using newly developed HPLC method. It was observed that SA-HW and SA-L contained far better amount of Salicin, Procyanidin B and Catechin as compared to SA-SB (SA-HW~SA-L≫SA-SB). Essential and toxic metal ions of all three parts were analysed using newly developed ICP-OES method, where SA-L were founded as a rich source of micronutrients and essential metal ions as compared to SA-SB and SA-HW. GC-MS analysis has shown the presence of fatty acids and volatile compounds. The observed TPC and TFC values for all three parts were ranged from 2.69 to 32.30 mg GAE/g of wt. and 37.57 to 220.76 mg QCE/g of wt. respectively. In DPPH assay the IC
    MeSH term(s) Catechin/pharmacology ; Antioxidants/analysis ; Antacids/analysis ; Antacids/metabolism ; Salix/chemistry ; Salix/metabolism ; Wood ; Plant Bark/chemistry ; Escherichia coli ; Staphylococcus aureus ; Plant Extracts/chemistry ; Anti-Ulcer Agents ; Phytochemicals/chemistry ; Anti-Bacterial Agents/metabolism ; Plant Leaves ; Anti-Infective Agents/metabolism
    Chemical Substances salicin (4649620TBZ) ; Catechin (8R1V1STN48) ; Antioxidants ; Antacids ; Plant Extracts ; Anti-Ulcer Agents ; Phytochemicals ; Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2023-11-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202301234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Quantification of Phytochemicals and Metal Ions as well as the Determination of Volatile Compounds, Antioxidant, Antimicrobial and Antacid Activities of the Mimosa pudica L. Leaf: Exploration of Neglected and Under-Utilized Part.

    Gandhi, Ms Yashika / Prasad, Shyam Baboo / Kumar, Vijay / Soni, Hemant / Rawat, Hemant / Mishra, Sujeet K / Grewal, Jyotika / Singh, Simranjeet / Charde, Vaibhav / Gupta, Akhil / Jha, Sudhanshu Kumar / Singh, Gagandeep / Tandon, Smriti / Mrkute, Akshada / Ramamurthy, Praveen C / Narasimhaji, Ch Venkata / Singh, Arjun / Singh, Ravindra / Srikanth, Narayan /
    Acharya, Rabinarayan / Webster, Thomas J

    Chemistry & biodiversity

    2023  Volume 20, Issue 10, Page(s) e202301049

    Abstract: Mimosa pudica L. (MP) is well-known plant in traditional medicinal system, especially in India. Unfortunately, leaves of MP are less explored. To determine the food and nutritional value of the neglected part of Mimosa pudica L. (MP), that is MP leaves, ... ...

    Abstract Mimosa pudica L. (MP) is well-known plant in traditional medicinal system, especially in India. Unfortunately, leaves of MP are less explored. To determine the food and nutritional value of the neglected part of Mimosa pudica L. (MP), that is MP leaves, phytochemicals and metal ions of MP were quantified by newly developed HPLC and ICPOES-based methods. The content of phytochemicals observed using HPLC analysis for chlorogenic acid, catechin, and epicatechin was 141.823 (±8.171), 666.621 (±11.432), and 293.175 (±12.743) μg/g, respectively. Using GC/MS/MS analysis, fatty acid like oleic acid were identified. In ICP-OES analysis, a significant content of Na, K, Ca, Cu, Fe, Mg, Mn, and Zn was observed. The observed TPC and TFC for MP leaf extracts was 44.327 (±1.041) mg GAE/ g of wt. and 214.217 (±4.372) mg QCE/ g of wt., respectively. The DPPH assay depicted a strong antioxidant activity of MP leaf extracts with IC
    Language English
    Publishing date 2023-09-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202301049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: High-Power Radiofrequency Catheter Ablation of Atrial Fibrillation: Using Late Gadolinium Enhancement Magnetic Resonance Imaging as a Novel Index of Esophageal Injury.

    Baher, Alex / Kheirkhahan, Mobin / Rechenmacher, Stephen J / Marashly, Qussay / Kholmovski, Eugene G / Siebermair, Johannes / Acharya, Madan / Aljuaid, Mossab / Morris, Alan K / Kaur, Gagandeep / Han, Frederick T / Wilson, Brent D / Steinberg, Benjamin A / Marrouche, Nassir F / Chelu, Mihail G

    JACC. Clinical electrophysiology

    2018  Volume 4, Issue 12, Page(s) 1583–1594

    Abstract: Objectives: This study retrospectively evaluated the feasibility and esophageal thermal injury (ETI) patterns of high-power short-duration (HPSD) radiofrequency atrial fibrillation (AF) ablation.: Background: ETI following AF ablation can lead to ... ...

    Abstract Objectives: This study retrospectively evaluated the feasibility and esophageal thermal injury (ETI) patterns of high-power short-duration (HPSD) radiofrequency atrial fibrillation (AF) ablation.
    Background: ETI following AF ablation can lead to serious complications. Little consensus exists on the optimal radiofrequency power setting or on the optimal strategy to assess ETI.
    Methods: A total of 687 patients undergoing first-time AF ablation with either HPSD ablation (50 W for 5 s, n = 574) or low-power long-duration ablation (LPLD, ≤35 W for 10 to 30 s, n = 113) were analyzed. ETI was assessed by late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) within 24 h post-ablation. Patients with moderate or severe esophageal LGE had a follow-up MRI within 24 h to 1 week, and esophagogastroduodenoscopies were performed when significant gastrointestinal symptoms or persistent LGE on repeat MRI was present. AF recurrence adjusted for potential confounders was analyzed.
    Results: The average age was 69.0 ± 11.8 years in the group undergoing HPSD ablation versus 68.3 ± 11.6 years in the LPLD group (p = 0.554), with 67.1% versus 59.3% male (p = 0.111). Esophageal LGE patterns were similar (64.8% vs. 57.5% none, 21.0% vs. 28.3% mild, 11.5% vs. 11.5% moderate, 2.8% vs. 2.7% severe for HPSD vs. LPLD, respectively; p = 0.370) with no atrioesophageal fistulas. Mean procedure length was significantly shorter in the HPSD group (149 ± 65 min vs. 251 ± 101 min; p < 0.001). AF recurrence rates were similar in the 2 groups for the mean 2.5-year follow-up period (adjusted, 42% vs. 41%; p = 0.571).
    Conclusions: HPSD ablation results in similar ETI patterns, as assessed by same-day LGE MRI, compared with the LPLD setting but with significantly shorter procedure times. Recurrence rates at 2.5-year follow-up are similar.
    MeSH term(s) Aged ; Aged, 80 and over ; Atrial Fibrillation/surgery ; Catheter Ablation/adverse effects ; Esophageal Diseases/diagnostic imaging ; Esophageal Diseases/etiology ; Esophagus/diagnostic imaging ; Esophagus/injuries ; Female ; Gadolinium/therapeutic use ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Retrospective Studies
    Chemical Substances Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2018-09-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2018.07.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Automated IMT estimation and BMI correlation using a low-quality carotid ultrasound image database from India.

    Molinari, Filippo / Gupta, Vipin / Prabhakaran, Poornima / Meiburger, Kristen M / Saba, Luca / Acharya, U Rajendra / Ledda, Giuseppe / Radha Krishna, K V / Walia, Gagandeep Kaur / Kinra, Sanjay / Nicolaides, Andrew / Ebrahim, Shah / Suri, Jasjit S

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2013  Volume 2013, Page(s) 3343–3346

    Abstract: This paper presents AtheroEdgeLowRes (AELR), an extention of AtheroEdge™ from AtheroPoint™, and a solution to carotid ultrasound IMT measurement in low-resolution and overall low quality images. The images were collected using a low-end ultrasound ... ...

    Abstract This paper presents AtheroEdgeLowRes (AELR), an extention of AtheroEdge™ from AtheroPoint™, and a solution to carotid ultrasound IMT measurement in low-resolution and overall low quality images. The images were collected using a low-end ultrasound machine during a screening study in India. We aim to demonstrate the accuracy and reproducibility of the AELR system by benchmarking it against an expert Reader's manual tracing and to show the correlation between the automatically measured intima media thickness (IMT) and the subjects' cardiovascular risk factors (i.e. body mass index--BMI). We introduced an innovative penalty function (PF) to our dual-snake segmentation technique, necessary due to the low image resolution. We processed 512 images from 256 patients, and correlated the AELR IMT values with the patients' age and BMI. AELR processed all 512 images, and the IMT measurement error was 0.011±0.099 mm with the PF correction and 0.173±0.127 mm without. AELR IMT values correlated with the Reader's values (r = 0.883) and also correlated with the subject's BMI and age. The AELR system showed accuracy and reproducibility levels that make it suitable to be used in large epidemiological and screening studies in emerging countries.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Algorithms ; Automation ; Body Mass Index ; Carotid Intima-Media Thickness ; Child ; Databases, Factual ; Female ; Humans ; Image Interpretation, Computer-Assisted ; India ; Male ; Middle Aged ; Reproducibility of Results ; Ultrasonics ; Young Adult
    Language English
    Publishing date 2013-10-08
    Publishing country United States
    Document type Journal Article
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC.2013.6610257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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