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Article: [Medical child abuse, another name for Munchausen's syndrome by proxy].

Ben-Yehuda, Yoram

2009 Volume 148, Issue 8, Page(s) 500–1, 574

Abstract: Medical child abuse or its better known name, Munchausen's Syndrome by Proxy, is a form of child maltreatment combining physical and emotional abuse as well as child neglect. As in other forms of child abuse and neglect that pediatricians encounter, the ... ...

Abstract	Medical child abuse or its better known name, Munchausen's Syndrome by Proxy, is a form of child maltreatment combining physical and emotional abuse as well as child neglect. As in other forms of child abuse and neglect that pediatricians encounter, the diagnosis is medical and is based on the existence of actual or potential harm to the child. A high index of suspicion is necessary when the medical team is faced with inexplicable findings as well as repeated treatment failure. There is extensive variability in the manifestation of this syndrome as well as a wide range of severity including the risk to the patient's life. In this article we describe medical child abuse and the means of diagnosing the syndrome. It is also stressed that, as in the case of any other form of child maltreatment, reporting is mandatory.
MeSH term(s)	Child ; Child Abuse/diagnosis ; Child Abuse/psychology ; Humans ; Mandatory Reporting ; Munchausen Syndrome by Proxy/diagnosis ; Munchausen Syndrome by Proxy/psychology ; Parent-Child Relations ; Physicians ; Treatment Failure
Language	Hebrew
Publishing date	2009-08
Publishing country	Israel
Document type	English Abstract ; Journal Article
ZDB-ID	953872-0
ISSN	0017-7768
ISSN	0017-7768
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Zs.B 291: Show issues

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Article ; Online: Comparison of the medical burden of COVID-19 with seasonal influenza and measles outbreaks.

Nesselroth, Dafna / Yakub Hana, Hussam / Gleyzer, Alexandra / Simoes, Eric A F / Abu Atta, Mahdi / Ben Yehuda, Yoram / Bibi, Haim / Somekh, Ido / Somekh, Eli

Acta paediatrica (Oslo, Norway : 1992)

2021 Volume 111, Issue 3, Page(s) 595–601

Abstract: Aim: To examine and compare the medical burden of measles, influenza and COVID-19 outbreaks in the city of Bnei Brak, Israel.: Methods: The study was conducted during 2018-2021. The numbers of hospitalisations for these infections and their ... ...

Abstract	Aim: To examine and compare the medical burden of measles, influenza and COVID-19 outbreaks in the city of Bnei Brak, Israel. Methods: The study was conducted during 2018-2021. The numbers of hospitalisations for these infections and their complications were recorded. Hospitalisation rates were determined by using the number of children residing in Bnei Brak and hospitalised with these infections during the study period as the numerators. The denominators were the estimated paediatric cases of measles, influenza and COVID-19 in Bnei Brak and were calculated under both pragmatic and conservative assumptions. Results: A total of 247, 65 and 32 children were hospitalised with influenza, COVID-19 and measles respectively. Complication rates were higher following measles than after influenza and SARS-CoV-2 infections. Hospitalisation rates were 10% for measles, 0.6%-1.2% for influenza and 0.15% - 0.25% for COVID-19 infections. Relative risks (RR) with 95% confidence intervals (CI) for hospitalisation following measles compared with COVID-19 ranged from 42 (26.3-67.3) to 70.1 (43.8-112.1), while the relative risks for influenza hospitalisation ranged from 2.5 (1.83-3.41) to 8.2 (6.0-11.2), compared with COVID-19 infection. Conclusion: Hospitalisation rates and direct medical burdens of measles and influenza were significantly higher than those of COVID-19 infection in children.
MeSH term(s)	COVID-19 ; Child ; Disease Outbreaks ; Hospitalization ; Humans ; Influenza, Human/epidemiology ; Measles/epidemiology ; SARS-CoV-2 ; Seasons
Language	English
Publishing date	2021-12-20
Publishing country	Norway
Document type	Journal Article
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.16210
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Article ; Online: Curcumin Protects Skin against UVB-Induced Cytotoxicity via the Keap1-Nrf2 Pathway: The Use of a Microemulsion Delivery System.

Ben Yehuda Greenwald, Maya / Frušić-Zlotkin, Marina / Soroka, Yoram / Ben Sasson, Shmuel / Bitton, Ronit / Bianco-Peled, Havazelet / Kohen, Ron

Oxidative medicine and cellular longevity

2017 Volume 2017, Page(s) 5205471

Abstract: Curcumin was found to be beneficial in treating several skin pathologies and diseases, providing antioxidant protection due to its reducing properties and its electrophilic properties (the ability to activate the ... ...

Abstract	Curcumin was found to be beneficial in treating several skin pathologies and diseases, providing antioxidant protection due to its reducing properties and its electrophilic properties (the ability to activate the Nrf
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article
ISSN	1942-0994
ISSN (online)	1942-0994
DOI	10.1155/2017/5205471
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Article: [The pediatrician's role in the field of child maltreatment].

Ben-Yehuda, Yoram / Arazi, Tal

Harefuah

2009 Volume 148, Issue 8, Page(s) 502–6, 574, 573

Abstract: Pediatricians have a direct linkage towards child maltreatment. Certain health conditions are sometimes risk factors for abusive behavior or neglect towards children, moreover, injuries, certain diseases and development problems can be the direct results ...

Abstract	Pediatricians have a direct linkage towards child maltreatment. Certain health conditions are sometimes risk factors for abusive behavior or neglect towards children, moreover, injuries, certain diseases and development problems can be the direct results of child abuse and neglect. It is therefore important that child maltreatment will be considered as a major health problem by pediatricians. This article reviews a variety of professional tasks that pediatricians should undertake concerning the treatment of victims of child abuse and neglect in dealing with child maltreatment phenomena. The review includes a wide range of activities and responsibilities, beginning with the immediate and routine role of the diagnostician and healer, while identifying the unique emphases, which are the result of the nature of the trauma, through to the conventional actions of the pediatrician. In the case of child abuse and neglect, this role is significantly more important and requires more attention, such as the manner of conversing with the child and recording documentation. This may encompass numerous unconventional tasks such as being an expert witness in court and participating in committees, task forces and organizations to promote and spread knowledge and policy change.
MeSH term(s)	Child ; Child Abuse/diagnosis ; Child Abuse/prevention & control ; Humans ; Pediatrics/standards ; Physician-Patient Relations ; Social Responsibility
Language	Hebrew
Publishing date	2009-08
Publishing country	Israel
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	953872-0
ISSN	0017-7768
ISSN	0017-7768
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Zs.B 291: Show issues

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Article ; Online: A novel role of topical iodine in skin: Activation of the Nrf2 pathway.

Ben-Yehuda Greenwald, Maya / Frušić-Zlotkin, Marina / Soroka, Yoram / Ben-Sasson, Shmuel / Bianco-Peled, Havazelet / Kohen, Ron

Free radical biology & medicine

2017 Volume 104, Page(s) 238–248

Abstract: For a long time iodine has been used as an active dermal agent in the treatment of inflammatory, immune-mediated and infectious diseases. Moreover, topical iodine application has been reported to provide protection against sulfur-mustard-induced skin ... ...

Abstract	For a long time iodine has been used as an active dermal agent in the treatment of inflammatory, immune-mediated and infectious diseases. Moreover, topical iodine application has been reported to provide protection against sulfur-mustard-induced skin lesions, heat-induced and acid-induced skin burns in both haired guinea-pigs and mouse ear swelling models. However, the exact mechanism of action underlying these benefits of iodine has not yet been elucidated. In the current study, a novel mechanism of action by which iodine provides skin protection and relief, based on its electrophilic nature, is suggested. This study demonstrates that both iodine and iodide are capable of activating the Nrf2 pathway in human skin. As a result, skin protection against UVB-induced damage was acquired and the secretion of pro-inflammatory cytokines (IL-6, IL-8) from LPS-challenged skin was reduced. Iodide role in the enhanced activation of this pathway is demonstrated. The mode of action by which iodine and iodide activate the Nrf2 pathway is discussed.
Language	English
Publishing date	2017-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2017.01.011
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Zs.A 2109: Show issues

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Article: Investigation of unexplained infant deaths in Israel: time for a different approach.

Eisenstein, Eli M / Ben-Yehuda, Yoram / Shemesh, Noa / Kharasch, Sigmund

The Israel Medical Association journal : IMAJ

2012 Volume 14, Issue 11, Page(s) 695–699

MeSH term(s)	Forensic Medicine/methods ; Humans ; Incidence ; Infant ; Israel/epidemiology ; Sudden Infant Death/epidemiology ; Sudden Infant Death/etiology ; Survival Rate/trends
Language	English
Publishing date	2012-11
Publishing country	Israel
Document type	Journal Article ; Review
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Zs.A 5470: Show issues

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Article: Ketamine increases opening cerebrospinal pressure in children undergoing lumbar puncture.

Ben Yehuda, Yoram / Watemberg, Nathan

Journal of child neurology

2006 Volume 21, Issue 6, Page(s) 441–443

Abstract: Intravenous ketamine, often administered concomitantly with midazolam, is one of the most commonly used drugs for procedural sedation in children. Although it is considered safe for use in children, ketamine can increase intracranial pressure. Hence, ... ...

Abstract	Intravenous ketamine, often administered concomitantly with midazolam, is one of the most commonly used drugs for procedural sedation in children. Although it is considered safe for use in children, ketamine can increase intracranial pressure. Hence, this study was carried out to determine whether adding ketamine to midazolam prior to performing lumbar puncture would be associated with a higher cerebrospinal fluid opening pressure in children with suspected aseptic meningitis. Thirty-nine children aged 6 months to 14 years were included: 26 in group A (intravenous midazolam plus ketamine) and 13 in group B (intravenous midazolam only). Mean cerebrospinal fluid opening pressure in group A was 24.4 cm H2O (median 23 cm H2O) compared with 20 cm H2O (median 19.8 cm H2O) in group B (P = .011). Intravenous ketamine prior to performing lumbar puncture is associated with a significantly higher lumbar cerebrospinal fluid opening pressure in children with aseptic meningitis. However, no outcome differences have been found between the two groups.
MeSH term(s)	Adolescent ; Anesthetics, Dissociative/administration & dosage ; Cerebrospinal Fluid Pressure/drug effects ; Child ; Child, Preschool ; Drug Therapy, Combination ; Female ; Humans ; Hypnotics and Sedatives/administration & dosage ; Infant ; Injections, Intravenous ; Ketamine/administration & dosage ; Male ; Meningitis, Aseptic/diagnosis ; Midazolam/administration & dosage ; Spinal Puncture
Chemical Substances	Anesthetics, Dissociative ; Hypnotics and Sedatives ; Ketamine (690G0D6V8H) ; Midazolam (R60L0SM5BC)
Language	English
Publishing date	2006-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	639288-x
ISSN	1708-8283 ; 0883-0738
ISSN (online)	1708-8283
ISSN	0883-0738
DOI	10.1177/08830738060210060601
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Zs.A 2301: Show issues

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Article ; Online: Nitroxide delivery system for Nrf2 activation and skin protection.

Ben Yehuda Greenwald, Maya / Frušić-Zlotkin, Marina / Soroka, Yoram / Sasson, Shmuel Ben / Bianco-Peled, Havazelet / Bitton, Ronit / Kohen, Ron

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

2015 Volume 94, Page(s) 123–134

Abstract: Cyclic nitroxides are a large group of compounds composed of diverse stable radicals also known as synthetic antioxidants. Although nitroxides are valuable for use in several skin conditions, in in vivo conditions they have several drawbacks, such as ... ...

Abstract	Cyclic nitroxides are a large group of compounds composed of diverse stable radicals also known as synthetic antioxidants. Although nitroxides are valuable for use in several skin conditions, in in vivo conditions they have several drawbacks, such as nonspecific dispersion in normal tissue, preferential renal clearance and rapid reduction of the nitroxide to the corresponding hydroxylamine. However, these drawbacks can be easily addressed by encapsulating the nitroxides within microemulsions. This approach would allow nitroxide activity and therefore their valuable effects (e.g. activation of the Keap1-Nrf2-EpRE pathway) to continue. In this work, nitroxides were encapsulated in a microemulsion composed of biocompatible ingredients. The nanometric size and shape of the vehicle microemulsion and nitroxide microemulsion displayed high similarity, indicating that the stability of the microemulsions was preserved. Our studies demonstrated that nitroxide microemulsions were more potent inducers of the Keap1-Nrf2-EpRE pathway than the free nitroxides, causing the activation of phase II enzymes. Moreover, microemulsions containing nitroxides significantly reduced UVB-induced cytotoxicity in the skin. Understanding the mechanism of this improved activity may expand the usage of many other Nrf2 modulating molecules in encapsulated form, as a skin protection strategy against oxidative stress-related conditions.
MeSH term(s)	Administration, Cutaneous ; Adult ; Antioxidant Response Elements ; Antioxidants/administration & dosage ; Antioxidants/chemistry ; Apoptosis/drug effects ; Apoptosis/radiation effects ; Cell Line ; Chemistry, Pharmaceutical ; Cryoelectron Microscopy ; Cyclic N-Oxides/administration & dosage ; Cyclic N-Oxides/chemistry ; Drug Carriers ; Drug Stability ; Emulsions ; Female ; Humans ; Inflammation Mediators/metabolism ; Interleukin-1beta/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Kelch-Like ECH-Associated Protein 1 ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Keratinocytes/radiation effects ; Light ; Lipids/chemistry ; Microscopy, Electron, Transmission ; Middle Aged ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Organ Culture Techniques ; Oxidative Stress/drug effects ; Oxidative Stress/radiation effects ; Particle Size ; RNA, Messenger/metabolism ; Scattering, Radiation ; Scattering, Small Angle ; Signal Transduction/drug effects ; Skin/drug effects ; Skin/metabolism ; Skin/radiation effects ; Surface-Active Agents/chemistry ; Technology, Pharmaceutical/methods ; Ultraviolet Rays ; Up-Regulation ; Young Adult
Chemical Substances	Antioxidants ; Cyclic N-Oxides ; Drug Carriers ; Emulsions ; IL1B protein, human ; Inflammation Mediators ; Interleukin-1beta ; Intracellular Signaling Peptides and Proteins ; KEAP1 protein, human ; Kelch-Like ECH-Associated Protein 1 ; Lipids ; NF-E2-Related Factor 2 ; NFE2L2 protein, human ; RNA, Messenger ; Surface-Active Agents ; 4-amino-TEMPO (14691-88-4) ; TEMPO (VQN7359ICQ)
Language	English
Publishing date	2015-05-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1065368-5
ISSN	1873-3441 ; 0939-6411
ISSN (online)	1873-3441
ISSN	0939-6411
DOI	10.1016/j.ejpb.2015.05.008
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Zs.B 1651: Show issues

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Article ; Online: Oropharyngeal injuries in children.

Marom, Tal / Russo, Eyal / Ben-Yehuda, Yoram / Roth, Yehudah

Pediatric emergency care

2007 Volume 23, Issue 12, Page(s) 914–918

Abstract: Background: Oral cavity and oropharyngeal injuries are common among pediatric patients seen in emergency rooms for head and neck trauma. The appropriate treatment of such injuries is often controversial.: Patients and methods: Audit of 6 months' ... ...

Abstract	Background: Oral cavity and oropharyngeal injuries are common among pediatric patients seen in emergency rooms for head and neck trauma. The appropriate treatment of such injuries is often controversial. Patients and methods: Audit of 6 months' admissions to the pediatric emergency room in a secondary care referral center. Sixty-four patients were treated for various injuries. Charts were reviewed for relevant data. Results: Description of distribution of types and sites of injuries and discussion of treatment recommendations. Conclusions: Most of oropharyngeal injuries heal without any intervention and therefore can be left untreated after being diagnosed. However, in certain injuries, treatment is indicated for better outcome results.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Emergency Service, Hospital/statistics & numerical data ; Humans ; Infant ; Oropharynx/injuries ; Wounds and Injuries/epidemiology ; Wounds and Injuries/etiology ; Wounds and Injuries/therapy
Language	English
Publishing date	2007-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	632588-9
ISSN	1535-1815 ; 0749-5161
ISSN (online)	1535-1815
ISSN	0749-5161
DOI	10.1097/pec.0b013e31815f6fa8
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Zs.A 2083: Show issues

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Article: Child abuse and neglect: reporting by health professionals and their need for training.

Ben Yehuda, Yoram / Attar-Schwartz, Shalhevet / Ziv, Amitai / Jedwab, Merav / Benbenishty, Rami

The Israel Medical Association journal : IMAJ

2010 Volume 12, Issue 10, Page(s) 598–602

Abstract: Background: For health professionals who interact professionally with children, adequate awareness and training regarding the clinical indicators of child abuse and neglect, as well as subsequent reporting and procedures, are essential.: Objectives: ... ...

Abstract	Background: For health professionals who interact professionally with children, adequate awareness and training regarding the clinical indicators of child abuse and neglect, as well as subsequent reporting and procedures, are essential. Objectives: To study Israeli health professionals experiences with identification and reporting of suspected cases of child abuse and neglect, and their perceived training needs in this area. Methods: The study group was a convenience sample comprising 95 Israeli health professionals (physicians, nurses, social workers, psychologists, etc.) attending workshops on medical aspects at a national conference on child abuse and neglect. In this cross-sectional survey, the health professionals were asked to complete an anonymous structured questionnaire on their experience with child abuse and neglect and on their training needs. Results: The participants in the survey had relatively high levels of involvement with child protection. Nevertheless, they strongly expressed their need for training, especially in mastering practice skills. The need for training was greater for professionals with less experience in child protection, and there were different needs according to profession. Conclusions: Despite their prior extensive experience in dealing with child abuse and neglect, most of the health professionals participating in the conference reported the need for training in certain areas.
MeSH term(s)	Adult ; Aged ; Child ; Child Abuse/diagnosis ; Child Abuse/legislation & jurisprudence ; Clinical Competence ; Cohort Studies ; Cross-Sectional Studies ; Female ; Humans ; Israel ; Male ; Mandatory Reporting ; Middle Aged ; Needs Assessment
Language	English
Publishing date	2010-10
Publishing country	Israel
Document type	Journal Article
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Zs.A 5470: Show issues

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