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Article ; Online: Lack of functional TCR-epitope interaction is associated with herpes zoster through reduced downstream T cell activation.

Boeren, Marlies / de Vrij, Nicky / Ha, My K / Valkiers, Sebastiaan / Souquette, Aisha / Gielis, Sofie / Kuznetsova, Maria / Schippers, Jolien / Bartholomeus, Esther / Van den Bergh, Johan / Michels, Nele / Aerts, Olivier / Leysen, Julie / Bervoets, An / Lambert, Julien / Leuridan, Elke / Wens, Johan / Peeters, Karin / Emonds, Marie-Paule /

Elias, George / Vandamme, Niels / Jansens, Hilde / Adriaensen, Wim / Suls, Arvid / Vanhee, Stijn / Hens, Niel / Smits, Evelien / Van Damme, Pierre / Thomas, Paul G / Beutels, Philippe / Ponsaerts, Peter / Van Tendeloo, Viggo / Delputte, Peter / Laukens, Kris / Meysman, Pieter / Ogunjimi, Benson

Cell reports

2024 Volume 43, Issue 4, Page(s) 114062

Abstract: The role of T cell receptor (TCR) diversity in infectious disease susceptibility is not well ...

Abstract	The role of T cell receptor (TCR) diversity in infectious disease susceptibility is not well understood. We use a systems immunology approach on three cohorts of herpes zoster (HZ) patients and controls to investigate whether TCR diversity against varicella-zoster virus (VZV) influences the risk of HZ. We show that CD4
MeSH term(s)	Humans ; Herpes Zoster/immunology ; Herpes Zoster/virology ; Receptors, Antigen, T-Cell/metabolism ; Receptors, Antigen, T-Cell/immunology ; Lymphocyte Activation/immunology ; Herpesvirus 3, Human/immunology ; Female ; Middle Aged ; Male ; CD4-Positive T-Lymphocytes/immunology ; Aged ; Adult ; Epitopes, T-Lymphocyte/immunology
Chemical Substances	Receptors, Antigen, T-Cell ; Epitopes, T-Lymphocyte
Language	English
Publishing date	2024-04-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2024.114062
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Article ; Online: Humanized Mice to Study Human T Cell Development.

Bonte, Sarah / Snauwaert, Sylvia / Vanhee, Stijn / Dolens, Anne-Catherine / Taghon, Tom / Vandekerckhove, Bart / Kerre, Tessa

Methods in molecular biology (Clifton, N.J.)

2016 Volume 1323, Page(s) 253–272

Abstract: While in vitro models exist to study human T cell development, they still lack the precise ... that can be used to study early T cell development. Models that study solely mature T cells, such as the SCID ...

Abstract	While in vitro models exist to study human T cell development, they still lack the precise environmental stimuli, such as the exact combination and levels of cytokines and chemokines, that are present in vivo. Moreover, studying the homing of hematopoietic stem (HSC) and progenitor (HPC) cells to the thymus can only be done using in vivo models. Although species-specific differences exist, "humanized" models are generated to circumvent these issues. In this chapter, we focus on the humanized mouse models that can be used to study early T cell development. Models that study solely mature T cells, such as the SCID-PBL (Tary-Lehmann et al., Immunol Today 16:529-533) are therefore not discussed here, but have recently been reviewed (Shultz et al., Nat Rev Immunol 12:786-798).
MeSH term(s)	Animals ; Cell Differentiation ; Hematopoietic Stem Cell Transplantation/methods ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Heterografts ; Humans ; Mice ; Models, Animal ; T-Lymphocytes/cytology ; T-Lymphocytes/metabolism
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-2809-5_21
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Article ; Online: In vitro generation of mature, naive antigen-specific CD8(+) T cells with a single T-cell receptor by agonist selection.

Snauwaert, S / Verstichel, G / Bonte, S / Goetgeluk, G / Vanhee, S / Van Caeneghem, Y / De Mulder, K / Heirman, C / Stauss, H / Heemskerk, M H M / Taghon, T / Leclercq, G / Plum, J / Langerak, A W / Thielemans, K / Kerre, T / Vandekerckhove, B

Leukemia

2013 Volume 28, Issue 4, Page(s) 830–841

Abstract: Peripheral blood T cells transduced with a tumor-specific T-cell receptor (TCR) face problems ... We here studied an alternative strategy for the efficient generation of naive CD8(+) T cells with a single ... hematopoietic progenitor cells (HPCs) were differentiated to CD4(+)CD8(+) double-positive T cells using OP9-Delta-like 1 (OP9-DL1 ...

Abstract	Peripheral blood T cells transduced with a tumor-specific T-cell receptor (TCR) face problems of auto-reactivity and lack of efficacy caused by cross-pairing of exogenous and endogenous TCR chains, as well as short term in vivo survival due to activation and growth factor-induced differentiation. We here studied an alternative strategy for the efficient generation of naive CD8(+) T cells with a single TCR. TCR-transduced human postnatal thymus-derived and adult mobilized blood-derived hematopoietic progenitor cells (HPCs) were differentiated to CD4(+)CD8(+) double-positive T cells using OP9-Delta-like 1 (OP9-DL1) cultures. Addition of the agonist peptide induced double positive cells to cross-present the peptide, leading, in the absence of co-stimulation, to cell cycle arrest and differentiation into mature CD8(+) T cells. Comprehensive phenotypic, molecular and functional analysis revealed the generation of naive and resting CD8(+) T cells through a process similar to thymic positive selection. These mature T cells show a near complete inhibition of endogenous TCRA and TCRB rearrangements and express high levels of the introduced multimer-reactive TCR. Upon activation, specific cytokine production and efficient killing of tumor cells were induced. Using this strategy, large numbers of high-avidity tumor-specific naive T cells can be generated from readily available HPCs without TCR chain cross-pairing.
MeSH term(s)	Adult ; CD8-Positive T-Lymphocytes/immunology ; Cell Differentiation ; Cell Line, Tumor ; Child ; Child, Preschool ; Gene Rearrangement, T-Lymphocyte ; Humans ; Immunotherapy, Adoptive ; Infant ; Infant, Newborn ; Receptors, Antigen, T-Cell/agonists ; Receptors, Antigen, T-Cell/physiology
Chemical Substances	Receptors, Antigen, T-Cell
Language	English
Publishing date	2013-10-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	807030-1
ISSN	1476-5551 ; 0887-6924
ISSN (online)	1476-5551
ISSN	0887-6924
DOI	10.1038/leu.2013.285
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Article ; Online: TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C.

Hoste, Levi / Roels, Lisa / Naesens, Leslie / Bosteels, Victor / Vanhee, Stijn / Dupont, Sam / Bosteels, Cedric / Browaeys, Robin / Vandamme, Niels / Verstaen, Kevin / Roels, Jana / Van Damme, Karel F A / Maes, Bastiaan / De Leeuw, Elisabeth / Declercq, Jozefien / Aegerter, Helena / Seys, Leen / Smole, Ursula / De Prijck, Sofie /

The Journal of experimental medicine

2021 Volume 219, Issue 2

Abstract: ... production in CD16+ NK cells and TIM3 expression on CD38+/HLA-DR+ T cells. Single-cell TCR profiling reveals ... T cells. Using NicheNet, we confirm IFNγ as a central cytokine in the communication between TIM3+/CD38+ ... HLA-DR+ T cells, CD16+ NK cells, and patrolling monocytes. Normalization of IFNγ, loss of TIM3 ...

Abstract	In rare instances, pediatric SARS-CoV-2 infection results in a novel immunodysregulation syndrome termed multisystem inflammatory syndrome in children (MIS-C). We compared MIS-C immunopathology with severe COVID-19 in adults. MIS-C does not result in pneumocyte damage but is associated with vascular endotheliitis and gastrointestinal epithelial injury. In MIS-C, the cytokine release syndrome is characterized by IFNγ and not type I interferon. Persistence of patrolling monocytes differentiates MIS-C from severe COVID-19, which is dominated by HLA-DRlo classical monocytes. IFNγ levels correlate with granzyme B production in CD16+ NK cells and TIM3 expression on CD38+/HLA-DR+ T cells. Single-cell TCR profiling reveals a skewed TCRβ repertoire enriched for TRBV11-2 and a superantigenic signature in TIM3+/CD38+/HLA-DR+ T cells. Using NicheNet, we confirm IFNγ as a central cytokine in the communication between TIM3+/CD38+/HLA-DR+ T cells, CD16+ NK cells, and patrolling monocytes. Normalization of IFNγ, loss of TIM3, quiescence of CD16+ NK cells, and contraction of patrolling monocytes upon clinical resolution highlight their potential role in MIS-C immunopathogenesis.
MeSH term(s)	Adolescent ; Alveolar Epithelial Cells/pathology ; B-Lymphocytes/immunology ; Blood Vessels/pathology ; COVID-19/complications ; COVID-19/immunology ; COVID-19/pathology ; Cell Proliferation ; Child ; Cohort Studies ; Complement Activation ; Cytokines/metabolism ; Enterocytes/pathology ; Female ; Hepatitis A Virus Cellular Receptor 2/metabolism ; Humans ; Immunity, Humoral ; Inflammation/pathology ; Interferon Type I/metabolism ; Interferon-gamma/metabolism ; Interleukin-15/metabolism ; Killer Cells, Natural/immunology ; Lymphocyte Activation/immunology ; Male ; Monocytes/metabolism ; Receptors, Antigen, T-Cell/metabolism ; Receptors, IgG/metabolism ; SARS-CoV-2/immunology ; Superantigens/metabolism ; Systemic Inflammatory Response Syndrome/immunology ; Systemic Inflammatory Response Syndrome/pathology ; T-Lymphocytes/immunology
Chemical Substances	Cytokines ; Hepatitis A Virus Cellular Receptor 2 ; Interferon Type I ; Interleukin-15 ; Receptors, Antigen, T-Cell ; Receptors, IgG ; Superantigens ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2021-12-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20211381
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Ua VI Zs.107: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway.

Van Coppernolle, S / Vanhee, S / Verstichel, G / Snauwaert, S / van der Spek, A / Velghe, I / Sinnesael, M / Heemskerk, M H / Taghon, T / Leclercq, G / Plum, J / Langerak, A W / Kerre, T / Vandekerckhove, B

Leukemia

2012 Volume 26, Issue 1, Page(s) 127–138

Abstract: In wild-type mice, T-cell receptor (TCR) γδ(+) cells differentiate along a CD4 CD8 double-negative ... TCRγδ(+) population during T-cell differentiation was elucidated. We demonstrate that human TCRγδ ... cells and to TCRαβ(+) cells. Finally, we show that the γδ subset of T-cell acute lymphoblastic leukemias ...

Abstract	In wild-type mice, T-cell receptor (TCR) γδ(+) cells differentiate along a CD4 CD8 double-negative (DN) pathway whereas TCRαβ(+) cells differentiate along the double-positive (DP) pathway. In the human postnatal thymus (PNT), DN, DP and single-positive (SP) TCRγδ(+) populations are present. Here, the precursor-progeny relationship of the various PNT TCRγδ(+) populations was studied and the role of the DP TCRγδ(+) population during T-cell differentiation was elucidated. We demonstrate that human TCRγδ(+) cells differentiate along two pathways downstream from an immature CD1(+) DN TCRγδ(+) precursor: a Notch-independent DN pathway generating mature DN and CD8αα SP TCRγδ(+) cells, and a Notch-dependent, highly proliferative DP pathway generating immature CD4 SP and subsequently DP TCRγδ(+) populations. DP TCRγδ(+) cells are actively rearranging the TCRα locus, and differentiate to TCR(-) DP cells, to CD8αβ SP TCRγδ(+) cells and to TCRαβ(+) cells. Finally, we show that the γδ subset of T-cell acute lymphoblastic leukemias (T-ALL) consists mainly of CD4 SP or DP phenotypes carrying significantly more activating Notch mutations than DN T-ALL. The latter suggests that activating Notch mutations in TCRγδ(+) thymocytes induce proliferation and differentiation along the DP pathway in vivo.
MeSH term(s)	Base Sequence ; CD4 Antigens/immunology ; CD8 Antigens/immunology ; Cell Differentiation ; Cell Proliferation ; Coculture Techniques ; DNA Primers ; Humans ; Real-Time Polymerase Chain Reaction ; Receptors, Antigen, T-Cell, gamma-delta/immunology ; Receptors, Notch/physiology ; Thymocytes/cytology ; Thymocytes/immunology
Chemical Substances	CD4 Antigens ; CD8 Antigens ; DNA Primers ; Receptors, Antigen, T-Cell, gamma-delta ; Receptors, Notch
Language	English
Publishing date	2012-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	807030-1
ISSN	1476-5551 ; 0887-6924
ISSN (online)	1476-5551
ISSN	0887-6924
DOI	10.1038/leu.2011.324
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Article: Prevalence, Caries, Dental Anxiety and Quality of Life in Children with MIH in Brussels, Belgium.

Vanhée, Tania / Poncelet, Julie / Cheikh-Ali, Shereen / Bottenberg, Peter

Journal of clinical medicine

2022 Volume 11, Issue 11

Abstract: Molar incisor hypomineralisation (MIH) is a dental enamel pathology responsible for unfavorable functional and aesthetic implications. The objective of this study is to assess the prevalence, dental anxiety, and quality of life related to oral health in ... ...

Abstract	Molar incisor hypomineralisation (MIH) is a dental enamel pathology responsible for unfavorable functional and aesthetic implications. The objective of this study is to assess the prevalence, dental anxiety, and quality of life related to oral health in children with MIH. In 14 schools in Brussels, Belgium, 290 children aged 8 to 9.5 answered Children’s Fear Survey Schedule-Dental Subscale (CFSS-DS) and Child-Oral Impact on Daily Performance (C-OIDP) questionnaires to assess dental anxiety and quality of life related to oral health (OHRQoL). Oral examinations allowed us to detect MIH according to standardized criteria. The MIH prevalence was 18.6%. The Decayed, Missing and Filled Teeth index (DMFT index) of MIH patients was significantly higher than non-MIH patients (p < 0.001), mainly due to more restored teeth. There was no significant association between MIH and dental anxiety or OHRQoL. Caries in the deciduous dentition was significantly associated with impaired quality of life. The MIH prevalence in Brussels is comparable to other European countries. MIH had no significant impact on dental anxiety and OHRQoL in this sample. The dynamic nature of MIH lesions requires early diagnosis and management to limit the evolution of the severity of the lesions and their implications. It is possible that older age groups may present more symptoms, however, this would require a longitudinal study.
Language	English
Publishing date	2022-05-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11113065
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Article: A Parental Behavior Scale in Pediatric Dentistry: The Development of an Observational Scale.

Vanhée, Tania / Dadoun, Farah / Vanden Abbeele, Astrid / Bottenberg, Peter / Jacquet, Wolfgang / Loeb, Isabelle

Children (Basel, Switzerland)

2023 Volume 10, Issue 2

Abstract: Children's treatment means a triangular relationship between the child, practitioner, and parent, with specific interactions influencing the procedure. The objective was to create and validate a hetero-rating scale of parental behavior and verify the ... ...

Abstract	Children's treatment means a triangular relationship between the child, practitioner, and parent, with specific interactions influencing the procedure. The objective was to create and validate a hetero-rating scale of parental behavior and verify the correlation between child and parental behavior during pediatric dentistry sessions. Treatment sessions were recorded and evaluated, including 60 children representing three age groups. Two raters interpreted the resulting video clips using the modified Venham scale for children and the new hetero-rating scale for parents. They analyzed the videos twice and attributed scores at different time points of the appointment. The correlation between parental behavior upon entrance and the children's behavioral at the dental office in the treatment stage was significantly positive in both raters (Kendall Tau: 0.20-0.30). Furthermore, a panel of 20 dental practitioners scored a randomized selection of five recordings per age group. The level of agreement between the two experts was higher than that between the 20 clinicians. Venham types of scale involving multiple aspects can be used in research, but their application in dental practice requires further development. The link between parental anxiety and child anxiety is confirmed, but further research is required to incorporate specific aspects of treatment and parental behavior.
Language	English
Publishing date	2023-01-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10020249
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Article: Les urgences en dentisterie pédiatrique.

Vanden Abbeele, A / Vanhée, T

Revue medicale de Bruxelles

2018 Volume 39, Issue 4, Page(s) 325

Abstract: Introduction: Emergencies in pediatric dentistry are a real challenge for any healthcare professional. As pediatric dentists, we are aware that this practitioner has to manage an emotional situation, often the first contact of a young child with ... ...

Title translation	Emergencies in paediatric dentistry.
Abstract	Introduction: Emergencies in pediatric dentistry are a real challenge for any healthcare professional. As pediatric dentists, we are aware that this practitioner has to manage an emotional situation, often the first contact of a young child with dentistry, with sometimes complex clinical circumstances. This review of the different emergency pathologies presents the characteristics, the diagnoses and treatments, analyzed with special attention to the role of the physician and the dentist. . Material and methods: Literature analysis is conducted using the Pubmed and Google Scholar databases. Results: The pathologies are of several types: nocturnal pains, mainly due to pulpitis or a septum syndrome, and the pains caused by hot, cold or sugar, can only be managed by a dentist because they are due to caries. Only acute pain is an emergency per se. The colorations must also be managed by a dentist due to the specificity of the differential diagnosis. Special attention is paid to baby bottle polycaries, still too common. Finally, the different types of trauma, dental or periodontal are discussed with their treatment. Conclusions: The dentist, the pediatrician and the physician have their role to play both in the management of the emergency consultation and in the early detection of traumatic and non- traumatic lesions such as polycaries, in order to avoid at best both dental and psychological complications.
Language	French
Publishing date	2018-11-26
Publishing country	Belgium
Document type	English Abstract ; Journal Article
ZDB-ID	760217-0
ISSN	0035-3639
ISSN	0035-3639
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Article ; Online: Behavior of Children during Dental Care with Rubber Dam Isolation: A Randomized Controlled Study.

Vanhée, Tania / Tassignon, Chloé / Porta, Pierre / Bottenberg, Peter / Charles, Thierry / Vanden Abbeele, Astrid

Dentistry journal

2021 Volume 9, Issue 8

Abstract: Background: The establishment of the dental dam improves dentist working conditions and patient protection. The purpose of this study was to analyze the behavior of the child during dental care with or without a dam.: Methods: In this interventional ... ...

Abstract	Background: The establishment of the dental dam improves dentist working conditions and patient protection. The purpose of this study was to analyze the behavior of the child during dental care with or without a dam. Methods: In this interventional randomized study, 51 patients are divided into two groups, one with a rubber dam and the other with cotton roll isolation. Their behavior was observed during the treatment of temporary molars. The duration of the treatment, the patient's feeling with a visual analogue scale (VAS), the behavior (B) of the child measured with a hetero-evaluation scale (modified Venham scale) and the cardiac frequency (CF) were measured. Results: The group treated with a rubber dam has a significant decrease in the various stress parameters that have been identified (B, Conclusions: Isolation with a rubber dam reduces child's stress during dental care. Although it is slightly more time-consuming and training is necessary for a quick and effective placement, it allows dentists to perform dental care in the best possible conditions, while reducing dental anxiety in young patients.
Language	English
Publishing date	2021-08-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681351-8
ISSN	2304-6767 ; 2304-6767
ISSN (online)	2304-6767
ISSN	2304-6767
DOI	10.3390/dj9080089
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Article: Regulation of p56(lck) messenger turnover upon T cell activation: involvement of the 3' untranslated region in stability as determined in cell-free extracts.

Vanhée-Brossollet, C / Vaquero, C

Biochemical and biophysical research communications

1997 Volume 233, Issue 2, Page(s) 419–424

Abstract: Full activation of T lymphocytes transiently downregulates the steady state level ...

Abstract	Full activation of T lymphocytes transiently downregulates the steady state level of the tyrosine kinase p56(lck) mRNA. Here, we show that a decrease in messenger stability is involved in this downmodulation followed thereafter by a rapid and marked increase in mRNA half-life. In order to facilitate the study of p56(lck) messenger stability, an in vitro mRNA decay assay was developed and used to determine whether the 451 nucleotide long 3' untranslated region (3'UTR) of the messenger is implicated in the regulation of mRNA stability. Indeed, deletion of most of the 3'UTR led to a substantial increase in transcript half-life whereas deletion of a limited 3' portion did not, thus showing that the 146 nucleotides located in 5' of the 3'UTR contain destabilizing elements. Furthermore, the stability of both truncated transcripts was still modulated upon activation, thereby suggesting that the activation-responsive elements are located in a region distinct from the 3'UTR.
MeSH term(s)	Cell-Free System ; Humans ; Lymphocyte Activation ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck) ; Oncogene Proteins, Viral/genetics ; RNA, Messenger/metabolism ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; src-Family Kinases/genetics
Chemical Substances	Oncogene Proteins, Viral ; RNA, Messenger ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck) (EC 2.7.10.2) ; src-Family Kinases (EC 2.7.10.2)
Language	English
Publishing date	1997-04-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1006/bbrc.1997.6477
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