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  1. Book ; Online ; E-Book: Inequalities in respiratory health

    Sinha, Ian P.

    (ERS monograph series ; number 99, March 2023)

    2023  

    Abstract: If we are to address deeply ingrained health inequalities, we need to reflect on what has driven them, and critically review the approaches that do and do not work. This Monograph brings together a collection of state-of-the-art articles, discussing the ... ...

    Author's details edited by Ian P. Sinha [und 3 weiteren]
    Series title ERS monograph series ; number 99, March 2023
    ERS monograph
    Collection ERS monograph
    Abstract If we are to address deeply ingrained health inequalities, we need to reflect on what has driven them, and critically review the approaches that do and do not work. This Monograph brings together a collection of state-of-the-art articles, discussing the drivers and consequences of respiratory inequality.

    Front cover -- Title page -- Contents -- Preface -- Guest Editor biographies -- Introduction -- List of abbreviations -- Understanding the mechanisms of poverty and respiratory ill health -- Chapter 1. How to read a paper about inequality in respiratory disease: basic epidemiological principles and how inequalities are measured -- Chapter 2. What causes poverty and how does this contribute to respiratory inequality? -- Chapter 3. Ethnic, racial and migrant inequalities inrespiratory health -- Chapter 4. Inequalities in respiratory health based on sex and gender -- Chapter 5. Air pollution and respiratory inequality: lessons from high-income countries -- Chapter 6. Food insecurity and respiratory ill health -- Chapter 7. Housing and respiratory health: exposures, health effects and interventions -- Chapter 8. Tobacco, novel tobacco and nicotine products, and respiratory health -- Chapter 9. Work and respiratory health: lessons from occupational lung disease -- Chapter 10. Antenatal determinants of child lung development -- Inequalities in disease and ill health: what are we observing, and what are the mechanisms? -- Chapter 11. Inequalities in cystic fibrosis -- Chapter 12. Health inequality and COPD -- Chapter 13. Inequalities in asthma -- Chapter 14. Lung cancer and inequalities in access to multidisciplinary lung cancer services -- Chapter 15. Societal drivers of antimicrobial resistance -- Chapter 16. Inclusion health: respiratory health among people affected by social exclusion -- A global view of respiratory inequalities and approaches to solve these -- Chapter 17. Preventable deaths from respiratory diseases in children in low- and middle-income countries -- Chapter 18. Air quality in low- and middle-income countries: what is the impact on respiratory morbidity and mortality? -- Chapter 19. Global inequalities in tuberculosis.
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xiii, 248 Seiten), Illustrationen
    Publisher European Respiratory Society
    Publishing place Sheffield
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030020420
    ISBN 978-1-84984-158-0 ; 9781849841573 ; 1-84984-158-6 ; 1849841578
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Respiratory diseases of the newborn infant

    Hurst, John R. / Sinha, Ian P.

    (ERS monograph ; number 92)

    2021  

    Author's details edited by Ian P. Sinha [und 3 weitere] ; editor-in-chief John R. Hurst
    Series title ERS monograph ; number 92
    Collection
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xi, 371 Seiten), Illustrationen
    Publisher European Respiratory Society
    Publishing place Sheffield
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021009054
    ISBN 978-1-84984-138-2 ; 9781849841368 ; 1-84984-138-1 ; 1849841365
    DOI 10.1183/2312508X.10015620
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Evidence suggests dexamethasone is a better choice than prednisolone for acute asthma attacks in children.

    Sinha, Ian P

    Archives of disease in childhood

    2021  

    Language English
    Publishing date 2021-05-24
    Publishing country England
    Document type Editorial
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2020-321499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Risk of COVID-19 hospital admission among children with asthma.

    Harwood, Rachel / Sinha, Ian P

    The Lancet. Respiratory medicine

    2021  Volume 10, Issue 2, Page(s) 128–130

    MeSH term(s) Asthma ; COVID-19 ; Child ; Hospitalization ; Hospitals ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-11-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00509-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ataluren and similar compounds (specific therapies for premature termination codon class I mutations) for cystic fibrosis.

    Aslam, Aisha A / Sinha, Ian P / Southern, Kevin W

    The Cochrane database of systematic reviews

    2023  Volume 3, Page(s) CD012040

    Abstract: ... confidence interval 2.46 to 66.65; P = 0.002; I ...

    Abstract Background: Cystic fibrosis (CF) is a common, life-shortening, genetic disorder in populations of Northern European descent caused by the mutation of a single gene that codes for the production of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This protein coordinates the transport of salt (and bicarbonate) across cell surfaces, and the mutation most notably affects the airways. In the lungs of people with CF, the defective protein compromises mucociliary clearance and makes the airway prone to chronic infection and inflammation, damaging the structure of the airways and eventually leading to respiratory failure. In addition, abnormalities in the truncated CFTR protein lead to other systemic complications, including malnutrition, diabetes and subfertility. Five classes of mutation have been described, depending on the impact of the mutation on the processing of the CFTR protein in the cell. In class I mutations, premature termination codons prevent the production of any functional protein, resulting in severe CF. Therapies targeting class I mutations aim to enable the normal cellular mechanism to read through the mutation, potentially restoring the production of the CFTR protein. This could, in turn, normalise salt transport in the cells and decrease the chronic infection and inflammation that characterises lung disease in people with CF. This is an update of a previously published review.
    Objectives: To evaluate the benefits and harms of ataluren and similar compounds on clinically important outcomes in people with CF with class I mutations (premature termination codons).
    Search methods: We searched the Cochrane Cystic Fibrosis Trials Register, which is compiled from electronic database searches and handsearching of journals and conference abstract books. We also searched the reference lists of relevant articles. The last search of the Cochrane Cystic Fibrosis Trials Register was conducted on 7 March 2022. We searched clinical trial registries maintained by the European Medicines Agency, the US National Institutes of Health and the World Health Organization. The last search of the clinical trials registries was conducted on 4 October 2022.
    Selection criteria: Randomised controlled trials (RCTs) of parallel design comparing ataluren and similar compounds (specific therapies for class I mutations) with placebo in people with CF who have at least one class I mutation.
    Data collection and analysis: For the included trials, the review authors independently extracted data, assessed the risk of bias and evaluated the certainty of the evidence using GRADE; trial authors were contacted for additional data.
    Main results: Our searches identified 56 references to 20 trials; of these, 18 trials were excluded. Both the included parallel RCTs compared ataluren to placebo for 48 weeks in 517 participants (males and females; age range six to 53 years) with CF who had at least one nonsense mutation (a type of class I mutation). The certainty of evidence and risk of bias assessments for the trials were moderate overall. Random sequence generation, allocation concealment and blinding of trial personnel were well documented; participant blinding was less clear. Some participant data were excluded from the analysis in one trial that also had a high risk of bias for selective outcome reporting. PTC Therapeutics Incorporated sponsored both trials with grant support from the Cystic Fibrosis Foundation, the US Food and Drug Administration's Office of Orphan Products Development and the National Institutes of Health. The trials reported no difference between treatment groups in terms of quality of life, and no improvement in respiratory function measures. Ataluren was associated with a higher rate of episodes of renal impairment (risk ratio 12.81, 95% confidence interval 2.46 to 66.65; P = 0.002; I
    MeSH term(s) Adolescent ; Adult ; Child ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Aminoglycosides ; Anti-Bacterial Agents ; Codon, Nonsense ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Mutation ; Persistent Infection
    Chemical Substances Aminoglycosides ; Anti-Bacterial Agents ; ataluren (K16AME9I3V) ; Codon, Nonsense ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2023-03-03
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ISSN 1469-493X
    ISSN (online) 1469-493X
    DOI 10.1002/14651858.CD012040.pub3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The impact of poor housing and indoor air quality on respiratory health in children.

    Holden, Karl A / Lee, Alice R / Hawcutt, Daniel B / Sinha, Ian P

    Breathe (Sheffield, England)

    2023  Volume 19, Issue 2, Page(s) 230058

    Abstract: It is becoming increasingly apparent that poor housing quality affects indoor air quality, significantly impacting on respiratory health in children and young people. Exposure to damp and/or mould in the home, cold homes and the presence of pests and ... ...

    Abstract It is becoming increasingly apparent that poor housing quality affects indoor air quality, significantly impacting on respiratory health in children and young people. Exposure to damp and/or mould in the home, cold homes and the presence of pests and pollutants all have a significant detrimental impact on child respiratory health. There is a complex relationship between features of poor-quality housing, such as being in a state of disrepair, poor ventilation, overcrowding and being cold, that favour an environment resulting in poor indoor air quality. Children living in rented (private or public) housing are more likely to come from lower-income backgrounds and are most at risk of living in substandard housing posing a serious threat to respiratory health. Children have the right to safe and adequate housing, and research has shown that either rehousing or making modifications to poor-quality housing to improve indoor air quality results in improved respiratory health. Urgent action is needed to address this threat to health. All stakeholders should understand the relationship between poor-quality housing and respiratory health in children and act, working with families, to redress this modifiable risk factor.
    Educational aims: The reader should understand how housing quality and indoor air quality affect respiratory health in children.The reader should understand which children are at most risk of living in poor-quality housing.The reader should understand what policy recommendations have been made and what actions need to be undertaken to improve housing quality and respiratory health in children and young people.
    Language English
    Publishing date 2023-08-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2562899-9
    ISSN 2073-4735 ; 1810-6838
    ISSN (online) 2073-4735
    ISSN 1810-6838
    DOI 10.1183/20734735.0058-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The role of pulmonary CT scans for children during the COVID-19 pandemic.

    Sinha, Ian P / Kaleem, Musa

    BMC medicine

    2020  Volume 18, Issue 1, Page(s) 171

    MeSH term(s) Adolescent ; Betacoronavirus ; COVID-19 ; Child ; Coronavirus Infections/diagnostic imaging ; Humans ; Lung/diagnostic imaging ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; SARS-CoV-2 ; Tomography, X-Ray Computed
    Keywords covid19
    Language English
    Publishing date 2020-06-05
    Publishing country England
    Document type Letter
    ISSN 1741-7015
    ISSN (online) 1741-7015
    DOI 10.1186/s12916-020-01647-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Ethnicity and COVID-19 infection: are the pieces of the puzzle falling into place?

    Mulholland, Rachel H / Sinha, Ian P

    BMC medicine

    2020  Volume 18, Issue 1, Page(s) 206

    MeSH term(s) Betacoronavirus ; Biological Specimen Banks ; COVID-19 ; Coronavirus Infections ; Ethnic Groups ; Humans ; Pandemics ; Pneumonia, Viral ; Prospective Studies ; SARS Virus ; SARS-CoV-2 ; Socioeconomic Factors ; United Kingdom
    Keywords covid19
    Language English
    Publishing date 2020-07-01
    Publishing country England
    Document type Letter ; Comment
    ISSN 1741-7015
    ISSN (online) 1741-7015
    DOI 10.1186/s12916-020-01669-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The role of pulmonary CT scans for children during the COVID-19 pandemic

    Ian P. Sinha / Musa Kaleem

    BMC Medicine, Vol 18, Iss 1, Pp 1-

    2020  Volume 2

    Keywords COVID-19 ; Imaging ; Children ; Diagnosis ; Medicine ; R ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Palivizumab immunoprophylaxis for infants with BPD has medium- and long-term benefits: myth or maxim?

    Quinn, Lauren A / Hirani, Sunaya H / Williams, Thomas C / Sinha, Ian P

    Breathe (Sheffield, England)

    2022  Volume 17, Issue 4, Page(s) 210110

    Abstract: It is uncertain whether immunoprophylaxis against RSV protects preterm babies with BPD against future respiratory problems. It is biologically plausible that it does, at least in some infants. ...

    Abstract It is uncertain whether immunoprophylaxis against RSV protects preterm babies with BPD against future respiratory problems. It is biologically plausible that it does, at least in some infants.
    Language English
    Publishing date 2022-01-14
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2562899-9
    ISSN 2073-4735 ; 1810-6838
    ISSN (online) 2073-4735
    ISSN 1810-6838
    DOI 10.1183/20734735.0110-2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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