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Article: Neonatal COVID-19 Pneumonia: Report of the First Case in a Preterm Neonate in Mayotte, an Overseas Department of France.

Abasse, Soumeth / Essabar, Laila / Costin, Tereza / Mahisatra, Voninavoko / Kaci, Mohamed / Braconnier, Axelle / Serhal, Roger / Collet, Louis / Fayssoil, Abdallah

Children (Basel, Switzerland)

2020 Volume 7, Issue 8

Abstract: We report the first case of COVID-19 pneumonia in a preterm neonate in Mayotte, an overseas department of France. The newborn developed an acute respiratory distress by 14 days of life with bilateral ground glass opacities on a chest CT scan and a 6-week- ...

Abstract	We report the first case of COVID-19 pneumonia in a preterm neonate in Mayotte, an overseas department of France. The newborn developed an acute respiratory distress by 14 days of life with bilateral ground glass opacities on a chest CT scan and a 6-week-long stay in the neonatal intensive care unit (NICU). This case report emphasizes the need for a cautious and close follow-up period for asymptomatic neonates born to mothers with COVID-19 infection. Vertical transmission cannot be excluded in this case.
Keywords	covid19
Language	English
Publishing date	2020-08-03
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children7080087
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Child sexual abuse: report of 311 cases with review of literature.

Essabar, Laila / Khalqallah, Abdenbi / Dakhama, Badr Sououd Benjelloun

The Pan African medical journal

2015 Volume 20, Page(s) 47

Abstract: Child sexual abuse (CSA) is a global problem that has significant consequences for public health; it has been a prominent topic of public concern for more than a decade, but many basic facts about the problem remain unclear or in dispute. We conducted a ... ...

Abstract	Child sexual abuse (CSA) is a global problem that has significant consequences for public health; it has been a prominent topic of public concern for more than a decade, but many basic facts about the problem remain unclear or in dispute. We conducted a study of 311 cases of CSA in order to highlight the epidemiological features and negative impact on victims' well-being and to emphasize the need for a multidisciplinary approach to the primary prevention and management of CSA. We noted an increase in cases number with male predominance. Most of our patients came from lower socioeconomic classes. The perpetrators were male in 100% of cases; acquaintances in 70% of cases and family members in 22 cases. Physical examination were normal in 61% of cases, however, a range of psychological and physical effects were identified with dramatic health consequences: three cases of attempted suicide, five pregnancies and one case of HIV virus infection.
MeSH term(s)	Adolescent ; Child ; Child Abuse, Sexual/prevention & control ; Child Abuse, Sexual/psychology ; Child Abuse, Sexual/statistics & numerical data ; Female ; HIV Infections/epidemiology ; HIV Infections/transmission ; HIV-1 ; Humans ; Male ; Morocco/epidemiology ; Pregnancy ; Pregnancy in Adolescence/statistics & numerical data ; Retrospective Studies ; Suicide, Attempted/psychology ; Suicide, Attempted/statistics & numerical data
Language	English
Publishing date	2015
Publishing country	Uganda
Document type	Journal Article ; Review
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2015.20.47.4569
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Neonatal COVID-19 Pneumonia

Soumeth Abasse / Laila Essabar / Tereza Costin / Voninavoko Mahisatra / Mohamed Kaci / Axelle Braconnier / Roger Serhal / Louis Collet / Abdallah Fayssoil

Children , Vol 7, Iss 87, p

Report of the First Case in a Preterm Neonate in Mayotte, an Overseas Department of France

2020 Volume 87

Abstract	We report the first case of COVID-19 pneumonia in a preterm neonate in Mayotte, an overseas department of France. The newborn developed an acute respiratory distress by 14 days of life with bilateral ground glass opacities on a chest CT scan and a 6-week-long stay in the neonatal intensive care unit (NICU). This case report emphasizes the need for a cautious and close follow-up period for asymptomatic neonates born to mothers with COVID-19 infection. Vertical transmission cannot be excluded in this case.
Keywords	COVID-19 ; preterm neonate ; pneumonia ; vertical transmission ; length of stay ; Pediatrics ; RJ1-570 ; covid19
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Child sexual abuse

Laila Essabar / Abdenbi Khalqallah / Badr Sououd Benjelloun Dakhama

The Pan African Medical Journal, Vol 20, Iss

report of 311 cases with review of literature

2015 Volume 47

Abstract	Child sexual abuse (CSA) is a global problem that has significant consequences for public health; it has been a prominent topic of public concern for more than a decade, but many basic facts about the problem remain unclear or in dispute. We conducted a study of 311 cases of CSA in order to highlight the epidemiological features and negative impact on victims' well-being and to emphasize the need for a multidisciplinary approach to the primary prevention and management of CSA. We noted an increase in cases number with male predominance. Most of our patients came from lower socioeconomic classes. The perpetrators were male in 100% of cases; acquaintances in 70% of cases and family members in 22 cases. Physical examination were normal in 61% of cases, however, a range of psychological and physical effects were identified with dramatic health consequences: three cases of attempted suicide, five pregnancies and one case of HIV virus infection.
Keywords	child ; rape ; incest ; reporting ; suicide ; depression ; Medicine ; R
Subject code	360
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	The Pan African Medical Journal
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Malignant infantile osteopetrosis: case report with review of literature.

Essabar, Laila / Meskini, Toufik / Ettair, Said / Erreimi, Naima / Mouane, Nezha

The Pan African medical journal

2014 Volume 17, Page(s) 63

Abstract: Malignant Infantile Osteopetrosis (MIOP) is a rare genetic disorder due to osteoclast abnormal activity. We report a thirteen month-old male patient, diagnosed as MIOP while investigating the cause of hepatosplenomegaly associated with hydrocephalus. His ...

Abstract	Malignant Infantile Osteopetrosis (MIOP) is a rare genetic disorder due to osteoclast abnormal activity. We report a thirteen month-old male patient, diagnosed as MIOP while investigating the cause of hepatosplenomegaly associated with hydrocephalus. His medical history revealed non consanguineous parents and one brother's death at the same age of unknown etiology (similar symptoms). Systemic examination showed hepatosplenomegaly, growth failure, developmental milestones delay, and rickets features. Ophthalmic exam yielded bilateral optic atrophy. Skeleton radiographs detected generalized dense bone and rickets. Cerebral CT scan revealed hydrocephalus. Histological examination showed hypoplastic bone marrow and extra-medullary hematopoeisis. Diagnosis was confirmed by genetic testing that showed two heterozygote mutations within the TCIRG1 gene. The patient received supportive treatment. He died from an acute respiratory distress. MIOP should be kept in mind as a rare cause of hepatosplenomegaly. Early diagnosis and timely Hematopoietic stem cell transplantation are the only curative approach for an otherwise fatal disease.
MeSH term(s)	Fatal Outcome ; Humans ; Hydrocephalus/complications ; Hydrocephalus/diagnosis ; Hydrocephalus/genetics ; Infant ; Male ; Osteopetrosis/complications ; Osteopetrosis/diagnosis ; Osteopetrosis/genetics ; Respiratory Insufficiency/complications ; Respiratory Insufficiency/diagnosis ; Respiratory Insufficiency/genetics ; Rickets/complications ; Rickets/diagnosis ; Rickets/genetics ; Vacuolar Proton-Translocating ATPases/genetics
Chemical Substances	TCIRG1 protein, human ; Vacuolar Proton-Translocating ATPases (EC 3.6.1.-)
Language	English
Publishing date	2014-01-27
Publishing country	Uganda
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2014.17.63.3759
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Neonatal COVID-19 Pneumonia: Report of the First Case in a Preterm Neonate in Mayotte, an Overseas Department of France

Abasse, Soumeth / Essabar, Laila / Costin, Tereza / Mahisatra, Voninavoko / Kaci, Mohamed / Braconnier, Axelle / Serhal, Roger / Collet, Louis / Fayssoil, Abdallah

Children

Abstract: We report the first case of COVID-19 pneumonia in a preterm neonate in Mayotte, an overseas department of France The newborn developed an acute respiratory distress by 14 days of life with bilateral ground glass opacities on a chest CT scan and a 6-week- ... ...

Abstract	We report the first case of COVID-19 pneumonia in a preterm neonate in Mayotte, an overseas department of France The newborn developed an acute respiratory distress by 14 days of life with bilateral ground glass opacities on a chest CT scan and a 6-week-long stay in the neonatal intensive care unit (NICU) This case report emphasizes the need for a cautious and close follow-up period for asymptomatic neonates born to mothers with COVID-19 infection Vertical transmission cannot be excluded in this case
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #693647
Database	COVID19

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Article ; Online: Gaucher's disease: report of 11 cases with review of literature.

Essabar, Laila / Meskini, Toufik / Lamalmi, Najat / Ettair, Said / Erreimi, Naima / Mouane, Nezha

The Pan African medical journal

2015 Volume 20, Page(s) 18

Abstract: Gaucher's disease (GD) is a lysosomal storage disorder due to glucocerebrosidase deficiency; it's one of the rare genetic diseases for which therapy is now available. The purpose of this work is to study the epidemiological features of the disease and to ...

Abstract	Gaucher's disease (GD) is a lysosomal storage disorder due to glucocerebrosidase deficiency; it's one of the rare genetic diseases for which therapy is now available. The purpose of this work is to study the epidemiological features of the disease and to highlight the diagnostic difficulties. We performed an 11-year retrospective study of 11 patients with GD followed-up in the department of paediatric hepatology gastroenterology and nutrition of Rabat children's Hospital. We observed 11 patients with GD: 6 males and 5 females. Age at onset ranged from 3 months to 10 years with an average of 3.41 years. Mean age at diagnosis was 4 years (range 3 months-14 years). Parental consanguinity was noted in 85% cases. According to the clinical presentation, we classified our patients into: 9 cases of type 1 (81%) and two cases of type 2 (19%), none of the patients presented GD type 3. GD type 1: The age at diagnosis ranged from 2 years to 14 year with an average of 6 years. Main symptoms were: splenomegaly, hepatomegaly, pallor, haemorrhagic appearance (40%), bone pain (40%). The diagnosis was based on histology showing the Gaucher's cells in various tissues (100%). Enzymatic activity dosage confirmed the diagnosis of GD for 4 patients (44.5%). The treatment was always symptomatic (analgesics, transfusion). A splenectomy was performed in one case presenting with multiple splenic abscesses and high transfusion requirements. None of the patients received a specific treatment (substitutive enzymotherapy). The follow-up period ranged from 3 months to 6 years with an average follow-up of 4 years. We noticed stability in 4 cases, 2 worsening cases with bone and spleen complications. Three patients were lost to follow-up. GD type 2: we observed two cases of GD type 2 diagnosed at 3 and 18 months. The visceral symptoms were serious and the neurological features included seizures, hypertony, squint, physical developmental milestones delay. Both of them died. Gaucher's disease is not exceptional in Morocco. Type 1 is the most common type. We noted through this study some diagnostic difficulties as the diagnosis was delayed and the enzymatic dosage was performed in only 42% of the cases as well as therapeutic difficulty with no prescription of the specific treatment given the high cost of the enzyme.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Consanguinity ; Female ; Gaucher Disease/epidemiology ; Gaucher Disease/pathology ; Gaucher Disease/therapy ; Humans ; Infant ; Male ; Retrospective Studies
Language	English
Publishing date	2015
Publishing country	Uganda
Document type	Journal Article ; Review
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2015.20.18.4112
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Malignant infantile osteopetrosis

Laila Essabar / Toufik Meskini / Said Ettair / Naima Erreimi / Nezha Mouane

The Pan African Medical Journal, Vol 17, Iss

case report with review of literature

2014 Volume 63

Abstract: Malignant Infantile Osteopetrosis (MIOP) is a rare genetic disorder due to osteoclast abnormal activity.We report a thirteen month-old male patient, diagnosed as MIOP while investigating the cause of hepatosplenomegaly associated with hydrocephalus. His ... ...

Abstract	Malignant Infantile Osteopetrosis (MIOP) is a rare genetic disorder due to osteoclast abnormal activity.We report a thirteen month-old male patient, diagnosed as MIOP while investigating the cause of hepatosplenomegaly associated with hydrocephalus. His medical history revealed non consanguineous parents and one brother's death at the same age of unknown etiology (similar symptoms).Systemic examination showed hepatosplenomegaly, growth failure, developmental milestones delay, and rickets features. Ophthalmic exam yielded bilateral optic atrophy. Skeleton radiographs detected generalized dense bone and rickets. Cerebral CT scan revealed hydrocephalus. Histological examination showed hypoplastic bone marrow and extra-medullary hematopoeisis. Diagnosis was confirmed by genetic testing that showed two heterozygote mutations within the TCIRG1 gene. The patient received supportive treatment. He died from an acute respiratory distress.MIOP should be kept in mind as a rare cause of hepatosplenomegaly. Early diagnosis and timely Hematopoietic stem cell transplantation are the only curative approach for an otherwise fatal disease.
Keywords	osteopetrosis ; infant ; hepatomegaly ; splenomegaly ; hydrocephalus ; rickets ; Medicine ; R
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	The Pan African Medical Journal
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Harmful Use of Veterinary Drugs

Laila Essabar / Toufik Meskini / Said Ettair / Naima Erreimi / Nezha Mouane

Asia Pacific Journal of Medical Toxicology , Vol 3, Iss 4, Pp 173-

Blindness Following Closantel Poisoning in a 5-Year-Old Girl

2014 Volume 175

Abstract: Background: Closantel is a veterinary drug used as anthelmintic for ruminants while it is contraindicated for humans. This report describes a rare case of blindness, increased liver enzymes and coagulopathy following closantel poisoning. Case report: A 5- ...

Abstract	Background: Closantel is a veterinary drug used as anthelmintic for ruminants while it is contraindicated for humans. This report describes a rare case of blindness, increased liver enzymes and coagulopathy following closantel poisoning. Case report: A 5-year-old girl was presented with acute blindness following closantel poisoning. She was given mistakenly a dose of 500 mg/day (25mg/kg/day) for 8 days. Clinical examination revealed a well-appearing child with bilateral mydriasis, loss of pupillary light reflex and absence of blinking to threat. Fundoscopic exam revealed bilateral pre-atrophic papilledema. Electroretinogram showed a highly significant decrease in retinal activity. Laboratory examinations revealed 52% increase in prothrombin time, prolongation of activated partial thromboplastin time to 1.3 times the normal and rise of aspartate aminotransferase to 120 IU/L. In addition, creatine kinase peaked at 904 IU/L. Moreover, normocytic normochromic anemia with hemoglobin at 10.7 mg/L and leukocytosis with lymphocytic predominance was noted. The patient received glucocorticoids, vitamin B12 and vitamin K and was discharged after correction of blood and coagulation parameters and normalization of liver enzymes. Partial recovery in visual acuity was found two months after ingestion of the last dose. Discussion:Closantel can cause significant spongiform change (intra-myelin vacuolation) in the white matter of the cerebrum and the cerebellum. It can also induce optic nerve damage as a result of Wallerian degeneration, fibrosis and atrophy. On the retina, closantel leads to papilledema, necrosis of the outer layers, and retinal detachment. It can also cause fatty change and hydropic degeneration in the liver and hepatocellular degeneration. Conclusion: Closantel is a toxic drug for humans causing blindness, hematologic and hepatic disorders. Public awareness should be raised regarding the risks of use of unapproved drugs for human.
Keywords	Acute Liver Failure ; Blindness ; Closantel ; Poisoning ; Salicylanilides ; Toxicology. Poisons ; RA1190-1270 ; Public aspects of medicine ; RA1-1270 ; Medicine ; R
Subject code	610
Language	English
Publishing date	2014-12-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Gaucher's disease

Laila Essabar / Toufik Meskini / Najat Lamalmi / Said Ettair / Naima Erreimi / Nezha Mouane

The Pan African Medical Journal, Vol 20, Iss

report of 11 cases with review of literature

2015 Volume 18

Abstract	Gaucher's disease (GD) is a lysosomal storage disorder due to glucocerebrosidase deficiency; it's one of the rare genetic diseases for which therapy is now available. The purpose of this work is to study the epidemiological features of the disease and to highlight the diagnostic difficulties. We performed an 11-year retrospective study of 11 patients with GD followed-up in the department of paediatric hepatology gastroenterology and nutrition of Rabat children's Hospital. We observed 11 patients with GD: 6 males and 5 females. Age at onset ranged from 3 months to 10 years with an average of 3.41 years. Mean age at diagnosis was 4 years (range 3months-14years).Parental consanguinity was noted in 85% cases. According to the clinical presentation, we classified our patients into: 9 cases of type 1 (81%) and two cases of type 2 (19%), none of the patients presented GD type 3. GD type 1: The age at diagnosis ranged from 2 years to 14 year with an average of 6 years. Main symptoms were: splenomegaly, hepatomegaly , pallor, haemorrhagic appearance (40%), bone pain (40%). The diagnosis was based on histology showing the Gaucher's cells in various tissues (100%). Enzymatic activity dosage confirmed the diagnosis of GD for 4 patients (44.5%). The treatment was always symptomatic (analgesics, transfusion). A splenectomy was performed in one case presenting with multiple splenic abscesses and high transfusion requirements. None of the patients received a specific treatment (substitutive enzymotherapy). The follow-up period ranged from 3 months to 6 years with an average follow-up of 4 years. We noticed stability in 4 cases, 2 worsening cases with bone and spleen complications. Three patients were lost to follow-up. GD type 2: we observed two cases of GD type 2 diagnosed at 3 and 18 months. The visceral symptoms were serious and the neurological features included seizures, hypertony, squint, physical developmental milestones delay. Both of them died. Gaucher's disease is not exceptional in Morocco. Type 1 is the most common type. We noted through this study some diagnostic difficulties as the diagnosis was delayed and the enzymatic dosage was performed in only 42% of the cases as well as therapeutic difficulty with no prescription of the specific treatment given the high cost of the enzyme.
Keywords	gaucher disease ; children ; hepatosplenomegaly ; enzymatic dosage ; splenectomy ; Medicine ; R
Subject code	610
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	The Pan African Medical Journal
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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