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Article ; Online: Authors' response to the Comments from S.M.J. Mortazavi regarding: "Occupational exposure to high-frequency electromagnetic fields and brain tumor risk in the INTEROCC study: An individualized assessment approach".

Vila, Javier / Turner, Michelle C / Gracia-Lavedan, Esther / Figuerola, Jordi / Bowman, Joseph D / Kincl, Laurel / Richardson, Lesley / Benke, Geza / Hours, Martine / Krewski, Daniel / McLean, Dave / Parent, Marie-Elise / Sadetzki, Siegal / Schlaefer, Klaus / Schlehofer, Brigitte / Schüz, Joachim / Siemiatycki, Jack / van Tongeren, Martie / Cardis, Elisabeth

Environment international

2018 Volume 121, Issue Pt 1, Page(s) 1025–1026

MeSH term(s)	Brain Neoplasms ; Electromagnetic Fields ; Humans ; Occupational Exposure
Language	English
Publishing date	2018-08-28
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2018.08.007
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Article ; Online: Examination of Genetic Susceptibility in Radiation-Associated Meningioma.

Pemov, A / Kim, J / Jones, K / Vogt, A / Sadetzki, S / Stewart, D R

Radiation research

2022 Volume 198, Issue 1, Page(s) 81–88

Abstract: Previous epidemiological studies have demonstrated elevated susceptibility to ionizing radiation in some families, thus suggesting the presence of genetic components that conferred increased rate of radiation-associated meningioma (RAM). In this study, ... ...

Abstract	Previous epidemiological studies have demonstrated elevated susceptibility to ionizing radiation in some families, thus suggesting the presence of genetic components that conferred increased rate of radiation-associated meningioma (RAM). In this study, we exome-sequenced and investigated the segregation pattern of rare deleterious variants in 11 RAM pedigrees. In addition, we performed a rare-variant association analysis in 92 unrelated familial cases of RAM that were ancestry-matched with 88 meningioma-free controls. In the pedigree analysis, we found that each family carried mostly a unique set of rare deleterious variants. A follow-up pathway analysis of the union of the genes that segregated within each of the 11 pedigrees identified a single statistically significant (q value = 7.90E-04) "ECM receptor interaction" set. In the case-control association analysis, we observed no statistically significant variants or genes after multiple testing correction; however, examination of ontological categories of the genes that associated with RAM at nominal P values <0.01 identified biologically relevant pathways such as DNA repair, cell cycle and apoptosis. These results suggest that it is unlikely that a small number of highly penetrant genes are involved in the pathogenesis of RAM. Substantially larger studies are needed to identify genetic risk variants and genes in RAM.
MeSH term(s)	Case-Control Studies ; Exome ; Genetic Predisposition to Disease ; Humans ; Pedigree ; Radiation, Ionizing
Language	English
Publishing date	2022-04-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	80322-4
ISSN	1938-5404 ; 0033-7587
ISSN (online)	1938-5404
ISSN	0033-7587
DOI	10.1667/RADE-21-00035.1
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Article ; Online: Fifteen-year survival of invasive epithelial ovarian cancer in women with BRCA1/2 mutations - the National Israeli Study of Ovarian Cancer.

Lavie, Ofer / Chetrit, Angela / Novikov, Ilya / Sadetzki, Siegal

Gynecologic oncology

2019 Volume 153, Issue 2, Page(s) 320–325

Abstract: Objective: Compare 5, 10 and 15 year survival in invasive epithelial ovarian cancer, between patients with and without BRCA1/2 germ line mutation in a nonselective group of patients diagnosed during 1994-99.: Methods: The analysis was based on 779 ... ...

Abstract	Objective: Compare 5, 10 and 15 year survival in invasive epithelial ovarian cancer, between patients with and without BRCA1/2 germ line mutation in a nonselective group of patients diagnosed during 1994-99. Methods: The analysis was based on 779 Jewish patients: 229 carriers to the Ashkenazi Jewish founder mutations in BRCA1 (185delAG; 5382insC) and BRCA2 (6174delT); and 550 non-carriers. Clinical characteristics were abstracted from the patients' medical records and vital status was updated through the National Population Registry up to 11/2015. The Kaplan-Meier method, log-rank tests, and Cox-regression model were used for survival analyses. Results: By the end of the follow-up period, (range 1-20 years), 629 (80.7%) deaths occurred. While considerably higher survival was observed during the first 5 years from diagnosis among carriers compared to non-carriers (46.7% vs. 36.2%, p = 0.0004), the survival rates at 15 years were 22.3% vs. 21.8% respectively (p = 0.04). The age-adjusted hazard ratio for all-cause mortality of carriers versus non-carriers was 0.74 (95%CI 0.60-0.91) in the first 5 years. For women who survived 5 and 10 years, the age-adjusted hazard ratios for mortality during 5 additional years, of carriers compared to non-carriers, were 1.38 (95%CI 0.93-2.04) and 1.08 (95%CI 0.61-1.92), respectively. Conclusion: The results of this study, with up to 20 years follow-up, support studies with shorter follow-up that suggested that the advantage in survival observed among BRCA1/2 carriers during the first 5 years decreases over time. Clinically, this may have implications for follow-up and therapy, especially of new agents that are particularly effective in BRCA carriers.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Carcinoma, Ovarian Epithelial/genetics ; Carcinoma, Ovarian Epithelial/mortality ; Carcinoma, Ovarian Epithelial/pathology ; Case-Control Studies ; Female ; Follow-Up Studies ; Genetic Testing ; Humans ; Israel/epidemiology ; Jews/genetics ; Kaplan-Meier Estimate ; Middle Aged ; Mutation ; Neoplasm Invasiveness/genetics ; Neoplasm Invasiveness/pathology ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/mortality ; Ovarian Neoplasms/pathology ; Survival Rate ; Young Adult
Chemical Substances	BRCA1 Protein ; BRCA1 protein, human ; BRCA2 Protein ; BRCA2 protein, human
Language	English
Publishing date	2019-03-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	801461-9
ISSN	1095-6859 ; 0090-8258
ISSN (online)	1095-6859
ISSN	0090-8258
DOI	10.1016/j.ygyno.2019.02.022
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Article ; Online: Upholding democracy in a global pandemic: the Israeli elections experience.

Afek, Arnon / Leshem, Eyal / Kaliner, Ehud / Fast, Dov / Sadetzki, Siegal

Journal of travel medicine

2020 Volume 27, Issue 7

MeSH term(s)	COVID-19 ; Communicable Disease Control/methods ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Democracy ; Female ; Humans ; Israel ; Male ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Politics ; Quarantine/organization & administration ; Universal Precautions/methods
Keywords	covid19
Language	English
Publishing date	2020-10-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1212504-0
ISSN	1708-8305 ; 1195-1982
ISSN (online)	1708-8305
ISSN	1195-1982
DOI	10.1093/jtm/taaa162
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Article: Excess lifetime cancer mortality risk attributed to radiation exposure from pediatric computed tomography scan.

Sadetzki, Siegal

The Israel Medical Association journal : IMAJ

2007 Volume 9, Issue 8, Page(s) 607–609

MeSH term(s)	Child ; Chronic Disease ; Humans ; Neoplasms, Radiation-Induced/mortality ; Risk Assessment ; Survival Analysis ; Time Factors ; Tomography, X-Ray Computed/adverse effects
Language	English
Publishing date	2007-08
Publishing country	Israel
Document type	Comment ; Editorial
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Article ; Online: Reply to cancer risk among Holocaust survivors in Israel.

Sadetzki, Siegal / Chetrit, Angela / Freedman, Laurence S

Cancer

2017 Volume 123, Issue 21, Page(s) 4295–4296

MeSH term(s)	Holocaust ; Humans ; Israel ; Jews ; Neoplasms ; Survivors
Language	English
Publishing date	2017-09-07
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1429-1
ISSN	1097-0142 ; 0008-543X ; 1934-662X
ISSN (online)	1097-0142
ISSN	0008-543X ; 1934-662X
DOI	10.1002/cncr.30974
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Article ; Online: Childhood Exposure to Low to Moderate Doses of Ionizing Radiation and the Risk of Vascular Diseases.

Sadetzki, Siegal / Chetrit, Angela / Boursi, Ben / Luxenburg, Osnat / Novikov, Ilya / Cohen, Arnon

American journal of epidemiology

2020 Volume 190, Issue 3, Page(s) 423–430

Abstract: In the Tinea Capitis Study (Israel, 1966-2011), we assessed the association between childhood exposure to low to moderate doses of ionizing radiation (IR) to the head and neck and the development of vascular diseases (ischemic heart disease, carotid ... ...

Abstract	In the Tinea Capitis Study (Israel, 1966-2011), we assessed the association between childhood exposure to low to moderate doses of ionizing radiation (IR) to the head and neck and the development of vascular diseases (ischemic heart disease, carotid artery stenosis, and stroke) in adulthood. The study included 17,734 individuals from the Tinea Capitis cohort (7,408 irradiated in childhood and 10,326 nonirradiated), insured by Israel's largest health provider. Individual dosimetry was estimated based on measurements made on a head phantom and original treatment records. The mean doses were 1.5, 0.09, 0.78, and 0.017 Gy to brain, thyroid, salivary gland, and breast, respectively. Data on vascular diseases was abstracted from computerized medical records. Using Poisson regressions, we examined the association of radiation with morbidity. Any vascular disease was reported for 2,221 individuals. Adjusted for age, sex, socioeconomic status, smoking, hypertension, and diabetes, exposure to IR increased the risk of developing any vascular diseases (relative risk (RR) = 1.19, 95% confidence interval (CI): 1.09, 1.29), stroke (RR = 1.35, 1.20, 1.53), carotid artery stenosis (RR = 1.32, 1.06, 1.64), and ischemic heart disease (RR = 1.12, 1.01, 1.26). The risk of developing vascular diseases was positively associated with dose and inversely associated with age at exposure. In conclusion, the results indicate that early exposure to low to moderate doses of IR increases the risk of cerebro- and cardiovascular impairments.
MeSH term(s)	Adolescent ; Age Factors ; Child ; Child, Preschool ; Dose-Response Relationship, Radiation ; Female ; Humans ; Infant ; Male ; Radiation, Ionizing ; Risk Factors ; Tinea Capitis/radiotherapy ; Vascular Diseases/epidemiology
Language	English
Publishing date	2020-09-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2937-3
ISSN	1476-6256 ; 0002-9262
ISSN (online)	1476-6256
ISSN	0002-9262
DOI	10.1093/aje/kwaa177
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Article ; Online: Implementation of a competency-based medical education approach in public health and epidemiology training of medical students.

Dankner, Rachel / Gabbay, Uri / Leibovici, Leonard / Sadeh, Maya / Sadetzki, Siegal

Israel journal of health policy research

2018 Volume 7, Issue 1, Page(s) 13

Abstract: Background: There is increasing agreement among medical educators regarding the importance of improving the integration between public health and clinical education, understanding and implementation of epidemiological methods, and the ability to ... ...

Abstract	Background: There is increasing agreement among medical educators regarding the importance of improving the integration between public health and clinical education, understanding and implementation of epidemiological methods, and the ability to critically appraise medical literature. The Sackler School of Medicine at Tel-Aviv University revised its public health and preventive medicine curriculum, during 2013-2014, according to the competency-based medical education (CBME) approach in training medical students. We describe the revised curriculum, which aimed to strengthen competencies in quantitative research methods, epidemiology, public health and preventive medicine, and health service organization and delivery. Methods: We report the process undertaken to establish a relevant 6-year longitudinal curriculum and describe its contents, implementation, and continuous assessment and evaluation. Results: Central competencies included: epidemiology and statistics for appraisal of the literature and implementation of research; the application of health promotion principles and health education strategies in disease prevention; the use of an evidence-based approach in clinical and public health decision making; the examination and analysis of disease trends at the population level; and knowledge of the structure of health systems and the role of the physician in these systems. Two new courses, in health promotion, and in public health, were added to the curriculum, and the courses in statistics and epidemiology were joined. Annual evaluation of each course results in continuous revisions of the syllabi as needed, while we continue to monitor the whole curriculum. Conclusions: The described revision in a 6 year-medical school training curriculum addresses the currently identified needs in public health. Ongoing feedback from students, and re-evaluation of syllabus by courses teams are held annually. Analysis of student's written feedbacks and courses evaluations of "before and after" the implementation of this intervention is taking place to examine the effect of the new curriculum on the perceived clinical and research capacities of our 6-year students.
MeSH term(s)	Competency-Based Education ; Curriculum ; Delivery of Health Care ; Education, Medical/methods ; Education, Medical/trends ; Epidemiology/education ; Humans ; Israel ; Longitudinal Studies ; Preventive Medicine/education ; Public Health/education ; Students, Medical
Language	English
Publishing date	2018-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2657655-7
ISSN	2045-4015 ; 2045-4015
ISSN (online)	2045-4015
ISSN	2045-4015
DOI	10.1186/s13584-017-0194-8
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Article ; Online: Breast cancer survivors: physical and mental quality of life 10 years following diagnosis, a case-control study.

Chetrit, Angela / Ben-Avraham, Sivan / Mandelzweig, Lori / Amitai, Tova / Danieli, Nava Siegelmann / Silverman, Barbara / Sadetzki, Siegal

Breast cancer research and treatment

2021 Volume 188, Issue 1, Page(s) 273–282

Abstract: Purpose: Improvements in diagnosis and treatment of Breast Cancer (BC) have resulted in an increase in the life expectancy of survivors and in the importance of quality of life in BC survivorship care. The current study aimed to assess the Health- ... ...

Abstract	Purpose: Improvements in diagnosis and treatment of Breast Cancer (BC) have resulted in an increase in the life expectancy of survivors and in the importance of quality of life in BC survivorship care. The current study aimed to assess the Health-Related Quality Of Life (HRQOL) of BC survivors and to investigate the association of comorbidities with HRQOL compared to a group of women with no history of cancer. Methods: Women were residents of the central district in Israel, the case group included 250 women diagnosed with BC between 1999 and 2003, with no prior cancer history and no evidence of disease after 8-12 years. The comparison group included 250 women with no cancer history, individually matched to cases by age and area of residence. Data were collected through in-person interviews, and HRQOL was assessed using the Short Form-36 (SF-36) questionnaire. Regression analyses were performed evaluating the influence of demographic, socioeconomic, lifestyle characteristics and comorbidities on physical and mental HRQOL. Results: The physical and mental summary scores means, were 48.5 ± 11.1 and 49.2 ± 10.8 compared to 51.5 ± 10.2 and 50.9 ± 10.6, in BC survivors and the comparison group, respectively (p = 0.002 and p = 0.097). BC survivors and controls did not differ in number and type of comorbidities and for both groups a negative association was seen with HRQOL. Controlling for age, income, number of comorbidities, BMI and physical activity, BC survivor had decreased physical (b = -2.49, p = 0.001) and mental summary scores (b = -1.27, p = 0.18). Conclusion: HRQOL of BC survivors should gain more attention in the area of cancer care, especially when comorbidities are present.
MeSH term(s)	Breast Neoplasms ; Cancer Survivors ; Case-Control Studies ; Female ; Humans ; Israel ; Quality of Life ; Survivors
Language	English
Publishing date	2021-04-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-021-06156-0
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Article ; Online: Upholding democracy in a global pandemic

Afek, Arnon / Leshem, Eyal / Kaliner, Ehud / Fast, Dov / Sadetzki, Siegal

Journal of Travel Medicine

the Israeli elections experience

2020 Volume 27, Issue 7

Abstract: The COVID-19 pandemic substantially impacted countries' democratic election. On March 2020 Israel held a general parliamentary elections. The participation rate was 71.5%, compared with a 70% rate on the previous elections held in September 2019. We ... ...

Abstract	The COVID-19 pandemic substantially impacted countries' democratic election. On March 2020 Israel held a general parliamentary elections. The participation rate was 71.5%, compared with a 70% rate on the previous elections held in September 2019. We review Israel's actions which lead to a safe elections process and enhanced participation rate.
Keywords	General Medicine ; covid19
Language	English
Publisher	Oxford University Press (OUP)
Publishing country	uk
Document type	Article ; Online
ZDB-ID	1212504-0
ISSN	1708-8305 ; 1195-1982
ISSN (online)	1708-8305
ISSN	1195-1982
DOI	10.1093/jtm/taaa162
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