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  1. Article ; Online: Casirivimab-imdevimab to Prevent SARS-CoV-2 Infections in Solid Organ Transplant Recipients.

    Dimeglio, Chloé / Del Bello, Arnaud / Chapuy-Regaud, Sabine / Esposito, Laure / Danet, Chloé / Couat, Chloé / Izopet, Jacques / Kamar, Nassim

    Transplantation

    2022  Volume 106, Issue 5, Page(s) e275–e276

    MeSH term(s) Antibodies, Monoclonal, Humanized ; COVID-19/prevention & control ; Humans ; Organ Transplantation/adverse effects ; SARS-CoV-2 ; Transplant Recipients
    Chemical Substances Antibodies, Monoclonal, Humanized ; imdevimab (2Z3DQD2JHM) ; casirivimab (J0FI6WE1QN)
    Language English
    Publishing date 2022-03-08
    Publishing country United States
    Document type Letter
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004087
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  2. Article: Study of the cellular and humoral immune responses to SARS-CoV-2 vaccination.

    Montmaneix-Engels, Faustine / Dimeglio, Chloé / Staes, Laeticia / Da Silva, Isabelle / Porcheron, Marion / Jougla, Isabelle / Hérin, Fabrice / Izopet, Jacques

    Heliyon

    2024  Volume 10, Issue 7, Page(s) e29116

    Abstract: Our understanding of cellular immunity in response to COVID-19 infection or vaccination is limited because of less commonly used techniques. We investigated both the cellular and humoral immune responses before and after the administration of a third ... ...

    Abstract Our understanding of cellular immunity in response to COVID-19 infection or vaccination is limited because of less commonly used techniques. We investigated both the cellular and humoral immune responses before and after the administration of a third dose of the SARS-CoV-2 vaccine among a group of healthcare workers. Cellular immunity was evaluated using the VIDAS interferon-gamma (IFNγ) RUO test, which enables automated measurement of IFNγ levels after stimulating peripheral blood lymphocytes. Booster doses significantly enhanced both cellular and humoral immunity. Concerning cellular response, the booster dose increased the percentage of positive IFNγ release assay (IGRA) results but no difference in IFNγ release was found. The cellular response was not associated with protection against SARS-CoV-2 infection. Interestingly, vaccinated and infected healthcare workers exhibited the highest levels of anti-spike and neutralizing antibodies. In conclusion, the IGRA is a simple method for measuring cellular immune responses after vaccination. However, its usefulness as a complement to the study of humoral responses is yet to be demonstrated in future research.
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e29116
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  3. Article: Weaker Effects of the Fourth Dose of BNT162b2 SARS-CoV-2 Vaccine on the Elderly Human Population.

    Dimeglio, Chloé / Da-Silva, Isabelle / Porcheron, Marion / Panero, Marie-Pierre / Staes, Laetitia / Trémeaux, Pauline / Villars, Hélène / Izopet, Jacques

    Vaccines

    2023  Volume 11, Issue 6

    Abstract: The vaccines presently available are less effective in older people due to senescence of their immune systems. We measured the antibody responses of 42 adults living in nursing homes after the third and the fourth doses of an mRNA vaccine and found that ... ...

    Abstract The vaccines presently available are less effective in older people due to senescence of their immune systems. We measured the antibody responses of 42 adults living in nursing homes after the third and the fourth doses of an mRNA vaccine and found that the strain (BA.2 and BA.2.75: from 64 to 128, BA.5: from 16 to 32, BQ.1.1: from 16 to 64 among the uninfected) influenced the effect of the fourth dose of vaccine on neutralizing antibodies. The fourth dose also increased binding antibodies (from 1036 BAU/mL to 5371 BAU/mL among the uninfected, from 3700 BAU/mL to 6773 BAU/mL among the BA.5 infected). This effect was less significant than that of the third dose of vaccine for both neutralizing (BA.2: from 8 to 128, BA.5: from 2 to 16, BA.2.75: from 8 to 64, BQ.1.1: from 2 to 16) and binding antibodies (from 139.8 BAU/mL to 2293 BAU/mL). However, the fourth dose attained the 5000 BAU/mL threshold conferring approximately 80% protection against a SARS-CoV-2 BA.2 infection in most individuals, unlike the third.
    Language English
    Publishing date 2023-06-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11061095
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  4. Article ; Online: Weaker Effects of the Fourth Dose of BNT162b2 SARS-CoV-2 Vaccine on the Elderly Human Population

    Chloé Dimeglio / Isabelle Da-Silva / Marion Porcheron / Marie-Pierre Panero / Laetitia Staes / Pauline Trémeaux / Hélène Villars / Jacques Izopet

    Vaccines, Vol 11, Iss 1095, p

    2023  Volume 1095

    Abstract: The vaccines presently available are less effective in older people due to senescence of their immune systems. We measured the antibody responses of 42 adults living in nursing homes after the third and the fourth doses of an mRNA vaccine and found that ... ...

    Abstract The vaccines presently available are less effective in older people due to senescence of their immune systems. We measured the antibody responses of 42 adults living in nursing homes after the third and the fourth doses of an mRNA vaccine and found that the strain (BA.2 and BA.2.75: from 64 to 128, BA.5: from 16 to 32, BQ.1.1: from 16 to 64 among the uninfected) influenced the effect of the fourth dose of vaccine on neutralizing antibodies. The fourth dose also increased binding antibodies (from 1036 BAU/mL to 5371 BAU/mL among the uninfected, from 3700 BAU/mL to 6773 BAU/mL among the BA.5 infected). This effect was less significant than that of the third dose of vaccine for both neutralizing (BA.2: from 8 to 128, BA.5: from 2 to 16, BA.2.75: from 8 to 64, BQ.1.1: from 2 to 16) and binding antibodies (from 139.8 BAU/mL to 2293 BAU/mL). However, the fourth dose attained the 5000 BAU/mL threshold conferring approximately 80% protection against a SARS-CoV-2 BA.2 infection in most individuals, unlike the third.
    Keywords vaccination ; vulnerable population ; SARS-CoV-2 ; immune monitoring ; Medicine ; R
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  5. Article ; Online: Quantifying the impact of public health protection measures on the spread of SARS-CoV-2.

    Dimeglio, Chloé / Loubes, Jean-Michel / Mansuy, Jean-Michel / Izopet, Jacques

    The Journal of infection

    2020  Volume 82, Issue 3, Page(s) 414–451

    Abstract: The new virus, SARS-CoV-2, has probably affected millions of people world-wide since December 2019 and killed thousand. We have designed a model and used it to quantify the effect of local protective measures on the SARS-CoV-2 epidemic, assess their ... ...

    Abstract The new virus, SARS-CoV-2, has probably affected millions of people world-wide since December 2019 and killed thousand. We have designed a model and used it to quantify the effect of local protective measures on the SARS-CoV-2 epidemic, assess their effectiveness and adapt health service strategies in Toulouse, France.
    MeSH term(s) COVID-19 ; Epidemics ; France/epidemiology ; Humans ; Public Health ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-10-28
    Publishing country England
    Document type Letter
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2020.10.026
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  6. Article ; Online: Intact proviruses are enriched in the colon and associated with PD-1+TIGIT− mucosal CD4+ T cells of people with HIV-1 on antiretroviral therapyResearch in context

    Camille Vellas / Manon Nayrac / Nived Collercandy / Mary Requena / Nicolas Jeanne / Justine Latour / Chloé Dimeglio / Michelle Cazabat / Karl Barange / Laurent Alric / Nicolas Carrere / Guillaume Martin-Blondel / Jacques Izopet / Pierre Delobel

    EBioMedicine, Vol 100, Iss , Pp 104954- (2024)

    2024  

    Abstract: Summary: Background: The persistence of intact replication-competent HIV-1 proviruses is responsible for the virological rebound off treatment. The gut could be a major reservoir of HIV-1 due to the high number of infected target cells. Methods: We ... ...

    Abstract Summary: Background: The persistence of intact replication-competent HIV-1 proviruses is responsible for the virological rebound off treatment. The gut could be a major reservoir of HIV-1 due to the high number of infected target cells. Methods: We collected blood samples and intestinal biopsies (duodenum, ileum, colon) from 42 people with HIV-1 receiving effective antiretroviral therapy. We used the Intact Proviral DNA Assay to estimate the frequency of intact HIV-1 proviruses in the blood and in the intestinal mucosa of these individuals. We analyzed the genetic complexity of the HIV-1 reservoir by performing single-molecule next-generation sequencing of HIV-1 env DNA. The activation/exhaustion profile of mucosal T lymphocytes was assessed by flow cytometry. Findings: Intact proviruses are particularly enriched in the colon. Residual HIV-1 transcription in the gut is associated with persistent mucosal and systemic immune activation. The HIV-1 intestinal reservoir appears to be shaped by the proliferation of provirus-hosting cells. The genetic complexity of the viral reservoir in the colon is positively associated with TIGIT expression but negatively with PD-1, and inversely related to its intact content. The size of the intact reservoir in the colon is associated with PD-1+TIGIT− mucosal CD4+ T cells, particularly in CD27+ memory cells, whose proliferation and survival could contribute to the enrichment of the viral reservoir by intact proviruses. Interpretation: Enrichment in intact proviruses makes the gut a key compartment for HIV-1 persistence on antiretroviral therapy. Funding: This project was supported by grants from the ANRS-MIE (ANRS EP61 GALT), Sidaction, and the Institut Universitaire de France.
    Keywords HIV reservoir ; Gut ; Intact and defective proviruses ; CD4+ memory T cells ; PD-1 ; TIGIT ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 570
    Language English
    Publishing date 2024-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Influence of age on the spread of SARS-CoV-2 variant B.1.1.7.

    Dimeglio, Chloé / Nicot, Florence / Miedougé, Marcel / Chappert, Jean-Loup / Donnadieu, Cécile / Izopet, Jacques

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

    2021  Volume 141, Page(s) 104872

    MeSH term(s) COVID-19 ; Humans ; Mutation ; SARS-CoV-2
    Language English
    Publishing date 2021-05-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1446080-4
    ISSN 1873-5967 ; 1386-6532
    ISSN (online) 1873-5967
    ISSN 1386-6532
    DOI 10.1016/j.jcv.2021.104872
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  8. Article ; Online: Protection of Healthcare Workers Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reinfection.

    Dimeglio, Chloé / Herin, Fabrice / Miedougé, Marcel / Martin-Blondel, Guillaume / Soulat, Jean-Marc / Izopet, Jacques

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 73, Issue 7, Page(s) 1323–1324

    MeSH term(s) COVID-19 ; Health Personnel ; Humans ; Reinfection ; SARS-CoV-2
    Language English
    Publishing date 2021-01-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab069
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    Zs.MO 480: Show issues

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  9. Article ; Online: Antibody titers and protection against a SARS-CoV-2 infection.

    Dimeglio, Chloé / Herin, Fabrice / Martin-Blondel, Guillaume / Miedougé, Marcel / Izopet, Jacques

    The Journal of infection

    2021  Volume 84, Issue 2, Page(s) 248–288

    MeSH term(s) Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 ; Humans ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus
    Language English
    Publishing date 2021-09-21
    Publishing country England
    Document type Letter
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2021.09.013
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  10. Article ; Online: COVID-19 pandemic period, where are the seasonal viruses?

    Mansuy, Jean-Michel / Bourcier, Maximin / Trémeaux, Pauline / Dimeglio, Chloé / Izopet, Jacques

    Journal of medical virology

    2021  Volume 93, Issue 7, Page(s) 4097–4098

    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; Communicable Disease Control ; Epidemics/prevention & control ; Humans ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Pandemics/prevention & control ; Picornaviridae Infections/epidemiology ; Picornaviridae Infections/prevention & control ; Prevalence ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Virus Infections/prevention & control ; Seasons
    Language English
    Publishing date 2021-04-15
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26959
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