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  1. Article: Noninfectious Granulomatous Lung Disease: Radiological Findings and Differential Diagnosis.

    Lassandro, Giulia / Picchi, Stefano Giusto / Corvino, Antonio / Massimo, Candida / Tamburrini, Stefania / Vanore, Laura / Urraro, Giovanna / Russo, Giuseppe / Lassandro, Francesco

    Journal of personalized medicine

    2024  Volume 14, Issue 2

    Abstract: Granulomatous lung diseases (GLDs) are a heterogeneous group of pathological entities that can have different clinical presentations and outcomes. Granulomas are histologically defined as focal aggregations of activated macrophages, Langerhans cells, and ...

    Abstract Granulomatous lung diseases (GLDs) are a heterogeneous group of pathological entities that can have different clinical presentations and outcomes. Granulomas are histologically defined as focal aggregations of activated macrophages, Langerhans cells, and lymphocytes, and may form in the lungs when the immune system cannot eliminate a foreign antigen and attempts to barricade it. The diagnosis includes clinical evaluation, laboratory testing, and radiological imaging, which especially consists of high-resolution computed tomography. bronchoalveolar lavage, transbronchial needle aspiration or cryobiopsy, positron emission tomography, while genetic evaluation can improve the diagnostic accuracy. Differential diagnosis is challenging due to the numerous different imaging appearances with which GLDs may manifest. Indeed, GLDs include both infectious and noninfectious, and necrotizing and non-necrotizing granulomatous diseases and the imaging appearance of some GLDs may mimic malignancy, leading to confirmatory biopsy. The purposes of our review are to report the different noninfectious granulomatous entities and to show their various imaging features to help radiologists recognize them properly and make an accurate differential diagnosis.
    Language English
    Publishing date 2024-01-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14020134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Musculoskeletal health in children and adolescents.

    Faienza, Maria Felicia / Urbano, Flavia / Chiarito, Mariangela / Lassandro, Giuseppe / Giordano, Paola

    Frontiers in pediatrics

    2023  Volume 11, Page(s) 1226524

    Abstract: The purpose of this narrative review was to investigate the key determinants of musculoskeletal health in childhood and adolescence, with particular attention to the role of physical activity. First, we examined the importance of bone modeling and ... ...

    Abstract The purpose of this narrative review was to investigate the key determinants of musculoskeletal health in childhood and adolescence, with particular attention to the role of physical activity. First, we examined the importance of bone modeling and remodeling in maintaining the bone health and the integrity and mechanical characteristic of the skeleton. In addition, we reported the evidence on an appropriate calcium and vitamin D intake, as well as local load variation in achieving proper peak bone mass. Proteomic and transcriptomic studies identified the skeletal muscle "secretoma", consisting of several myokines involved in endocrine and paracrine functions. Among these, we explored the role of irisin, a myokine involved in the muscle-bone crosstalk, and in the regulation of metabolic pathways. It is known that physical activity during growing positively impacts on skeleton and can protect by bone loss in adulthood. However, there are still concerns about the optimal interval duration and exercise intensity, particularly at the pubertal growth spurt which represents a window of opportunity to increase skeletal strength. We reported data from clinical trials performed in the last 5 years analyzing the impact of the type and timing of physical activity during childhood on skeletal development. Finally, we reported recent data on the significance of physical activity in some rare diseases.
    Language English
    Publishing date 2023-12-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2023.1226524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mechanical and Thermal Effects of Using Fine Recycled PET Aggregates in Common Screeds

    Cristiano Giuseppe Coviello / Paola Lassandro / Maria Francesca Sabbà / Dora Foti

    Sustainability, Vol 15, Iss 24, p

    2023  Volume 16692

    Abstract: The increasing consumption of plastics has necessitated the need to find a sustainable solution to reuse PET within common building materials. Recycled PET reinforcement would reduce plastic waste that is difficult to dispose of and CO 2 emissions, ... ...

    Abstract The increasing consumption of plastics has necessitated the need to find a sustainable solution to reuse PET within common building materials. Recycled PET reinforcement would reduce plastic waste that is difficult to dispose of and CO 2 emissions, representing a sustainable solution for generating lighter building materials. The goal of this work was to define a new cementitious mixture design and to study the mechanical and thermal behavior of three typologies of screeds with fine recycled polyethylene terephthalate (PET) aggregates. A weight percentage of PET of 1%, 2%, and 3% was used. The test results for sustainable screeds (S-Screeds) with waste PET were compared with a reference screed without the addition of plastic. In the fresh state, the workability and the air content were measured, while in the hardened state, the density, thermal conductivity, and compressive and flexural strength were investigated. These properties showed improvement for some tested S-Screeds after the introduction of fine (a few millimeters in size) and irregularly shaped waste plastic aggregates. Scanning electron microscopy (SEM) analysis showed the presence of a release surface between the cementitious mixtures and the plastic material, even if the mechanical interaction between the matrix and PET still existed.
    Keywords sustainable screed ; fine PET aggregate ; mechanical properties ; waste plastic ; thermal conductivity ; SEM analysis ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 690
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Promoting Sports Practice in Persons with Hemophilia: A Survey of Clinicians' Perspective.

    Lassandro, Giuseppe / Accettura, Domenico / Giordano, Paola

    International journal of environmental research and public health

    2021  Volume 18, Issue 22

    Abstract: Historically, people with hemophilia have been warned to avoid physical activities as a possible cause of bleeding; however, currently, sport is considered necessary, especially in the developmental age, for providing a good quality of life. A survey was ...

    Abstract Historically, people with hemophilia have been warned to avoid physical activities as a possible cause of bleeding; however, currently, sport is considered necessary, especially in the developmental age, for providing a good quality of life. A survey was proposed to a group of hematologists and sports physicians working in Puglia, Italy, to explore their approach to physical activities for their patients with hemophilia and to obtain suggestions about possible interventions to promote the access of patients to sports. The survey was answered by 6 hematologists and 15 sports physicians. In total, 71% (about six patients/year/physician) of patients with hemophilia seen by sports physicians asked for counseling about sports, and 67% (about five patients/year/physician) actually practiced sports. On the other hand, only 31% (about 16 patients/year/hematologist) of patients asked hematologists questions on sports, and only 16% (about seven patients/year/hematologist) of patients with hemophilia and that were followed-up by hematologists practiced sports. The sports most often recommended to patients with hemophilia by physicians included swimming, athletics, tennis, running and gymnastics. According to hematologists, physical activity was very efficient in improving the quality of life of patients; stability of joints; their psychological, social and musculoskeletal wellbeing; and in reducing the risk of bleedings. On the other hand, physical activity was considered less important in all these areas by sport physicians. In conclusion, answers to this survey suggested that sports could be promoted among hemophilic patients by increasing the sports physicians' knowledge about hemophilia and their special role in this area. In addition, interviewed clinicians were of the opinion that increased awareness of specific guidelines and clinical practice protocols among both hematologists and sports physicians could be beneficial. Finally, answers suggested that access to fitness certification should be facilitated.
    MeSH term(s) Hemophilia A ; Humans ; Medicine ; Quality of Life ; Surveys and Questionnaires ; Swimming
    Language English
    Publishing date 2021-11-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph182211841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Quick drop of platelet counts in children with chronic immune thrombocytopenia after COVID-19 mRNA vaccination: case reports.

    Lassandro, Giuseppe / Carriero, Francesco / Palladino, Valentina / Vecchio, Giovanni Carlo Del / Giordano, Paola

    Clinical and experimental vaccine research

    2022  Volume 11, Issue 3, Page(s) 290–293

    Abstract: Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia. Many viruses and some vaccines have been identified as triggering the autoimmune process, including parvovirus, human immunodeficiency virus, Epstein-Barr ...

    Abstract Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia. Many viruses and some vaccines have been identified as triggering the autoimmune process, including parvovirus, human immunodeficiency virus, Epstein-Barr virus, rubella, and measles. However, ITP in association with coronavirus disease 2019 (COVID-19) vaccination has not been reported so far. We describe the cases of two young girls affected by ITP presenting a quick reduction of platelet count after receiving Pfizer-BioNTech COVID-19 vaccine.
    Language English
    Publishing date 2022-09-30
    Publishing country Korea (South)
    Document type Case Reports
    ZDB-ID 2684652-4
    ISSN 2287-366X ; 2287-3651
    ISSN (online) 2287-366X
    ISSN 2287-3651
    DOI 10.7774/cevr.2022.11.3.290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mechanisms of Bone Impairment in Sickle Bone Disease.

    Giordano, Paola / Urbano, Flavia / Lassandro, Giuseppe / Faienza, Maria Felicia

    International journal of environmental research and public health

    2021  Volume 18, Issue 4

    Abstract: Sickle bone disease (SBD) is a chronic and invalidating complication of Sickle cell disease (SCD), a multisystem autosomal recessive genetic disorder affecting millions of people worldwide. Mechanisms involved in SBD are not completely known, especially ... ...

    Abstract Sickle bone disease (SBD) is a chronic and invalidating complication of Sickle cell disease (SCD), a multisystem autosomal recessive genetic disorder affecting millions of people worldwide. Mechanisms involved in SBD are not completely known, especially in pediatric age. Among the hypothesized pathogenetic mechanisms underlying SBD are bone marrow compensatory hyperplasia and bone ischemic damage, both secondary to vaso-occlusive crisis (VOC), which leads to cell sickling, thus worsening local hypoxia with a negative impact on osteoblast recruitment. Furthermore, the hypoxia is a strong activator of erythropoietin, which in turn stimulates osteoclast precursors and induces bone loss. Hemolysis and iron overload due to a chronic transfusion regimen could also contribute to the onset of bone complications. Vitamin D deficiency, which is frequently seen in SCD subjects, may worsen SBD by increasing the resorptive state that is responsible for low bone mineral density, acute/chronic bone pain, and high fracture risk. An imbalance between osteoblasts and osteoclasts, with a relative decrease of osteoblast recruitment and activity, is a further possible mechanism responsible for the impairment of bone health in SCD. Moreover, delayed pubertal growth spurt and low peak bone mass may explain the high incidence of fracture in SCD adolescents. The aim of this review was to focus on the pathogenesis of SBD, updating the studies on biochemical, instrumental, and biological markers of bone metabolism. We also evaluated the growth development and endocrine complications in subjects affected with SCD.
    MeSH term(s) Adolescent ; Anemia, Sickle Cell/complications ; Blood Transfusion ; Bone Diseases/epidemiology ; Bone Diseases/etiology ; Child ; Humans ; Osteoclasts ; Vitamin D Deficiency
    Language English
    Publishing date 2021-02-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18041832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Promoting Sports Practice in Persons with Hemophilia

    Giuseppe Lassandro / Domenico Accettura / Paola Giordano

    International Journal of Environmental Research and Public Health, Vol 18, Iss 11841, p

    A Survey of Clinicians’ Perspective

    2021  Volume 11841

    Abstract: Historically, people with hemophilia have been warned to avoid physical activities as a possible cause of bleeding; however, currently, sport is considered necessary, especially in the developmental age, for providing a good quality of life. A survey was ...

    Abstract Historically, people with hemophilia have been warned to avoid physical activities as a possible cause of bleeding; however, currently, sport is considered necessary, especially in the developmental age, for providing a good quality of life. A survey was proposed to a group of hematologists and sports physicians working in Puglia, Italy, to explore their approach to physical activities for their patients with hemophilia and to obtain suggestions about possible interventions to promote the access of patients to sports. The survey was answered by 6 hematologists and 15 sports physicians. In total, 71% (about six patients/year/physician) of patients with hemophilia seen by sports physicians asked for counseling about sports, and 67% (about five patients/year/physician) actually practiced sports. On the other hand, only 31% (about 16 patients/year/hematologist) of patients asked hematologists questions on sports, and only 16% (about seven patients/year/hematologist) of patients with hemophilia and that were followed-up by hematologists practiced sports. The sports most often recommended to patients with hemophilia by physicians included swimming, athletics, tennis, running and gymnastics. According to hematologists, physical activity was very efficient in improving the quality of life of patients; stability of joints; their psychological, social and musculoskeletal wellbeing; and in reducing the risk of bleedings. On the other hand, physical activity was considered less important in all these areas by sport physicians. In conclusion, answers to this survey suggested that sports could be promoted among hemophilic patients by increasing the sports physicians’ knowledge about hemophilia and their special role in this area. In addition, interviewed clinicians were of the opinion that increased awareness of specific guidelines and clinical practice protocols among both hematologists and sports physicians could be beneficial. Finally, answers suggested that access to fitness certification should be facilitated.
    Keywords hemophilia ; sports ; quality of life ; bleeding ; survey ; Medicine ; R
    Subject code 796
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: The risk of venipuncture in newborn with severe hemophilia: Case report of a large elbow hemorrhage and literature review of compartment syndrome.

    Lassandro, Giuseppe / Amoruso, Anna / Palladino, Valentina / Palmieri, Viviana Valeria / Giordano, Paola

    Hematology reports

    2021  Volume 13, Issue 2, Page(s) 8967

    Abstract: Hemophilias are hemorrhagic congenital rare diseases. The gold standard of therapy in hemophilics is the intravenously replacement therapy. We can infuse intravenously plasma derived factors (FVIII for Hemophilia A and FIX for Hemophilia B) or ... ...

    Abstract Hemophilias are hemorrhagic congenital rare diseases. The gold standard of therapy in hemophilics is the intravenously replacement therapy. We can infuse intravenously plasma derived factors (FVIII for Hemophilia A and FIX for Hemophilia B) or recombinant products (
    Language English
    Publishing date 2021-06-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2586645-X
    ISSN 2038-8330 ; 2038-8322
    ISSN (online) 2038-8330
    ISSN 2038-8322
    DOI 10.4081/hr.2021.8967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Mechanisms of Bone Impairment in Sickle Bone Disease

    Paola Giordano / Flavia Urbano / Giuseppe Lassandro / Maria Felicia Faienza

    International Journal of Environmental Research and Public Health, Vol 18, Iss 1832, p

    2021  Volume 1832

    Abstract: Sickle bone disease (SBD) is a chronic and invalidating complication of Sickle cell disease (SCD), a multisystem autosomal recessive genetic disorder affecting millions of people worldwide. Mechanisms involved in SBD are not completely known, especially ... ...

    Abstract Sickle bone disease (SBD) is a chronic and invalidating complication of Sickle cell disease (SCD), a multisystem autosomal recessive genetic disorder affecting millions of people worldwide. Mechanisms involved in SBD are not completely known, especially in pediatric age. Among the hypothesized pathogenetic mechanisms underlying SBD are bone marrow compensatory hyperplasia and bone ischemic damage, both secondary to vaso-occlusive crisis (VOC), which leads to cell sickling, thus worsening local hypoxia with a negative impact on osteoblast recruitment. Furthermore, the hypoxia is a strong activator of erythropoietin, which in turn stimulates osteoclast precursors and induces bone loss. Hemolysis and iron overload due to a chronic transfusion regimen could also contribute to the onset of bone complications. Vitamin D deficiency, which is frequently seen in SCD subjects, may worsen SBD by increasing the resorptive state that is responsible for low bone mineral density, acute/chronic bone pain, and high fracture risk. An imbalance between osteoblasts and osteoclasts, with a relative decrease of osteoblast recruitment and activity, is a further possible mechanism responsible for the impairment of bone health in SCD. Moreover, delayed pubertal growth spurt and low peak bone mass may explain the high incidence of fracture in SCD adolescents. The aim of this review was to focus on the pathogenesis of SBD, updating the studies on biochemical, instrumental, and biological markers of bone metabolism. We also evaluated the growth development and endocrine complications in subjects affected with SCD.
    Keywords sickle cell disease ; bone ; metabolism ; growth ; endocrine complications ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Successful Eltrombopag Therapy in a Child with MYH9-Related Inherited Thrombocytopenia.

    Lassandro, Giuseppe / Carriero, Francesco / Noviello, Domenico / Palladino, Valentina / Del Vecchio, Giovanni Carlo / Faienza, Maria Felicia / Giordano, Paola

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 12

    Abstract: Inherited thrombocytopenias represents a heterogenous group of diseases characterized by a congenital reduction in the platelet count that could lead to a bleeding tendency. MYH9-related disorders are characterized by large platelets and congenital ... ...

    Abstract Inherited thrombocytopenias represents a heterogenous group of diseases characterized by a congenital reduction in the platelet count that could lead to a bleeding tendency. MYH9-related disorders are characterized by large platelets and congenital thrombocytopenia. Thrombopoietin-receptor agonists: eltrombopag and romiplostim are currently approved in many countries for the treatment of different forms of acquired thrombocytopenia, such as immune thrombocytopenia. We report, instead, the successful use of eltrombopag to treat inherited thrombocytopenia in a patient with an MHY9-related disease. This is the first report of a chronic use of eltrombopag to elevate platelets in MYH9-related disorders without side effects.
    Language English
    Publishing date 2022-11-28
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9121839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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