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  1. Article ; Online: Letter by Jin-shan and Xue-bin Regarding Article, "Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions".

    Jin-Shan, He / Xue-Bin, Li

    Circulation

    2017  Volume 137, Issue 2, Page(s) 215–216

    MeSH term(s) ADAMTS7 Protein/genetics ; Heart Diseases/genetics ; Humans ; Smoking
    Chemical Substances ADAMTS7 Protein (EC 3.4.24.-) ; ADAMTS7 protein, human (EC 3.4.24.-)
    Language English
    Publishing date 2017-10-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.117.030675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.60: Show issues Location:
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  2. Article: Improving blast resistance of Jin 23B and its hybrid rice by marker-assisted gene pyramiding

    Jiang, Haichao / Feng, Yutao / Bao, Liang / Li, Xin / Gao, Guanjun / Zhang, Qinglu / Xiao, Jinghua / Xu, Caiguo / He, Yuqing

    Molecular breeding. 2012 Dec., v. 30, no. 4

    2012  

    Abstract: Rice blast is one of the most serious diseases in rice (Oryza sativa L.) worldwide. Jin 23B is ... the maintainer line, a parent for a number of hybrid rice varieties used widely in China. However, Jin 23B is ... resistance of Jin 23B and its derived hybrids, Jinyou 402 and Jinyou 207, by marker-assisted selection (MAS ...

    Abstract Rice blast is one of the most serious diseases in rice (Oryza sativa L.) worldwide. Jin 23B is the maintainer line, a parent for a number of hybrid rice varieties used widely in China. However, Jin 23B is highly susceptible to rice blast. In this study, Pi1, Pi2, and D12 were introgressed to improve the blast resistance of Jin 23B and its derived hybrids, Jinyou 402 and Jinyou 207, by marker-assisted selection (MAS). The improved Jin 23B, which carried single, two, and three genes, were evaluated for their resistance to rice blast using natural inoculation methods in disease nursery of Xianfeng, Hubei, China. The results showed that, the greater the number of genes contained in the improved Jin 23B and hybrids, the higher the resistance to rice blast. Pi1, Pi2, and D12 showed a strong dosage effect on the resistance to blast in the hybrid background during the entire growth duration in the field condition, being very useful for breeding blast-resistant hybrids. The result of examining agronomic traits showed that the improved Jin 23B and its derived hybrid rice were taller than or similar to controls, when there was no disease stress.
    Keywords Oryza sativa ; agronomic traits ; blast disease ; dose response ; genes ; hybrids ; inoculation methods ; marker-assisted selection ; rice
    Language English
    Dates of publication 2012-12
    Size p. 1679-1688.
    Publishing place Springer-Verlag
    Document type Article
    ZDB-ID 1230924-2
    ISSN 1572-9788 ; 1380-3743
    ISSN (online) 1572-9788
    ISSN 1380-3743
    DOI 10.1007/s11032-012-9751-6
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 6088: Show issues

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  3. Article: Chinese Medicine in Fighting against Covid-19: Role and Inspiration.

    Li, Jin-Gen / Xu, Hao

    Chinese journal of integrative medicine

    2021  Volume 27, Issue 1, Page(s) 3–6

    Abstract: Covid-19 pandemic has caused hundreds of thousands deaths and millions of infections and continued spreading violently. Although researchers are racing to find or develop effective drugs or vaccines, no drugs from modern medical system have been proven ... ...

    Abstract Covid-19 pandemic has caused hundreds of thousands deaths and millions of infections and continued spreading violently. Although researchers are racing to find or develop effective drugs or vaccines, no drugs from modern medical system have been proven effective and the high mutant rates of the virus may lead it resistant to whatever drugs or vaccines developed following modern drug development procedure. Current evidence has demonstrated impressive healing effects of several Chinese medicines (CMs) for Covid-19, which urges us to reflect on the role of CM in the era of modern medicine. Undoubtedly, CM could be promising resources for developing drug candidates for the treatment of Covid-19 in a way similar to the development of artemisinin. But the theory that builds CM, like the emphasis of driving away exogenous pathogen (virus, etc.) by restoring self-healing capacity rather than killing the pathogen directly from the inside and the 'black-box' mode of diagnosing and treating patients, is as important, yet often ignored, an treasure as CM herbs and should be incorporated into modern medicine for future advancement and innovation of medical science.
    MeSH term(s) Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/epidemiology ; COVID-19/therapy ; Disease Outbreaks ; Drug Development/methods ; Drug Development/standards ; Drug Resistance, Viral/genetics ; Drug Therapy, Combination ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Medicine, Chinese Traditional/methods ; Medicine, Chinese Traditional/trends ; Mutation Rate ; Pandemics ; Phytotherapy/methods ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology
    Chemical Substances Antiviral Agents ; Drugs, Chinese Herbal ; Xuebijing ; huashi baidu ; jinhua qinggan granules ; lianhuaqingwen ; qingfei paidu decoction
    Language English
    Publishing date 2021-01-08
    Publishing country China
    Document type Journal Article
    ZDB-ID 2171254-2
    ISSN 1993-0402 ; 1672-0415
    ISSN (online) 1993-0402
    ISSN 1672-0415
    DOI 10.1007/s11655-020-2860-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5823: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Integrated analysis of transcriptome and small RNAome reveals regulatory network of rapid and long-term response to heat stress in Rhododendron moulmainense.

    Liu, Si-Jia / Cai, Chang / Cai, Hong-Yue / Bai, Yu-Qing / Wang, Ding-Yue / Zhang, Hua / Peng, Jin-Gen / Xie, Li-Juan

    Planta

    2024  Volume 259, Issue 5, Page(s) 104

    Abstract: ... Through WGCNA analysis, we identified gene association patterns and potential key regulatory genes responsible ...

    Abstract Main conclusion: The post-transcriptional gene regulatory pathway and small RNA pathway play important roles in regulating the rapid and long-term response of Rhododendron moulmainense to high-temperature stress. The Rhododendron plays an important role in maintaining ecological balance. However, it is difficult to domesticate for use in urban ecosystems due to their strict optimum growth temperature condition, and its evolution and adaptation are little known. Here, we combined transcriptome and small RNAome to reveal the rapid response and long-term adaptability regulation strategies in Rhododendron moulmainense under high-temperature stress. The post-transcriptional gene regulatory pathway plays important roles in stress response, in which the protein folding pathway is rapidly induced at 4 h after heat stress, and alternative splicing plays an important role in regulating gene expression at 7 days after heat stress. The chloroplasts oxidative damage is the main factor inhibiting photosynthesis efficiency. Through WGCNA analysis, we identified gene association patterns and potential key regulatory genes responsible for maintaining the ROS steady-state under heat stress. Finally, we found that the sRNA synthesis pathway is induced under heat stress. Combined with small RNAome, we found that more miRNAs are significantly changed under long-term heat stress. Furthermore, MYBs might play a central role in target gene interaction network of differentially expressed miRNAs in R. moulmainense under heat stress. MYBs are closely related to ABA, consistently, ABA synthesis and signaling pathways are significantly inhibited, and the change in stomatal aperture is not obvious under heat stress. Taken together, we gained valuable insights into the transplantation and long-term conservation domestication of Rhododendron, and provide genetic resources for genetic modification and molecular breeding to improve heat resistance in Rhododendron.
    MeSH term(s) Transcriptome/genetics ; Rhododendron/genetics ; Rhododendron/metabolism ; Ecosystem ; Heat-Shock Response/genetics ; MicroRNAs/genetics ; Gene Expression Profiling
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-03-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 208909-9
    ISSN 1432-2048 ; 0032-0935 ; 1866-2749
    ISSN (online) 1432-2048
    ISSN 0032-0935 ; 1866-2749
    DOI 10.1007/s00425-024-04375-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Should Beta-Blockers Be Routinely Prescribed for Myocardial Infarction Without Heart Failure or Ventricular Dysfunction?

    Li, Jin-Gen / Xu, Hao

    Journal of the American College of Cardiology

    2017  Volume 70, Issue 13, Page(s) 1685–1686

    MeSH term(s) Adrenergic beta-Antagonists ; Heart Failure ; Humans ; Myocardial Infarction ; Ventricular Dysfunction
    Chemical Substances Adrenergic beta-Antagonists
    Language English
    Publishing date 2017-09-20
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2017.07.760
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1846: Show issues Location:
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    Zs.MO 196: Show issues

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  6. Article ; Online: Study on Medication Rules of Traditional Chinese Medicine in Treating Constipation through Data Mining and Network Pharmacology.

    Xu, Shu-Min / Bai, Li-Peng / Lu, Jin-Gen / Dong, Qing-Jun / Cao, Bo

    BioMed research international

    2022  Volume 2022, Page(s) 6733851

    Abstract: ... GeneCards databases, Protein-protein interaction network (PPI) was drawn by STRING database, and enrichment ...

    Abstract Background: To explore the rules of TCM medication in the treatment of constipation in network pharmacology.
    Methods: Collect and screen the clinical intervention literature on TCM for constipation from China's national knowledge infrastructure, Wanfang and VIP databases established a database of TCM for constipation, applied R software (3.3.1) to analyze the pattern of prescriptions for TCM for constipation, and summarized the core prescription. The effective active compounds and action targets in the core prescription were screened by Traditional Chinese Medicine Systems Pharmacology (TCMSP) and Traditional Chinese Medicine Integrated Databases (TCMID), constipation-related targets were derived from the DisGeNET and GeneCards databases, Protein-protein interaction network (PPI) was drawn by STRING database, and enrichment analysis was conducted by the Clusterprofiler package in R software (3.3.1). Finally, molecular docking was used to validate the binding ability of candidate compounds to potential targets.
    Results: Two hundred sixteen target prescriptions were screened through data mining, involving 226 herbs. Association rule analysis results suggested that the "Angelicae sinensis-Radix-dried rehmanniae-Cistanche deserticola-Atractylodes macrocephala-Astragali Radix" was a strong affinity for medicine. Network pharmacology analysis of the core prescription resulted in the screening of 115 candidate compounds, such as quercetin, kaempferol, mangostin, eugenol A, and beta-sitosterol; 131 potential targets, such as PTGS2, PTGS1, and CHRM3; and 160 signaling pathways, such as lipid and atherosclerosis, proteoglycans in cancer, hepatitis B, Kaposi's sarcoma-associated herpesvirus infection, and PI3K/AKT pathways. Molecular docking showed that PTGS1-formononetin, PTGS2-kaempferol, and CHRM3-kaempferol were all well bound and well matched.
    Conclusions: This study provides a new method and ideas for clinical applications of integrated Chinese and western medicine in treating constipation.
    MeSH term(s) Humans ; Medicine, Chinese Traditional ; Kaempferols ; Molecular Docking Simulation ; Cyclooxygenase 2 ; Quercetin ; Eugenol ; Network Pharmacology ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Drugs, Chinese Herbal/chemistry ; Data Mining ; Constipation/drug therapy ; Proteoglycans ; Lipids
    Chemical Substances Kaempferols ; Cyclooxygenase 2 (EC 1.14.99.1) ; Quercetin (9IKM0I5T1E) ; Eugenol (3T8H1794QW) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Drugs, Chinese Herbal ; Proteoglycans ; Lipids ; CHRM3 protein, human
    Language English
    Publishing date 2022-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2022/6733851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Consensus on Diagnosis and Treatment of Chronic Heart Failure by Integrative Medicine: Highlights and Connotation].

    Li, Jin-gen / Xu, Hao

    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

    2016  Volume 36, Issue 2, Page(s) 142–145

    MeSH term(s) Chronic Disease ; Consensus ; Heart Failure/diagnosis ; Heart Failure/therapy ; Humans ; Integrative Medicine
    Language Chinese
    Publishing date 2016-02
    Publishing country China
    Document type Journal Article
    ZDB-ID 1195456-5
    ISSN 1003-5370
    ISSN 1003-5370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2863: Show issues Location:
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  8. Article: [Two cases of spinal epidural abscess caused by acupuncture].

    Jiang, Jia-Yao / Li, Hong / Cai, Fu-Jin / Jin, Gen-Yang

    Zhongguo gu shang = China journal of orthopaedics and traumatology

    2023  Volume 36, Issue 5, Page(s) 402–405

    MeSH term(s) Humans ; Epidural Abscess/etiology ; Acupuncture Therapy/adverse effects ; Magnetic Resonance Imaging/adverse effects ; Epidural Space ; Spinal Diseases
    Language Chinese
    Publishing date 2023-05-21
    Publishing country China
    Document type Case Reports ; Journal Article
    ISSN 1003-0034
    ISSN 1003-0034
    DOI 10.12200/j.issn.1003-0034.2023.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: A New Perspective for Chinese Medicine Intervention for Coronary Artery Disease: Targeting Inflammation.

    Li, Si-Ming / Li, Jin-Gen / Xu, Hao

    Chinese journal of integrative medicine

    2018  Volume 25, Issue 1, Page(s) 3–8

    Abstract: Inflammation, which plays a critical role in atherosclerosis and the occurrence of acute cardiovascular events, may be a new target for treatment of coronary artery disease (CAD) to reduce residual cardiovascular risk. Recently, Antiinflammatory Therapy ... ...

    Abstract Inflammation, which plays a critical role in atherosclerosis and the occurrence of acute cardiovascular events, may be a new target for treatment of coronary artery disease (CAD) to reduce residual cardiovascular risk. Recently, Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease (CANTOS), the largest scale clinical trial that targeted inflammation but not lipids, has affirmed for the first time the inflammatory hypothesis of artherosclerosis and marked the advent of an exciting era of targeting inflammation for the prevention and treatment of cardiovascular diseases. Chinese medicine (CM) is a promising adjuvant therapy for CAD in light of its safety and pleiotropic effect of anti-inflammation, anti-platelet, lipid-regulating, endothelium-protection, microcirculation-improving, etc. In recent years, exploration of anti-inflammatory treatment of CAD with CM has been going on from theory to practice. Taking CANTOS as an example, the design strategy to combine CM and Western medicine to inhibit inflammation were discussed in this paper, which might provide a new perspective for CM intervention on CAD.
    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; Antibodies, Monoclonal/therapeutic use ; Coronary Artery Disease/drug therapy ; Humans ; Medicine, Chinese Traditional
    Chemical Substances Anti-Inflammatory Agents ; Antibodies, Monoclonal ; canakinumab (37CQ2C7X93)
    Language English
    Publishing date 2018-08-22
    Publishing country China
    Document type Journal Article
    ZDB-ID 2171254-2
    ISSN 1993-0402 ; 1672-0415
    ISSN (online) 1993-0402
    ISSN 1672-0415
    DOI 10.1007/s11655-018-2995-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5823: Show issues Location:
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  10. Article ; Online: Acute exacerbation of chronic obstructive pulmonary disease treated by extracorporeal carbon dioxide removal.

    Li, Min / Gu, Si-Chao / Xia, Jin-Gen / Zhan, Qing-Yuan

    Chinese medical journal

    2019  Volume 132, Issue 20, Page(s) 2505–2507

    MeSH term(s) Aged ; Carbon Dioxide ; China ; Extracorporeal Circulation/methods ; Humans ; Male ; Pulmonary Disease, Chronic Obstructive/pathology ; Pulmonary Disease, Chronic Obstructive/therapy
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2019-09-30
    Publishing country China
    Document type Journal Article
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000000461
    Database MEDical Literature Analysis and Retrieval System OnLINE

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