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Article ; Online: Correction for: Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.

Jiang, Xiao-Lin / Tai, He / Kuang, Jin-Song / Zhang, Jing-Yi / Cui, Shi-Chao / Lu, Yu-Xuan / Qi, Shu-Bo / Zhang, Shi-Yu / Li, Shun-Min / Chen, Jian-Ping / Meng, Xian-Sheng

Aging

2023 Volume 15, Issue 6, Page(s) 2358–2360

Language	English
Publishing date	2023-03-30
Publishing country	United States
Document type	Journal Article ; Published Erratum
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204637
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Clinical and whole exome sequencing findings in children from Yunnan Yi minority ethnic group with retinitis pigmentosa: two case reports.

Xiao, Yi-Shuang / He, Wen-Ji / Jiang, Hong-Chao / Tan, Li / Ma, Jing / Zhang, Zhen

Journal of medical case reports

2023 Volume 17, Issue 1, Page(s) 226

Abstract: ... of cases.: Case presentation: Two non-consanguineous Yi minority ethnic group families who have a 6.4 ... retinitis pigmentosa genes and give these two Yi minority ethnic group families from Yunnan more precise ...

Abstract	Background: Retinitis pigmentosa is a group of rare hereditary retinal dystrophy diseases that lead to difficulty seeing at night, progressive loss of peripheral field vision (tunnel vision), and eventual loss of central vision. However, a genetic cause cannot be determined in approximately 60% of cases. Case presentation: Two non-consanguineous Yi minority ethnic group families who have a 6.4-year-old boy and a 0.5-year-old boy, respectively, were recruited for genetic diagnosis. Here, we used whole-exome sequencing to detect mutations in the genes of the probands of the retinitis pigmentosa families, and Sanger sequencing to confirm the causal mutations identified by whole exome sequencing. In addition, we report two cases with retinitis pigmentosa caused by RDH12 (c.524C > T) and PRPF4 (c.1273G > A) pathogenic mutations. Conclusions: These results might extend the mutation spectrum of known retinitis pigmentosa genes and give these two Yi minority ethnic group families from Yunnan more precise genetic counseling and more specific prognoses.
MeSH term(s)	Male ; Humans ; Child ; Infant ; Exome Sequencing ; Ethnicity/genetics ; Exome/genetics ; DNA Mutational Analysis ; China ; Retinitis Pigmentosa/genetics ; Retinitis Pigmentosa/diagnosis ; Retinitis Pigmentosa/pathology ; Mutation ; Pedigree ; Alcohol Oxidoreductases/genetics
Chemical Substances	RDH12 protein, human (EC 1.1.1.105) ; Alcohol Oxidoreductases (EC 1.1.-)
Language	English
Publishing date	2023-06-02
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-023-03830-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Efficacy of Shu-yi-ning-chang decoction on IBS-D: Modulating Nr4a3 pathway to reduce visceral hypersensitivity.

Guo, Yajing / Lu, Qiongqiong / Yang, Xiao-Jun / He, Yuxi / Wu, Yue / Qin, Baijun / Li, Ting / Duan, Min / Liu, Nvping / Wu, Xin / He, Yuanjun

PloS one

2024 Volume 19, Issue 4, Page(s) e0299376

Abstract: Aim of the study: To evaluate the therapeutic effect of SYNC in diarrhea irritable bowel syndrome (IBS-D) and explore its underlying mechanism through transcriptomic sequencing (RNA-Seq).: Materials and methods: A rat model of IBS-D was constructed ... ...

Abstract	Aim of the study: To evaluate the therapeutic effect of SYNC in diarrhea irritable bowel syndrome (IBS-D) and explore its underlying mechanism through transcriptomic sequencing (RNA-Seq). Materials and methods: A rat model of IBS-D was constructed to elucidate the effects of SYNC. Abdominal withdrawal reflex (AWR), fecal water content (FWC), and recording body weight were calculated to assess visceral sensitivity in rats. Histopathological changes in the colon and alterations in mast cell (MC) count were determined. Immunohistochemistry was employed to assess mast cell tryptase (MCT) expression in rat colons. Serum levels of corticotropin-releasing Hormone (CRH), interleukin-6 (IL-6), calcitonin gene-related peptide (CGRP), and 5-hydroxytryptamine (5-HT) were quantified using ELISA. RNA-Seq of colon tissue was performed, followed by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Western blot analysis was conducted to quantify the expression levels of key proteins in the Nr4a3 pathway in the colon and hypothalamus tissues of rats. Results: SYNC alleviated visceral hypersensitivity and mood disorders in rats with IBS-D. Moreover, it was positively correlated with its dosage and the observed effects, such as the enhancement of the colon's mucosal lining condition and reduction in the number and activation of MCs within the model group. SYNC reduced the expression levels of factors related to the brain-gut axis and inflammatory markers in the bloodstream. RNA-Seq analysis indicated that SYNC down-regulated the expression of Nr4a3 and PI3K. These SYNC-targeted genes primarily played roles in immune regulation and inflammatory responses, correlating with the modulation of Nr4a3 and the PI3K/AKT pathway. Western blot analysis further confirmed SYNC's influence on inflammation-related MC activation by downregulating key proteins in the Nr4a3/PI3K pathway. Conclusions: SYNC inhibited mast cell activation and attenuated visceral hypersensitivity in the colon tissues of IBS-D rats. These effects were mediated by the Nr4a3/PI3K signaling pathway.
MeSH term(s)	Rats ; Animals ; Irritable Bowel Syndrome/pathology ; Rats, Sprague-Dawley ; Phosphatidylinositol 3-Kinases ; Diarrhea ; Corticotropin-Releasing Hormone/metabolism ; DNA-Binding Proteins ; Nerve Tissue Proteins
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Corticotropin-Releasing Hormone (9015-71-8) ; Nr4a3 protein, rat ; DNA-Binding Proteins ; Nerve Tissue Proteins
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0299376
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.

Jiang, Xiao-Lin / Tai, He / Kuang, Jin-Song / Zhang, Jing-Yi / Cui, Shi-Chao / Lu, Yu-Xuan / Qi, Shu-Bo / Zhang, Shi-Yu / Li, Shun-Min / Chen, Jian-Ping / Meng, Xian-Sheng

Aging

2022 Volume 14, Issue 20, Page(s) 8321–8345

Abstract: As a widely applied traditional Chinese medicine (TCM), Jian-Pi-Yi-Shen (JPYS) decoction maybe ...

Abstract	As a widely applied traditional Chinese medicine (TCM), Jian-Pi-Yi-Shen (JPYS) decoction maybe applied in curing premature ovarian failure (POF) besides chronic kidney disease (CKD).
MeSH term(s)	Rats ; Female ; Humans ; Animals ; Primary Ovarian Insufficiency/metabolism ; Triptorelin Pamoate/metabolism ; Triptorelin Pamoate/pharmacology ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Apoptosis ; Granulosa Cells/metabolism ; Mitochondria/metabolism
Chemical Substances	Triptorelin Pamoate (08AN7WA2G0) ; Drugs, Chinese Herbal
Language	English
Publishing date	2022-10-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204320
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Article ; Online: Clinical and whole exome sequencing findings in children from Yunnan Yi minority ethnic group with retinitis pigmentosa

Yi-shuang Xiao / Wen-Ji He / Hong-chao Jiang / Li Tan / Jing Ma / Zhen Zhang

Journal of Medical Case Reports, Vol 17, Iss 1, Pp 1-

two case reports

2023 Volume 6

Abstract: ... of cases. Case presentation Two non-consanguineous Yi minority ethnic group families who have a 6.4-year ... retinitis pigmentosa genes and give these two Yi minority ethnic group families from Yunnan more precise ...

Abstract	Abstract Background Retinitis pigmentosa is a group of rare hereditary retinal dystrophy diseases that lead to difficulty seeing at night, progressive loss of peripheral field vision (tunnel vision), and eventual loss of central vision. However, a genetic cause cannot be determined in approximately 60% of cases. Case presentation Two non-consanguineous Yi minority ethnic group families who have a 6.4-year-old boy and a 0.5-year-old boy, respectively, were recruited for genetic diagnosis. Here, we used whole-exome sequencing to detect mutations in the genes of the probands of the retinitis pigmentosa families, and Sanger sequencing to confirm the causal mutations identified by whole exome sequencing. In addition, we report two cases with retinitis pigmentosa caused by RDH12 (c.524C > T) and PRPF4 (c.1273G > A) pathogenic mutations. Conclusions These results might extend the mutation spectrum of known retinitis pigmentosa genes and give these two Yi minority ethnic group families from Yunnan more precise genetic counseling and more specific prognoses.
Keywords	Mutation ; Retinitis pigmentosa ; Pediatric population ; Yunnan ; Medicine ; R
Subject code	360
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Genetic polymorphism of 19 autosomal STR loci in the Yi ethnic minority of Liangshan Yi autonomous prefecture from Sichuan province in China.

Cheng, Jingliang / Song, Binghui / Fu, Jiewen / Zheng, Xiaoli / He, Tao / Fu, Junjiang

Scientific reports

2021 Volume 11, Issue 1, Page(s) 16327

Abstract: The Yi is one of fifty-six ethnic populations and one of the most ancient ethnic groups in China ... The Liangshan Yi Autonomous Prefecture (LYAP) in Sichuan Province has the single largest Yi community in China ... To establish a Yi population database in the LYAP of Sichuan in China, a Goldeneye™ DNA Identification System ...

Abstract	The Yi is one of fifty-six ethnic populations and one of the most ancient ethnic groups in China. The Liangshan Yi Autonomous Prefecture (LYAP) in Sichuan Province has the single largest Yi community in China. To establish a Yi population database in the LYAP of Sichuan in China, a Goldeneye™ DNA Identification System 20A Kit with 19 autosomal STRs (short tandem repeats) was used. As a result, the total discrimination power (TDP) and the cumulative probability of exclusion (CPE) for these STRs in 1016 unrelated individuals were 0.999999999999999999999897 and 0.9999999597, respectively. Totals of 273 alleles for 19 STRs and 8-22 alleles for each locus were found. The allelic frequencies ranged from 0.0005 to 0.5084. The forensic parameter averages of these STRs were as follows: observed heterozygosity (H
MeSH term(s)	Asian Continental Ancestry Group/genetics ; China ; Ethnic Groups/genetics ; Gene Frequency/genetics ; Genetics, Population/methods ; Humans ; Microsatellite Repeats/genetics ; Minority Groups ; Phylogeny ; Polymorphism, Genetic/genetics
Language	English
Publishing date	2021-08-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-95883-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Increasing prevalence of overweight and obesity in Yi farmers and migrants from 2007 to 2015 in China: the Yi migrant study.

Wang, Ye / Pan, Li / Wan, Shaoping / Yi, Huowuli / Yang, Fang / He, Huijing / Li, Zheng / Zhang, Jia / Wang, Xiaoyang / Yong, Zhengping / Shan, Guangliang

BMC public health

2018 Volume 18, Issue 1, Page(s) 659

Abstract: ... and related factors of overweight and obesity in Yi farmers and migrants in southwest China from 2007 ... prevalence of overweight increased in both groups (from 5.54 to 16.65% in Yi farmers, from 27.91 to 33.61 ... in Yi migrants). Standardized prevalence of obesity increased only in Yi farmers (from 0.37 to 3.13 ...

Abstract	Background: With the social development and lifestyle transition, increasing trends of overweight and obesity prevalence are commonly reported worldwide. Data focusing on overweight and obesity trends in rural residents and rural-to-urban migrants in China are limited. This study aims to assess the changes and related factors of overweight and obesity in Yi farmers and migrants in southwest China from 2007 to 2015, and to assess the disparities in prevalence changes. Methods: Pseudo-panel data was obtained from two cross-sectional studies conducted in Sichuan province, southwest China in 2007 and 2015. Standardized prevalence of overweight and obesity were evaluated by direct method using the 2010 national census population as the standard. Prevalence differences of overweight and obesity were calculated in each group and compared between groups to evaluate the disparity in prevalence changes. Generalized linear mixed model was performed to determine factors related to overweight/obesity. Results: Standardized prevalence of overweight increased in both groups (from 5.54 to 16.65% in Yi farmers, from 27.91 to 33.61% in Yi migrants). Standardized prevalence of obesity increased only in Yi farmers (from 0.37 to 3.13%). Prevalence difference of overweight in Yi farmers was higher than that in Yi migrants (11.11 vs. 5.70), but prevalence differences of obesity were not significantly different between Yi farmers and migrants. Conclusions: Prevalence of overweight and obesity in Yi farmers, and prevalence of overweight in Yi migrants increased from 2007 to 2015. Yi farmers were developing overweight at a greater pace than migrants. More attention should be paid to spread health knowledge and encourage healthy lifestyle in Yi people, especially Yi farmers.
MeSH term(s)	Adult ; Agriculture/statistics & numerical data ; China/epidemiology ; Cross-Sectional Studies ; Farmers/statistics & numerical data ; Female ; Health Status ; Humans ; Male ; Middle Aged ; Obesity/epidemiology ; Prevalence ; Rural Population/statistics & numerical data ; Transients and Migrants/statistics & numerical data
Language	English
Publishing date	2018-05-24
Publishing country	England
Document type	Journal Article
ISSN	1471-2458
ISSN (online)	1471-2458
DOI	10.1186/s12889-018-5577-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effects of Yi Jin Jing on juvenile cervical spondylopathy in China: A parallel, randomized, assessor-blinded clinical trial.

Guo, W / Xing, H / Gong, X / He, L / Zhang, Z / Jia, C

Nigerian journal of clinical practice

2023 Volume 26, Issue 9, Page(s) 1234–1241

Abstract: ... the efficacy of Chinese fitness exercise Yi Jin Jing exercise in intervening the cervical spondylopathy ... with cervical spondylopathy, with 30 patients in each group. The observation group was required to take Yi Jin ... at follow-up, while the reduction in scores of the Yi Jin Jing group was more significant. Cervical ...

Abstract	Background: Cervical spondylopathy is a common musculo-articular disorder, multiple exercises are recommended. Chinese fitness exercises are prevalent and used to treat various diseases. Aim: To explore the efficacy of Chinese fitness exercise Yi Jin Jing exercise in intervening the cervical spondylopathy in adolescents. Patients and methods: The study was conducted in 60 adolescent patients with cervical spondylopathy, with 30 patients in each group. Methods: The study was conducted in 60 adolescent patients with cervical spondylopathy, with 30 patients in each group. The observation group was required to take Yi Jin Jing exercise, and the control group took the brisk walking exercise. The first week was the preparatory period for the patients, and then the participants were required to do exercises three times a week for at least 30 minutes in the later 3 weeks. Before and after treatment, Neck Disability Index (NDI) scores, pain visual analog scale (VAS) scores, and cervical curvature in both groups were observed, and the incidence of adverse events in both groups was recorded during the trial. Results: The NDI and VAS scores in both groups statistically decreased after intervention and mildly increased at follow-up, while the reduction in scores of the Yi Jin Jing group was more significant. Cervical curvature in both groups improved on day 28 compared to day 0. There were no adverse reactions during the evaluation period. Conclusion: The Chinese health-care qigong Yi Jin Jing exercise is more effective than brisk walking in improving the cervical range of motion and relieving pain in adolescents with cervical spondylopathy. Trial registration/Protocol registration: Clinical Trial Registry (ChiCTR2000030723).
MeSH term(s)	Humans ; Adolescent ; Neck ; Exercise ; China ; Exercise Therapy ; Pain ; Treatment Outcome ; Cervical Vertebrae
Language	English
Publishing date	2023-10-04
Publishing country	India
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1458330-6
ISSN	1119-3077
ISSN	1119-3077
DOI	10.4103/njcp.njcp_410_22
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Article: Protective effects and regulatory mechanisms of Shen-shuai-yi recipe on renal fibrosis in unilateral ureteral obstruction-induced mice.

Lin, Ping-Lan / Weng, Tao-Tao / Duan, Lian-Xiang / Zhang, Lin-Zhang / Wei, Xia / Qi, Sheng-Lan / You, Jia-Wen / Cao, Yu / Ge, Guang-Bo / Liu, Wei / He, Xiao-Li / Hu, Jing

Heliyon

2023 Volume 9, Issue 7, Page(s) e17908

Abstract: ... Shen-shuai-yi Recipe (SSYR) is a classical Chinese herbal formula for the treatment of CKD ...

Abstract	Renal fibrosis (RF) is a common pathological feature of chronic kidney disease (CKD), which remains a major public health problem. As now, there is still lack of chemical or biological drugs to reverse RF. Shen-shuai-yi Recipe (SSYR) is a classical Chinese herbal formula for the treatment of CKD. However, the effects and mechanisms of SSYR in treating RF are still not clear. In this study, the active constituents SSYR for treating RF were explored by UHPLC-Q-Orbitrap HRMS. Bioinformatics analyses were employed to analyze the key pharmacological targets and the core active constituents of SSYR in the treatment of RF. In experimental validation, vehicle or SSYR at doses of 2.12 g/kg/d and 4.25 g/kg/d were given by orally to unilateral ureteric obstruction (UUO) mice. 13 days after treatment, we detected the severity of renal fibrosis, extracellular collagen deposition and pre-fibrotic signaling pathways. Bioinformatics analysis suggested that signal transducer and activator of transcription 3 (STAT3) was the core target and lenticin, luteolin-7-O-rutinoside, hesperidin, kaempferol-3-O-rutinoside, and 3,5,6,7,8,3',4'-heptamethoxyflavone were the key constituents in SSYR for treating RF. SSYR significantly reduced the expressions of fibronectin (FN), α-smooth muscle actin (α-SMA), collagen-I and alleviated renal interstitial collagen deposition in UUO kidneys. In mechanism, SSYR potently blocked the phosphorylation of STAT3 and Smad3 and suppressed the expression of connective tissue growth factor (CTGF). Collectively, SSYR can ameliorate RF
Language	English
Publishing date	2023-07-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e17908
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Article ; Online: Association between age at arrival, duration of migration, and overweight/obesity in Chinese rural-to-urban migrants: the Yi migrant study.

Wang, Ye / Pan, Li / Wan, Shao-Ping / Yi, Huo-Wu-Li / Yang, Fang / He, Hui-Jing / Li, Zheng / Zhang, Jia / Yong, Zheng-Ping / Shan, Guang-Liang

Chinese medical journal

2020 Volume 134, Issue 1, Page(s) 60–67

Abstract: ... duration of migration, and the corresponding association with overweight/obesity in Yi migrants in China ... of migration and overweight/obesity (BMI ≥ 25 kg/m2).: Results: A total of 3056 Yi people (1894 Yi farmers ... and 1162 Yi migrants) aged 20 to 80 years were enrolled. After adjusting for age, sex, and ...

Abstract	Background: Urbanization in China is rapidly proceeding, but rural-to-urban migration and its association with overweight and obesity is not well studied. This study aimed to explore the age at arrival, duration of migration, and the corresponding association with overweight/obesity in Yi migrants in China. Methods: A cross-sectional study was conducted in rural and urban areas in 2015 in Sichuan province, China. Demographic characteristics, lifestyle factors, and anthropometry were collected. General linear regression models were used to assess the effect of duration of migration (1-10, 11-20, 21-30, and >30 years) on body mass index (BMI). Multi-variable logistic regression was used to examine the association between duration of migration and overweight/obesity (BMI ≥ 25 kg/m2). Results: A total of 3056 Yi people (1894 Yi farmers and 1162 Yi migrants) aged 20 to 80 years were enrolled. After adjusting for age, sex, and other potential confounders, Yi migrants had 1.71 kg/m2 (95% confidence interval [CI]: 1.36-2.06) higher BMI and a 2.13-fold (95% CI: 1.71-2.65) higher risk of overweight/obesity than Yi farmers. In Yi migrants, stratified by age at arrival, no significant association between duration of migration and overweight/obesity was observed in those who were 0 to 20 years old at arrival. In comparison, in migrants >20 years old at arrival, compared with the reference group (1-10 years), long-term migration (>30 years) was found to be associated with overweight/obesity after adjustment (odds ratio: 1.85, 95% CI: 1.04-3.29). Conclusions: Yi migrants were observed to have greater risk of overweight/obesity than Yi farmers. In Yi migrants, the risk of overweight/obesity increased according to the duration of migration, especially in those who were older upon their arrival.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; China/epidemiology ; Cross-Sectional Studies ; Humans ; Middle Aged ; Obesity/epidemiology ; Overweight/epidemiology ; Prevalence ; Rural Population ; Transients and Migrants ; Urban Population ; Young Adult
Language	English
Publishing date	2020-08-20
Publishing country	China
Document type	Journal Article
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000000973
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