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Article: Mechanism of analgesic effect of fire needle on peripheral sensitization in rats with neuropathic pain induced by chemotherapy.

Zeng, Jing-Chun / Chen, Yue-Xuan / Li, Jing-Jing / Wang, Xin-Dong / Xiao, Xi / Zhang, Rui-Lin / Ji, Kai-Song / Lu, Li-Ming

Zhen ci yan jiu = Acupuncture research

2023 Volume 48, Issue 11, Page(s) 1095–1102

Abstract: Objectives: This study aims to explore the analgesic mechanism of fire needle on peripheral sensitization in rats with neuropathic pain(NP) induced by oxaliplatin, so as to investigate its mechanism in improving peri-pheral sensitization.: Methods: ... ...

Title translation	火针对化疗所致神经病理性疼痛大鼠外周敏化的镇痛作用机制.
Abstract	Objectives: This study aims to explore the analgesic mechanism of fire needle on peripheral sensitization in rats with neuropathic pain(NP) induced by oxaliplatin, so as to investigate its mechanism in improving peri-pheral sensitization. Methods: Male SD rats aged 8 weeks were randomly divided into 4 groups：normal group( Results: Compared with the normal group, the model group had decreased paw withdrawal threshold(PWT) after modeling( Conclusions: Fire needle can improve mechanical pain threshold and reduce the contents of peripheral inflammatory factors in rats with oxaliplatin-induced NP. This effect may be related to the inhibition of mast cell activation and the inhibition of TPS, TRPV1 and PAR2 protein expressions, in the local areas of acupoints.
MeSH term(s)	Rats ; Male ; Animals ; Rats, Sprague-Dawley ; Oxaliplatin/adverse effects ; Tumor Necrosis Factor-alpha/genetics ; Interleukin-6/genetics ; Neuralgia/etiology ; Neuralgia/genetics ; Edema
Chemical Substances	Oxaliplatin (04ZR38536J) ; Tumor Necrosis Factor-alpha ; Interleukin-6
Language	Chinese
Publishing date	2023-11-19
Publishing country	China
Document type	Journal Article
ZDB-ID	1283179-7
ISSN	1000-0607
ISSN	1000-0607
DOI	10.13702/j.1000-0607.20221165
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Article: Anti-obesity effects exerted by

Li, Sheng-Nan / Zhang, Dian-Long / Wang, Zhen-Hui / Song, Wen-Ting / Chen, Wen-Bo / Hu, Ge-Li / Han, Lu-Ying / Zhou, Jing-Chun

Food science & nutrition

2023 Volume 11, Issue 10, Page(s) 6459–6469

Abstract: Obesity is characterized by chronic inflammation, insulin resistance, and gut microbiota dysbiosis. ...

Abstract	Obesity is characterized by chronic inflammation, insulin resistance, and gut microbiota dysbiosis.
Language	English
Publishing date	2023-08-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703010-6
ISSN	2048-7177
ISSN	2048-7177
DOI	10.1002/fsn3.3588
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Article: A newly proposed heatstroke-induced coagulopathy score in patients with heat illness: A multicenter retrospective study in China.

Lin, Qing-Wei / Zhong, Lin-Cui / He, Long-Ping / Zeng, Qing-Bo / Zhang, Wei / Song, Qing / Song, Jing-Chun

Chinese journal of traumatology = Zhonghua chuang shang za zhi

2023 Volume 27, Issue 2, Page(s) 83–90

Abstract: Purpose: In patients with heatstroke, disseminated intravascular coagulation (DIC) is associated with greater risk of in-hospital mortality. However, time-consuming assays or a complex diagnostic system may delay immediate treatment. Therefore, the ... ...

Abstract	Purpose: In patients with heatstroke, disseminated intravascular coagulation (DIC) is associated with greater risk of in-hospital mortality. However, time-consuming assays or a complex diagnostic system may delay immediate treatment. Therefore, the present study proposes a new heatstroke-induced coagulopathy (HIC) score in patients with heat illness as an early warning indicator for DIC. Methods: This retrospective study enrolled patients with heat illness in 24 Chinese hospitals from March 2021 to May 2022. Patients under 18 years old, with a congenital clotting disorder or liver disease, or using anticoagulants were excluded. Data were collected on demographic characteristics, routine blood tests, conventional coagulation assays and biochemical indexes. The risk factors related to coagulation function in heatstroke were identified by regression analysis, and used to construct a scoring system for HIC. The data of patients who met the diagnostic criteria for HIC and International Society on Thrombosis and Haemostasis defined-DIC were analyzed. All statistical analyses were performed using SPSS 26.0. Results: The final analysis included 302 patients with heat illness, of whom 131 (43.4%) suffered from heatstroke, including 7 death (5.3%). Core temperature (OR = 1.681, 95% CI 1.291 - 2.189, p < 0.001), prothrombin time (OR = 1.427, 95% CI 1.175 - 1.733, p < 0.001) and D-dimer (OR = 1.242, 95% CI 1.049 - 1.471, p = 0.012) were independent risk factors for heatstroke, and therefore used to construct an HIC scoring system because of their close relation with abnormal coagulation. A total score ≥ 3 indicated HIC, and HIC scores correlated with the score for International Society of Thrombosis and Hemostasis -DIC (r = 0.8848, p < 0.001). The incidence of HIC (27.5%) was higher than that of DIC (11.2%) in all of 131 heatstroke patients. Meanwhile, the mortality rate of HIC (19.4%) was lower than that of DIC (46.7%). When HIC developed into DIC, parameters of coagulation dysfunction changed significantly: platelet count decreased, D-dimer level rose, and prothrombin time and activated partial thromboplastin time prolonged (p < 0.05). Conclusions: The newly proposed HIC score may provide a valuable tool for early detection of HIC and prompt initiation of treatment.
MeSH term(s)	Humans ; Adolescent ; Retrospective Studies ; Disseminated Intravascular Coagulation/diagnosis ; Disseminated Intravascular Coagulation/epidemiology ; Disseminated Intravascular Coagulation/etiology ; Blood Coagulation Disorders/diagnosis ; Blood Coagulation Disorders/epidemiology ; Blood Coagulation Disorders/etiology ; Thrombosis ; Heat Stroke/complications
Language	English
Publishing date	2023-08-04
Publishing country	China
Document type	Multicenter Study ; Journal Article
ZDB-ID	2276839-7
ISSN	1008-1275
ISSN	1008-1275
DOI	10.1016/j.cjtee.2023.08.001
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Article: Translation and validation of traditional Chinese version of the pediatric eating assessment Tool-10.

Wang, Sz-Ting / Kang, Kun-Tai / Weng, Wen-Chin / Lu, Pin-Hung / Chang, Chi-Fen / Lin, Yuh-Yu / Lee, Yu-Chen / Chen, Chen-Yu / Song, Jing-Chun / Hsu, Wei-Chung

Journal of the Formosan Medical Association = Taiwan yi zhi

2024

Abstract: Background: /Purpose: The Pediatric Eating Assessment Tool-10 (Pedi-EAT-10) is a caregiver-administrated subjective questionnaire for evaluating swallowing and feeding disorders among children. This study translated the Pedi-EAT-10 into Traditional ... ...

Abstract	Background: /Purpose: The Pediatric Eating Assessment Tool-10 (Pedi-EAT-10) is a caregiver-administrated subjective questionnaire for evaluating swallowing and feeding disorders among children. This study translated the Pedi-EAT-10 into Traditional Chinese and tested the translated version's reliability and validity. Methods: Pedi-EAT-10 was translated into Traditional Chinese by experts and finalized after discussion and testing. A total of 168 participants, consisting of 32 children with dysphagia from a tertiary medical center and 136 healthy controls from its Children Care Center for Employees, were recruited. All participants were assessed by an otolaryngologist and speech-language pathologist. The reliability, validity, and efficacy of the translated Pedi-EAT-10 were analyzed to ensure it could be used to identify pediatric dysphagia and feeding problems. Results: The Traditional Chinese version of the Pedi-EAT-10 had significant clinical discriminative validity between the dysphagia group and the control group (total score = 9.6 vs. 2.6, P < 0.001), acceptable test-retest reliability (intraclass correlation = 0.63), and excellent internal consistency (Cronbach's α = 0.91 for the entire cohort). The overall performance of the test for distinguishing children with dysphagia from normal controls was acceptable, and the area under the curve was 74.8% (sensitivity = 71.9%; specificity = 69.9%). The optimal cutoff score was ≥3 on the Youdex index. Conclusions: The Traditional Chinese version of the Pedi-EAT-10 has fair reliability and validity and can be quickly and easily completed by caregivers. The translated Ped-EAT-10 can be used as a first-line tool for assessing the need for further referral and instrumental examination.
Language	English
Publishing date	2024-04-22
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2096659-3
ISSN	1876-0821 ; 0929-6646
ISSN (online)	1876-0821
ISSN	0929-6646
DOI	10.1016/j.jfma.2024.04.010
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Article ; Online: GRK5 promoted renal fibrosis via HDAC5/Smad3 signaling pathway.

Xiang, Huiling / Huang, Jing / Song, Anni / Liu, Feng / Xiong, Jing / Zhang, Chun

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2024 Volume 38, Issue 2, Page(s) e23422

Abstract: Renal fibrosis is a common pathological feature of chronic kidney diseases (CKD), poses a significant burden in the aging population, and is a major cause of end-stage renal disease (ESRD). In this study, we investigated the role of G protein-coupled ... ...

Abstract	Renal fibrosis is a common pathological feature of chronic kidney diseases (CKD), poses a significant burden in the aging population, and is a major cause of end-stage renal disease (ESRD). In this study, we investigated the role of G protein-coupled receptor kinases (GRKs) 5 in the pathogenesis of renal fibrosis. GRK5 is a serine/threonine kinase that regulates G protein-coupled receptor (GPCR) signaling. GRK5 has been shown to play a role in various diseases including cardiac disorders and cancer. However, the role of GRK5 in renal fibrosis remains largely unknown. Our finding revealed that GRK5 was significantly overexpressed in renal fibrosis. Specifically, GRK5 was transferred into the nucleus via its nuclear localization sequence to regulate histone deacetylases (HDAC) 5 expression under renal fibrosis. GRK5 acted as an upstream regulator of HDAC5/Smad3 signaling pathway. HDAC5 regulated and prevented the transcriptional activity of myocyte enhancer factor 2A (MEF2A) to repress the transcription of Smad7 which leading to the activation of Smad3. These findings first revealed that GRK5 may be a potential therapeutic target for the treatment of renal fibrosis. Inhibition of GRK5 activity may be a promising strategy to attenuate the progression of renal fibrosis.
MeSH term(s)	Humans ; Fibrosis ; G-Protein-Coupled Receptor Kinase 5/genetics ; Histone Deacetylases/genetics ; Receptors, G-Protein-Coupled ; Renal Insufficiency, Chronic ; Signal Transduction
Chemical Substances	G-Protein-Coupled Receptor Kinase 5 (EC 2.7.11.16) ; GRK5 protein, human (EC 2.7.11.16) ; HDAC5 protein, human (EC 3.5.1.98) ; Histone Deacetylases (EC 3.5.1.98) ; Receptors, G-Protein-Coupled ; SMAD3 protein, human
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.202301595RRR
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Article: Expert consensus for diagnosis and treatment of coagulation dysfunction in COVID-19/ 新型冠状病毒肺炎重症患者相关凝血功能障碍诊疗专家共识

Jing-Chun, Song / Gang, Wang / Wei, Zhang / Yang, Zhang / Wei-Qin, Li / Zhou, Zhou

Med. J. Chin. Peoples Liberation Army

Abstract: Since December 2019, a novel type of coronavirus disease (COVID-19) in Wuhan led to an outbreak throughout the world. To date, there have been more than 1,260,000 COVID-19 patients, with a mortality rate of approximately 5.44%. Studies have shown that ... ...

Abstract	Since December 2019, a novel type of coronavirus disease (COVID-19) in Wuhan led to an outbreak throughout the world. To date, there have been more than 1,260,000 COVID-19 patients, with a mortality rate of approximately 5.44%. Studies have shown that coagulation dysfunction is a major cause of death in patients with severe COVID-19. Therefore, the People's Liberation Army Professional Committee of Critical Care Medicine and Chinese Thrombosis and Hemostasis Committee grouped experts from the frontline of the Wuhan epidemic to come together and develop an expert consensus on diagnosis and treatment of coagulation dysfunction associated with severe COVID-19 infection. This consensus includes an overview of COVID-19-related coagulation dysfunction, tests for coagulation, anticoagulation therapy, replacement therapy, supportive therapy and prevention. The consensus produced 18 recommendations which are being used to guide clinical work.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #619690
Database	COVID19

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Article ; Online: Expert consensus on the diagnosis and treatment of heat stroke in China.

Liu, Shu-Yuan / Song, Jing-Chun / Mao, Han-Ding / Zhao, Jin-Bao / Song, Qing

Military Medical Research

2020 Volume 7, Issue 1, Page(s) 1

Abstract: Heat stroke (HS) is a fatal disease caused by thermal damage in the body, and it has a very high mortality rate. In 2015, the People's Liberation Army Professional Committee of Critical Care Medicine published the first expert consensus on HS in China, ... ...

Abstract	Heat stroke (HS) is a fatal disease caused by thermal damage in the body, and it has a very high mortality rate. In 2015, the People's Liberation Army Professional Committee of Critical Care Medicine published the first expert consensus on HS in China, Expert consensus on standardized diagnosis and treatment for heat stroke. With an increased understanding of HS and new issues that emerged during the HS treatment in China in recent years, the 2015 consensus no longer meet the requirements for HS prevention and treatment. It is necessary to update the consensus to include the latest research evidence and establish a new consensus that has broader coverage, is more practical and is more in line with China's national conditions. This new expert consensus includes new concept of HS, recommendations for laboratory tests and auxiliary examinations, new understanding of diagnosis and differential diagnosis, On-site emergency treatment and In-hospital treatment, translocation of HS patients and prevention of HS.
MeSH term(s)	China/epidemiology ; Consensus ; Diagnosis, Differential ; Exercise/physiology ; Heat Stroke/diagnosis ; Heat Stroke/epidemiology ; Heat Stroke/therapy ; Hot Temperature/adverse effects ; Humans
Language	English
Publishing date	2020-01-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2768940-2
ISSN	2054-9369 ; 2054-9369
ISSN (online)	2054-9369
ISSN	2054-9369
DOI	10.1186/s40779-019-0229-2
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Article ; Online: Chinese expert consensus on diagnosis and treatment of coagulation dysfunction in COVID-19.

Song, Jing-Chun / Wang, Gang / Zhang, Wei / Zhang, Yang / Li, Wei-Qin / Zhou, Zhou

Military Medical Research

2020 Volume 7, Issue 1, Page(s) 19

Abstract: Since December 2019, a novel type of coronavirus disease (COVID-19) in Wuhan led to an outbreak throughout China and the rest of the world. To date, there have been more than 1,260,000 COVID-19 patients, with a mortality rate of approximately 5.44%. ... ...

Abstract	Since December 2019, a novel type of coronavirus disease (COVID-19) in Wuhan led to an outbreak throughout China and the rest of the world. To date, there have been more than 1,260,000 COVID-19 patients, with a mortality rate of approximately 5.44%. Studies have shown that coagulation dysfunction is a major cause of death in patients with severe COVID-19. Therefore, the People's Liberation Army Professional Committee of Critical Care Medicine and Chinese Society on Thrombosis and Hemostasis grouped experts from the frontline of the Wuhan epidemic to come together and develop an expert consensus on diagnosis and treatment of coagulation dysfunction associated with a severe COVID-19 infection. This consensus includes an overview of COVID-19-related coagulation dysfunction, tests for coagulation, anticoagulation therapy, replacement therapy, supportive therapy and prevention. The consensus produced 18 recommendations which are being used to guide clinical work.
MeSH term(s)	Aged ; Anticoagulants/therapeutic use ; Betacoronavirus ; Blood Coagulation Disorders/diagnosis ; Blood Coagulation Disorders/drug therapy ; Blood Coagulation Disorders/virology ; COVID-19 ; China ; Consensus ; Coronavirus Infections/complications ; Humans ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2
Chemical Substances	Anticoagulants
Keywords	covid19
Language	English
Publishing date	2020-04-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2768940-2
ISSN	2054-9369 ; 2054-9369
ISSN (online)	2054-9369
ISSN	2054-9369
DOI	10.1186/s40779-020-00247-7
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Article ; Online: Chinese expert consensus on diagnosis and treatment of trauma-induced hypercoagulopathy.

Song, Jing-Chun / Yang, Li-Kun / Zhao, Wei / Zhu, Feng / Wang, Gang / Chen, Yao-Peng / Li, Wei-Qin

Military Medical Research

2021 Volume 8, Issue 1, Page(s) 25

Abstract: Trauma-induced coagulopathy (TIC) is caused by post-traumatic tissue injury and manifests as hypercoagulability that leads to thromboembolism or hypocoagulability that leads to uncontrollable massive hemorrhage. Previous studies on TIC have mainly ... ...

Abstract	Trauma-induced coagulopathy (TIC) is caused by post-traumatic tissue injury and manifests as hypercoagulability that leads to thromboembolism or hypocoagulability that leads to uncontrollable massive hemorrhage. Previous studies on TIC have mainly focused on hemorrhagic coagulopathy caused by the hypocoagulable phenotype of TIC, while recent studies have found that trauma-induced hypercoagulopathy can occur in as many as 22.2-85.1% of trauma patients, in whom it can increase the risk of thrombotic events and mortality by 2- to 4-fold. Therefore, the Chinese People's Liberation Army Professional Committee of Critical Care Medicine and the Chinese Society of Thrombosis, Hemostasis and Critical Care, Chinese Medicine Education Association jointly formulated this Chinese Expert Consensus comprising 15 recommendations for the definition, pathophysiological mechanism, assessment, prevention, and treatment of trauma-induced hypercoagulopathy.
MeSH term(s)	China ; Consensus ; Humans ; Incidence ; Severity of Illness Index ; Thrombophilia/diagnosis ; Thrombophilia/etiology ; Thrombophilia/therapy ; Wounds and Injuries/complications
Language	English
Publishing date	2021-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2768940-2
ISSN	2054-9369 ; 2054-9369
ISSN (online)	2054-9369
ISSN	2054-9369
DOI	10.1186/s40779-021-00317-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of alprostadil combined with nucleoside antiviral drugs on liver function, liver fibrosis markers and serum inflammatory factors in patients with decompensated liver cirrhosis with HBV infection

Jing-Chun Song / Hai-Tao Zhang / Bin Liu / Hui-Fang Sun

Journal of Hainan Medical University, Vol 25, Iss 8, Pp 36-

2019 Volume 40

Abstract: Objective: To explore the Effects of alprostadil combined with nucleoside antiviral drugs on liver function, liver fibrosis markers and serum inflammatory factors in patients with decompensated liver cirrhosis with HBV infection. Methods: 136 patients ... ...

Abstract	Objective: To explore the Effects of alprostadil combined with nucleoside antiviral drugs on liver function, liver fibrosis markers and serum inflammatory factors in patients with decompensated liver cirrhosis with HBV infection. Methods: 136 patients with decompensated cirrhosis of HBV infection who were hospitalized in Linxi Hospital of Kailuan General Hospital, Tangshan Infectious Disease Hospital and North China University of Technology Hospital from January to February 2018, 2017 were selected. All patients were divided into control group and case group by random number table method, 68 cases in each group. The control group was treated with routine liver protection and antiviral therapy, while the case group was treated with alprostadil on the basis of the control group. The changes of liver function, liver fibrosis, liver and spleen imaging indexes, anti-virus related indexes and inflammatory factors were observed before and after treatment in the two groups. Results: The total effective rate of the case group was 97.06%, which was significantly higher than that of the control group (85.29%), and the difference was statistically significant. The ALT, AST, TBIL, LN, HA, PCIII, CIV, portal vein diameter, spleen vein diameter, spleen thickness, IL-6, hs-CRP, TNF-α and TGF-β1 were significantly lower in the case group than in the control group. ALB, HBV DNA conversion rate, HBsAg negative rate, and HBeAg negative rate were significantly higher than the control group, the difference was statistically significant. Conclusion: Alprostadil combined with nucleoside antiviral drugs can significantly improve the decompensation of HBV infection Liver function in patients with cirrhosis, reduce the degree of liver fibrosis, inhibit the production of serum inflammatory factors, and can effectively inhibit HBV replication, clinical efficacy is significant, with certain clinical application value.
Keywords	alprostadil ; nucleoside antiviral drugs ; decompensated cirrhosis ; liver function ; liver fibrosis ; Medicine ; R
Subject code	610
Language	English
Publishing date	2019-04-01T00:00:00Z
Publisher	Editorial Board of Journal of Hainan Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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