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  1. Book ; Online ; E-Book: Regenerative Medicine

    Qiu, Tingting / Toumi, Mondher

    Unlocking Patient Access and Commercial Potential

    (Pharmaceuticals, Health Economics and Market Access Series)

    2023  

    Abstract: A comprehensive review of the challenges that exist in patient accessibility to advanced therapy medicinal products (ATMPs), presenting clinical trials, marketing authorization, HTA, pricing, reimbursement, affordability, payment and partnership ... ...

    Author's details Tingting Qiu, Mondher Toumi
    Series title Pharmaceuticals, Health Economics and Market Access Series
    Abstract "A comprehensive review of the challenges that exist in patient accessibility to advanced therapy medicinal products (ATMPs), presenting clinical trials, marketing authorization, HTA, pricing, reimbursement, affordability, payment and partnership agreements of RMs and commercialisation. Specfically, we investigated how COVID-19 has impacted the RMs industry by elaborating on the disruptions it caused but also the new opportunities it brought. The ultimate goal of this work is to make strategic recommendations for manufacturers and decisions-markers on effective strategies to address the above obstacles and facilitate patient access to promising regenerative medicines"--
    Keywords Regenerative medicine
    Subject code 571.889
    Language English
    Size 1 online resource (251 pages)
    Publisher CRC Press
    Publishing place Boca Raton, FL
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-00-336667-8 ; 1-003-36667-8 ; 1-000-88489-9 ; 1-03-243198-9 ; 1-03-243296-9 ; 978-1-00-336667-6 ; 978-1-003-36667-6 ; 978-1-000-88489-0 ; 978-1-03-243198-7 ; 978-1-03-243296-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Editorial: Benefits and risks of drug combination therapy for chronic metabolic diseases.

    Qiu, Tingting / Yan, Dan

    Frontiers in endocrinology

    2024  Volume 15, Page(s) 1390248

    MeSH term(s) Humans ; Drugs, Chinese Herbal/therapeutic use ; Medicine, Chinese Traditional ; Chronic Disease ; Metabolic Diseases/drug therapy ; Risk Assessment ; Drug Combinations
    Chemical Substances Drugs, Chinese Herbal ; Drug Combinations
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2024.1390248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Three new anti-inflammatory stilbenoids and a diphenyl ether derivative from

    Yao, Liyuan / Huang, Xiaobao / Lin, Tingting / Qiu, Sheng-Xiang

    Natural product research

    2024  , Page(s) 1–8

    Abstract: Three new stilbenoids, namely two rare plant-derived phenanthrenes denominated Cajananthrenes A and B ( ...

    Abstract Three new stilbenoids, namely two rare plant-derived phenanthrenes denominated Cajananthrenes A and B (
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2023.2297862
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Physiology and transcriptome of

    Liu, Jia / Qiu, Sumei / Xue, Tingting / Yuan, Yingdan

    Plant signaling & behavior

    2024  Volume 19, Issue 1, Page(s) 2329487

    Abstract: E. ulmoides (Eucommia ulmoides) ...

    Abstract E. ulmoides (Eucommia ulmoides)
    MeSH term(s) Plant Growth Regulators/metabolism ; Germination/genetics ; Eucommiaceae/genetics ; Eucommiaceae/metabolism ; Transcriptome/genetics ; Abscisic Acid/metabolism ; Gibberellins/metabolism ; Hormones/metabolism ; Seeds/metabolism ; Gene Expression Regulation, Plant/genetics
    Chemical Substances Plant Growth Regulators ; Abscisic Acid (72S9A8J5GW) ; Gibberellins ; Hormones
    Language English
    Publishing date 2024-03-17
    Publishing country United States
    Document type Journal Article
    ISSN 1559-2324
    ISSN (online) 1559-2324
    DOI 10.1080/15592324.2024.2329487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Physiology and transcriptome of Sapindus mukorossi seeds at different germination stages.

    Liu, Jia / Qiu, Sumei / Xue, Tingting / Yuan, Yingdan

    Genomics

    2024  Volume 116, Issue 3, Page(s) 110822

    Abstract: Sapindus mukorossi has a wide distribution range, high application value, and broad developmental potential. Previous studies have mostly focused on the medicinal and economic value of soapberry; however, few studies have been conducted on its seed ... ...

    Abstract Sapindus mukorossi has a wide distribution range, high application value, and broad developmental potential. Previous studies have mostly focused on the medicinal and economic value of soapberry; however, few studies have been conducted on its seed germination. This study measured the physiological indicators and hormone content of soapberry seeds at different germination stages and preliminarily determined that abscisic acid (ABA) and indole-3-acetic acid (IAA) are the key hormones that affect the germination of soapberry seeds. Both Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG enrichment) analyses detected hormone transduction pathways, further confirming the key role of plant hormones in the germination process of soapberry seeds. Through transcriptome analysis, we speculated that CYP707A and IPA are key genes in the ABA and IAA synthesis pathways, respectively. This study revealed the close relationship between plant hormones and soapberry seed germination and provided new ideas for further exploration of the germination mechanism of soapberry seeds.
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 356334-0
    ISSN 1089-8646 ; 0888-7543
    ISSN (online) 1089-8646
    ISSN 0888-7543
    DOI 10.1016/j.ygeno.2024.110822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2367: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Ho(III)-coordination Complex: Fluorescence Performances and Combined with Captopril-Hydrogels against Glioma.

    Cong, Yuwei / Zhang, Tingting / Li, Heng / Pan, Jie / Qiu, Jiping

    Journal of fluorescence

    2024  

    Abstract: In this study, a novel dinuclear lanthanide complex, denoted as [ ... ...

    Abstract In this study, a novel dinuclear lanthanide complex, denoted as [Ho
    Language English
    Publishing date 2024-02-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2016892-5
    ISSN 1573-4994 ; 1053-0509
    ISSN (online) 1573-4994
    ISSN 1053-0509
    DOI 10.1007/s10895-024-03600-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Four new isocoumarins from

    Yao, Liyuan / Jumai, Aikebaier / Huang, Xiaobao / Lin, Tingting / Tao, Zhengguo / Qiu, Sheng-Xiang

    RSC advances

    2024  Volume 14, Issue 11, Page(s) 7763–7769

    Abstract: Four novel new isocoumarins, cajanolactone B, C, D1 and D2 (1-4), were isolated from ethanolic extracts of the leaves ... ...

    Abstract Four novel new isocoumarins, cajanolactone B, C, D1 and D2 (1-4), were isolated from ethanolic extracts of the leaves of
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra08149d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: GCNT3 regulated MUC13 to promote the development of hepatocellular carcinoma through the GSK3β/β-catenin pathway.

    Kang, Qiu / Tingting, Wu / Bingzi, Dong / Hao, Zou / Yuwei, Xie / Chuandong, Sun / Chengzhan, Zhu

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2024  

    Abstract: Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. Extensive research is currently directed at identifying novel targets for its diagnosis and treatment.: Aims: We investigated the biological functions ... ...

    Abstract Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. Extensive research is currently directed at identifying novel targets for its diagnosis and treatment.
    Aims: We investigated the biological functions and clinical significance of mucin-type N-acetylglucosaminyltransferase 3 (GCNT3) in HCC.
    Methods: Variations in the mRNA expression of GCNT3 were examined in normal and HCC tissues. Cell function assays and animal models characterized the effects of GCNT3 on the proliferation, invasion, and migration abilities of HCC cells. Western blot and immunofluorescence analyses were performed to explore further the specific mechanisms whereby GCNT3 affects HCC progression.
    Results: There is a strong correlation between GCNT3 overexpression and tumor formation and metastasis in vivo and in vitro. GCNT3 acted as a regulator of the synthesis of mucin-type O-glycans by interacting with mucin 13 (MUC13) to regulate its expression levels, activating the GSK3β/β-catenin signaling pathway. The activation of GSK3β/β-catenin signaling by GCNT3 was mitigated by MUC13 knockdown. In clinical HCC specimens, GCNT3 expression was upregulated in HCC tissues compared to non-tumor tissues. Further, there was a significant correlation between high GCNT3 expression and poor patient survival.
    Conclusions: GCNT3 regulated tumor progression in HCC through the MUC13/GSK3-β/β-catenin signaling pathway.
    Language English
    Publishing date 2024-02-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2024.01.198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1134: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: A Hybrid Algorithm of Ant Colony and Benders Decomposition for Large-Scale Mixed Integer Linear Programming.

    Shan, Tingting / Qiu, Zhaoxuan

    publication RETRACTED

    Computational intelligence and neuroscience

    2022  Volume 2022, Page(s) 1634995

    Abstract: The mixed integer linear programming (MILP) has been widely applied in many fields such as supply chain management and robot control, while how to develop a more efficient algorithm to solve large-scale MILP is still in discussion. This study addresses a ...

    Abstract The mixed integer linear programming (MILP) has been widely applied in many fields such as supply chain management and robot control, while how to develop a more efficient algorithm to solve large-scale MILP is still in discussion. This study addresses a hybrid algorithm of the ant colony and Benders decomposition to improve the efficiency. We firstly introduce the design of our algorithm, in which the Benders algorithm decomposes the MILP into a master problem and a slack problem, the ant colony algorithm generates initial solutions for the master problem, and heuristic rules obtain feasible solutions for the slack problem. Then, the computational experiments are carried out to verify efficiency, with a benchmark test and some medium-large scale examples. Compared with other algorithms like CPLEX, GUROBI, and traditional ACA, our algorithm shows a better performance with a 0.3%-4.0% optimality gap, as well as a significant decrease of 54.3% and 33.6% on average in the CPU time and iterations, respectively. Our contribution is to provide a low-workload, time-saving, and high-accuracy hybrid algorithm to solve MILP problems with a large amount of variables, which can be widely used in more commercial solvers and promote the utilization of the artificial intelligence.
    MeSH term(s) Algorithms ; Artificial Intelligence ; Programming, Linear
    Language English
    Publishing date 2022-08-31
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2388208-6
    ISSN 1687-5273 ; 1687-5273
    ISSN (online) 1687-5273
    ISSN 1687-5273
    DOI 10.1155/2022/1634995
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Editorial

    Tingting Liu / Liang Pei / Liming Wang / Weiwen Qiu

    Frontiers in Environmental Science, Vol

    Migration and transformation rules, evaluation and remediation methods of pollutants in “water-soil-plants”

    2023  Volume 11

    Keywords industrial pollutant ; mining pollutant ; transformation law ; risk assessment ; resource utilization ; Environmental sciences ; GE1-350
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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