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  1. Book ; Online ; E-Book: Natural Biopolymers in Drug Delivery and Tissue Engineering

    Jayakumar, Rangasamy / Murali, Vishnu Priya

    (Woodhead Publishing Series in Biomaterials Series)

    2023  

    Series title Woodhead Publishing Series in Biomaterials Series
    Subject code 615.19
    Language English
    Size 1 online resource (709 pages)
    Edition 1st ed.
    Publisher Elsevier Science & Technology
    Publishing place San Diego
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-98648-X ; 9780323988278 ; 978-0-323-98648-9 ; 032398827X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Article: Diabetic Pedal Osteomyelitis and Its Treatment.

    Venkatesan, Vidyaalakshmi / Rangasamy, Jayakumar

    Chonnam medical journal

    2023  Volume 59, Issue 2, Page(s) 109–114

    Abstract: Diabetes is a fast-growing chronic metabolic disorder that is widely associated with foot ulcers. The major challenge among these ulcers is wound infections, altered inflammatory responses, and a lack of angiogenesis that can complicate limb amputation. ... ...

    Abstract Diabetes is a fast-growing chronic metabolic disorder that is widely associated with foot ulcers. The major challenge among these ulcers is wound infections, altered inflammatory responses, and a lack of angiogenesis that can complicate limb amputation. The foot, because of its architecture, becomes the part most prone to complications and the infection rate is higher mainly between the toes due to the humid nature. Therefore, the infection rate is significantly higher. Wound healing in diabetes is a dynamic process usually delayed due to poor immune function. Diabetes-related pedal neuropathy and perfusion disturbances can lead to a loss of sensation in the foot. This neuropathy can further be a risk factor for ulcer development due to repetitive mechanical stress that later might get infected by the invasion of microorganisms extending to the bone and causing an infection called pedal osteomyelitis. This review details the pathophysiology, the biomaterials aiding in the infection cure and regeneration of bone along with their limitations, as well as their future prospects.
    Language English
    Publishing date 2023-05-25
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2536217-3
    ISSN 2233-7393 ; 2233-7385 ; 0377-9564
    ISSN (online) 2233-7393
    ISSN 2233-7385 ; 0377-9564
    DOI 10.4068/cmj.2023.59.2.109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Biomedical applications of polymeric nanofibers

    Beachley, Vince / Jayakumar, Rangasamy

    (Advances in polymer science ; 246)

    2012  

    Author's details vol. ed.: R. Jayakumar ... With contributions by V. Beachley
    Series title Advances in polymer science ; 246
    Collection
    Keywords Biologisch abbaubarer Kunststoff ; Nanofaser ; Biomaterial ; Herstellung ; Tissue Engineering ; Trägersubstanz
    Subject Trägermaterial ; Trägersubstanzen ; Tissue-Engineering ; Gewebezucht ; Biomedizinisches Material ; Nanofibers ; Nanofibres ; Biologisch abbaubare Polymere ; Bioabbaubare Polymere ; Erzeugung ; Anfertigung
    Language English
    Size XII, 287 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT017125489
    ISBN 978-3-642-27147-2 ; 3-642-27147-2 ; 9783642271489 ; 3642271480
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 719 order for loan Magazin

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  4. Book: Chitosan for Biomaterials

    Arami, Hamed / Jayakumar, Rangasamy

    (Advances in polymer science ; ...)

    2011  

    Author's details vol. ed. J. Jayakumar ... with contributions by H. Arami
    Series title Advances in polymer science
    ...
    Language English
    Dates of publication 2011-9999
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT017009734
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Book: Chitosan for Biomaterials / 1

    Arami, Hamed / Jayakumar, Rangasamy

    (Advances in polymer science ; 243)

    2011  

    Author's details vol. ed. J. Jayakumar ... with contributions by H. Arami
    Series title Advances in polymer science ; 243
    Chitosan for Biomaterials
    Collection Chitosan for Biomaterials
    Language English
    Size XI, 236 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT017009749
    ISBN 978-3-642-23113-1 ; 9783642231148 ; 3-642-23113-6 ; 3642231144
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 4346 order for loan Magazin

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  6. Article ; Online: Mechanical properties of tissue adhesives used for retaining extraoral silicone prostheses in maxillofacial defects: A systematic review.

    J L, Jaini / V, Manju / Rangasamy, Jayakumar / Ramanarayanan, Venkitachalam / Nair, Priya K

    The Journal of prosthetic dentistry

    2024  

    Abstract: Statement of problem: Different tissue adhesives are available for retaining extraoral silicone prostheses in maxillofacial defects. Comparative assessment of their mechanical properties will help the clinician select the right product for a specific ... ...

    Abstract Statement of problem: Different tissue adhesives are available for retaining extraoral silicone prostheses in maxillofacial defects. Comparative assessment of their mechanical properties will help the clinician select the right product for a specific clinical situation, but a systematic review is lacking.
    Purpose: The purpose of this systematic review was to analyze the existing data in the literature regarding 5 mechanical properties of tissue adhesives for extraoral silicone prostheses: peel strength, tensile strength, shear strength, torsional strength, and tack.
    Material and methods: A manual and electronic search was performed in appropriate databases to identify relevant publications with specific inclusion and exclusion criteria. The retrieved studies were screened for eligibility using the title, abstract, and published full texts. To evaluate the risk of bias, a methodological quality assessment was performed using the Joanna Briggs Institute Critical Appraisal Checklists for Randomized Controlled Trials. A custom data extraction template was used, and the results pooled using descriptive methods.
    Results: After screening, 15 articles, 5 in vitro studies, and 10 clinical studies were eligible for data extraction. In vitro studies assessed tack and peel bond strength. In contrast, clinical studies assessed peel strength, tensile strength, shear strength, and torsional strength through direct comparisons and in diverse settings.
    Conclusions: The assessed studies showed considerable methodological heterogeneity. When silicone-based tissue adhesives (Secure2 Medical Adhesive; Factor II, Hollister Colostomy Adhesive; Hollister Inc, Dow Corning 355 Medical adhesives; Dow Corning Europe Inc) were compared with water-based adhesives (Pros-Aide Adhesive; ADM Tronics Inc, PSA 1; Cosmedica Ltd, Daro adhesive; Factor II, Epithane-3; Daro Products), the silicone-based adhesives showed a higher peel bond strength (PBS), while double-sided medical adhesive tapes showed lower PBS. A few studies evaluated variations in the PBS as being affected by the addition of stone wool fibers, immersion in water, application of skin protective dressings and adhesive removers, application of multiple layers of adhesive, and usage of urethane liner.
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 218157-5
    ISSN 1097-6841 ; 0022-3913
    ISSN (online) 1097-6841
    ISSN 0022-3913
    DOI 10.1016/j.prosdent.2024.03.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul III Zs.145: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Injectable Pectin-Alginate Hydrogels for Improving Vascularization and Adipogenesis of Human Fat Graft.

    Janarthanan, Ramu / Jayakumar, Rangasamy / Iyer, Subramania

    Journal of functional biomaterials

    2023  Volume 14, Issue 8

    Abstract: Autologous fat grafting (AFG) is the most prevailing tool for soft tissue regeneration in clinics, although efficiency is limited to unpredictable volume resorption due to poor vascularization and eventual necrosis. This study sought to improve the AFG ... ...

    Abstract Autologous fat grafting (AFG) is the most prevailing tool for soft tissue regeneration in clinics, although efficiency is limited to unpredictable volume resorption due to poor vascularization and eventual necrosis. This study sought to improve the AFG efficiency using a hydrogel as a carrier for human fat graft (F) with and without platelet-rich plasma (PRP). PRP is clinically well known for the local release of several endogenous growth factors and has been in clinical use already. A human-fat-graft-encapsulated pectin-alginate hydrogel (FG) was developed and characterized. PRP was added to F to develop a human fat graft with PRP (FP). FP was admixed with a pectin-alginate hydrogel to develop FGP. FG and FGP showed the smooth injectable, elastic, and shear-thinning properties. FG and FGP groups showed enhanced cell viability and proliferation compared to the control F in vitro. We also investigated the in vivo angiogenesis and neo-adipogenesis ability of F, FG, FGP, and FP in nude mice after subcutaneous injection. After 2 and 4 weeks, an MRI of the mice was conducted, followed by graft explantation. The explanted grafts were also assessed histologically and with immunohistochemistry (IHC) studies. MRI and histology results revealed better vascularity of the FG and FGP system compared to fat graft alone. Further, the IHC studies, CD 31, and perilipin staining also revealed better vasculature and adipogenesis of FG and FGP systems. These results indicate the enhanced angiogenesis and adipogenesis of FG and FGP. Thus, developed pectin-alginate hydrogel-based fat graft systems FG and FGP replenish the native microenvironment by mediating angiogenesis and adipogenesis, thereby maximizing the clinical outcomes of autologous fat grafting.
    Language English
    Publishing date 2023-08-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb14080409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Lyophilized platelet rich fibrin and gelatin incorporated bioadhesive bone cement composite for repair of mandibular continuity defects.

    Anthraper, Mary Susan J / Chandramouli, Arthi / Srinivasan, Sowmya / Rangasamy, Jayakumar

    International journal of biological macromolecules

    2023  Volume 258, Issue Pt 2, Page(s) 129086

    Abstract: Mandibular continuity defects stem from conditions such as malignancies, trauma, cysts, osteomyelitis and osteoradionecrosis, presenting significant challenges. If mandibular reconstruction fails, it can result in facial collapse, causing significant ... ...

    Abstract Mandibular continuity defects stem from conditions such as malignancies, trauma, cysts, osteomyelitis and osteoradionecrosis, presenting significant challenges. If mandibular reconstruction fails, it can result in facial collapse, causing significant aesthetic and functional concerns for the patient. In the present study we developed a bio-adhesive Bone Cement (BC) enriched with lyophilised PRF and gelatin to enhance bone repair and induce regeneration. The developed BC consisted of a mixture of Tetracalcium Phosphate (TTCP) and O-Phospho-l-serine (OPLS) in addition to lyophilised Platelet Rich Fibrin (PRF) for sustained growth factor release and gelatin (GE) for improved cement resorption. It is primarily designed for in-situ application, conforming to the shape and size of the defect for effective bone repair and regeneration. The study evaluated four groups: (i) BC (control), (ii) BC-GE (control), (iii) BC-PRF, and (iv) BC-GE-PRF. All the four groups were characterised using FTIR, SEM and XRD. The mechanical studies of the prepared beads exhibited a significant increase in the compressive strength of the PRF loaded bone cement composites. In vitro degradation study of the beads over a 60-day period revealed a significantly higher percentage of bone cement resorption in the gelatin-incorporated groups, BC-GE (44 ± 0.5 %), and BC-GE-PRF (45 ± 2 %). The assessment of growth factor release (TGF-β and VEGF) using ELISA revealed a prolonged and sustained release of both growth factors over a 28-day period. In vitro studies were performed on human Dental Follicle Stem Cells (DFSCs) to assess cell attachment, proliferation, mineralisation and osteogenic differentiation. These studies clearly depicted that BC-PRF and BC-GE-PRF showed significantly greater proliferation of DFSCs. Furthermore, BC-PRF and BC-GE-PRF samples exhibited notably elevated expression of Runx2 and OPN (osteogenic markers), as well as a higher intensity of alizarin red stain (mineralisation). Therefore, it was concluded that PRF incorporated bioadhesive bone cement composites greatly enhance the cell attachment, proliferation, mineralisation and osteogenic differentiation of the DFSCs. Thus, the PRF and gelatin incorporated bone cement composites is expected to facilitate effective and faster bone regeneration and healing in a wide range of dental and maxillofacial defects.
    MeSH term(s) Humans ; Platelet-Rich Fibrin/metabolism ; Osteogenesis ; Gelatin/metabolism ; Bone Cements ; Intercellular Signaling Peptides and Proteins/metabolism
    Chemical Substances Gelatin (9000-70-8) ; Bone Cements ; Intercellular Signaling Peptides and Proteins
    Language English
    Publishing date 2023-12-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.129086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
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  9. Article ; Online: Nanocurcumin and arginine entrapped injectable chitosan hydrogel for restoration of hypoxia induced endothelial dysfunction.

    Mohandas, Annapoorna / Rangasamy, Jayakumar

    International journal of biological macromolecules

    2020  Volume 166, Page(s) 471–482

    Abstract: Hypoxia is a condition that gradually leads to ischemic damages in organs which is marked by poor tissue perfusion. Depending on the severity of the condition, revascularisation therapies are needed for reducing the risk of organ dysfunction. This study ... ...

    Abstract Hypoxia is a condition that gradually leads to ischemic damages in organs which is marked by poor tissue perfusion. Depending on the severity of the condition, revascularisation therapies are needed for reducing the risk of organ dysfunction. This study was aimed at developing an injectable nanocurcumin and arginine incorporated chitosan hydrogel (nC/R) that can prevent hypoxia induced endothelial damage. The prepared hydrogel has shear thinning, stable and injectable nature. The (nC and nC/R) hydrogels showed significant antioxidant activity and biodegradation in vitro. The release of curucmin and arginine from the nC/R was found to be higher at acidic pH, which predominates in an ischemic site. To mimic low oxygen environment, an in vitro hypoxic endothelial dysfunction model was developed which showed decreased expressions of phosphorylated eNOS (serine 1177) when compared to the cells cultured in normoxic condition. In vitro tube formation assay demonstrated the protective effect of nC/R towards hypoxia induced reduction of tube width. The nC/R hydrogel was found to enhance phosphorylation of eNOS at serine 1177 site in cultured endothelial cells subjected to hypoxia. Therefore, nC/R hydrogel could effectively deliver both curcumin and arginine and therapeutically reduce the effect of hypoxia induced endothelial dysfunction.
    MeSH term(s) Antioxidants/pharmacology ; Arginine/pharmacology ; Biphenyl Compounds/chemistry ; Cell Hypoxia/drug effects ; Chitosan/chemistry ; Curcumin/pharmacology ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/pathology ; Humans ; Hydrogels/chemistry ; Nanoparticles/chemistry ; Nanoparticles/ultrastructure ; Neovascularization, Physiologic/drug effects ; Nitric Oxide Synthase Type III/metabolism ; Phosphorylation/drug effects ; Picrates/chemistry ; Spectroscopy, Fourier Transform Infrared ; Superoxides/chemistry
    Chemical Substances Antioxidants ; Biphenyl Compounds ; Hydrogels ; Picrates ; Superoxides (11062-77-4) ; Chitosan (9012-76-4) ; Arginine (94ZLA3W45F) ; 1,1-diphenyl-2-picrylhydrazyl (DFD3H4VGDH) ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; Curcumin (IT942ZTH98)
    Language English
    Publishing date 2020-10-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2020.10.205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2374: Show issues Location:
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  10. Article: Role of FGF-18 in Bone Regeneration.

    Murugaiyan, Kavipriya / Amirthalingam, Sivashanmugam / Hwang, Nathaniel Suk-Yeon / Jayakumar, Rangasamy

    Journal of functional biomaterials

    2023  Volume 14, Issue 1

    Abstract: In tissue engineering, three key components are cells, biological/mechanical cues, and scaffolds. Biological cues are normally proteins such as growth factors and their derivatives, bioactive molecules, and the regulators of a gene. Numerous growth ... ...

    Abstract In tissue engineering, three key components are cells, biological/mechanical cues, and scaffolds. Biological cues are normally proteins such as growth factors and their derivatives, bioactive molecules, and the regulators of a gene. Numerous growth factors such as VEGF, FGF, and TGF-β are being studied and applied in different studies. The carriers used to release these growth factors also play an important role in their functioning. From the early part of the 1990s, more research has beenconductedon the role of fibroblast growth factors on the various physiological functions in our body. The fibroblast growth factor family contains 22 members. Fibroblast growth factors such as 2, 9, and 18 are mainly associated with the differentiation of osteoblasts and in bone regeneration. FGF-18 stimulates the PI3K/ERK pathway and smad1/5/8 pathway mediated via BMP-2 by blocking its antagonist, which is essential for bone formation. FGF-18 incorporated hydrogel and scaffolds had showed enhanced bone regeneration. This review highlights these functions and current trends using this growth factor and potential outcomes in the field of bone regeneration.
    Language English
    Publishing date 2023-01-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb14010036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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