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  1. Book ; Online ; E-Book: Polysaccharide nanoparticles

    Venkatesan, Jayachandran

    preparation and biomedical applications

    (Micro and Nano Technologies)

    2022  

    Author's details edited by Jayachandran Venkatesan [and three others]
    Series title Micro and Nano Technologies
    Keywords Polysaccharides/Synthesis ; Polysaccharides/Biotechnology
    Subject code 547.782
    Language English
    Size 1 online resource (692 pages)
    Publisher Elsevier
    Publishing place Amsterdam, Netherlands ; Oxford, United Kingdom ; Cambridge, MA
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-12-822356-1 ; 9780128223512 ; 978-0-12-822356-7 ; 0128223510
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book ; Online ; E-Book: Marine antioxidants

    Shin, Kyung-Hoon / Kim, Se-Kwon / Venkatesan, Jayachandran

    preparations, syntheses, and applications

    2023  

    Author's details edited by Se-Kwon Kim, Kyung-Hoon Shin, and Jayachandran Venkatesan
    Keywords Marine microbiology ; Antioxidants
    Subject code 579.177
    Language English
    Size 1 online resource (534 pages)
    Publisher Academic press
    Publishing place London, England ; San Diego, California ; Cambridge, Massachusetts
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-95087-6 ; 9780323950862 ; 978-0-323-95087-9 ; 0323950868
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Feasibility of Combining Functional Mobilisation with Resistance and Endurance Training for Mechanically Ventilated Patients in Intensive Care Unit Setting-A Pilot Study.

    Jayachandran, Balachandran / Venkatesan, Kumaresh / Tan, Sunny Boon Chai / Yeo, Lynn Soo Hoon / Venkatacham, Jonathen / Selvakumar, Mohena Priyaa / Tan, Bryan Yijia

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-04-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Casein-assisted exfoliation of tungsten disulfide nanosheets for biomedical applications.

    Dalavi, Pandurang Appana / Prabhu, Ashwini / M, Sajida / Murugan, Sesha Subramanian / Jayachandran, Venkatesan

    Colloids and surfaces. B, Biointerfaces

    2023  Volume 232, Page(s) 113595

    Abstract: Our regular life can be more challenging by bone abnormalities. Bone tissue engineering is used for repairing, regenerating, or replacing bone tissue that has been injured or infected. It is effective in overcoming the drawbacks of conventional bone ... ...

    Abstract Our regular life can be more challenging by bone abnormalities. Bone tissue engineering is used for repairing, regenerating, or replacing bone tissue that has been injured or infected. It is effective in overcoming the drawbacks of conventional bone grafting methods like autograft and allograft by enhancing the effectiveness of bone regeneration. Recent discoveries have shown that the exfoliation of transition metal dichalcogenides (TMDs) with protein is in great demand for bone tissue engineering applications. WS
    MeSH term(s) Caseins ; Sulfides ; Bone Regeneration ; Alginates/pharmacology
    Chemical Substances tungsten sulfide ; Caseins ; Sulfides ; Alginates
    Language English
    Publishing date 2023-10-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2023.113595
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Pharmacokinetics and bioequivalence of

    Kim, Se-Kwon / Venkatesan, Jayachandran / Rathi, Priyank / Antony, Benny

    Heliyon

    2023  Volume 9, Issue 12, Page(s) e22843

    Abstract: Introduction: Withania somnifera: Methods: This randomized, double-blind, single-dose crossover study of 16 healthy human volunteers evaluated the acute oral bioavailability of withanolides and the bioequivalence of two WS extracts, WS-35 and WS-2.5. ...

    Abstract Introduction: Withania somnifera
    Methods: This randomized, double-blind, single-dose crossover study of 16 healthy human volunteers evaluated the acute oral bioavailability of withanolides and the bioequivalence of two WS extracts, WS-35 and WS-2.5. WS-35 was standardized to total withanolides not less than 40% comprising not less than 35% withanolide glycosides and WS-2.5 was standardized to 2.5% withanolides. The clinical dosages were normalized to 185 mg of total withanolide in each extract at the bioequivalent dosages. The pharmacokinetic parameters of withanolide A, withanoside IV, withaferin A, and total withanolides were quantified in the blood plasma using a validated LC-MS/MS method.
    Results: The half-life, C-max, and mean residence time of the total withanolides were 5.18, 5.62 and 4.13 times significantly higher and had lower systemic clearance with WS-35 than with WS-2.5 extract. Considering the plasma AUC 0-inf of total withanolides per mg of each WS extract administered orally, WS-35 was 280.74 times more bioavailable than WS-2.5.
    Conclusion: The results of this study highlight the importance of withanolide glycosides in improving the pharmacokinetics of WS extracts. Owing to its superior pharmacokinetic profile, WS-35, with 35% withanolide glycosides, is a promising candidate for further studies on
    Clinical trial registration: CTRI/2020/10/028397 [registered on:13/10/2020] (Trial prospectively registered) http://ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=42149&EncHid=&userName=CTRI/2020/10/028397.
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e22843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Fucoidan-based nanoparticles: Preparations and applications.

    Venkatesan, Jayachandran / Murugan, Sesha Subramanian / Seong, Gi Hun

    International journal of biological macromolecules

    2022  Volume 217, Page(s) 652–667

    Abstract: Nanoparticle-based therapy has gained much attention in the pharmaceutical industry. Fucoidan is a sulfated polysaccharide naturally derived from marine brown algae and is widely used for medical applications. We explore preparation of fucoidan-based ... ...

    Abstract Nanoparticle-based therapy has gained much attention in the pharmaceutical industry. Fucoidan is a sulfated polysaccharide naturally derived from marine brown algae and is widely used for medical applications. We explore preparation of fucoidan-based nanoparticles and their biomedical applications in the current review. The fucoidan-based nanoparticles have been synthesized using microwave, emulsion, solvent evaporation, green synthesis, polyelectrolyte self-assembly, precipitation, and ultrasonication methods. The synthesized nanoparticles have particle sizes ranging from 100 to 400 nm. Therefore, fucoidan-based nanoparticles have a variety of potential therapeutic applications, including drug delivery, cancer therapies, tissue engineering, antimicrobial applications, magnetic resonance imaging contrast, and atherothrombosis imaging. For example, fucoidan nanoparticles have been used to deliver curcumin, dextran, gentamicin, epigallocatechin gallate, and cisplatin for cancer therapies. Furthermore, fucoidan nanoparticles coupled with metal nanoparticles have been used to target and recognize clinical conditions for diagnostic purposes. Hence, fucoidan-based nanoparticles have been helpful for biomedical applications.
    MeSH term(s) Drug Delivery Systems ; Humans ; Metal Nanoparticles ; Nanoparticles ; Neoplasms/drug therapy ; Polysaccharides/therapeutic use
    Chemical Substances Polysaccharides ; fucoidan (9072-19-9)
    Language English
    Publishing date 2022-07-13
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2022.07.068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article: Hydroxyapatite Derived from Marine Resources and their Potential Biomedical Applications

    Venkatesan, Jayachandran / Anil, Sukumaran

    Biotechnology and bioprocess engineering. 2021 June, v. 26, no. 3

    2021  

    Abstract: Utilization of bone graft substitutes have increased due to the rising number of accidents, trauma, and aging population. Autograft is still considered as a gold standard for treating bone defects. However, limitations such as insufficient donor sites ... ...

    Abstract Utilization of bone graft substitutes have increased due to the rising number of accidents, trauma, and aging population. Autograft is still considered as a gold standard for treating bone defects. However, limitations such as insufficient donor sites and secondary surgery, leads to the development of alternative grafts. Hydroxyapatite (HA) from natural resources gained much attention in recent years as a bone graft substitute due to its biocompatibility, excellent osteointegration, osteoconductive, and osteoinductive properties. In the current review, we have presented the isolation procedures of HA from marine fishbone and cuttlefish bone. Further, composite preparation using marine derived HA with other polymeric and ceramic materials were discussed, and cell-materials interaction were reviewed in detail towards bone tissue construction. Composite biomaterials with HA showed better cell proliferation, cell adhesion, increased gene expression (collagen, osteocalcin, osteopontin, bone sialoprotein, BMP-2 etc.), and in vivo studies demonstrated significant bone formation with HA composite materials. Hence, composite biomaterials with hydroxyapatite will be potential candidates for artificial synthetic bone graft substitute.
    Keywords Sepiidae ; autografting ; biocompatibility ; biocompatible materials ; bioprocessing ; biotechnology ; bone formation ; bone transplantation ; bones ; cell adhesion ; cell proliferation ; ceramics ; collagen ; gene expression ; hydroxyapatite ; osteocalcin ; osteopontin ; polymers
    Language English
    Dates of publication 2021-06
    Size p. 312-324.
    Publishing place The Korean Society for Biotechnology and Bioengineering
    Document type Article
    Note Review
    ZDB-ID 2125481-3
    ISSN 1976-3816 ; 1226-8372
    ISSN (online) 1976-3816
    ISSN 1226-8372
    DOI 10.1007/s12257-020-0359-0
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Pharmacokinetics and bioequivalence of Withania somnifera (Ashwagandha) extracts – A double blind, crossover study in healthy adults

    Se-Kwon Kim / Jayachandran Venkatesan / Priyank Rathi / Benny Antony

    Heliyon, Vol 9, Iss 12, Pp e22843- (2023)

    2023  

    Abstract: Introduction: Withania somnifera (WS) or ashwagandha is an adaptogenic plant used extensively in traditional medicines and as a food supplement. Despite a long history of use and numerous clinical trials, the human pharmacokinetics of withanolides, the ... ...

    Abstract Introduction: Withania somnifera (WS) or ashwagandha is an adaptogenic plant used extensively in traditional medicines and as a food supplement. Despite a long history of use and numerous clinical trials, the human pharmacokinetics of withanolides, the active phytochemicals in WS extracts, have not been fully evaluated. This study evaluated the oral pharmacokinetics and bioequivalence of active withanolides in human plasma after administration of a single dose of two commercial ashwagandha extracts containing equal amounts of total withanolides. Methods: This randomized, double-blind, single-dose crossover study of 16 healthy human volunteers evaluated the acute oral bioavailability of withanolides and the bioequivalence of two WS extracts, WS-35 and WS-2.5. WS-35 was standardized to total withanolides not less than 40% comprising not less than 35% withanolide glycosides and WS-2.5 was standardized to 2.5% withanolides. The clinical dosages were normalized to 185 mg of total withanolide in each extract at the bioequivalent dosages. The pharmacokinetic parameters of withanolide A, withanoside IV, withaferin A, and total withanolides were quantified in the blood plasma using a validated LC-MS/MS method. Results: The half-life, C-max, and mean residence time of the total withanolides were 5.18, 5.62 and 4.13 times significantly higher and had lower systemic clearance with WS-35 than with WS-2.5 extract. Considering the plasma AUC 0-inf of total withanolides per mg of each WS extract administered orally, WS-35 was 280.74 times more bioavailable than WS-2.5. Conclusion: The results of this study highlight the importance of withanolide glycosides in improving the pharmacokinetics of WS extracts. Owing to its superior pharmacokinetic profile, WS-35, with 35% withanolide glycosides, is a promising candidate for further studies on Withania somnifera. Clinical trial registration: CTRI/2020/10/028397 [registered on:13/10/2020] (Trial prospectively registered) ...
    Keywords Ashwagandha ; Withania somnifera ; Bioavailability ; Bioequivalence ; Withaferin A ; Withanolide A ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article: Fucoidan-based nanoparticles: Preparations and applications

    Venkatesan, Jayachandran / Murugan, Sesha Subramanian / Seong, Gi Hun

    International journal of biological macromolecules. 2022 Sept. 30, v. 217

    2022  

    Abstract: Nanoparticle-based therapy has gained much attention in the pharmaceutical industry. Fucoidan is a sulfated polysaccharide naturally derived from marine brown algae and is widely used for medical applications. We explore preparation of fucoidan-based ... ...

    Abstract Nanoparticle-based therapy has gained much attention in the pharmaceutical industry. Fucoidan is a sulfated polysaccharide naturally derived from marine brown algae and is widely used for medical applications. We explore preparation of fucoidan-based nanoparticles and their biomedical applications in the current review. The fucoidan-based nanoparticles have been synthesized using microwave, emulsion, solvent evaporation, green synthesis, polyelectrolyte self-assembly, precipitation, and ultrasonication methods. The synthesized nanoparticles have particle sizes ranging from 100 to 400 nm. Therefore, fucoidan-based nanoparticles have a variety of potential therapeutic applications, including drug delivery, cancer therapies, tissue engineering, antimicrobial applications, magnetic resonance imaging contrast, and atherothrombosis imaging. For example, fucoidan nanoparticles have been used to deliver curcumin, dextran, gentamicin, epigallocatechin gallate, and cisplatin for cancer therapies. Furthermore, fucoidan nanoparticles coupled with metal nanoparticles have been used to target and recognize clinical conditions for diagnostic purposes. Hence, fucoidan-based nanoparticles have been helpful for biomedical applications.
    Keywords cisplatin ; curcumin ; dextran ; electrolytes ; emulsions ; epigallocatechin gallate ; evaporation ; fucoidan ; gentamicin ; magnetism ; pharmaceutical industry ; solvents ; therapeutics ; ultrasonic treatment
    Language English
    Dates of publication 2022-0930
    Size p. 652-667.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2022.07.068
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
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  10. Article: Metformin Reduces the Progression of Atherogenesis by Regulating the Sestrin2-mTOR Pathway in Obese and Diabetic Rats.

    Sundararajan, Saravanakumar / Jayachandran, Isaivani / Pandey, Gautam Kumar / Venkatesan, Saravanakumar / Rajagopal, Anusha / Gokulakrishnan, Kuppan / Balasubramanyam, Muthuswamy / Mohan, Viswanathan / Manickam, Nagaraj

    Journal of lipid and atherosclerosis

    2023  Volume 12, Issue 3, Page(s) 290–306

    Abstract: Objective: In previous research, we found that Sestrin2 has a strong association with plasma atherogenicity and combats the progression of atherogenesis by regulating the AMPK-mTOR pathway. Metformin, an activator of AMPK, is widely used as a first-line ...

    Abstract Objective: In previous research, we found that Sestrin2 has a strong association with plasma atherogenicity and combats the progression of atherogenesis by regulating the AMPK-mTOR pathway. Metformin, an activator of AMPK, is widely used as a first-line therapy for diabetes, but its role in preventing atherosclerosis and cardiac outcomes is unclear. Hence, we aimed to assess the effect of metformin on preventing atherosclerosis and its regulatory role in the Sestrin2-AMPK -mTOR pathway in obese/diabetic rats.
    Methods: Animals were fed a high-fat diet to induce obesity, administered streptozotocin to induce diabetes, and then treated with metformin (150 mg/kg body weight) for 14 weeks. Aorta and heart tissues were analyzed for Sestrin2 status by western blotting and immunohistochemistry, AMPK and mTOR activities were investigated using western blotting, and atherogenicity-related events were evaluated using reverse transcription quantitative polymerase chain reaction and histology.
    Results: Obese and diabetic rats showed significant decrease in Sestrin2 levels and AMPK activity, accompanied by increased mTOR activity in the heart and aorta tissues. Metformin treatment significantly restored Sestrin2 and AMPK levels, reduced mTOR activity, and restored the altered expression of inflammatory markers and adhesion molecules in obese and diabetic rats to normal levels. A histological analysis of samples from obese and diabetic rats showed atherosclerotic lesions both in aorta and heart tissues. The metformin-treated rats showed a decrease in atherosclerotic lesions, cardiac hypertrophy, and cardiomyocyte degeneration.
    Conclusion: This study presents further insights into the beneficial effects of metformin and its protective role against atherosclerosis through regulation of the Sestrin2-AMPK-mTOR pathway.
    Language English
    Publishing date 2023-09-06
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3016001-7
    ISSN 2288-2561 ; 2287-2892
    ISSN (online) 2288-2561
    ISSN 2287-2892
    DOI 10.12997/jla.2023.12.3.290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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