LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 20341

Search options

  1. Article ; Online: Selective benzylic C

    Yao, Changguang / Zhang, Tonghuan / Gonçalves, Théo P / Huang, Kuo-Wei

    Chemical communications (Cambridge, England)

    2022  Volume 58, Issue 10, Page(s) 1593–1596

    Abstract: In contrast to the typical C ...

    Abstract In contrast to the typical C
    Language English
    Publishing date 2022-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc06507f
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: A Gd@C

    Zhang, Kangkang / Wang, Cong / Zhang, Minhao / Bai, Zhanbin / Xie, Fang-Fang / Tan, Yuan-Zhi / Guo, Yilv / Hu, Kuo-Juei / Cao, Lu / Zhang, Shuai / Tu, Xuecou / Pan, Danfeng / Kang, Lin / Chen, Jian / Wu, Peiheng / Wang, Xuefeng / Wang, Jinlan / Liu, Junming / Song, You /
    Wang, Guanghou / Song, Fengqi / Ji, Wei / Xie, Su-Yuan / Shi, Su-Fei / Reed, Mark A / Wang, Baigeng

    Nature nanotechnology

    2020  Volume 15, Issue 12, Page(s) 1019–1024

    Abstract: ... of a gate-controlled switching between two electronic states in Gd@C ...

    Abstract Electrets are dielectric materials that have a quasi-permanent dipole polarization. A single-molecule electret is a long-sought-after nanoscale component because it can lead to miniaturized non-volatile memory storage devices. The signature of a single-molecule electret is the switching between two electric dipole states by an external electric field. The existence of these electrets has remained controversial because of the poor electric dipole stability in single molecules. Here we report the observation of a gate-controlled switching between two electronic states in Gd@C
    Language English
    Publishing date 2020-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2254964-X
    ISSN 1748-3395 ; 1748-3387
    ISSN (online) 1748-3395
    ISSN 1748-3387
    DOI 10.1038/s41565-020-00778-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Comparing CLIF-C ACLF, CLIF-C ACLF

    Kuo, Chao-Cheng / Huang, Chien-Hao / Chang, Ching / Chen, Pin-Cheng / Chen, Bo-Huan / Chen, Wei-Ting / Ho, Yu-Pin

    Journal of personalized medicine

    2021  Volume 11, Issue 2

    Abstract: ... Three new prognostic scores of ACLF, including CLIF-C ACLF (Chronic Liver Failure Consortium Acute ... on-chronic Liver Failure score), CLIF-C ACLF-D (CLIF-C ACLF Development score), and CLLF-C ACLF ...

    Abstract Patients with liver cirrhosis have a higher risk of developing acute-on-chronic liver failure (ACLF). Poor prognosis with a high rate of short-term mortality leads to limited opportunities for further liver transplantation. Thus, precise prognostic evaluation of patients with ACLF is necessary before transplant surgery. In this study, a total of one hundred and thirty-five patients with ACLF admitted to the hepato-gastroenterologic intensive care unit (ICU) for intensive monitoring and treatment at Chang-Gung Memorial Hospital (CGMH, Linkou, Taiwan) were screened from November 2012 to April 2015 and tracked until April 2017. Three new prognostic scores of ACLF, including CLIF-C ACLF (Chronic Liver Failure Consortium Acute-on-chronic Liver Failure score), CLIF-C ACLF-D (CLIF-C ACLF Development score), and CLLF-C ACLF
    Language English
    Publishing date 2021-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm11020079
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: A c-di-GMP signaling module controls responses to iron in Pseudomonas aeruginosa.

    Zhan, Xueliang / Zhang, Kuo / Wang, Chenchen / Fan, Qiao / Tang, Xiujia / Zhang, Xi / Wang, Ke / Fu, Yang / Liang, Haihua

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1860

    Abstract: Cyclic dimeric guanosine monophosphate (c-di-GMP) serves as a bacterial second messenger ... studies have conducted comprehensive analysis of c-di-GMP. However, the mechanisms by which certain ... environmental signals such as iron control intracellular c-di-GMP levels are unclear. Here, we show that iron ...

    Abstract Cyclic dimeric guanosine monophosphate (c-di-GMP) serves as a bacterial second messenger that modulates various processes including biofilm formation, motility, and host-microbe symbiosis. Numerous studies have conducted comprehensive analysis of c-di-GMP. However, the mechanisms by which certain environmental signals such as iron control intracellular c-di-GMP levels are unclear. Here, we show that iron regulates c-di-GMP levels in Pseudomonas aeruginosa by modulating the interaction between an iron-sensing protein, IsmP, and a diguanylate cyclase, ImcA. Binding of iron to the CHASE4 domain of IsmP inhibits the IsmP-ImcA interaction, which leads to increased c-di-GMP synthesis by ImcA, thus promoting biofilm formation and reducing bacterial motility. Structural characterization of the apo-CHASE4 domain and its binding to iron allows us to pinpoint residues defining its specificity. In addition, the cryo-electron microscopy structure of ImcA in complex with a c-di-GMP analog (GMPCPP) suggests a unique conformation in which the compound binds to the catalytic pockets and to the membrane-proximal side located at the cytoplasm. Thus, our results indicate that a CHASE4 domain directly senses iron and modulates the crosstalk between c-di-GMP metabolic enzymes.
    MeSH term(s) Bacterial Proteins/metabolism ; Pseudomonas aeruginosa/metabolism ; Cryoelectron Microscopy ; Escherichia coli Proteins/metabolism ; Cyclic GMP/metabolism ; Cyclic GMP/analogs & derivatives ; Biofilms ; Gene Expression Regulation, Bacterial ; Inosine Monophosphate/analogs & derivatives ; Thionucleotides
    Chemical Substances bis(3',5')-cyclic diguanylic acid (61093-23-0) ; 5'-deoxy-5'-thioinosine 5'-monophosphate (21959-63-7) ; Bacterial Proteins ; Escherichia coli Proteins ; Cyclic GMP (H2D2X058MU) ; Inosine Monophosphate (131-99-7) ; Thionucleotides
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46149-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Leveraging the Stereochemical Complexity of Octahedral Diastereomeric-at-Metal Catalysts to Unlock Regio-, Diastereo-, and Enantioselectivity in Alcohol-Mediated C-C Couplings via Hydrogen Transfer.

    Shezaf, Jonathan Z / Santana, Catherine G / Ortiz, Eliezer / Meyer, Cole C / Liu, Peng / Sakata, Ken / Huang, Kuo-Wei / Krische, Michael J

    Journal of the American Chemical Society

    2024  Volume 146, Issue 12, Page(s) 7905–7914

    Abstract: Experimental and computational studies illuminating the factors that guide metal-centered stereogenicity and, therefrom, selectivity in transfer hydrogenative carbonyl additions of alcohol proelectrophiles catalyzed by chiral-at-metal-and-ligand ... ...

    Abstract Experimental and computational studies illuminating the factors that guide metal-centered stereogenicity and, therefrom, selectivity in transfer hydrogenative carbonyl additions of alcohol proelectrophiles catalyzed by chiral-at-metal-and-ligand octahedral d
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.4c01857
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: VEGF-C

    Dai, Chengqian / Kuo, Shu-Jui / Hu, Sung-Lin / Tsai, Chun-Hao / Huang, Yuan-Li / Huang, Chien-Chung / Wang, Lihong / Xu, Guohong / Su, Chen-Ming / Tang, Chih-Hsin

    International journal of medical sciences

    2019  Volume 16, Issue 10, Page(s) 1397–1403

    Abstract: Vascular endothelial growth factor C (VEGF-C) promotes angiogenesis, a prominent feature ...

    Abstract Vascular endothelial growth factor C (VEGF-C) promotes angiogenesis, a prominent feature in rheumatoid synovitis, contributing to the perpetuation of the global burden of rheumatoid arthritis (RA).
    MeSH term(s) Adult ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/genetics ; Biomarkers ; Case-Control Studies ; Drug Monitoring/methods ; Female ; Genetic Predisposition to Disease ; Genotyping Techniques ; Healthy Volunteers ; Humans ; Male ; Methotrexate/therapeutic use ; Middle Aged ; Polymorphism, Single Nucleotide ; Prednisolone/therapeutic use ; Real-Time Polymerase Chain Reaction ; Risk Assessment/methods ; Treatment Outcome ; Vascular Endothelial Growth Factor C/genetics ; Young Adult
    Chemical Substances Antirheumatic Agents ; Biomarkers ; VEGFC protein, human ; Vascular Endothelial Growth Factor C ; Prednisolone (9PHQ9Y1OLM) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2019-09-20
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2151424-0
    ISSN 1449-1907 ; 1449-1907
    ISSN (online) 1449-1907
    ISSN 1449-1907
    DOI 10.7150/ijms.34659
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Discovery of C

    Wada, Koji / Goto, Masuo / Tanaka, Hisano / Mizukami, Megumi / Suzuki, Yuji / Lee, Kuo-Hsiung / Yamashita, Hiroshi

    ACS omega

    2022  Volume 7, Issue 32, Page(s) 28173–28181

    Abstract: ... of hetisine-type C ...

    Abstract Although many diterpenoid alkaloids have been evaluated recently for antiproliferative activity against human cancer cell lines, little data have been offered relating to the antiproliferative effects of hetisine-type C
    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c02363
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Crystalline C

    Gao, Dexiang / Tang, Xingyu / Xu, Jingqin / Yang, Xin / Zhang, Peijie / Che, Guangwei / Wang, Yajie / Chen, Yongjin / Gao, Xiang / Dong, Xiao / Zheng, Haiyan / Li, Kuo / Mao, Ho-Kwang

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 17, Page(s) e2201165119

    Abstract: ... solely by C–N bonds along the thread. A “peri-cage” reaction, the concerted bonding between six C and N ... the critical bonding distance between the nearest intermolecular C and N was ∼2.9 Å. The formation ... of a “structure-specific” crystalline CNTh with C and N orderly distributed highlighted the importance of reaction ...

    Abstract Carbon nanothread (CNTh) is a “one-dimensional diamond polymer” that combines high tensile strength and flexibility, but it severely suffers from intrathread disorder. Here, by modifying the reactivity and the stacking ordering of the aromatic precursor, crystalline C3N3H3 CNTh with perfect hexagonal orientation and stacking was synthesized at 10.2 GPa and 573 K from s-triazine. By Rietveld refinement of X-ray diffraction data, gas chromatography mass spectrometry investigation, and theoretical calculation, we found that synthesized CNTh has a tube (3,0) structure, with the repeating s-triazine residue connected solely by C–N bonds along the thread. A “peri-cage” reaction, the concerted bonding between six C and N atoms, instead of [4 + 2] or [1,4] addition reactions, was concluded for the formation of CNThs, and the critical bonding distance between the nearest intermolecular C and N was ∼2.9 Å. The formation of a “structure-specific” crystalline CNTh with C and N orderly distributed highlighted the importance of reaction selectivity and stacking order of reactant molecules, which have great significance for understanding the polymerization of aromatic molecules under high pressure and developing new crystalline CNThs.
    Language English
    Publishing date 2022-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2201165119
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition.

    Zhan, Chunjun / Lee, Namil / Lan, Guangxu / Dan, Qingyun / Cowan, Aidan / Wang, Zilong / Baidoo, Edward E K / Kakumanu, Ramu / Luckie, Bridget / Kuo, Rita C / McCauley, Joshua / Liu, Yuzhong / Valencia, Luis / Haushalter, Robert W / Keasling, Jay D

    Nature metabolism

    2023  Volume 5, Issue 7, Page(s) 1127–1140

    Abstract: ... availability, causes growth inhibition in C. glutamicum. The mechanism of this inhibition was unclear ... growth inhibition in C. glutamicum. We then show that growth inhibition can be relieved by introducing methylmalonyl ... glyoxylate pathway to a new methylcitrate pathway. Together, our results show that C. glutamicum is a capable ...

    Abstract Corynebacterium glutamicum is a promising host for production of valuable polyketides. Propionate addition, a strategy known to increase polyketide production by increasing intracellular methylmalonyl-CoA availability, causes growth inhibition in C. glutamicum. The mechanism of this inhibition was unclear before our work. Here we provide evidence that accumulation of propionyl-CoA and methylmalonyl-CoA induces growth inhibition in C. glutamicum. We then show that growth inhibition can be relieved by introducing methylmalonyl-CoA-dependent polyketide synthases. With germicidin as an example, we used adaptive laboratory evolution to leverage the fitness advantage of polyketide production in the presence of propionate to evolve improved germicidin production. Whole-genome sequencing revealed mutations in germicidin synthase, which improved germicidin titer, as well as mutations in citrate synthase, which effectively evolved the native glyoxylate pathway to a new methylcitrate pathway. Together, our results show that C. glutamicum is a capable host for polyketide production and we can take advantage of propionate growth inhibition to drive titers higher using laboratory evolution or to screen for production of polyketides.
    MeSH term(s) Polyketides ; Propionates/metabolism
    Chemical Substances Polyketides ; Propionates
    Language English
    Publishing date 2023-07-13
    Publishing country Germany
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-023-00830-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Lewis Acidic Support Boosts C-C Coupling in the Pulsed Electrochemical CO

    Chang, Chia-Jui / Lai, Yi-An / Chu, You-Chiuan / Peng, Chun-Kuo / Tan, Hui-Ying / Pao, Chih-Wen / Lin, Yan-Gu / Hung, Sung-Fu / Chen, Hsiao-Chien / Chen, Hao Ming

    Journal of the American Chemical Society

    2023  Volume 145, Issue 12, Page(s) 6953–6965

    Abstract: Copper-oxide electrocatalysts have been demonstrated to effectively perform the electrochemical ... ...

    Abstract Copper-oxide electrocatalysts have been demonstrated to effectively perform the electrochemical CO
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c00472
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top