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Article ; Online: Hybrid supramolecular gels of Fmoc-F/halloysite nanotubes: systems for sustained release of camptothecin.

Rizzo, C / Arrigo, R / D'Anna, F / Di Blasi, F / Dintcheva, N T / Lazzara, G / Parisi, F / Riela, S / Spinelli, G / Massaro, M

Journal of materials chemistry. B

2017 Volume 5, Issue 17, Page(s) 3217–3229

Abstract: Supramolecular gel hybrids obtained by self-assembly of Fmoc-l-phenylalanine (Fmoc-F ... in the presence of functionalized halloysite nanotubes (f-HNT) were obtained in biocompatible solvents and ... employed as carriers for the delivery of camptothecin (CPT) molecules. The synthesis of the new f-HNT ...

Abstract	Supramolecular gel hybrids obtained by self-assembly of Fmoc-l-phenylalanine (Fmoc-F) in the presence of functionalized halloysite nanotubes (f-HNT) were obtained in biocompatible solvents and employed as carriers for the delivery of camptothecin (CPT) molecules. The synthesis of the new f-HNT material as well as its characterization are described. The properties of the hybrid hydrogels and organogels were analyzed by several techniques. The presence of small amounts of f-HNT allows good dispersion of the tubes and the subsequent formation of homogeneous gels. The experimental results show that f-HNT functions only as an additive in the hybrid gels and does not demonstrate gelator behavior. The in vitro kinetic release from both f-HNT/CPT and Fmoc-F/f-HNT/CPT was studied in media that imitates physiological conditions, and the factors controlling the release process were determined and discussed. Furthermore, the antiproliferative in vitro activities of the gels were evaluated towards human cervical cancer HeLa cells. A comparison of data collected in both systems shows the synergistic action of f-HNT and the gel matrix in controlling the release of CPT in the media and maintaining the drug in its active form. Finally, a comparison with pristine HNT is also reported. This study suggests a suitable strategy to obtain two-component gel hybrids based on nanocarriers with controlled drug carrier capacity for biomedical applications.
Language	English
Publishing date	2017-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/c7tb00297a
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Article: Hybrid supramolecular gels of Fmoc-F/halloysite nanotubes: systems for sustained release of camptothecin

Rizzo, C / Arrigo, R / D'Anna, F / Di Blasi, F / Dintcheva, N. T / Lazzara, G / Parisi, F / Riela, S / Spinelli, G / Massaro, M

Journal of materials chemistry B. 2017 May 3, v. 5, no. 17

2017

Abstract	Supramolecular gel hybrids obtained by self-assembly of Fmoc-l-phenylalanine (Fmoc-F) in the presence of functionalized halloysite nanotubes (f-HNT) were obtained in biocompatible solvents and employed as carriers for the delivery of camptothecin (CPT) molecules. The synthesis of the new f-HNT material as well as its characterization are described. The properties of the hybrid hydrogels and organogels were analyzed by several techniques. The presence of small amounts of f-HNT allows good dispersion of the tubes and the subsequent formation of homogeneous gels. The experimental results show that f-HNT functions only as an additive in the hybrid gels and does not demonstrate gelator behavior. The in vitro kinetic release from both f-HNT/CPT and Fmoc-F/f-HNT/CPT was studied in media that imitates physiological conditions, and the factors controlling the release process were determined and discussed. Furthermore, the antiproliferative in vitro activities of the gels were evaluated towards human cervical cancer HeLa cells. A comparison of data collected in both systems shows the synergistic action of f-HNT and the gel matrix in controlling the release of CPT in the media and maintaining the drug in its active form. Finally, a comparison with pristine HNT is also reported. This study suggests a suitable strategy to obtain two-component gel hybrids based on nanocarriers with controlled drug carrier capacity for biomedical applications.
Keywords	data collection ; halloysite ; humans ; hydrogels ; illicit drugs ; nanocarriers ; nanotubes ; organogels ; solvents ; synergism ; uterine cervical neoplasms
Language	English
Dates of publication	2017-0503
Size	p. 3217-3229.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/c7tb00297a
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Article ; Online: A prospective analysis of ¹⁸F-FDG PET/CT in patients with uveal melanoma: comparison between metabolic rate of glucose (MRglu) and standardized uptake value (SUV) and correlations with histopathological features.

Calcagni, Maria Lucia / Mattoli, Maria Vittoria / Blasi, Maria Antonietta / Petrone, Gianluigi / Sammarco, Maria Grazia / Indovina, Luca / Mulè, Antonino / Rufini, Vittoria / Giordano, Alessandro

European journal of nuclear medicine and molecular imaging

2013 Volume 40, Issue 11, Page(s) 1682–1691

Abstract: ... with histopathological features; and to assess the role of (18)F-FDG PET/CT for evaluating prognosis.: Methods: Of 34 ... brain and whole-body (18)F-FDG PET/CT, and surgery.: Results: Of the 26 ocular lesions, 23 showed (18 ... F-FDG uptake, with a sensitivity of 88 %. MRglu was significantly higher in the epithelioid cell ...

Abstract	Purpose: To evaluate whether standardized uptake value (SUV) and/or metabolic rate of glucose (MRglu) are different among epithelioid, mixed, and spindle cell uveal melanomas, as well as between low and high risk melanomas; to correlate ultrasonographic data and metabolic parameters with histopathological features; and to assess the role of (18)F-FDG PET/CT for evaluating prognosis. Methods: Of 34 eligible patients prospectively enrolled with clinical suspicion of medium/large uveal melanoma, 26 (15 men, mean age 62.8 ± 11.8 years) were evaluated. All patients underwent metastatic work-up, 3-D dynamic brain and whole-body (18)F-FDG PET/CT, and surgery. Results: Of the 26 ocular lesions, 23 showed (18)F-FDG uptake, with a sensitivity of 88 %. MRglu was significantly higher in the epithelioid cell melanomas than in the spindle cell melanomas, as well as in high-risk lesions than in low-risk lesions (p = 0.01, p = 0.02, respectively). SUV and MRglu were correlated with histopathological features while ultrasonographic data were not. Conclusion: MRglu is useful for distinguishing the different cell types in uveal melanoma, as well as high-risk from low-risk lesions, while SUV is not. MRglu provides a more accurate evaluation of glucose consumption, whereas SUV provides only an estimation. In addition, the metabolic parameters correlate with histopathological features, well also reflecting cellular behaviour in ocular malignancy. A longer follow-up is needed to assess the role of (18)F-FDG in evaluating prognosis.
MeSH term(s)	Aged ; Female ; Fluorodeoxyglucose F18/pharmacokinetics ; Glucose/metabolism ; Humans ; Male ; Melanoma/diagnostic imaging ; Melanoma/metabolism ; Melanoma/pathology ; Middle Aged ; Multimodal Imaging ; Positron-Emission Tomography ; Prospective Studies ; Radiopharmaceuticals/pharmacokinetics ; Tomography, X-Ray Computed ; Uveal Neoplasms/diagnostic imaging ; Uveal Neoplasms/metabolism ; Uveal Neoplasms/pathology
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2013-07-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-013-2488-6
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Article ; Online: Vaccinations: What's best?

Blasi, F / Aliberti, S

Pulmonology

2022 Volume 28, Issue 6, Page(s) 419–420

MeSH term(s)	Humans ; Vaccination
Language	English
Publishing date	2022-09-28
Publishing country	Spain
Document type	Editorial
ZDB-ID	3009651-0
ISSN	2531-0437 ; 2531-0429
ISSN (online)	2531-0437
ISSN	2531-0429
DOI	10.1016/j.pulmoe.2022.07.008
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Article ; Online: There is still no established and accepted definition of COPD.

Cazzola, Mario / Blasi, Francesco

Respiratory medicine

2023 Volume 214, Page(s) 107262

MeSH term(s)	Humans ; Pulmonary Disease, Chronic Obstructive/diagnosis
Language	English
Publishing date	2023-05-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1003348-8
ISSN	1532-3064 ; 0954-6111
ISSN (online)	1532-3064
ISSN	0954-6111
DOI	10.1016/j.rmed.2023.107262
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Article: Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin.

Yamasaki, S / Baumeister, A / Binz, T / Blasi, J / Link, E / Cornille, F / Roques, B / Fykse, E M / Südhof, T C / Jahn, R

The Journal of biological chemistry

1994 Volume 269, Issue 17, Page(s) 12764–12772

Abstract: ... such as synaptobrevin (TeTx, BoNT/B, BoNT/F), SNAP-25 (BoNT/A), and syntaxin (BoNT/C1). Here we show that BoNT/D cleaves ... is cleaved by BoNT/F with similar potency. Cleavage by BoNT/D occurs at the peptide bond Lys59-Leu60 ... which is adjacent to the BoNT/F cleavage site (Gln58-Lys59) and again differs from the site hydrolyzed ...

Abstract	Tetanus toxin (TeTx) and the various forms of botulinal neurotoxins (BoNT/A to BoNT/G) potently inhibit neurotransmission by means of their L chains which selectively proteolyze synaptic proteins such as synaptobrevin (TeTx, BoNT/B, BoNT/F), SNAP-25 (BoNT/A), and syntaxin (BoNT/C1). Here we show that BoNT/D cleaves rat synaptobrevin 1 and 2 in toxified synaptosomes and in isolated vesicles. In contrast, synaptobrevin 1, as generated by in vitro translation, is only a poor substrate for BoNT/D, whereas this species is cleaved by BoNT/F with similar potency. Cleavage by BoNT/D occurs at the peptide bond Lys59-Leu60 which is adjacent to the BoNT/F cleavage site (Gln58-Lys59) and again differs from the site hydrolyzed by TeTx and BoNT/B (Gln76-Phe77). Cellubrevin, a recently discovered isoform expressed outside the nervous system, is efficiently cleaved by all three toxins examined. For further characterization of the substrate requirements of BoNT/D, we tested amino- and carboxyl-terminal deletion mutants of synaptobrevin 2 as well as synthetic peptides. Shorter peptides containing up to 15 amino acids on either side of the cleavage site were not cleaved, and a peptide extending from Arg47 to Thr116 was a poor substrate for all three toxins tested. However, cleavability was restored when the peptide is further extended at the NH2 terminus (Thr27-Thr116) demonstrating that NH2 terminally located sequences of synaptobrevin which are distal from the respective cleavage sites are required for proteolysis. To further examine the isoform specificity, several mutants of rat synaptobrevin 2 were generated in which individual amino acids were replaced with those found in rat synaptobrevin 1. We show that a Met46 to Ile46 substitution drastically diminishes cleavability by BoNT/D and that the presence of Val76 instead of Gln76 dictates the reduced cleavability of synaptobrevin isoforms by TeTx.
MeSH term(s)	Amino Acid Sequence ; Animals ; Base Sequence ; Binding Sites ; Botulinum Toxins/pharmacology ; DNA Primers ; Hydrolysis ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Molecular Sequence Data ; Mutation ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; R-SNARE Proteins ; Rats ; Tetanus Toxin/pharmacology
Chemical Substances	DNA Primers ; Membrane Proteins ; Nerve Tissue Proteins ; R-SNARE Proteins ; Tetanus Toxin ; Botulinum Toxins (EC 3.4.24.69)
Language	English
Publishing date	1994-04-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
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Article ; Online: Heightened fearfulness as a developmental adaptation.

Bjorklund, David F / Hernández Blasi, Carlos

The Behavioral and brain sciences

2023 Volume 46, Page(s) e56

Abstract: Although we find many merits to Grossmann's fearful ape hypothesis, unlike Grossmann, we see heightened fearfulness as an ontogenetic adaptation, signaling helplessness and fostering caregiving during infancy, which subsequently became exapted to promote ...

Abstract	Although we find many merits to Grossmann's fearful ape hypothesis, unlike Grossmann, we see heightened fearfulness as an ontogenetic adaptation, signaling helplessness and fostering caregiving during infancy, which subsequently became exapted to promote cooperation. We also argue that, rather than being the "breeding ground" for enhanced infant fearfulness, cooperative care is more likely the evolved product of enhanced fearfulness.
MeSH term(s)	Humans ; Infant ; Fear
Language	English
Publishing date	2023-05-08
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	423721-3
ISSN	1469-1825 ; 0140-525X
ISSN (online)	1469-1825
ISSN	0140-525X
DOI	10.1017/S0140525X22001996
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Article ; Online: Translational regulation by Hfq-Crc assemblies emerges from polymorphic ribonucleoprotein folding.

Dendooven, Tom / Sonnleitner, Elisabeth / Bläsi, Udo / Luisi, Ben F

The EMBO journal

2022 Volume 42, Issue 3, Page(s) e111129

Abstract: The widely occurring bacterial RNA chaperone Hfq is a key factor in the post-transcriptional control of hundreds of genes in Pseudomonas aeruginosa. How this broadly acting protein can contribute to the regulatory requirements of many different genes ... ...

Abstract	The widely occurring bacterial RNA chaperone Hfq is a key factor in the post-transcriptional control of hundreds of genes in Pseudomonas aeruginosa. How this broadly acting protein can contribute to the regulatory requirements of many different genes remains puzzling. Here, we describe cryo-EM structures of higher order assemblies formed by Hfq and its partner protein Crc on control regions of different P. aeruginosa target mRNAs. Our results show that these assemblies have mRNA-specific quaternary architectures resulting from the combination of multivalent protein-protein interfaces and recognition of patterns in the RNA sequence. The structural polymorphism of these ribonucleoprotein assemblies enables selective translational repression of many different target mRNAs. This system elucidates how highly complex regulatory pathways can evolve with a minimal economy of proteinogenic components in combination with RNA sequence and fold.
MeSH term(s)	Ribonucleoproteins/genetics ; Ribonucleoproteins/metabolism ; Bacterial Proteins/metabolism ; Gene Expression Regulation, Bacterial ; RNA, Bacterial/metabolism ; Host Factor 1 Protein/genetics ; Host Factor 1 Protein/metabolism
Chemical Substances	Ribonucleoproteins ; Bacterial Proteins ; RNA, Bacterial ; Host Factor 1 Protein
Language	English
Publishing date	2022-12-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.15252/embj.2022111129
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Article ; Online: Lung Diseases: Chronic Respiratory Infections.

Blasi, Francesco

International journal of molecular sciences

2018 Volume 19, Issue 10

MeSH term(s)	Animals ; Humans ; Pneumonia/drug therapy ; Pneumonia/immunology ; Pneumonia/microbiology
Language	English
Publishing date	2018-10-07
Publishing country	Switzerland
Document type	Editorial ; Introductory Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms19103051
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Article ; Online: Long-Term Outcomes in Severe Community-Acquired Pneumonia.

Carella, Francesco / Aliberti, Stefano / Stainer, Anna / Voza, Antonio / Blasi, Francesco

Seminars in respiratory and critical care medicine

2024 Volume 45, Issue 2, Page(s) 266–273

Abstract: Community-acquired pneumonia (CAP) is globally one of the major causes of hospitalization and mortality. Severe CAP (sCAP) presents great challenges and need a comprehensive understanding of its long-term outcomes. Cardiovascular events and neurological ... ...

Abstract	Community-acquired pneumonia (CAP) is globally one of the major causes of hospitalization and mortality. Severe CAP (sCAP) presents great challenges and need a comprehensive understanding of its long-term outcomes. Cardiovascular events and neurological impairment, due to persistent inflammation and hypoxemia, contribute to long-term outcomes in CAP, including mortality. Very few data are available in the specific population of sCAP. Multiple studies have reported variable 1-year mortality rates for patients with CAP up to 40.7%, with a clear influence by age, comorbidities, and disease severity. In terms of treatment, the potential protective role of macrolides in reducing mortality emphasizes the importance of appropriate empiric antibiotic therapy. This narrative review explores the growing interest in the literature focusing on the long-term implications of sCAP. Improved understanding of long-term outcomes in sCAP can facilitate targeted interventions and enhance posthospitalization care protocols.
MeSH term(s)	Humans ; Pneumonia/drug therapy ; Community-Acquired Infections/drug therapy ; Hospitalization
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1183617-9
ISSN	1098-9048 ; 1069-3424
ISSN (online)	1098-9048
ISSN	1069-3424
DOI	10.1055/s-0044-1781426
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