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Article ; Online: Regulatory T cells in kidney transplant recipients with LIMS1 rs893403 risk genotype.

Mirioglu, Safak / Kiran, Bayram / Lentine, Krista L / Edwards, John C / Caliskan, Yasar

2024 Volume 38, Issue 4, Page(s) e15293

MeSH term(s)	Humans ; Kidney Transplantation ; T-Lymphocytes, Regulatory ; Genotype ; Immunosuppressive Agents ; Transplant Recipients ; Membrane Proteins/genetics ; Adaptor Proteins, Signal Transducing/genetics ; LIM Domain Proteins/genetics
Chemical Substances	Immunosuppressive Agents ; LIMS1 protein, human ; Membrane Proteins ; Adaptor Proteins, Signal Transducing ; LIM Domain Proteins
Language	English
Publishing date	2024-03-28
Publishing country	Denmark
Document type	Letter ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.15293
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Article ; Online: Crassulacean acid metabolism (CAM) at the crossroads: a special issue to honour 50 years of CAM research by Klaus Winter.

Sage, Rowan F / Edwards, Erika J / Heyduk, Karolina / Cushman, John C

Annals of botany

2023 Volume 132, Issue 4, Page(s) 553–561

MeSH term(s)	Crassulacean Acid Metabolism ; Photosynthesis ; Seasons
Language	English
Publishing date	2023-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1461328-1
ISSN	1095-8290 ; 0305-7364
ISSN (online)	1095-8290
ISSN	0305-7364
DOI	10.1093/aob/mcad160
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Article ; Online: Investigation of Solid Phase Microextraction Gas Chromatography–Mass Spectrometry, Fourier Transform Infrared Spectroscopy and 1H qNMR Spectroscopy as Potential Methods for the Authentication of Baijiu Spirits

Fitzgerald, Neil / Edwards, John C.

Beverages. 2023 Mar. 08, v. 9, no. 1

2023

Abstract: The baijiu spirit is often the focus of fraudulent activity due to the widely varying prices of the products. In this work, Solid Phase Microextraction Gas Chromatography (SPME GCMS), Fourier Transform Infrared (FTIR) Spectroscopy and ¹H qNMR ... ...

Abstract	The baijiu spirit is often the focus of fraudulent activity due to the widely varying prices of the products. In this work, Solid Phase Microextraction Gas Chromatography (SPME GCMS), Fourier Transform Infrared (FTIR) Spectroscopy and ¹H qNMR spectroscopy were evaluated as potential methods to authenticate baijiu samples. Data were collected for 30 baijiu samples produced by seven different distilleries. The data from the SPME GCMS and FTIR methods were treated by a Principal Component Analysis to identify clusters that would suggest chemical differences in the products from different distilleries. The results suggest that SPME GCMS has the potential to be a fully portable method for baijiu authentication. FTIR did not appear suitable for authentication but can be used to find the %ABV range of the sample. ¹H quantitative NMR (¹H qNMR) was utilized to quantify the ethanol concentrations and calculate the observable congener chemistry comprising ester, ethanol, methanol, fusel alcohol, and organic acids. Discrepancies in ethanol content were observed in three samples, and a lack of major congeners in two samples indicates the possible presence of a counterfeit product. Detailed and quantitative congener chemistry is obtainable by NMR and provides a possible fingerprint analysis for the authentication and quality control of baijiu style, producer, and the length of the ageing process.
Keywords	Fourier transform infrared spectroscopy ; chemistry ; ethanol ; gas chromatography-mass spectrometry ; methanol ; principal component analysis ; quality control ; solid phase microextraction
Language	English
Dates of publication	2023-0308
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2785444-9
ISSN	2306-5710
ISSN	2306-5710
DOI	10.3390/beverages9010025
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Kidney-disease-associated variants of Apolipoprotein L1 show gain of function in cation channel activity.

Bruno, Jonathan / Edwards, John C

The Journal of biological chemistry

2021 Volume 296, Page(s) 100238

Abstract: Variants in Apolipoprotein L1 (ApoL1) are known to be responsible for increased risk of some progressive kidney diseases among people of African ancestry. ApoL1 is an amphitropic protein that can insert into phospholipid membranes and confer anion- or ... ...

Abstract	Variants in Apolipoprotein L1 (ApoL1) are known to be responsible for increased risk of some progressive kidney diseases among people of African ancestry. ApoL1 is an amphitropic protein that can insert into phospholipid membranes and confer anion- or cation-selective permeability to phospholipid membranes depending on pH. Whether these activities differ among the variants or whether they contribute to disease pathogenesis is unknown. We used assays of voltage-driven ion flux from phospholipid vesicles and of stable membrane association to assess differences among ApoL1 isoforms. There is a significant (approximately twofold) increase in the cation-selective ion permease activity of the two kidney-disease-associated variants compared with the reference protein. In contrast, we find no difference in the anion-selective permease activity at low pH among the isoforms. Compared with the reference sequence, the two disease-associated variants show increased stable association with phospholipid vesicles under conditions that support the cation permease activity, suggesting that the increased activity may be due to more efficient membrane association and insertion. There is no difference in membrane association among isoforms under optimal conditions for the anion permease activity. These data support a model in which enhanced cation permeability may contribute to the progressive kidney diseases associated with high-risk ApoL1 alleles.
MeSH term(s)	Apolipoprotein L1/genetics ; Biological Transport/genetics ; Black People/genetics ; Cations/metabolism ; Cell Membrane/genetics ; Cell Membrane/metabolism ; Cell Membrane Permeability/genetics ; Gain of Function Mutation/genetics ; Genetic Predisposition to Disease ; Humans ; Ion Transport/genetics ; Kidney/metabolism ; Kidney/pathology ; Kidney Diseases/genetics ; Kidney Diseases/pathology ; Lipoproteins, HDL/genetics ; Signal Transduction/genetics ; Voltage-Dependent Anion Channels/chemistry ; Voltage-Dependent Anion Channels/genetics
Chemical Substances	APOL1 protein, human ; Apolipoprotein L1 ; Cations ; Lipoproteins, HDL ; Voltage-Dependent Anion Channels
Language	English
Publishing date	2021-01-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.RA120.013943
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Article ; Online: Does an interim dressing with calcium hydroxide reduce endotoxins between endodontic appointments?

Edwards, David C / Whitworth, John M

Evidence-based dentistry

2021 Volume 22, Issue 3, Page(s) 96–97

Abstract: Data sources PubMed, Cochrane Library, LILACS/Biblioteca Brasileira de Odontologica, Web of Science, Embase, Scopus, grey literature.Study selection Randomised and non-randomised clinical studies, experimental studies. Population: human studies with ... ...

Abstract	Data sources PubMed, Cochrane Library, LILACS/Biblioteca Brasileira de Odontologica, Web of Science, Embase, Scopus, grey literature.Study selection Randomised and non-randomised clinical studies, experimental studies. Population: human studies with permanent dentition; Intervention: evaluation of lipopolysaccharide (LPS) after dressing with calcium hydroxide (CH); Comparison: evaluation of LPS before dressing with CH; Outcome: antimicrobial efficacy against LPS.Data extraction and synthesis A modified Cochrane Risk of Bias (RoB) tool was used to evaluate internal validity of randomised controlled trials, Robins-1 tool for non-randomised controlled trials, and the 'Before and After' tool for experimental studies. Meta-analyses were conducted by subgrouping according to CH use, chemo-mechanical preparation (CMP), antimicrobial substance (AS), and irrigant. Further analyses explored incidence of LPS reduction. All subgroups were assessed for heterogeneity through I2 test and the random-effect model was applied. Sensitivity analysis was performed to evaluate the influence of studies with RoB in effect significance.Results Nine studies were included for qualitative assessment, of which seven were included for meta-analysis. Three studies were assessed as low RoB, one was medium risk, with two having a high RoB. Three studies presented with 'some concerns'. After dressing with CH, no AS resulted in 61.7% of teeth with reduction in LPS (95% CI: 37.7%-82.9%, I2 = 96.7%), compared to AS where 98.9% of teeth showed an LPS reduction (95% CI: 97.4%-99.8%, I2 = 38.6%). Where mean reductions in LPS were compared, CH with or without AS, reduced mean LPSs before (standardised mean difference [SMD] = 21.087 [CI: 21.453 to 20.721], P = 0.001, I2 = 58.7%) and after CMP (SMD = 20.919 [CI: 21.156 to 20.682], P = 0.001, I2 = 24.7%) using a CH dressing. Considering the irrigant solutions, the overall results showed a reduction before (SMD = 21.053 [CI: 21.311 to 20.795], P = 0.001, I2 = 58.7%) and after CMP (SMD = 20.938 [CI: 21.147 to 20.729], P = 0.001, I2 = 24.6%) using a CH dressing. There was a reduction in mean LPS over time, up to 30 days. All analyses presented a very low certainty of evidence.Conclusions An interim dressing with CH reduces LPS levels below those achieved with CMP and AS, but does not eliminate LPS completely. No evidence is presented on improved clinical outcomes following multiple-visit treatment with CH dressing.
MeSH term(s)	Bandages ; Calcium Hydroxide/therapeutic use ; Dentition, Permanent ; Endotoxins ; Humans ; Incidence
Chemical Substances	Endotoxins ; Calcium Hydroxide (PF5DZW74VN)
Language	English
Publishing date	2021-11-04
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1457588-7
ISSN	1476-5446 ; 1462-0049
ISSN (online)	1476-5446
ISSN	1462-0049
DOI	10.1038/s41432-021-0199-6
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Zs.A 4972: Show issues

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Article ; Online: The emergence of benchtop NMR systems and the exciting future of the technology.

Edwards, John C

Magnetic resonance in chemistry : MRC

2016 Volume 54, Issue 6, Page(s) 492–493

Language	English
Publishing date	2016-05-17
Publishing country	England
Document type	Editorial
ZDB-ID	1475029-6
ISSN	1097-458X ; 0749-1581
ISSN (online)	1097-458X
ISSN	0749-1581
DOI	10.1002/mrc.4439
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Article ; Online: Cation Channel Activity of Apolipoprotein L1 is Modulated by Haplotype Background.

Winkler, Rebecca L / Bruno, Jonathan / Buchanan, Paula / Edwards, John C

Journal of the American Society of Nephrology : JASN

2022 Volume 33, Issue 9, Page(s) 1673–1675

MeSH term(s)	Apolipoprotein L1/genetics ; Haplotypes ; Ion Transport ; Signal Transduction ; Cations
Chemical Substances	Apolipoprotein L1 ; Cations
Language	English
Publishing date	2022-07-15
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.2022020213
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Article: Extradural arachnoid cyst with bony erosion: a rare case report.

Bowman, John J / Edwards, Charles C

Journal of spine surgery (Hong Kong)

2020 Volume 6, Issue 4, Page(s) 736–742

Abstract: The authors present the case of an otherwise healthy 38-year-old female with an atypical extradural arachnoid cyst with multi-level involvement in the lumbar spine leading to left quadriceps weakness and dysesthesia. Upon presentation, a lumbar spine MRI ...

Abstract	The authors present the case of an otherwise healthy 38-year-old female with an atypical extradural arachnoid cyst with multi-level involvement in the lumbar spine leading to left quadriceps weakness and dysesthesia. Upon presentation, a lumbar spine MRI with contrast and plain radiographs revealed extensive L4 bony erosion. An MR angiogram and cervical spine MRI with contrast were then obtained in order to rule out any aortic root or cervical spine pathology. With no other apparent clinically relevant pathology revealed by these additional tests, an L3-5 posterior decompression and fusion procedure was performed. Her preoperative symptoms were successfully resolved following the procedure, with no resultant surgical complications. The cyst is atypical not only due to its size and location, but also due of the significant bony erosion of the left L4 pedicle and vertebral body. To the authors' knowledge, this is the first reported case of an extradural arachnoid cyst in the lumbar spine with bony erosion of the pedicle and vertebral body. In cases such as this, a CT myelogram may be useful in planning the operative approach through visualization of the exact communication between cyst and dura. This approach may also aid in diagnosing and identifying atypical cyst presentations such as the one presented here.
Language	English
Publishing date	2020-12-28
Publishing country	China
Document type	Case Reports
ZDB-ID	2874556-5
ISSN	2414-4630 ; 2414-469X
ISSN (online)	2414-4630
ISSN	2414-469X
DOI	10.21037/jss-20-590
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Article ; Online: Identification and assessment of the 1,6-dihydroxy-pyridin-2-one moiety as privileged scaffold for HBV ribonuclease H inhibition.

Giannakopoulou, Erofili / Pardali, Vasiliki / Edwards, Tiffany C / Woodson, Molly / Tajwar, Razia / Tavis, John E / Zoidis, Grigoris

Antiviral research

2024 Volume 223, Page(s) 105833

Abstract: The Hepatitis B Virus (HBV) ribonuclease H (RNase H) although promising remains an unexploited therapeutic target. HBV RNase H inhibition causes premature termination of viral minus-polarity DNA strands, prevents the synthesis of the viral positive- ... ...

Abstract	The Hepatitis B Virus (HBV) ribonuclease H (RNase H) although promising remains an unexploited therapeutic target. HBV RNase H inhibition causes premature termination of viral minus-polarity DNA strands, prevents the synthesis of the viral positive-polarity DNA strand, and causes accumulation of RNA:DNA heteroduplexes within viral capsids. As part of our ongoing research to develop more potent anti-HBV RNase H inhibitors, we designed, synthesized and analyzed a library of 18 novel compounds (17 N-hydroyxpyridinedione (HPD) imine derivatives and 1 barbituric acid analogue) as potential leads for HBV treatment development. In cell assays, fourteen HPDs showed significant anti-HBV activity with EC
MeSH term(s)	Hepatitis B virus ; Antibodies ; DNA, Viral ; Imines ; Ribonuclease H
Chemical Substances	Antibodies ; DNA, Viral ; Imines ; Ribonuclease H (EC 3.1.26.4)
Language	English
Publishing date	2024-02-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	306628-9
ISSN	1872-9096 ; 0166-3542
ISSN (online)	1872-9096
ISSN	0166-3542
DOI	10.1016/j.antiviral.2024.105833
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Article: Detection of and response to gender-based violence: a quality improvement project across three secondary mental health services in London.

Keynejad, Roxanne C / Boardman-Pretty, Theo / Barber, Sarah / Tweed, John / Forshall, Emily / Edwards, Alice / Shotton, Joshua / Wilson, Claire A

BJPsych bulletin

2024 , Page(s) 1–6

Abstract: Aims and method: Our team of core and higher psychiatry trainees aimed to improve secondary mental health service detection of and response to gender-based violence (GBV) in South East London. We audited home treatment team (HTT), drug and alcohol (D&A) ...

Abstract	Aims and method: Our team of core and higher psychiatry trainees aimed to improve secondary mental health service detection of and response to gender-based violence (GBV) in South East London. We audited home treatment team (HTT), drug and alcohol (D&A) service and in-patient ward clinical records ( Results: Documented enquiry about exposure to GBV increased by 30% (HTT), 15% (ward) and 7% (D&A), post-intervention. We identified staff training needs and support for improving GBV care. Up to 56% of records identified psychiatric symptoms related to GBV exposure. Clinical implications: Moves to make mental healthcare more trauma-informed rely on services first being supportive environments for enquiry, disclosure and response to traumatic stressors. Our collaborative approach across clinical services increased GBV enquiry and documentation. The quality of response is more difficult to measure and requires concerted attention.
Language	English
Publishing date	2024-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2816886-0
ISSN	2056-4708 ; 2056-4694
ISSN (online)	2056-4708
ISSN	2056-4694
DOI	10.1192/bjb.2024.34
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