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Article: Use of vitamin E in the treatment of keloids.

EDGERTON, M T / HANRAHAN, E M / DAVIS, W B

Plastic and reconstructive surgery (1946)

2004 Volume 8, Issue 3, Page(s) 224–233

MeSH term(s)	Fibroma/therapy ; Keloid ; Vitamin E/therapeutic use
Chemical Substances	Vitamin E (1406-18-4)
Language	English
Publishing date	2004-03-01
Publishing country	United States
Document type	Journal Article
ISSN	1075-1270
ISSN	1075-1270
DOI	10.1097/00006534-195109000-00006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Pilot Study Investigating Employee Utilization of Corporate Telehealth Services.

Edgerton, Seena Shazowee

Perspectives in health information management

2017 Volume 14, Issue Fall, Page(s) 1g

Abstract: ... throughout the program's first year of operation. This pilot study examined the number of videoconference visits (e-visits ...

Abstract	In line with the vision of the University of Mississippi Medical Center (UMMC) to improve health outcomes and eliminate healthcare disparities in Mississippi, a corporate telehealth program was initiated beginning May 2014. A descriptive study was performed to discover common characteristics among enrolled employee users who took advantage of UMMC's corporate telehealth services offered in their workplace throughout the program's first year of operation. This pilot study examined the number of videoconference visits (e-visits) throughout the first year of operation, from May 2014 through April 2015. This examination of common user traits may help identify characteristics that indicate an employee's likelihood of using corporate telehealth. The study revealed the highest use among employees between the ages of 30 and 49 years and among those who attended a formal orientation session including both the employer's human resources personnel and a UMMC corporate telehealth representative. Corporations may find that offering corporate telehealth serves as an effective means to reduce overall healthcare costs and productivity loss. Furthermore, the identification of common variables in this study may help the UMMC corporate telehealth program develop additional methods to reach and assist employees who may not otherwise seek medical treatment.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Female ; Humans ; Male ; Middle Aged ; Occupational Health ; Patient Acceptance of Health Care/statistics & numerical data ; Pilot Projects ; Residence Characteristics/statistics & numerical data ; Salaries and Fringe Benefits ; Sex Factors ; Telemedicine/utilization ; Videoconferencing/utilization ; Young Adult
Language	English
Publishing date	2017-10-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2422433-9
ISSN	1559-4122 ; 1559-4122
ISSN (online)	1559-4122
ISSN	1559-4122
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Article ; Online: Consensus-driven model to establish paediatric emergency care measures for low-volume emergency departments.

Remick, Katherine E / Bartley, Krystle A / Gonzales, Louis / MacRae, Kate S / Edgerton, Elizabeth A

BMJ open quality

2022 Volume 11, Issue 3

MeSH term(s)	Child ; Consensus ; Emergency Medical Services ; Emergency Service, Hospital ; Humans
Language	English
Publishing date	2022-07-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-6641
ISSN (online)	2399-6641
DOI	10.1136/bmjoq-2021-001803
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Article ; Online: Brunelleschi's mirror, Alberti's window, and Galileo's 'perspective tube' O espelho de Brunelleschi, a janela de Alberti e o 'tubo' de Galileu

Samuel Y. Edgerton

História, Ciências, Saúde: Manguinhos, Vol 13, Pp 151-

2006 Volume 179

Abstract: ... geométricas da reflexão em espelho ótico. Esse acontecimento veio a exercer uma profunda e inesperada ...

Abstract	This essay argues that the advent of linear perspective, ca. 1425, when Filippo Brunelleschi painted a small panel of the Florentine Baptistery by applying the geometric rules of optical mirror reflection, was more than just an artistic event. Indeed, it subsequently had the most profound - and quite unanticipated - influence on the rise of modern science. Surely, by 1609, Galileo would not have understood what he saw when observing the moon through his newly invented optical telescope, then called the 'perspective tube,' had it not been for his training in perspective drawing. Yet, Brunelleschi's original dependence on the mirror two centuries earlier was intended not to reveal objective 'scientific' reality, but rather to reinforce Christian spiritual 'reality.' In 1435-6, Leon Battista Alberti, when codifying Brunelleschi's perspective in his famous "Treatise on Painting," substituted a gridded window for Brunelleschi's mirror, thus redirecting the purpose of perspective art away from revealing God's divine order as reflected on earth, to a more secular physical reality viewed directly in relation to human moral order. O presente ensaio defende que não foi somente um acontecimento artístico o advento da perspectiva linear (c. 1425), quando Filippo Brunelleschi ao pintar um pequeno painel no Batistério Florentino lançou mão das regras geométricas da reflexão em espelho ótico. Esse acontecimento veio a exercer uma profunda e inesperada influência no surgimento da ciência moderna. Com certeza, por volta de 1609, Galileu não teria compreendido o que via quando observava a lua através de seu recém-criado telescópio ótico, então chamado 'tubo de perspectiva', se não fosse sua familiaridade com o desenho em perspectiva. No entanto, a original dependência do espelho que Brunelleschi desenvolveu dois séculos antes não almejava revelar uma realidade 'científica' objetiva, mas sim reforçar a realidade espiritual cristã. Em 1435-36, Leon Battista Alberti, ao codificar a perspectiva de Brunelleschi em seu famoso "Tratado ...
Keywords	perspectiva linear ; arte do Renascimento ; ciência moderna ; linear perspective ; Renaissance art ; modern science ; History of medicine. Medical expeditions ; R131-687
Language	English
Publishing date	2006-10-01T00:00:00Z
Publisher	Fundação Oswaldo Cruz, Casa de Oswaldo Cruz
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Functional ultrasound imaging of the human spinal cord.

Agyeman, K A / Lee, D J / Russin, J / Kreydin, E I / Choi, W / Abedi, A / Lo, Y T / Cavaleri, J / Wu, K / Edgerton, V R / Liu, C / Christopoulos, V N

Neuron

2024

Abstract: Utilizing the first in-human functional ultrasound imaging (fUSI) of the spinal cord, we demonstrate the integration of spinal functional responses to electrical stimulation. We record and characterize the hemodynamic responses of the spinal cord to a ... ...

Abstract	Utilizing the first in-human functional ultrasound imaging (fUSI) of the spinal cord, we demonstrate the integration of spinal functional responses to electrical stimulation. We record and characterize the hemodynamic responses of the spinal cord to a neuromodulatory intervention commonly used for treating pain and increasingly used for the restoration of sensorimotor and autonomic function. We found that the hemodynamic response to stimulation reflects a spatiotemporal modulation of the spinal cord circuitry not previously recognized. Our analytical capability offers a mechanism to assess blood flow changes with a new level of spatial and temporal precision in vivo and demonstrates that fUSI can decode the functional state of spinal networks in a single trial, which is of fundamental importance for developing real-time closed-loop neuromodulation systems. This work is a critical step toward developing a vital technique to study spinal cord function and effects of clinical neuromodulation.
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2024.02.012
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Zs.A 2496: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 92: Show issues

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Article: sPinal cOrd neUromodulatioN to treat Cerebral palsy in pEdiatrics: POUNCE Multisite Randomized Clinical Trial.

Girshin, Kristin / Sachdeva, Rahul / Cohn, Richard / Gad, Parag / Krassioukov, Andrei V / Edgerton, V Reggie

Frontiers in neuroscience

2023 Volume 17, Page(s) 1221809

Abstract: ... impairments in various sensory modalities, e.g., vision, hearing ability and proprioception. Current standard ...

Abstract	Introduction: Cerebral palsy (CP) affects up to 4 children in 1,000 live births, making it the most common motor disorder in children. It impairs the child's ability to move voluntarily and maintain balance and posture, and results in a wide range of other functional disorders during early development impairments in various sensory modalities, e.g., vision, hearing ability and proprioception. Current standard of care therapy focuses on symptom management and does not mitigate the progression of many of these underlying neurological impairments. The goal of this trial is to conduct a prospective multicenter, double-blinded, sham-controlled, crossover, randomized control trial to demonstrate the safety and efficacy of noninvasive spinal cord neuromodulation (SCiP™, SpineX Inc.) in conjunction with activity-based neurorehabilitation therapy (ABNT) to improve voluntary sensorimotor function in children with cerebral palsy. Methods and analysis: Sixty participants (aged 2-13 years) diagnosed with CP classified as Gross Motor Function Classification Scale Levels I-V will be recruited and divided equally into two groups (G1 and G2). Both groups will receive identical ABNT 2 days/wk. G1 will initially receive sham stimulation, whereas G2 will receive therapeutic SCiP™ therapy for 8 weeks. After 8 weeks, G1 will cross over and receive therapeutic SCiP™ therapy for 8 weeks, whereas G2 will continue to receive SCiP™ therapy for another 8 weeks, for a total of 16 weeks. Primary and secondary outcome measures will include Gross Motor Function Measure-88 and Modified Ashworth Scale, respectively. Frequency and severity of adverse events will be established by safety analyses. Ethics and dissemination: The trial is registered on clinicaltrials.gov (NCT05720208). The results from this trial will be reported on clinicaltrials.gov, published in peer-reviewed journals and presented at scientific and clinical conferences.
Language	English
Publishing date	2023-07-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2023.1221809
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Article ; Online: A physiologic increase in brain glucagon action alters the hepatic gluconeogenic/glycogenolytic ratio but not glucagon's overall effect on glucose production.

Edgerton, Dale S / Kraft, Guillaume / Smith, Marta / Farmer, Ben / Williams, Phillip / Cherrington, Alan D

American journal of physiology. Endocrinology and metabolism

2023 Volume 324, Issue 2, Page(s) E199–E208

Abstract: ... with a modest reduction in net hepatic gluconeogenic flux. However, offsetting autoregulation by the liver (i.e ...

Abstract	It has been proposed that brain glucagon action inhibits glucagon-stimulated hepatic glucose production (HGP), which may explain, at least in part, why glucagon's effect on HGP is transient. However, the pharmacologic off-target effects of glucagon in the brain may have been responsible for previously observed effects. Therefore, the aim of this study was to determine if central glucagon action plays a physiologic role in the regulation of HGP. Insulin was maintained at baseline while glucagon was either infused into the carotid and vertebral arteries or into a peripheral (leg) vein at rates designed to increase glucagon in the head in one group, while keeping glucagon at the liver matched between groups. The extraction rate of glucagon across the head was high (double that of the liver), and hypothalamic cAMP increased twofold, in proportion to the exposure of the brain to increased glucagon, but HGP was not reduced by the increase in brain glucagon signaling, as had been suggested previously (the areas under the curve for HGP were 840 ± 14 vs. 871 ± 36 mg/kg/240 min in head vs. peripheral infusion groups, respectively). Central nervous system glucagon action reduced circulating free fatty acids and glycerol, and this was associated with a modest reduction in net hepatic gluconeogenic flux. However, offsetting autoregulation by the liver (i.e., a reciprocal increase in net hepatic glycogenolysis) prevented a change in HGP. Thus, while physiologic engagement of the brain by glucagon can alter hepatic carbon flux, it does not appear to be responsible for the transient fall in HGP that occurs following the stimulation of HGP during a square wave rise in glucagon.
MeSH term(s)	Blood Glucose/metabolism ; Brain/metabolism ; Fatty Acids, Nonesterified/metabolism ; Glucagon/metabolism ; Gluconeogenesis ; Glucose/metabolism ; Glycerol/metabolism ; Glycogenolysis ; Insulin/metabolism ; Liver/metabolism ; Animals
Chemical Substances	Blood Glucose ; Fatty Acids, Nonesterified ; Glucagon (9007-92-5) ; Glucose (IY9XDZ35W2) ; Glycerol (PDC6A3C0OX) ; Insulin
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	603841-4
ISSN	1522-1555 ; 0193-1849
ISSN (online)	1522-1555
ISSN	0193-1849
DOI	10.1152/ajpendo.00304.2022
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Uc I Zs.89: Show issues

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Article ; Online: Analysis of laboratory data transmission between two healthcare institutions using a widely used point-to-point health information exchange platform: a case report.

Luu, Hung S / Campbell, Walter S / Cholan, Raja A / Edgerton, Mary E / Englund, Andrea / Keller, Alana / Korte, Elizabeth D / Mitchell, Sandra H / Watkins, Greg T / Westervelt, Lindsay / Wyman, Daniel / Powell, Stephen

JAMIA open

2024 Volume 7, Issue 2, Page(s) ooae032

Abstract: Objective: The objective was to identify information loss that could affect clinical care in laboratory data transmission between 2 health care institutions via a Health Information Exchange platform.: Materials and methods: Data transmission results ...

Abstract	Objective: The objective was to identify information loss that could affect clinical care in laboratory data transmission between 2 health care institutions via a Health Information Exchange platform. Materials and methods: Data transmission results of 9 laboratory tests, including LOINC codes, were compared in the following: between sending and receiving electronic health record (EHR) systems, the individual Health Level Seven International (HL7) Version 2 messages across the instrument, laboratory information system, and sending EHR. Results: Loss of information for similar tests indicated the following potential patient safety issues: (1) consistently missing specimen source; (2) lack of reporting of analytical technique or instrument platform; (3) inconsistent units and reference ranges; (4) discordant LOINC code use; and (5) increased complexity with multiple HL7 versions. Discussion and conclusions: Using an HIE with standard messaging, SHIELD (Systemic Harmonization and Interoperability Enhancement for Laboratory Data) recommendations, and enhanced EHR functionality to support necessary data elements would yield consistent test identification and result value transmission.
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Case Reports
ISSN	2574-2531
ISSN (online)	2574-2531
DOI	10.1093/jamiaopen/ooae032
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Management of Snakebites in the Upper Extremity.

Edgerton, Michael T / Koepplinger, Matthew E

The Journal of hand surgery

2018 Volume 44, Issue 2, Page(s) 137–142

Abstract: Encounters with venomous snakes can lead to substantial morbidity or mortality if managed inappropriately. Medical management is the mainstay of treatment, but surgery may be necessary in rare cases. The hand surgeon should be well versed in the types of ...

Abstract	Encounters with venomous snakes can lead to substantial morbidity or mortality if managed inappropriately. Medical management is the mainstay of treatment, but surgery may be necessary in rare cases. The hand surgeon should be well versed in the types of venomous snakes, the mechanism of action of venom, and the management of these injuries, given the frequency of hand envenomation. The indications for surgery are not well established and rely on clinical judgment and practitioner's experience. An understanding of previously reported outcomes and an algorithmic approach to treatment will help improve patient care and avoid complications.
MeSH term(s)	Analgesics, Opioid/therapeutic use ; Animals ; Antivenins/therapeutic use ; Child ; Compartment Syndromes/etiology ; Compartment Syndromes/surgery ; Debridement ; Fasciotomy ; Humans ; Immunoglobulin Fab Fragments/therapeutic use ; Male ; Necrosis/surgery ; Snake Bites/therapy ; Snake Venoms/immunology ; Tetanus Toxoid ; Upper Extremity/injuries ; Upper Extremity/surgery
Chemical Substances	Analgesics, Opioid ; Antivenins ; Crotalidae Polyvalent immune Fab ; Immunoglobulin Fab Fragments ; Snake Venoms ; Tetanus Toxoid
Language	English
Publishing date	2018-07-26
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	605716-0
ISSN	1531-6564 ; 0363-5023
ISSN (online)	1531-6564
ISSN	0363-5023
DOI	10.1016/j.jhsa.2018.06.016
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Zs.A 1431: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Aquatic Plant Invasion and Management in Riverine Reservoirs: Proactive Management via a Priori Simulation of Management Alternatives

Edgerton, Elizabeth / Wang, Hsiao-Hsuan / Grant, William E. / Masser, Michael

Diversity. 2022 Dec. 14, v. 14, no. 12

2022

Abstract: Negative impacts from aquatic invasive plants in the United States include economic costs, loss of commercial and recreational use, and environmental damage. Simulation models are valuable tools for predicting the invasion potentials of species and for ... ...

Abstract	Negative impacts from aquatic invasive plants in the United States include economic costs, loss of commercial and recreational use, and environmental damage. Simulation models are valuable tools for predicting the invasion potentials of species and for the management of existing infestations. We developed a spatially explicit, agent-based model representing the invasion, growth, and senescence of aquatic weeds as functions of day length, water temperature, water depth, and the response of aquatic weeds to biological control. As a case study to evaluate its potential utility, we parameterized the model to represent two historical invasions (1975–1983 and 2004–2007) of Hydrilla (Hydrilla verticillata (L. fil.) Royle) in Lake Conroe, Texas, USA, and their subsequent biological control using grass carp (Ctenopharyngodon idella). Results of several hypothetical alternative management schemes indicated that grass carp stocking densities needed to control Hydrilla infestation increased exponentially as the lag time between initial invasion and initial stocking increased, whereas stocking densities needed to control infestation decreased as the amount of time allowed to control the infestation increased. Predictions such as those produced by our model aid managers in developing proactive management plans for areas most likely to be invaded.
Keywords	Ctenopharyngodon idella ; Hydrilla verticillata ; aquatic plants ; biological control ; case studies ; ecological invasion ; lakes ; models ; photoperiod ; riparian areas ; water temperature ; Texas
Language	English
Dates of publication	2022-1214
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2518137-3
ISSN	1424-2818
ISSN	1424-2818
DOI	10.3390/d14121113
Database	NAL-Catalogue (AGRICOLA)

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