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Article ; Online: What the Silent Retina Tells You: Serous Retinal Detachment in Waldenström's Macroglobulinemia.

Amaador, Karima / Diederen, Roselie / Coumou, Jeroen / Vos, Josephine

HemaSphere

2021 Volume 5, Issue 2, Page(s) e527

Language	English
Publishing date	2021-01-20
Publishing country	United States
Document type	Case Reports
ISSN	2572-9241
ISSN (online)	2572-9241
DOI	10.1097/HS9.0000000000000527
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chloroquine als mogelijke behandeling van COVID-19.

Coumou, Jeroen / de Vries, Peter J

Nederlands tijdschrift voor geneeskunde

2020 Volume 164

Abstract: Since the outbreak of COVID-19, chloroquine has been mentioned as a possible treatment. In vitro studies have shown anti-viral activity of chloroquine against SARS-CoV-2. Recently, the Dutch National Institute for Public Health and the Environment ... ...

Title translation	Chloroquine as a possible treatment for COVID-19.
Abstract	Since the outbreak of COVID-19, chloroquine has been mentioned as a possible treatment. In vitro studies have shown anti-viral activity of chloroquine against SARS-CoV-2. Recently, the Dutch National Institute for Public Health and the Environment published treatment options for antiviral treatment for COVID-19 where chloroquine was suggested as first choice for off-label treatment, beside remdesivir en lopinavir/ritonavir. In this commentary, we provide a background and history of chloroquine, the evidence for antiviral efficacy of chloroquine and the arguments for off-label use of chloroquine in COVID-19.
MeSH term(s)	Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; Antiviral Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Chloroquine/therapeutic use ; Coronavirus Infections/drug therapy ; Humans ; Lopinavir/therapeutic use ; Off-Label Use ; Pandemics ; Pneumonia, Viral/drug therapy ; Ritonavir/therapeutic use ; SARS-CoV-2 ; Treatment Outcome
Chemical Substances	Antiviral Agents ; Lopinavir (2494G1JF75) ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Chloroquine (886U3H6UFF) ; Ritonavir (O3J8G9O825) ; Alanine (OF5P57N2ZX)
Keywords	covid19
Language	Dutch
Publishing date	2020-03-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Chloroquine as a possible treatment for COVID-19]

Coumou, Jeroen / de Vries, Peter J.

Ned Tijdschr Geneeskd

Abstract: Since the outbreak of COVID-19, chloroquine has been mentioned as a possible treatment In vitro studies have shown anti-viral activity of chloroquine against SARS-CoV-2 Recently, the Dutch National Institute for Public Health and the Environment ... ...

Abstract	Since the outbreak of COVID-19, chloroquine has been mentioned as a possible treatment In vitro studies have shown anti-viral activity of chloroquine against SARS-CoV-2 Recently, the Dutch National Institute for Public Health and the Environment published treatment options for antiviral treatment for COVID-19 where chloroquine was suggested as first choice for off-label treatment, beside remdesivir en lopinavir/ritonavir In this commentary, we provide a background and history of chloroquine, the evidence for antiviral efficacy of chloroquine and the arguments for off-label use of chloroquine in COVID-19
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #242142
Database	COVID19

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Article: Chloroquine als mogelijke behandeling van COVID-19./ [Chloroquine as a possible treatment for COVID-19]

Coumou, Jeroen / de Vries, Peter J

Ned. tijdschr. geneeskd

Abstract	Since the outbreak of COVID-19, chloroquine has been mentioned as a possible treatment. In vitro studies have shown anti-viral activity of chloroquine against SARS-CoV-2. Recently, the Dutch National Institute for Public Health and the Environment published treatment options for antiviral treatment for COVID-19 where chloroquine was suggested as first choice for off-label treatment, beside remdesivir en lopinavir/ritonavir. In this commentary, we provide a background and history of chloroquine, the evidence for antiviral efficacy of chloroquine and the arguments for off-label use of chloroquine in COVID-19.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32391999
Database	COVID19

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Book ; Online: Modelled storm surge changes in a warmer world

Scussolini, Paolo / Dullaart, Job / Muis, Sanne / Rovere, Alessio / Bakker, Pepijn / Coumou, Dim / Renssen, Hans / Ward, Philip J. / Aerts, Jeroen C. J. H.

eISSN:

the Last Interglacial

2023

Abstract: The Last Interglacial (LIG; ca. 125 ka) is a period of interest for climate research as it is the most recent period of the Earth's history when the boreal climate was warmer than at present. Previous research, based on models and geological evidence, ... ...

Abstract	The Last Interglacial (LIG; ca. 125 ka) is a period of interest for climate research as it is the most recent period of the Earth's history when the boreal climate was warmer than at present. Previous research, based on models and geological evidence, suggests that the LIG may have featured enhanced patterns of ocean storminess, but this remains hotly debated. Here, we apply state-of-the-art climate and hydrodynamic modeling to simulate changes in sea level extremes caused by storm surges, under LIG and pre-industrial climate forcings. Significantly higher seasonal LIG sea level extremes emerge for coastlines along northern Australia, the Indonesian archipelago, much of northern and eastern Africa, the Mediterranean Sea, the Gulf of Saint Lawrence, the Arabian Sea, the east coast of North America, and islands of the Pacific Ocean and of the Caribbean. Lower seasonal LIG sea level extremes emerge for coastlines along the North Sea, the Bay of Bengal, China, Vietnam, and parts of Central America. Most of these anomalies are associated with anomalies in seasonal sea level pressure minima and in eddy kinetic energy calculated from near-surface wind fields, and therefore seem to originate from anomalies in the meridional position and intensity of the predominant wind bands. In a qualitative comparison, LIG sea level extremes seem generally higher than those projected for future warmer climates. These results help to constrain the interpretation of coastal archives of LIG sea level indicators.
Subject code	551
Language	English
Publishing date	2023-01-16
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Modeled storm surge changes in a warmer world

Scussolini, Paolo / Dullaart, Job / Muis, Sanne / Rovere, Alessio / Bakker, Pepijn / Coumou, Dim / Renssen, Hans / Ward, Philip J. / Aerts, Jeroen C. J. H.

eISSN: 1814-9332

the Last Interglacial

2023

Abstract	The Last Interglacial (LIG; ca. 125 ka) is a period of interest for climate research as it is the most recent period of the Earth's history when the boreal climate was warmer than at present. Previous research, based on models and geological evidence, suggests that the LIG may have featured enhanced patterns of ocean storminess, but this remains hotly debated. Here, we apply state-of-the-art climate and hydrodynamic modeling to simulate changes in sea level extremes caused by storm surges, under LIG and pre-industrial climate forcings. Significantly higher seasonal LIG sea level extremes emerge for coastlines along northern Australia, the Indonesian archipelago, much of northern and eastern Africa, the Mediterranean Sea, the Gulf of Saint Lawrence, the Arabian Sea, the east coast of North America, and islands of the Pacific Ocean and of the Caribbean. Lower seasonal LIG sea level extremes emerge for coastlines along the North Sea, the Bay of Bengal, China, Vietnam, and parts of Central America. Most of these anomalies are associated with anomalies in seasonal sea level pressure minima and in eddy kinetic energy calculated from near-surface wind fields, and therefore seem to originate from anomalies in the meridional position and intensity of the predominant wind bands. In a qualitative comparison, LIG sea level extremes seem generally higher than those projected for future warmer climates. These results help to constrain the interpretation of coastal archives of LIG sea level indicators.
Subject code	551
Language	English
Publishing date	2023-01-16
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification of novel conserved Ixodes vaccine candidates; a promising role for non-secreted salivary gland proteins.

Trentelman, Jos J A / de Vogel, Fons A / Colstrup, Emil / Sima, Radek / Coumou, Jeroen / Koetsveld, Joris / Klouwens, Michelle J / Nayak, Abhijeet / Ersoz, Jasmin / Barriales, Diego / Tomás-Cortázar, Julen / Narasimhan, Sukanya / Hajdusek, Ondrej / Anguita, Juan / Hovius, Joppe W

Vaccine

2022 Volume 40, Issue 52, Page(s) 7593–7603

Abstract: Ixodes ricinus and Ixodes scapularis are the main vectors for the causative agents of Lyme borreliosis and a wide range of other pathogens. Repeated tick-bites are known to lead to tick rejection; a phenomenon designated as tick immunity. Tick immunity ... ...

Abstract	Ixodes ricinus and Ixodes scapularis are the main vectors for the causative agents of Lyme borreliosis and a wide range of other pathogens. Repeated tick-bites are known to lead to tick rejection; a phenomenon designated as tick immunity. Tick immunity is mainly directed against tick salivary gland proteins (TSGPs) and has been shown to partially protect against experimental Lyme borreliosis. TSGPs recognized by antibodies from tick immune animals could therefore be interesting candidates for an anti-tick vaccine, which might also block pathogen transmission. To identify conserved Ixodes TSGPs that could serve as a universal anti-tick vaccine in both Europe and the US, a Yeast Surface Display containing salivary gland genes of nymphal I. ricinus expressed at 24, 48 and 72 h into tick feeding was probed with either sera from rabbits repeatedly exposed for 24 h to I. ricinus nymphal ticks and/or sera from rabbits immune to I. scapularis. Thus, we identified thirteen TSGP vaccine candidates, of which ten were secreted. For vaccination studies in rabbits, we selected six secreted TSGPs, five full length and one conserved peptide. None of these proteins hampered tick feeding. In contrast, vaccination of guinea pigs with four non-secreted TSGPs - two from the current and two from a previous human immunoscreening - did significantly reduce tick attachment and feeding. Therefore, non-secreted TSGPs appear to be involved in the development of tick immunity and are interesting candidates for an anti-tick vaccine.
MeSH term(s)	Animals ; Guinea Pigs ; Humans ; Rabbits ; Ixodes ; Lyme Disease/prevention & control ; Salivary Glands ; Salivary Proteins and Peptides/genetics ; Salivary Proteins and Peptides/metabolism ; Vaccines
Chemical Substances	Salivary Proteins and Peptides ; Vaccines
Language	English
Publishing date	2022-11-08
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2022.10.032
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

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Article ; Online: The role of Mannose Binding Lectin in the immune response against Borrelia burgdorferi sensu lato.

Coumou, Jeroen / Wagemakers, Alex / Narasimhan, Sukanya / Schuijt, Tim J / Ersoz, Jasmin I / Oei, Anneke / de Boer, Onno J / Roelofs, Joris J T H / Fikrig, Erol / Hovius, Joppe W

Scientific reports

2019 Volume 9, Issue 1, Page(s) 1431

Abstract: The causative agents of Lyme borreliosis, spirochetes belonging to the Borrelia burgdorferi sensu lato group, have developed several ways to protect themselves against killing by the host complement system. In addition, it has been shown that serum ... ...

Abstract	The causative agents of Lyme borreliosis, spirochetes belonging to the Borrelia burgdorferi sensu lato group, have developed several ways to protect themselves against killing by the host complement system. In addition, it has been shown that serum sensitive isolates are (partially) protected by the Ixodes Tick Salivary Lectin Pathway Inhibitor (TSLPI) protein; a salivary gland protein that inhibits the function of Mannose Binding Lectin (MBL). MBL is a C-type lectin that recognizes oligosaccharides on pathogens and activates the complement system via the lectin pathway. MBL deficiency has been linked to a more severe course of several infectious diseases and humans with detectable antibodies against B. burgdorferi are significantly more often MBL deficient compared to humans without antibodies against B. burgdorferi. Here we set out to investigate the role of MBL in the immune response against B. burgdorferi in more detail. We demonstrate that B. burgdorferi N40 needle-infected C57BL/6 MBL deficient mice harbored significantly higher B. burgdorferi numbers in skin tissue during the early course of infection. In line with these findings they also developed higher anti-B. burgdorferi IgG serum antibodies compared to WT controls. In contrast, B. burgdorferi loads in distant tissue such as heart, joints or bladder at later time points were similar for both mouse strains. These in vivo findings were corroborated using a B. burgdorferi N40-infected I. scapularis infestation model. We showed that MBL is capable of binding B. burgdorferi through its carbohydrate recognition domains, but in vitro complement killing assays, peritoneal macrophage and whole blood stimulations, phagocytosis assays and an in vivo migration experiment did not reveal the mechanism by which MBL facilitates early clearance of B. burgdorferi. To conclude, we show a protective role of MBL in the early stages of B. burgdorferi infection, yet the underlying mechanism warrants further investigation.
MeSH term(s)	Animals ; Bacterial Load ; Borrelia burgdorferi/immunology ; Borrelia burgdorferi/pathogenicity ; Cells, Cultured ; Female ; Heart/microbiology ; Humans ; Immunoglobulin G/immunology ; Joints/microbiology ; Lyme Disease/immunology ; Macrophages, Peritoneal/immunology ; Macrophages, Peritoneal/microbiology ; Male ; Mannose-Binding Lectins/metabolism ; Mice ; Mice, Inbred C57BL ; Phagocytosis ; Polysaccharides, Bacterial/metabolism ; Protein Binding ; Urinary Bladder/microbiology
Chemical Substances	Immunoglobulin G ; Mannose-Binding Lectins ; Polysaccharides, Bacterial
Language	English
Publishing date	2019-02-05
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-37922-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A tick gut protein with fibronectin III domains aids Borrelia burgdorferi congregation to the gut during transmission.

Narasimhan, Sukanya / Coumou, Jeroen / Schuijt, Tim J / Boder, Eric / Hovius, Joppe W / Fikrig, Erol

PLoS pathogens

2014 Volume 10, Issue 8, Page(s) e1004278

Abstract: Borrelia burgdorferi transmission to the vertebrate host commences with growth of the spirochete in the tick gut and migration from the gut to the salivary glands. This complex process, involving intimate interactions of the spirochete with the gut ... ...

Abstract	Borrelia burgdorferi transmission to the vertebrate host commences with growth of the spirochete in the tick gut and migration from the gut to the salivary glands. This complex process, involving intimate interactions of the spirochete with the gut epithelium, is pivotal to transmission. We utilized a yeast surface display library of tick gut proteins to perform a global screen for tick gut proteins that might interact with Borrelia membrane proteins. A putative fibronectin type III domain-containing tick gut protein (Ixofin3D) was most frequently identified from this screen and prioritized for further analysis. Immunization against Ixofin3D and RNA interference-mediated reduction in expression of Ixofin3D resulted in decreased spirochete burden in tick salivary glands and in the murine host. Microscopic examination showed decreased aggregation of spirochetes on the gut epithelium concomitant with reduced expression of Ixofin3D. Our observations suggest that the interaction between Borrelia and Ixofin3D facilitates spirochete congregation to the gut during transmission, and provides a "molecular exit" direction for spirochete egress from the gut.
MeSH term(s)	Animals ; Arthropod Proteins/metabolism ; Borrelia burgdorferi ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay ; Fibronectins/metabolism ; Host-Parasite Interactions/physiology ; Lyme Disease/transmission ; Mice ; Microscopy, Confocal ; Molecular Sequence Data ; Polymerase Chain Reaction ; Ticks/metabolism
Chemical Substances	Arthropod Proteins ; Fibronectins
Language	English
Publishing date	2014-08-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7366
ISSN (online)	1553-7374
ISSN	1553-7366
DOI	10.1371/journal.ppat.1004278
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Vaccination against Bm86 Homologues in Rabbits Does Not Impair Ixodes ricinus Feeding or Oviposition.

Coumou, Jeroen / Wagemakers, Alex / Trentelman, Jos J / Nijhof, Ard M / Hovius, Joppe W

PloS one

2014 Volume 10, Issue 4, Page(s) e0123495

Abstract: Human tick-borne diseases that are transmitted by Ixodes ricinus, such as Lyme borreliosis and tick borne encephalitis, are on the rise in Europe. Diminishing I. ricinus populations in nature can reduce tick exposure to humans, and one way to do so is by ...

Abstract	Human tick-borne diseases that are transmitted by Ixodes ricinus, such as Lyme borreliosis and tick borne encephalitis, are on the rise in Europe. Diminishing I. ricinus populations in nature can reduce tick exposure to humans, and one way to do so is by developing an anti-vector vaccine against tick antigens. Currently, there is only one anti-vector vaccine available against ticks, which is a veterinary vaccine based on the tick antigen Bm86 in the gut of Rhipicephalus microplus. Bm86 vaccine formulations cause a reduction in the number of Rhipicephalus microplus ticks that successfully feed, i.e. lower engorgement weights and a decrease in the number of oviposited eggs. Furthermore, Bm86 vaccines reduce transmission of bovine Babesia spp. Previously two conserved Bm86 homologues in I. ricinus ticks, designated as Ir86-1 and Ir86-2, were described. Here we investigated the effect of a vaccine against recombinant Ir86-1, Ir86-2 or a combination of both on Ixodes ricinus feeding. Recombinant Ixodes ricinus Bm86 homologues were expressed in a Drosophila expression system and rabbits were immunized with rIr86-1, rIr86-2, a combination of both or ovalbumin as a control. Each animal was infested with 50 female adults and 50 male adults Ixodes ricinus and tick mortality, engorgement weights and egg mass were analyzed. Although serum IgG titers against rIr86 proteins were elicited, no effect was found on tick feeding between the rIr86 vaccinated animals and ovalbumin vaccinated animals. We conclude that vaccination against Bm86 homologues in Ixodes ricinus is not an effective approach to control Ixodes ricinus populations, despite the clear effects of Bm86 vaccination against Rhipicephalus microplus.
MeSH term(s)	Animals ; Antigens/genetics ; Antigens/immunology ; Drosophila melanogaster/genetics ; Female ; Ixodes/drug effects ; Ixodes/genetics ; Ixodes/immunology ; Male ; Oviposition/drug effects ; Rabbits/immunology ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology ; Tick Infestations/prevention & control ; Tick Infestations/veterinary ; Vaccination/methods ; Vaccines/immunology
Chemical Substances	Antigens ; Recombinant Proteins ; Vaccines
Language	English
Publishing date	2014
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0123495
Database	MEDical Literature Analysis and Retrieval System OnLINE

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