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  1. Article ; Online: Liver transplantation due to fulminant hepatitis A in a traveller visiting friends and relatives in Comoros.

    Diallo, Safiétou / Borentain, Patrick / Motte, Anne / Gautret, Philippe / Colson, Philippe

    Journal of travel medicine

    2023  Volume 31, Issue 3

    MeSH term(s) Humans ; Liver Transplantation ; Comoros ; Friends ; Massive Hepatic Necrosis ; Hepatitis A
    Language English
    Publishing date 2023-12-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taad153
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4120: Show issues Location:
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  2. Article: The emergence, dynamics and significance of SARS-CoV-2 variants.

    Colson, Philippe / Parola, Philippe / Raoult, Didier

    New microbes and new infections

    2022  Volume 45, Page(s) 100962

    Language English
    Publishing date 2022-02-01
    Publishing country England
    Document type Editorial
    ZDB-ID 2750179-6
    ISSN 2052-2975
    ISSN 2052-2975
    DOI 10.1016/j.nmni.2022.100962
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  3. Article ; Online: Central venous oxygen saturation to adjust transfusion trigger in cardiac surgery. Comment on Br J Anaesth 2021; 128: 37-44.

    Gaudard, Philippe / Colson, Pascal

    British journal of anaesthesia

    2022  Volume 128, Issue 4, Page(s) e291–e292

    MeSH term(s) Blood Transfusion ; Cardiac Surgical Procedures ; Humans ; Oximetry ; Oxygen Saturation
    Language English
    Publishing date 2022-02-11
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2022.01.017
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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Horse Chestnut Saponins-Escins, Isoescins, Transescins, and Desacylescins.

    Savarino, Philippe / Colson, Emmanuel / André, Julien / Gerbaux, Pascal

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 5

    Abstract: Escins constitute an abundant family of saponins (saponosides) and are the most active components ... ...

    Abstract Escins constitute an abundant family of saponins (saponosides) and are the most active components in
    MeSH term(s) Escin/chemistry ; Saponins ; Aesculus/chemistry ; Pharmaceutical Preparations ; Plant Extracts
    Chemical Substances Escin (6805-41-0) ; Saponins ; Pharmaceutical Preparations ; Plant Extracts
    Language English
    Publishing date 2023-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28052087
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  5. Article ; Online: Reinfection with SARS-CoV-2 Omicron BA.4 and BA.5 variants.

    Nguyen, Nhu Ngoc / Houhamdi, Linda / Meddeb, Line / Colson, Philippe / Gautret, Philippe

    Journal of medical virology

    2023  Volume 95, Issue 8, Page(s) e29033

    MeSH term(s) Humans ; Reinfection ; SARS-CoV-2/genetics ; COVID-19
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29033
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
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  6. Article ; Online: Global Discrepancies between Numbers of Available SARS-CoV-2 Genomes and Human Development Indexes at Country Scales.

    Colson, Philippe / Raoult, Didier

    Viruses

    2021  Volume 13, Issue 5

    Abstract: It has now been over a year since SARS-CoV-2 first emerged in China, in December 2019, and it has spread rapidly around the world. Some variants are currently considered of great concern. We aimed to analyze the numbers of SARS-CoV-2 genome sequences ... ...

    Abstract It has now been over a year since SARS-CoV-2 first emerged in China, in December 2019, and it has spread rapidly around the world. Some variants are currently considered of great concern. We aimed to analyze the numbers of SARS-CoV-2 genome sequences obtained in different countries worldwide until January 2021. On 28 January 2021, we downloaded the deposited genome sequence origin from the GISAID database, and from the "Our world in data" website we downloaded numbers of SARS-CoV-2-diagnosed cases, numbers of SARS-CoV-2-associated deaths, population size, life expectancy, gross domestic product (GDP) per capita, and human development index per country. Files were merged and data were analyzed using Microsoft Excel software. A total of 450,968 SARS-CoV-2 genomes originating from 135 countries on the 5 continents were available. When considering the 19 countries for which the number of genomes per 100 deaths was >100, six were in Europe, while eight were in Asia, three were in Oceania and two were in Africa. Six (30%) of these countries are beyond rank 75, regarding the human development index and four (20%) are beyond rank 80 regarding GDP per capita. Moreover, the comparisons of the number of genomes sequenced per 100 deaths to the human development index by country show that some Western European countries have released similar or lower numbers of genomes than many African or Asian countries with a lower human development index. Previous data highlight great discrepancies between the numbers of available SARS-CoV-2 genomes per 100 cases and deaths and the ranking of countries regarding wealth and development.
    MeSH term(s) Africa/epidemiology ; Asia/epidemiology ; COVID-19/epidemiology ; COVID-19/virology ; Databases, Genetic ; Europe/epidemiology ; Genome, Viral ; Global Health ; High-Throughput Nucleotide Sequencing ; Humans ; Pandemics ; SARS-CoV-2/genetics
    Language English
    Publishing date 2021-04-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13050775
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Is it time to switch to a formulation other than the live attenuated poliovirus vaccine to prevent poliomyelitis?

    Devaux, Christian Albert / Pontarotti, Pierre / Levasseur, Anthony / Colson, Philippe / Raoult, Didier

    Frontiers in public health

    2024  Volume 11, Page(s) 1284337

    Abstract: The polioviruses (PVs) are mainly transmitted by direct contact with an infected person through the fecal-oral route and respiratory secretions (or more rarely via contaminated water or food) and have a primary tropism for the gut. After their ... ...

    Abstract The polioviruses (PVs) are mainly transmitted by direct contact with an infected person through the fecal-oral route and respiratory secretions (or more rarely via contaminated water or food) and have a primary tropism for the gut. After their replication in the gut, in rare cases (far less than 1% of the infected individuals), PVs can spread to the central nervous system leading to flaccid paralysis, which can result in respiratory paralysis and death. By the middle of the 20th century, every year the wild polioviruses (WPVs) are supposed to have killed or paralyzed over half a million people. The introduction of the oral poliovirus vaccines (OPVs) through mass vaccination campaigns (combined with better application of hygiene measures), was a success story which enabled the World Health Organization (WHO) to set the global eradication of poliomyelitis as an objective. However this strategy of viral eradication has its limits as the majority of poliomyelitis cases today arise in individuals infected with circulating vaccine-derived polioviruses (cVDPVs) which regain pathogenicity following reversion or recombination. In recent years (between January 2018 and May 2023), the WHO recorded 8.8 times more cases of polio which were linked to the attenuated OPV vaccines (3,442 polio cases after reversion or recombination events) than cases linked to a WPV (390 cases). Recent knowledge of the evolution of RNA viruses and the exchange of genetic material among biological entities of the intestinal microbiota, call for a reassessment of the polio eradication vaccine strategies.
    MeSH term(s) Humans ; Poliomyelitis/prevention & control ; Central Nervous System ; Behavior Therapy ; Poliovirus Vaccines ; Vaccines
    Chemical Substances Poliovirus Vaccines ; Vaccines
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1284337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Bulevirtide 2mg-based real-life treatment of hepatitis Delta with genotypes 1 and 5 viruses at more than 20 months of follow-up.

    Dassetto, Clara / Borentain, Patrick / Gérolami, René / Colson, Philippe

    Clinics and research in hepatology and gastroenterology

    2022  Volume 46, Issue 10, Page(s) 102035

    MeSH term(s) Humans ; Hepatitis Delta Virus/genetics ; Follow-Up Studies ; Antiviral Agents/therapeutic use ; Genotype ; Polyethylene Glycols ; Recombinant Proteins ; Treatment Outcome
    Chemical Substances bulevirtide ; Antiviral Agents ; Polyethylene Glycols (3WJQ0SDW1A) ; Recombinant Proteins
    Language English
    Publishing date 2022-10-20
    Publishing country France
    Document type Letter
    ZDB-ID 2594333-9
    ISSN 2210-741X ; 2210-7401
    ISSN (online) 2210-741X
    ISSN 2210-7401
    DOI 10.1016/j.clinre.2022.102035
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  9. Article ; Online: Horse Chestnut Saponins–Escins, Isoescins, Transescins, and Desacylescins

    Philippe Savarino / Emmanuel Colson / Julien André / Pascal Gerbaux

    Molecules, Vol 28, Iss 2087, p

    2023  Volume 2087

    Abstract: Escins constitute an abundant family of saponins (saponosides) and are the most active components in Aesculum hippocastanum (horse chestnut—HC) seeds. They are of great pharmaceutical interest as a short-term treatment for venous insufficiency. Numerous ... ...

    Abstract Escins constitute an abundant family of saponins (saponosides) and are the most active components in Aesculum hippocastanum (horse chestnut—HC) seeds. They are of great pharmaceutical interest as a short-term treatment for venous insufficiency. Numerous escin congeners (slightly different compositions), as well as numerous regio-and stereo-isomers, are extractable from HC seeds, making quality control trials mandatory, especially since the structure–activity relationship (SAR) of the escin molecules remains poorly described. In the present study, mass spectrometry, microwave activation, and hemolytic activity assays were used to characterize escin extracts (including a complete quantitative description of the escin congeners and isomers), modify the natural saponins (hydrolysis and transesterification) and measure their cytotoxicity (natural vs. modified escins). The aglycone ester groups characterizing the escin isomers were targeted. A complete quantitative analysis, isomer per isomer, of the weight content in the saponin extracts as well as in the seed dry powder is reported for the first time. An impressive 13% in weight of escins in the dry seeds was measured, confirming that the HC escins must be absolutely considered for high-added value applications, provided that their SAR is established. One of the objectives of this study was to contribute to this development by demonstrating that the aglycone ester functions are mandatory for the toxicity of the escin derivative, and that the cytotoxicity also depends on the relative position of the ester functions on the aglycone.
    Keywords mass spectrometry ; structure–activity relationship ; microwave activation ; liquid chromatography ; hemolytic activity ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Global Discrepancies between Numbers of Available SARS-CoV-2 Genomes and Human Development Indexes at Country Scales

    Colson, Philippe / Raoult, Didier

    Viruses. 2021 Apr. 28, v. 13, no. 5

    2021  

    Abstract: It has now been over a year since SARS-CoV-2 first emerged in China, in December 2019, and it has spread rapidly around the world. Some variants are currently considered of great concern. We aimed to analyze the numbers of SARS-CoV-2 genome sequences ... ...

    Abstract It has now been over a year since SARS-CoV-2 first emerged in China, in December 2019, and it has spread rapidly around the world. Some variants are currently considered of great concern. We aimed to analyze the numbers of SARS-CoV-2 genome sequences obtained in different countries worldwide until January 2021. On 28 January 2021, we downloaded the deposited genome sequence origin from the GISAID database, and from the “Our world in data” website we downloaded numbers of SARS-CoV-2-diagnosed cases, numbers of SARS-CoV-2-associated deaths, population size, life expectancy, gross domestic product (GDP) per capita, and human development index per country. Files were merged and data were analyzed using Microsoft Excel software. A total of 450,968 SARS-CoV-2 genomes originating from 135 countries on the 5 continents were available. When considering the 19 countries for which the number of genomes per 100 deaths was >100, six were in Europe, while eight were in Asia, three were in Oceania and two were in Africa. Six (30%) of these countries are beyond rank 75, regarding the human development index and four (20%) are beyond rank 80 regarding GDP per capita. Moreover, the comparisons of the number of genomes sequenced per 100 deaths to the human development index by country show that some Western European countries have released similar or lower numbers of genomes than many African or Asian countries with a lower human development index. Previous data highlight great discrepancies between the numbers of available SARS-CoV-2 genomes per 100 cases and deaths and the ranking of countries regarding wealth and development.
    Keywords Internet ; Severe acute respiratory syndrome coronavirus 2 ; computer software ; databases ; genome ; gross domestic product ; human development ; longevity ; nucleotide sequences ; population size ; Africa ; China ; Europe ; Pacific Ocean Islands
    Language English
    Dates of publication 2021-0428
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13050775
    Database NAL-Catalogue (AGRICOLA)

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