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Article: Has the knowledge economy a role to play in transfusion medicine?

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

2024 Volume 63, Issue 2, Page(s) 103892

Abstract: The history of blood transfusion has been dominated by the search for compatibility for species specificity, the search for how to transfer blood from one individual into another or infuse. Safety has become a major issue since it became clear that blood ...

Abstract	The history of blood transfusion has been dominated by the search for compatibility for species specificity, the search for how to transfer blood from one individual into another or infuse. Safety has become a major issue since it became clear that blood was not only able to allow mystical miracles to take place but could transmit infectious diseases. The science behind these ideas reflects observation, a thinking and exchange of knowledge and skills, originally documented in reports or case studies of what has happened and was observed, and peer presented - knowledge economy.
MeSH term(s)	Humans ; Transfusion Medicine ; Blood Transfusion
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2046795-3
ISSN	1878-1683 ; 1473-0502
ISSN (online)	1878-1683
ISSN	1473-0502
DOI	10.1016/j.transci.2024.103892
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Article ; Online: De aankoop van de menagerie van Cornelis van Aken door het Amsterdamse genootschap ‘Natura Artis Magistra’

Pieter Smit

Studium : Tijdschrift voor Wetenschaps- en Universiteits-Geschiedenis, Vol 19, Iss 3, Pp 133-

1996 Volume 152

Abstract: ... by Cornelis van Aken The Amsterdam Society 'Natura Artis Magistra' was established in 1838 by Amsterdam ... by the Dutchman Cornelis van Aken. He travelled all over Europe to show them, but as he heard from the Society's ... he had to be sacked only one and a half year later. Cornelis van Aken died in 1844, his animals were ...

Abstract	The Amsterdam Society 'Natura Artis Magistra' and their acquisition of the menagerie owned by Cornelis van Aken The Amsterdam Society 'Natura Artis Magistra' was established in 1838 by Amsterdam citizens among whom the bookseller Frederik Westerman (1807-1890) was the driving force. The two main aims of the society were to set up a zoo and to study all objects from nature. The acquisition of the animals for the zoo is the subject of this article. During the eighteenth and nineteenth century exotic animals were exhibited at country fairs. One of Europe's largest collection of such exotic animals was owned by the Dutchman Cornelis van Aken. He travelled all over Europe to show them, but as he heard from the Society's plan for a zoo, he immediately offered his animals for sale. Negotiations between the Society and Van Aken took almost a year, but finally at the end of November 1839 the animals arrived in Amsterdam. Among them were an elephant, lions, tigers, monkeys, all kinds of birds, snakes etcetera, in total over a hundred animals. Van Aken was appointed as 'custos'. This appeared to be a failure, as he started drinking and did not look after the animals properly. In spite of all efforts of his wife together with the Society he had to be sacked only one and a half year later. Cornelis van Aken died in 1844, his animals were the foundation for the still existing Amsterdam Zoo 'Artis'.
Keywords	Van Aken ; Natura Artis Magistra ; Zoo ; Science (General) ; Q1-390 ; Science ; Q
Subject code	630
Language	Dutch
Publishing date	1996-07-01T00:00:00Z
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Review of the European

van Achterberg, Cornelis / Smit, John T / Ljubomirov, Toshko

ZooKeys

2023 Volume 1143, Page(s) 93–163

Abstract: The European species of the potter wasp ... ...

Abstract	The European species of the potter wasp genus
Language	English
Publishing date	2023-01-31
Publishing country	Bulgaria
Document type	Journal Article
ZDB-ID	2445640-8
ISSN	1313-2970 ; 1313-2989
ISSN (online)	1313-2970
ISSN	1313-2989
DOI	10.3897/zookeys.1143.94951
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Article ; Online: Review of the European Eumenes Latreille (Hymenoptera, Vespidae) using morphology and DNA barcodes, with an illustrated key to species

Cornelis van Achterberg / John T. Smit / Toshko Ljubomirov

ZooKeys, Vol 1143, Iss , Pp 93-

2023 Volume 163

Abstract: The European species of the potter wasp genus Eumenes Latreille, 1802 (Vespidae, Eumeninae) are illustrated and a new illustrated key to the 13 recognised species is presented. Eumenes mediterraneus aemilianus Guiglia, 1951 is synonymised with E. ... ...

Abstract	The European species of the potter wasp genus Eumenes Latreille, 1802 (Vespidae, Eumeninae) are illustrated and a new illustrated key to the 13 recognised species is presented. Eumenes mediterraneus aemilianus Guiglia, 1951 is synonymised with E. papillarius (Christ, 1791) (syn. nov.), E. obscurus André, 1884 and E. andrei Dalla Torre, 1894 with E. pedunculatus (Panzer, 1799) (syn. nov.) and E. crimensis Blüthgen, 1938 with E. sareptanus André, 1884 (syn. nov.).
Keywords	Zoology ; QL1-991
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Pensoft Publishers
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Cornelis de Mooy, Arzt und Erfinder (1834-1926)

Sypkens Smit, J. H

Proceedings of the XXIII International Congress of the History of Medicine, London, 2-9 September 1972

1974

Author's details	J. H. Sypkens Smit
MeSH term(s)	Military Medicine/history ; Transportation of Patients/history ; History, Modern 1601-
Keywords	Netherlands
Language	German
Size	p. 483-487.
Publisher	Wellcome Institute of the History of Medicine
Publishing place	London
Document type	Article
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Vancomycin Clearance in Obese Adults is not Predictive of Clearance in Obese Adolescents.

Zhang, Tan / Smit, Cornelis / Sherwin, Catherine M T / Knibbe, Catherijne A J / Krekels, Elke H J

Clinical pharmacokinetics

2023 Volume 62, Issue 5, Page(s) 749–759

Abstract: Background and objective: Contradictory pharmacokinetic (PK) results have been observed between obese adults and obese adolescents, with absolute clearance (CL) reported to be either unaltered, lower, or higher in obese adolescents compared to obese ... ...

Abstract	Background and objective: Contradictory pharmacokinetic (PK) results have been observed between obese adults and obese adolescents, with absolute clearance (CL) reported to be either unaltered, lower, or higher in obese adolescents compared to obese adults. This study investigates the PK of vancomycin in adolescents and adults who are overweight or obese. Methods: Data from 125 overweight and obese adolescents (aged 10-18 years, weight 28.3-188 kg) and 81 overweight and obese adults (aged 29-88 years, weight 66.7-143 kg) were analysed using population PK modelling. In addition to age, sex, renal function estimates, and regular weight descriptors, we evaluated standard weight (WT Results: Analyzing adolescents and adults together, vancomycin CL was found to increase with TBW and decrease with increasing age (p < 0.001). A covariate analysis investigating adolescents and adults separately found that vancomycin CL increased with WT Conclusion: There are apparent differences in vancomycin CL in overweight and obese adults versus overweight and obese adolescents, implying that dosing of vancomycin cannot be directly extrapolated between these populations.
MeSH term(s)	Male ; Female ; Adolescent ; Humans ; Adult ; Overweight ; Vancomycin ; Pediatric Obesity ; Weight Gain ; Models, Biological
Chemical Substances	Vancomycin (6Q205EH1VU)
Language	English
Publishing date	2023-04-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	197627-8
ISSN	1179-1926 ; 0312-5963
ISSN (online)	1179-1926
ISSN	0312-5963
DOI	10.1007/s40262-023-01227-5
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Article ; Online: Drug pharmacokinetics in the obese population: challenging common assumptions on predictors of obesity-related parameter changes.

Zhang, Tan / Krekels, Elke H J / Smit, Cornelis / Knibbe, Catherijne A J

Expert opinion on drug metabolism & toxicology

2022 Volume 18, Issue 10, Page(s) 657–674

Abstract: Introduction: Obesity is associated with many physiological changes. We review available evidence regarding five commonly accepted assumptions to : Areas covered: The investigated assumptions are: 1) lean body weight is the preferred descriptor of ... ...

Abstract	Introduction: Obesity is associated with many physiological changes. We review available evidence regarding five commonly accepted assumptions to Areas covered: The investigated assumptions are: 1) lean body weight is the preferred descriptor of clearance and dose adjustments; 2) volume of distribution increases for lipophilic, but not for hydrophilic drugs; 3) CYP-3A4 activity is suppressed and UGT activity is increased, implying decreased and increased dose requirements for substrates of these enzyme systems, respectively; 4) glomerular filtration rate is enhanced, necessitating higher doses for drugs cleared through glomerular filtration; 5) drug dosing information from obese adults can be extrapolated to obese adolescents. Expert opinion: Available literature contradicts, or at least limits the generalizability, of all five assumptions. Clinical studies should focus on quantifying the impact of duration and severity of obesity on drug PK in adults and adolescents, and also include oral bioavailability and pharmacodynamics in these studies. Physiologically based PK approaches can be used to predict PK changes for individual drugs but can also be used to define in general terms based on patient characteristics and drug properties, when certain assumptions can or cannot be expected to be systematically accurate.
MeSH term(s)	Adolescent ; Adult ; Humans ; Obesity ; Glomerular Filtration Rate ; Pharmacokinetics
Language	English
Publishing date	2022-10-20
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2214462-6
ISSN	1744-7607 ; 1742-5255
ISSN (online)	1744-7607
ISSN	1742-5255
DOI	10.1080/17425255.2022.2132931
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Article ; Online: Optimizing moxidectin dosing for Strongyloides stercoralis infections

Daniela Hofmann / Cornelis Smit / Somphou Sayasone / Marc Pfister / Jennifer Keiser

Clinical and Translational Science, Vol 15, Iss 3, Pp 700-

Insights from pharmacometric modeling

2022 Volume 708

Abstract: Abstract Moxidectin is a frontrunner drug candidate in the treatment of strongyloidiasis. A dose of 8 mg is recommended to treat this indication, which shows a reasonably good efficacy and tolerability profile. Yet, owing to the unique life cycle of ... ...

Abstract	Abstract Moxidectin is a frontrunner drug candidate in the treatment of strongyloidiasis. A dose of 8 mg is recommended to treat this indication, which shows a reasonably good efficacy and tolerability profile. Yet, owing to the unique life cycle of Strongyloides stercoralis (S. stercoralis) that entails internal autoinfection, a curative treatment would be desirable. Population‐based pharmacometric modeling that would help to identify an ideal dosing strategy are yet lacking. The aims of this study were to (i) explore the exposure‐efficacy response relationship of moxidectin in treating S. stercoralis and (ii) evaluate whether moxidectin treatment outcomes in terms of cure rates at baseline as compared to post‐treatment could be optimized. Our pharmacodynamic model suggests high predictive power (area under the concentration time curve‐receiver operating characteristic [AUC‐ROC] 0.817) in the probability of being cured by linking an exposure metric (i.e., AUC0‐24 or maximum concentration [Cmax]) to baseline infection intensity. Pharmacometric simulations indicate that with a minimum dose of 4 mg a maximum cure rate of ~ 95% is established in the low infection intensity group (larvae per gram [LPG] ≥0.4–1), whereas in the moderate‐to‐high intensity group (LPG >1) the cure rate plateaus at ~ 87%, following an 8 mg dose. To enhance efficacy further, studies using repeated dosing based on the duration of the autoinfection cycle, for example a two‐dose regimen 3 weeks apart should be considered. Simulations revealed similar Cmax in both treatment courses of a two‐dose regimen; hence safety should not be a concern. Collectively, our results provide evidence‐based guidance for enhanced dosing strategies and should be considered when designing future treatment strategies.
Keywords	Therapeutics. Pharmacology ; RM1-950 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
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Article ; Online: Optimizing moxidectin dosing for Strongyloides stercoralis infections: Insights from pharmacometric modeling.

Hofmann, Daniela / Smit, Cornelis / Sayasone, Somphou / Pfister, Marc / Keiser, Jennifer

Clinical and translational science

2021 Volume 15, Issue 3, Page(s) 700–708

Abstract: Moxidectin is a frontrunner drug candidate in the treatment of strongyloidiasis. A dose of 8 mg is recommended to treat this indication, which shows a reasonably good efficacy and tolerability profile. Yet, owing to the unique life cycle of Strongyloides ...

Abstract	Moxidectin is a frontrunner drug candidate in the treatment of strongyloidiasis. A dose of 8 mg is recommended to treat this indication, which shows a reasonably good efficacy and tolerability profile. Yet, owing to the unique life cycle of Strongyloides stercoralis (S. stercoralis) that entails internal autoinfection, a curative treatment would be desirable. Population-based pharmacometric modeling that would help to identify an ideal dosing strategy are yet lacking. The aims of this study were to (i) explore the exposure-efficacy response relationship of moxidectin in treating S. stercoralis and (ii) evaluate whether moxidectin treatment outcomes in terms of cure rates at baseline as compared to post-treatment could be optimized. Our pharmacodynamic model suggests high predictive power (area under the concentration time curve-receiver operating characteristic [AUC-ROC] 0.817) in the probability of being cured by linking an exposure metric (i.e., AUC
MeSH term(s)	Animals ; Humans ; Macrolides/adverse effects ; Strongyloides stercoralis ; Strongyloidiasis/diagnosis ; Strongyloidiasis/drug therapy ; Treatment Outcome
Chemical Substances	Macrolides ; moxidectin (NGU5H31YO9)
Language	English
Publishing date	2021-12-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2433157-0
ISSN	1752-8062 ; 1752-8054
ISSN (online)	1752-8062
ISSN	1752-8054
DOI	10.1111/cts.13189
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Article ; Online: How to Dose Vancomycin in Overweight and Obese Patients with Varying Renal (Dys)function in the Novel Era of AUC 400-600 mg·h/L-Targeted Dosing.

Zhang, Tan / Krekels, Elke H J / Smit, Cornelis / van Dongen, Eric P A / Brüggemann, Roger J M / Knibbe, Catherijne A J

Clinical pharmacokinetics

2023 Volume 63, Issue 1, Page(s) 79–91

Abstract: Background and objective: The latest vancomycin guideline recommends area under the curve (AUC)-targeted dosing and monitoring for efficacy and safety. However, guidelines for AUC-targeted starting dosing in patients with obesity and/or renal ... ...

Abstract	Background and objective: The latest vancomycin guideline recommends area under the curve (AUC)-targeted dosing and monitoring for efficacy and safety. However, guidelines for AUC-targeted starting dosing in patients with obesity and/or renal insufficiency are currently lacking. This study quantifies the pharmacokinetics (PK) of vancomycin in this population and provides AUC-targeted dosing recommendations. Methods: Vancomycin concentrations (n = 1188) from therapeutic drug monitoring of 210 overweight and obese patients with varying degrees of renal (dys)function from the ward (74.8%) and intensive care unit (ICU, 25.2%) were pooled with published rich concentration-time data (n = 207) from 20 (morbidly) obese subjects undergoing bariatric surgery. A population model was developed using NONMEM 7.4. Stochastic simulations were performed to design dosing guidelines targeting an AUC Results: Vancomycin clearance (CL) was found to increase linearly with total bodyweight and with renal function (CKD-EPI) in a power relation. Additionally, CL proved 15.5% lower in ICU patients. Our model shows that, to reach the target AUC between 400 and 600 mg·h/L in the first 48 h, two loading doses are required for both continuous infusion and intermittent dosing regimens. Maintenance doses were found to require adjustment for total bodyweight, renal function, and ICU admission status. With this guideline, the median AUC Conclusions: To achieve safe and effective vancomycin exposure for maintenance doses in overweight and obese patients, renal function, total bodyweight, and ICU admission status should be taken into account. Trial registration: The AMIGO trial was registered in the Dutch Trial Registry [NTR6058].
MeSH term(s)	Humans ; Anti-Bacterial Agents/pharmacokinetics ; Area Under Curve ; Kidney ; Obesity/complications ; Obesity/drug therapy ; Overweight/complications ; Overweight/drug therapy ; Vancomycin/pharmacokinetics
Chemical Substances	Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU)
Language	English
Publishing date	2023-11-16
Publishing country	Switzerland
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197627-8
ISSN	1179-1926 ; 0312-5963
ISSN (online)	1179-1926
ISSN	0312-5963
DOI	10.1007/s40262-023-01324-5
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